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The map label for this gene is dxs [H]

Identifier: 121997774

GI number: 121997774

Start: 1055088

End: 1056962

Strand: Reverse

Name: dxs [H]

Synonym: Hhal_0983

Alternate gene names: 121997774

Gene position: 1056962-1055088 (Counterclockwise)

Preceding gene: 121997775

Following gene: 121997773

Centisome position: 39.46

GC content: 70.35

Gene sequence:

>1875_bases
ATGACCATGGGAACGCACGACGAGGACAAGGTATTGCTGTCGGCCATCGACGATCCGGAGGATCTGCGGCGCCTGCCGCT
GGAGCGATTGCCGGCCGTGGCCCAGGAGATGCGCGACTATCTGGTCGAGAGCGTCTCGCAGAGCGGGGGGCACCTCGCTG
CCGGGCTCGGGGCCGTGGAGCTGACCCTGGCGCTGCACTACGCCCTGGATACCCCCCGCGATCGGCTCGTATGGGACGTT
GGCCACCAGTGCTACGCCCACAAGGTCCTGACCGGCCGGCGCAGCCAGCTGCCCCGCATCCGCCAGGCCGGCGGTCCCGC
CGGTTTCCCCGTACGCGACGAGAGTCCCTACGACGCCTTCGGGGTCGGCCACTCCTCGACGAGCATCAGCGCCGCCCTAG
GCATGGCGCTGGCCGAGCGCGCCGGCGGCGAACACCGGCGGTGCGCCGCGATCATCGGCGACGGTGGGCTCAGCGCCGGC
GAGGCACTGGAGGCACTCAACCACGCCGGCGACGTGAAGGCCGATCTGCTGGTGGTGCTCAACGACAACGAGATGTCCAT
CTCGGAGAACGTCGGCGCCCTTTCCAACTACCTGACCCGGTTGCTCTCCGAGCCGTTGGCGGGGCAGTTGCGCCGCGGTG
CCCGGGACATGCTCCGCTATCTGCCGCCGATTCACGAGTTGGCCCGGCGCACCGAAGGCCATGTGAAGGGGCTGCTGGCT
CCGGCCACGCTCTTCGAGGAACTGGGCTTCCACTACTTCGGCCCGGTGGACGGGCACAACGTCGAGGGGCTGGTACGCGT
CCTGCGCAACCTCCGTGATCAGCCCGGTCCGCGGCTGCTCCACGTGGTTACCCGCAAGGGCAAGGGGTACGCCCCGGCCG
AGGAAGACCCCATCTCCTACCACGGGGTGAGCTGCTTCGACCCGGCCCGCGGGCTCACCAAGGGCACACCGGCCAAGCTC
AACTACACCGATGTCTTCAGTCGCTGGATCTGCCGGGCTGCCTGCACCGACGAGCGGGTGGTGGCCATCACTCCGGCGAT
GCGCGAGGGCTCGGGACTGGTGGAGTACGCCCGGCGCTTCCCCGAACGCTTCTTCGATGTCGGCATCGCCGAGCAGCACG
CTGTCACCCTGGCTGCCGGGCTGGCCTGCGAGGGCGCGCGCCCGGTGGTGGCTATCTACTCCACCTTCCTGCAGCGTGGT
TACGACCAGGTCATCCACGACGTCGCCCTGCAGCGCCTGCCGGTGCTCTTCGCCGTGGATCGGGCGGGCATCGTCGGCGC
CGATGGGGCCACCCACCAGGGCACCTACGACCTCAGCTACCTGCGCTGCATCCCGGATCTCACCGTCATGGCCCCGGCCG
ACGAGGCGGAGTGCTGGCGGATGCTCGCCACGGGGCTGGTGCTCGAGGGCGCCTCGGCGGTGCGCTACCCGCGCGGGACC
GGTCCCGGCGAGGCCCTGCCCGACGACATGGAACCCCTGCCTGTGGGACAGGCCGAGGTGCGCCGAGAGGGCGGCAGTGG
GGTGGCCCTGCTCGCCTTCGGTGCCCTGCTCCCGGTGGCCGAGGCCGTTGGCGAAGAGCTTGACGCCACGGTGGTGAACA
TGCGCTTCGTCAAGCCGCTGGATGAGGCCCTGCTGCGCCGGCTGGCCGGCGAGTGTCGCCACCTGGTGACGCTGGAGGAG
AACGTCATCGCCGGCGGCGCCGGCAGCGGTGTTGCCGAGTACCTGTCCAGCATCGGCGTGCATACCCCGATCACCCACCT
GGGGCTGCCGGACGCCCCTGTGCACCACGGGGCGCGCAATGACATCCTGGCCGAGCATGGCCTGGACCGGGACGGGGTGC
GCCGGACCGTGCAGGGTCTCCTGCAGCAGTCGTAG

