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The map label for this gene is ipk

Identifier: 121997781

GI number: 121997781

Start: 1062255

End: 1063121

Strand: Reverse

Name: ipk

Synonym: Hhal_0990

Alternate gene names: 121997781

Gene position: 1063121-1062255 (Counterclockwise)

Preceding gene: 121997782

Following gene: 121997780

Centisome position: 39.69

GC content: 71.51

Gene sequence:

>867_bases
ATGACTGAATGGAGCGTCTGGCCGGCCCCGGCCAAGATCAACCTCTTTCTCCACGTCCTCGGCCGGCGTGCCGACGGCTA
CCACGAGCTGCAGACCGCCTTCCAGCTGCTCGGCTACGGGGATCGCATCTGGCTGCGCCCGCGTGTCGACGGACGGGTGG
AGCGCTGCAGCCATCTGCCCGGCGTGGCCGCGGAGGACGACCTCACCGTTCGCGCAGCGCGGGCGCTTCAGGCGGCCACC
GGCAGCGCGGGCGGGGTCGATATCCACGTGGACAAGCGCCTGCCGGCCGGCGGGGGAGTCGGTGGCGGTTCCTCGGACGC
CGCCACCGTGCTGGTCGCCCTGAACCATCTGTGGCAGACGGGGCTGGATGAGGAGGCGCTGGCCGGCATCGGTCTGGCCC
TGGGGGCCGACGTCCCGGTGTTCGTGCGCGGGCGCAGCGCCTGGGGCGAGGGGGTGGGCGAGCAGCTGCGCCCCATGCCG
GTGGACCCGGCGGGTAGCCGCTGGTATCTGGTGGTCGACCCGGGGGCGAGTATCTCCACCGCCGAAGTCTTTGGCGCGCC
GGAATTGACACGGGATACGTCTCCGATCACAATACCCGACCTTCGCGCCGGCGCCGTTCGCAACGACTGTGAGCCGGTGG
TTCGGAGCCGCTGGCCGGCAGTCGCCGAGGCGCTCGAGTGGCTCGGCCGGCACGGTCAGGCGCGAATGAGTGGTACCGGC
AGCTGCTGTTTCGTCGGCTTCCCCGGTGAGGCCGAGGCGCAAGCTGCCCTGGAGCGTCTACCCGGAGCGTGGTCCGGGTT
CGTCGCTCAGGCCGTGGAACGGTCTCCGCTGCACCTTACGCTCGCGGAGGCCGCCCGTACCGGCTGA

Upstream 100 bases:

>100_bases
GGGTGGACGGACGTCGATGGGGTCGATCTGCCGAGCCGGGTCGATCTGACCCGCGGTTCGACGCAGATGCGGGTCGCCCT
CTCAGGCTGGAGTCGCAGCG

Downstream 100 bases:

>100_bases
CCTGTCAACAACTGGGGCGTAGCCAAGCGGTAAGGCACCGGTTTTTGGTACCGGGATTCGCAGGTTCGAATCCTGCCGCC
CCAGCCATATCCGCTACACG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTEWSVWPAPAKINLFLHVLGRRADGYHELQTAFQLLGYGDRIWLRPRVDGRVERCSHLPGVAAEDDLTVRAARALQAAT
GSAGGVDIHVDKRLPAGGGVGGGSSDAATVLVALNHLWQTGLDEEALAGIGLALGADVPVFVRGRSAWGEGVGEQLRPMP
VDPAGSRWYLVVDPGASISTAEVFGAPELTRDTSPITIPDLRAGAVRNDCEPVVRSRWPAVAEALEWLGRHGQARMSGTG
SCCFVGFPGEAEAQAALERLPGAWSGFVAQAVERSPLHLTLAEAARTG

Sequences:

>Translated_288_residues
MTEWSVWPAPAKINLFLHVLGRRADGYHELQTAFQLLGYGDRIWLRPRVDGRVERCSHLPGVAAEDDLTVRAARALQAAT
GSAGGVDIHVDKRLPAGGGVGGGSSDAATVLVALNHLWQTGLDEEALAGIGLALGADVPVFVRGRSAWGEGVGEQLRPMP
VDPAGSRWYLVVDPGASISTAEVFGAPELTRDTSPITIPDLRAGAVRNDCEPVVRSRWPAVAEALEWLGRHGQARMSGTG
SCCFVGFPGEAEAQAALERLPGAWSGFVAQAVERSPLHLTLAEAARTG
>Mature_287_residues
TEWSVWPAPAKINLFLHVLGRRADGYHELQTAFQLLGYGDRIWLRPRVDGRVERCSHLPGVAAEDDLTVRAARALQAATG
SAGGVDIHVDKRLPAGGGVGGGSSDAATVLVALNHLWQTGLDEEALAGIGLALGADVPVFVRGRSAWGEGVGEQLRPMPV
DPAGSRWYLVVDPGASISTAEVFGAPELTRDTSPITIPDLRAGAVRNDCEPVVRSRWPAVAEALEWLGRHGQARMSGTGS
CCFVGFPGEAEAQAALERLPGAWSGFVAQAVERSPLHLTLAEAARTG

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=278, Percent_Identity=52.158273381295, Blast_Score=260, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_HALHL (A1WVQ4)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002568.1
- ProteinModelPortal:   A1WVQ4
- STRING:   A1WVQ4
- GeneID:   4709377
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0990
- eggNOG:   COG1947
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- PhylomeDB:   A1WVQ4
- ProtClustDB:   PRK00343
- BioCyc:   HHAL349124:HHAL_0990-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 30391; Mature: 30259

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: ACT_SITE 12-12 ACT_SITE 137-137

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEWSVWPAPAKINLFLHVLGRRADGYHELQTAFQLLGYGDRIWLRPRVDGRVERCSHLP
CCCCCCCCCCHHHEEHHEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCC
GVAAEDDLTVRAARALQAATGSAGGVDIHVDKRLPAGGGVGGGSSDAATVLVALNHLWQT
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GLDEEALAGIGLALGADVPVFVRGRSAWGEGVGEQLRPMPVDPAGSRWYLVVDPGASIST
CCCHHHHHHHHHHHCCCCCEEEECCCHHHCCHHHHCCCCCCCCCCCEEEEEECCCCCCCH
AEVFGAPELTRDTSPITIPDLRAGAVRNDCEPVVRSRWPAVAEALEWLGRHGQARMSGTG
HHHCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCEEECCCC
SCCFVGFPGEAEAQAALERLPGAWSGFVAQAVERSPLHLTLAEAARTG
CEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEHHHHCCC
>Mature Secondary Structure 
TEWSVWPAPAKINLFLHVLGRRADGYHELQTAFQLLGYGDRIWLRPRVDGRVERCSHLP
CCCCCCCCCHHHEEHHEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCC
GVAAEDDLTVRAARALQAATGSAGGVDIHVDKRLPAGGGVGGGSSDAATVLVALNHLWQT
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GLDEEALAGIGLALGADVPVFVRGRSAWGEGVGEQLRPMPVDPAGSRWYLVVDPGASIST
CCCHHHHHHHHHHHCCCCCEEEECCCHHHCCHHHHCCCCCCCCCCCEEEEEECCCCCCCH
AEVFGAPELTRDTSPITIPDLRAGAVRNDCEPVVRSRWPAVAEALEWLGRHGQARMSGTG
HHHCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCEEECCCC
SCCFVGFPGEAEAQAALERLPGAWSGFVAQAVERSPLHLTLAEAARTG
CEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA