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The map label for this gene is ycsA [H]

Identifier: 121997620

GI number: 121997620

Start: 910971

End: 912140

Strand: Reverse

Name: ycsA [H]

Synonym: Hhal_0829

Alternate gene names: 121997620

Gene position: 912140-910971 (Counterclockwise)

Preceding gene: 121997621

Following gene: 121997619

Centisome position: 34.05

GC content: 74.96

Gene sequence:

>1170_bases
ATGGAACAGAACCAGGAGTCCTGGCAGGTCGCCGTGATGCCCGGCGATGGCATCGGCCCGGAGGTCATGGCCGCCACCCG
CCACGCCCTGGAGGCCCTCCCCGGGCCCGCCCTGGTGCTGACCGAGCTGGGCTGGCCCGCCCACGCCTGGCACCGCGACC
ACGGCGAGATGATGCCCGCCGACTGGCGCGGGCAGCTCGCCGGCTACGACGCACTGCTCCTCGGCGCCCTGGGTGACCCC
GGGCCCAGCCACGACGCCCAGCGCTACTGCCTTCCCGACGGCGTCTCGCTGGCGCCGCTGCTGCAGCTGCGCAAGGGGCT
CGACCTGTGGGCCTGCGAGCGCCCGGCGGTGCCCTTGGCCGGCGCCCCCATGCCCCTGTCGGACCCGCGGGCGCTGCACA
CCGACCTGCTCGTCATCCGCGAGAACAGCGAGGGCGAGTACGTCGACCAGGGCGGCCGCCTGGCCGCCGGCACCCCGCGC
GAGACCGCCACCCAGCTGGAGGTCTTCACCCGCGCCGGTACCGAGCGGATCATCCGCCACGCCTTCGAGCGCGCCGCGCG
GCGGGCCGAGGAGCGCCGCCAGGGGCTGCGCGCCCCGCGCTACGCCGCCGCAGACGGCGCTGCCGACGCCGCGGTGTGCG
TGGTCACCAAGCGCAACGCCGTGCAGTACGCCGGTGAGCTGTGGAGCGAGGTGTTCGCCGAGGTGGCCGCCGAGTACCCC
GGCATCGCCACCCACCACGAGCTCATCGACGCGTGCTGCATGAAGTTCGTCAGCCAGCCGTGGCAGTTCGACGTGGTGGT
GGCCAGCAACCTCCACGGCGACATTCTCACTGATTTGGCCGCGGTGCTCGCCGGCGGCATGGGCGTCGCCCCCTCGGCCA
ACCTCAACCCCGCCGACCGCAGCGTACCGCCGCTGTTCGAACCCACCCACGGCAGCGCCCCGGATATCGCCGGCGCCGAT
CGCGCCCACCCAGCAGCCATGCTGCTCACCGCCGCCGCCATGCTCGAGTGGATGGGCGAGGTGGACCCGGTGGCCGCCCG
CTCGGCGGTGCAGCTCCAGCGCGCCGTGGCCGAGGACATCGCCGAGCACGGTATGGGCGGGCGCGGCTGCGCCGAGGTCG
GCCGCGCCGTGGCGCAACGCATCCGGACGGCCGGCGCGCCGTCCGCGTAG

Upstream 100 bases:

>100_bases
GCATGGACCAAACCGCCGCCGAGCTCGCCGAAGAGCGTGACGCGGTGGCGCATCTGCTGCCCTGAGCGGCAGCGGCGGAC
AACGCCCGGGGAGGGCCCGC

Downstream 100 bases:

>100_bases
ACGGAGGCAGAACCCATGCGACTGCACTTCTACGGTGCCACCCGCCAGGTCACCGGCTCCTGCATGCTCCTCGAGGCCGG
CGGGCGTCGGGTGCTCATCG

Product: 3-isopropylmalate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MEQNQESWQVAVMPGDGIGPEVMAATRHALEALPGPALVLTELGWPAHAWHRDHGEMMPADWRGQLAGYDALLLGALGDP
GPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGAPMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPR
ETATQLEVFTRAGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYP
GIATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSVPPLFEPTHGSAPDIAGAD
RAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAEHGMGGRGCAEVGRAVAQRIRTAGAPSA

Sequences:

>Translated_389_residues
MEQNQESWQVAVMPGDGIGPEVMAATRHALEALPGPALVLTELGWPAHAWHRDHGEMMPADWRGQLAGYDALLLGALGDP
GPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGAPMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPR
ETATQLEVFTRAGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYP
GIATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSVPPLFEPTHGSAPDIAGAD
RAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAEHGMGGRGCAEVGRAVAQRIRTAGAPSA
>Mature_389_residues
MEQNQESWQVAVMPGDGIGPEVMAATRHALEALPGPALVLTELGWPAHAWHRDHGEMMPADWRGQLAGYDALLLGALGDP
GPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGAPMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPR
ETATQLEVFTRAGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYP
GIATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSVPPLFEPTHGSAPDIAGAD
RAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAEHGMGGRGCAEVGRAVAQRIRTAGAPSA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=383, Percent_Identity=30.2872062663185, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI28178816, Length=353, Percent_Identity=29.4617563739377, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI28178821, Length=353, Percent_Identity=29.4617563739377, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4758582, Length=379, Percent_Identity=28.4960422163588, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI28178838, Length=333, Percent_Identity=28.8288288288288, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI28178819, Length=176, Percent_Identity=34.6590909090909, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788101, Length=363, Percent_Identity=39.6694214876033, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI87081683, Length=377, Percent_Identity=35.8090185676393, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787381, Length=276, Percent_Identity=27.536231884058, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71986051, Length=381, Percent_Identity=31.496062992126, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI25144293, Length=335, Percent_Identity=30.4477611940298, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17550882, Length=338, Percent_Identity=28.4023668639053, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=384, Percent_Identity=27.8645833333333, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324709, Length=365, Percent_Identity=32.3287671232877, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322097, Length=355, Percent_Identity=29.8591549295775, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324291, Length=362, Percent_Identity=29.2817679558011, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319830, Length=386, Percent_Identity=27.4611398963731, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24643270, Length=386, Percent_Identity=30.5699481865285, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24643268, Length=386, Percent_Identity=30.5699481865285, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24661184, Length=383, Percent_Identity=27.4151436031332, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI161078633, Length=363, Percent_Identity=25.6198347107438, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24650122, Length=363, Percent_Identity=25.6198347107438, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161078637, Length=363, Percent_Identity=25.6198347107438, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161078635, Length=363, Percent_Identity=25.6198347107438, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161078639, Length=361, Percent_Identity=25.4847645429363, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281362242, Length=341, Percent_Identity=24.3401759530792, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24648872, Length=341, Percent_Identity=24.3401759530792, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI20130355, Length=381, Percent_Identity=22.8346456692913, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 41275; Mature: 41275

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQNQESWQVAVMPGDGIGPEVMAATRHALEALPGPALVLTELGWPAHAWHRDHGEMMPA
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCCCCCCCCC
DWRGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLA
CCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCC
GAPMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRH
CCCCCCCCCCHHCCEEEEEEECCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHH
AFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
GIATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADR
CCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SVPPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AEHGMGGRGCAEVGRAVAQRIRTAGAPSA
HHHCCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEQNQESWQVAVMPGDGIGPEVMAATRHALEALPGPALVLTELGWPAHAWHRDHGEMMPA
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCCCCCCCCC
DWRGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLA
CCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCC
GAPMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRH
CCCCCCCCCCHHCCEEEEEEECCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHH
AFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
GIATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADR
CCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SVPPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AEHGMGGRGCAEVGRAVAQRIRTAGAPSA
HHHCCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]