Upstream 100 bases:

>100_bases
ATCCTAGCCCGGGCCGTCCGCCCTTAGGGCCGGGCGATGGGCGAGGCACTTCGACGCCGACCCTAGTCCAGGCCGCGCCT
GAATCGGCTATCATGCCCCG

Downstream 100 bases:

>100_bases
GGAAGGGGGCGCCATGCCCGAGGCTTCGCTGGTCGAGGACGCGCTGGCCCGCAACAAGGCGCGGCACGAGCACTACGCCG
GGCTGGATTACGTCCGGCTC

Product: deoxyxylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MTMGTHDEDKVLLSAIDDPEDLRRLPLERLPAVAQEMRDYLVESVSQSGGHLAAGLGAVELTLALHYALDTPRDRLVWDV
GHQCYAHKVLTGRRSQLPRIRQAGGPAGFPVRDESPYDAFGVGHSSTSISAALGMALAERAGGEHRRCAAIIGDGGLSAG
EALEALNHAGDVKADLLVVLNDNEMSISENVGALSNYLTRLLSEPLAGQLRRGARDMLRYLPPIHELARRTEGHVKGLLA
PATLFEELGFHYFGPVDGHNVEGLVRVLRNLRDQPGPRLLHVVTRKGKGYAPAEEDPISYHGVSCFDPARGLTKGTPAKL
NYTDVFSRWICRAACTDERVVAITPAMREGSGLVEYARRFPERFFDVGIAEQHAVTLAAGLACEGARPVVAIYSTFLQRG
YDQVIHDVALQRLPVLFAVDRAGIVGADGATHQGTYDLSYLRCIPDLTVMAPADEAECWRMLATGLVLEGASAVRYPRGT
GPGEALPDDMEPLPVGQAEVRREGGSGVALLAFGALLPVAEAVGEELDATVVNMRFVKPLDEALLRRLAGECRHLVTLEE
NVIAGGAGSGVAEYLSSIGVHTPITHLGLPDAPVHHGARNDILAEHGLDRDGVRRTVQGLLQQS

Sequences:

>Translated_624_residues
MTMGTHDEDKVLLSAIDDPEDLRRLPLERLPAVAQEMRDYLVESVSQSGGHLAAGLGAVELTLALHYALDTPRDRLVWDV
GHQCYAHKVLTGRRSQLPRIRQAGGPAGFPVRDESPYDAFGVGHSSTSISAALGMALAERAGGEHRRCAAIIGDGGLSAG
EALEALNHAGDVKADLLVVLNDNEMSISENVGALSNYLTRLLSEPLAGQLRRGARDMLRYLPPIHELARRTEGHVKGLLA
PATLFEELGFHYFGPVDGHNVEGLVRVLRNLRDQPGPRLLHVVTRKGKGYAPAEEDPISYHGVSCFDPARGLTKGTPAKL
NYTDVFSRWICRAACTDERVVAITPAMREGSGLVEYARRFPERFFDVGIAEQHAVTLAAGLACEGARPVVAIYSTFLQRG
YDQVIHDVALQRLPVLFAVDRAGIVGADGATHQGTYDLSYLRCIPDLTVMAPADEAECWRMLATGLVLEGASAVRYPRGT
GPGEALPDDMEPLPVGQAEVRREGGSGVALLAFGALLPVAEAVGEELDATVVNMRFVKPLDEALLRRLAGECRHLVTLEE
NVIAGGAGSGVAEYLSSIGVHTPITHLGLPDAPVHHGARNDILAEHGLDRDGVRRTVQGLLQQS
>Mature_623_residues
TMGTHDEDKVLLSAIDDPEDLRRLPLERLPAVAQEMRDYLVESVSQSGGHLAAGLGAVELTLALHYALDTPRDRLVWDVG
HQCYAHKVLTGRRSQLPRIRQAGGPAGFPVRDESPYDAFGVGHSSTSISAALGMALAERAGGEHRRCAAIIGDGGLSAGE
ALEALNHAGDVKADLLVVLNDNEMSISENVGALSNYLTRLLSEPLAGQLRRGARDMLRYLPPIHELARRTEGHVKGLLAP
ATLFEELGFHYFGPVDGHNVEGLVRVLRNLRDQPGPRLLHVVTRKGKGYAPAEEDPISYHGVSCFDPARGLTKGTPAKLN
YTDVFSRWICRAACTDERVVAITPAMREGSGLVEYARRFPERFFDVGIAEQHAVTLAAGLACEGARPVVAIYSTFLQRGY
DQVIHDVALQRLPVLFAVDRAGIVGADGATHQGTYDLSYLRCIPDLTVMAPADEAECWRMLATGLVLEGASAVRYPRGTG
PGEALPDDMEPLPVGQAEVRREGGSGVALLAFGALLPVAEAVGEELDATVVNMRFVKPLDEALLRRLAGECRHLVTLEEN
VIAGGAGSGVAEYLSSIGVHTPITHLGLPDAPVHHGARNDILAEHGLDRDGVRRTVQGLLQQS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=666, Percent_Identity=24.024024024024, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI4507521, Length=666, Percent_Identity=24.024024024024, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI225637461, Length=428, Percent_Identity=24.7663551401869, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225637459, Length=428, Percent_Identity=24.7663551401869, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225637463, Length=428, Percent_Identity=24.7663551401869, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786622, Length=611, Percent_Identity=56.6284779050737, Blast_Score=715, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=590, Percent_Identity=24.7457627118644, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24666278, Length=618, Percent_Identity=27.0226537216829, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45551847, Length=625, Percent_Identity=24.48, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45550715, Length=625, Percent_Identity=24.48, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24645119, Length=582, Percent_Identity=24.914089347079, Blast_Score=92, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67052; Mature: 66921

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMGTHDEDKVLLSAIDDPEDLRRLPLERLPAVAQEMRDYLVESVSQSGGHLAAGLGAVE
CCCCCCCCCCHHEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHH
LTLALHYALDTPRDRLVWDVGHQCYAHKVLTGRRSQLPRIRQAGGPAGFPVRDESPYDAF
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHCCCCCCCCCCCCCCCCCC
GVGHSSTSISAALGMALAERAGGEHRRCAAIIGDGGLSAGEALEALNHAGDVKADLLVVL
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEE
NDNEMSISENVGALSNYLTRLLSEPLAGQLRRGARDMLRYLPPIHELARRTEGHVKGLLA
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHH
PATLFEELGFHYFGPVDGHNVEGLVRVLRNLRDQPGPRLLHVVTRKGKGYAPAEEDPISY
HHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCC
HGVSCFDPARGLTKGTPAKLNYTDVFSRWICRAACTDERVVAITPAMREGSGLVEYARRF
CCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHCCCCHHHHHHHH
PERFFDVGIAEQHAVTLAAGLACEGARPVVAIYSTFLQRGYDQVIHDVALQRLPVLFAVD
HHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEC
RAGIVGADGATHQGTYDLSYLRCIPDLTVMAPADEAECWRMLATGLVLEGASAVRYPRGT
CCCEECCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCCC
GPGEALPDDMEPLPVGQAEVRREGGSGVALLAFGALLPVAEAVGEELDATVVNMRFVKPL
CCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEALLRRLAGECRHLVTLEENVIAGGAGSGVAEYLSSIGVHTPITHLGLPDAPVHHGARN
HHHHHHHHHHHHHHHEEECCCEEECCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCC
DILAEHGLDRDGVRRTVQGLLQQS
CHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TMGTHDEDKVLLSAIDDPEDLRRLPLERLPAVAQEMRDYLVESVSQSGGHLAAGLGAVE
CCCCCCCCCHHEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHH
LTLALHYALDTPRDRLVWDVGHQCYAHKVLTGRRSQLPRIRQAGGPAGFPVRDESPYDAF
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHCCCCCCCCCCCCCCCCCC
GVGHSSTSISAALGMALAERAGGEHRRCAAIIGDGGLSAGEALEALNHAGDVKADLLVVL
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEE
NDNEMSISENVGALSNYLTRLLSEPLAGQLRRGARDMLRYLPPIHELARRTEGHVKGLLA
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHH
PATLFEELGFHYFGPVDGHNVEGLVRVLRNLRDQPGPRLLHVVTRKGKGYAPAEEDPISY
HHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCC
HGVSCFDPARGLTKGTPAKLNYTDVFSRWICRAACTDERVVAITPAMREGSGLVEYARRF
CCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHCCCCHHHHHHHH
PERFFDVGIAEQHAVTLAAGLACEGARPVVAIYSTFLQRGYDQVIHDVALQRLPVLFAVD
HHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEC
RAGIVGADGATHQGTYDLSYLRCIPDLTVMAPADEAECWRMLATGLVLEGASAVRYPRGT
CCCEECCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCCC
GPGEALPDDMEPLPVGQAEVRREGGSGVALLAFGALLPVAEAVGEELDATVVNMRFVKPL
CCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEALLRRLAGECRHLVTLEENVIAGGAGSGVAEYLSSIGVHTPITHLGLPDAPVHHGARN
HHHHHHHHHHHHHHHEEECCCEEECCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCC
DILAEHGLDRDGVRRTVQGLLQQS
CHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA