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The map label for this gene is rmlA1 [C]

Identifier: 121997809

GI number: 121997809

Start: 1090025

End: 1090711

Strand: Reverse

Name: rmlA1 [C]

Synonym: Hhal_1018

Alternate gene names: 121997809

Gene position: 1090711-1090025 (Counterclockwise)

Preceding gene: 121997810

Following gene: 121997808

Centisome position: 40.72

GC content: 73.51

Gene sequence:

>687_bases
ATGCGTGCCATGATCCTGGCCGCCGGGCGCGGCGAGCGGATGCGACCGTTGACCGACACCACTCCGAAACCGCTGCTGGA
GGTGGCGGGGCAGCCGCTGATCGGCTGGCAGCTGCAGCGCCTCGCGGCTGCCGGGGCCGAGACCGTGGTGATCAACACCG
CCTGGCTGGGCGAGCAGATCGAGGCTGTCGTCGGGGACGGCCGGGCCTGGGGGGTGTGTGTGCACTACAGCCGCGAGCCG
GAAGGTGCCCTAGATACCGGGGGCGGGATCCGCGAGGCGCTGCCGTTGCTGGGCGACGGCCTCTTCTGGGTGGTCAATGG
CGACGTTTGGAGCGACTATCCACTGGGGCAGCTGCCGCGCACGCTCAGCGCGGCCGCGCACCTGGTGCTGGTGGACAACC
CGGCCCATCACCCCGACGGCGACTTCGCCCTCGACGACGAAGGGCGCGTGGGCACCGGGGGCGGGCGGCGGCTGACCTTT
GCCGGGATCGGCGCCTTCCACCCTCGCCTTTGGTGGGACTGCCGGCGCGGGCGCTTCCCGCTGGCGCCGCTGCTGCGCGA
CGCGGCACGGCGCGGCGAACTCTCCGGCGAGCACTGGGCGGGGGCCTGGTCCGATATCGGGACCCCGGAGCGGCTCGAGC
AACTGCGCCGCGAGGTGGCCACCGGCGCCGCACCGGTGCCGGAGTAA

Upstream 100 bases:

>100_bases
GCCGCAGCCGAGGAGCAGGCGGCGCTGCGACCGCTGGTCGATGAGGTGCTGGCCCTGGCGGCGGTGCCGGGCCGCGTGTC
GTACGCCGAGGTGGACTGAG

Downstream 100 bases:

>100_bases
CGCGGGGGGGCGACGTGGGACAGGAGATCGGTCGGGCACGGTTCGGGAGCGATGACTTCAGCGCCTTTCGTCAGCGGCTC
CGGGCGGAGACCCGATTGCT

Product: nucleotidyl transferase

Products: dTDPglucose; Diphosphate [C]

Alternate protein names: Nucleotidyltransferase Family Protein; Nucleoside-Diphosphate-Sugar Pyrophosphorylase; Nucleotidyl Transferase Family Protein; Mannose-1-Phosphate Guanyltransferase; Sugar-Phosphate Nucleotidyl Transferase; Nucleotidyltransferase; Mannose-1-Phosphate Guanylyltransferase; Nucleotidyl Transferase Superfamily; Mannose-1-Phosphate Guanyltransferase-Related Protein; Nucleotidyl Transferase Protein; Nucleotidyltransferase Protein; Transaldolase AB; ADP-Glucose Pyrophosphorylase; Mannose-1-Phosphate Guanyltransferase Protein; Sugar Phosphate Nucleotidyltransferase; D-Alpha-D-Mannose-1-Phosphate Guanylyltransferase ManB; Aminoglycoside Phosphotransferase; Glucose-1-Phosphate Nucleotidyltransferase; Nucleotidyl Transferase Superfamily Protein

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRAMILAAGRGERMRPLTDTTPKPLLEVAGQPLIGWQLQRLAAAGAETVVINTAWLGEQIEAVVGDGRAWGVCVHYSREP
EGALDTGGGIREALPLLGDGLFWVVNGDVWSDYPLGQLPRTLSAAAHLVLVDNPAHHPDGDFALDDEGRVGTGGGRRLTF
AGIGAFHPRLWWDCRRGRFPLAPLLRDAARRGELSGEHWAGAWSDIGTPERLEQLRREVATGAAPVPE

Sequences:

>Translated_228_residues
MRAMILAAGRGERMRPLTDTTPKPLLEVAGQPLIGWQLQRLAAAGAETVVINTAWLGEQIEAVVGDGRAWGVCVHYSREP
EGALDTGGGIREALPLLGDGLFWVVNGDVWSDYPLGQLPRTLSAAAHLVLVDNPAHHPDGDFALDDEGRVGTGGGRRLTF
AGIGAFHPRLWWDCRRGRFPLAPLLRDAARRGELSGEHWAGAWSDIGTPERLEQLRREVATGAAPVPE
>Mature_228_residues
MRAMILAAGRGERMRPLTDTTPKPLLEVAGQPLIGWQLQRLAAAGAETVVINTAWLGEQIEAVVGDGRAWGVCVHYSREP
EGALDTGGGIREALPLLGDGLFWVVNGDVWSDYPLGQLPRTLSAAAHLVLVDNPAHHPDGDFALDDEGRVGTGGGRRLTF
AGIGAFHPRLWWDCRRGRFPLAPLLRDAARRGELSGEHWAGAWSDIGTPERLEQLRREVATGAAPVPE

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11761621, Length=229, Percent_Identity=28.3842794759825, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI11761619, Length=229, Percent_Identity=28.3842794759825, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=230, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=121, Percent_Identity=36.3636363636364, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21355443, Length=229, Percent_Identity=29.6943231441048, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24644084, Length=229, Percent_Identity=29.6943231441048, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.7.24 [C]

Molecular weight: Translated: 24597; Mature: 24597

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMILAAGRGERMRPLTDTTPKPLLEVAGQPLIGWQLQRLAAAGAETVVINTAWLGEQI
CCEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEHHCCHHH
EAVVGDGRAWGVCVHYSREPEGALDTGGGIREALPLLGDGLFWVVNGDVWSDYPLGQLPR
HHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHCCH
TLSAAAHLVLVDNPAHHPDGDFALDDEGRVGTGGGRRLTFAGIGAFHPRLWWDCRRGRFP
HHHHCEEEEEECCCCCCCCCCEEECCCCCEECCCCCEEEEEECCCCCCHHHHHHCCCCCC
LAPLLRDAARRGELSGEHWAGAWSDIGTPERLEQLRREVATGAAPVPE
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRAMILAAGRGERMRPLTDTTPKPLLEVAGQPLIGWQLQRLAAAGAETVVINTAWLGEQI
CCEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEHHCCHHH
EAVVGDGRAWGVCVHYSREPEGALDTGGGIREALPLLGDGLFWVVNGDVWSDYPLGQLPR
HHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHCCH
TLSAAAHLVLVDNPAHHPDGDFALDDEGRVGTGGGRRLTFAGIGAFHPRLWWDCRRGRFP
HHHHCEEEEEECCCCCCCCCCEEECCCCCEECCCCCEEEEEECCCCCCHHHHHHCCCCCC
LAPLLRDAARRGELSGEHWAGAWSDIGTPERLEQLRREVATGAAPVPE
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dTTP; D-Glucose 1-phosphate; H+ [C]

Specific reaction: dTTP + D-Glucose 1-phosphate + H+ --> dTDPglucose + Diphosphate [C]

General reaction: Nucleotidyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA