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The map label for this gene is 121997619

Identifier: 121997619

GI number: 121997619

Start: 909525

End: 910955

Strand: Reverse

Name: 121997619

Synonym: Hhal_0828

Alternate gene names: NA

Gene position: 910955-909525 (Counterclockwise)

Preceding gene: 121997620

Following gene: 121997618

Centisome position: 34.01

GC content: 71.42

Gene sequence:

>1431_bases
ATGCGACTGCACTTCTACGGTGCCACCCGCCAGGTCACCGGCTCCTGCATGCTCCTCGAGGCCGGCGGGCGTCGGGTGCT
CATCGACTGCGGCCTGATCCAGGGCGGTGGCAAGCAGGAGGCCCGCAACCGCGAGCCGTTCCCCTTCGACCCGACCACCC
TCGACGCCGTGGTGCTCACCCACGCCCATCTGGATCACAGCGGCCGCCTGCCGCTGCTGGTGCGTTCCGGCTACGACGGC
CCCATCCACACCCACACCGCCGGTGCCGCCCTGGTCGACATCCTGCTGCGCGATGCCGCCTTCCTCGCCGAGCGTGACGC
GGCCATCGAGAACAAGAAGCGCCGCCGCCGTCACGACGAGCCCGTCGAGCCCACCTACACCGTCGCCGACGCCGAGCAGA
CCATCGAGGCCCTGGTCGGCCACGCCTACGACGAACCGTGGCAGCCGGTCCCCGGCGTCACCGTGCGCCTGCGCGACGCC
GGCCACATCCTCGGCTCGGCCATCGTCGAGATGTGGATCGAGGCCGACGGCGAGCGCCGCAAGGTGGTCTTCTCCGGCGA
CCTGGGCCACGCCGGGGCGCCGATCCTGCGCAACCCCACCGAGGTGGGCGAGGCCGATCTGCTGGTCATGGAGAGCACCT
ACGGCGACCGCGACCACCGCTCCTGGGAGGAGACCTGGGAGGAACTCGGCGAGATCATCCGTAACGCCCGGGCCTCCCAC
GGCAACATCCTGGTGCCCGCCTTCGCCGTCGGCCGTACCCAGGAGCTGCTCTACATCCTTGCCCGCCACTACGAGGCCTG
GGAGCTCGGCGACTGGAGCGTGTTCCTCGACAGCCCCATGGCCATCGAGGCGACCAAGGTCTACGCCCGCTTCCCCGAGC
TCTACGACGCCGAGACCGCCGCCTTCTACGCCGAGCCGGACCACCACCGCTTCCAGCTGCCCAACCTGCGCCTCACCCCC
CAGGCCGAAGACTCCATGGCCATCAACCGCGTGCAGTCCGGGGCGCTGATCATCGCCGGCTCGGGGATGTGCAACGGTGG
GCGCATCCGCCACCATTTCAAGCACAACCTGTGGCGGCGCAACTGCAACGTCATCATGGTCGGCTTCCAGGCCCAGGGCA
CCCCGGGGCGCGCCCTGGTCGACGGCGCCAGCGAACTCAACCTGTGGGGCGAGTCGGTGCGGGTCGGCGCCAAGGTGCAC
ACCGTCGGCGGGCTCTCCGCCCACGCCGGGCGCTCGGAGCTTATCGCCTGGGCCGAGCACTTCGCCACGGCCCCCCGGGT
GGCCCTGGTCCACGGCGAGGCCGGGGCCATGGACAGCCTCGCCGAGGCGCTGCGCGGGCGCGGTCTCGAGGTCGAGACCC
CGGAGGAGGGCGCGAGTATCGACCTGCGCCAGCTGCCCGCCCGCAGCGCAGAGCCGCCCGAAGCAAGCTAG

Upstream 100 bases:

>100_bases
GCACGGTATGGGCGGGCGCGGCTGCGCCGAGGTCGGCCGCGCCGTGGCGCAACGCATCCGGACGGCCGGCGCGCCGTCCG
CGTAGACGGAGGCAGAACCC

Downstream 100 bases:

>100_bases
TTTAGTCCAGAGAGGGCCGCCGCGCGGCGGCCCAGCAGTCAACGGCCAAGGCAACCGGCCGAGCGGAGGACCTGCACCAT
GAGCGACGCGCACAAGACCG

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MRLHFYGATRQVTGSCMLLEAGGRRVLIDCGLIQGGGKQEARNREPFPFDPTTLDAVVLTHAHLDHSGRLPLLVRSGYDG
PIHTHTAGAALVDILLRDAAFLAERDAAIENKKRRRRHDEPVEPTYTVADAEQTIEALVGHAYDEPWQPVPGVTVRLRDA
GHILGSAIVEMWIEADGERRKVVFSGDLGHAGAPILRNPTEVGEADLLVMESTYGDRDHRSWEETWEELGEIIRNARASH
GNILVPAFAVGRTQELLYILARHYEAWELGDWSVFLDSPMAIEATKVYARFPELYDAETAAFYAEPDHHRFQLPNLRLTP
QAEDSMAINRVQSGALIIAGSGMCNGGRIRHHFKHNLWRRNCNVIMVGFQAQGTPGRALVDGASELNLWGESVRVGAKVH
TVGGLSAHAGRSELIAWAEHFATAPRVALVHGEAGAMDSLAEALRGRGLEVETPEEGASIDLRQLPARSAEPPEAS

Sequences:

>Translated_476_residues
MRLHFYGATRQVTGSCMLLEAGGRRVLIDCGLIQGGGKQEARNREPFPFDPTTLDAVVLTHAHLDHSGRLPLLVRSGYDG
PIHTHTAGAALVDILLRDAAFLAERDAAIENKKRRRRHDEPVEPTYTVADAEQTIEALVGHAYDEPWQPVPGVTVRLRDA
GHILGSAIVEMWIEADGERRKVVFSGDLGHAGAPILRNPTEVGEADLLVMESTYGDRDHRSWEETWEELGEIIRNARASH
GNILVPAFAVGRTQELLYILARHYEAWELGDWSVFLDSPMAIEATKVYARFPELYDAETAAFYAEPDHHRFQLPNLRLTP
QAEDSMAINRVQSGALIIAGSGMCNGGRIRHHFKHNLWRRNCNVIMVGFQAQGTPGRALVDGASELNLWGESVRVGAKVH
TVGGLSAHAGRSELIAWAEHFATAPRVALVHGEAGAMDSLAEALRGRGLEVETPEEGASIDLRQLPARSAEPPEAS
>Mature_476_residues
MRLHFYGATRQVTGSCMLLEAGGRRVLIDCGLIQGGGKQEARNREPFPFDPTTLDAVVLTHAHLDHSGRLPLLVRSGYDG
PIHTHTAGAALVDILLRDAAFLAERDAAIENKKRRRRHDEPVEPTYTVADAEQTIEALVGHAYDEPWQPVPGVTVRLRDA
GHILGSAIVEMWIEADGERRKVVFSGDLGHAGAPILRNPTEVGEADLLVMESTYGDRDHRSWEETWEELGEIIRNARASH
GNILVPAFAVGRTQELLYILARHYEAWELGDWSVFLDSPMAIEATKVYARFPELYDAETAAFYAEPDHHRFQLPNLRLTP
QAEDSMAINRVQSGALIIAGSGMCNGGRIRHHFKHNLWRRNCNVIMVGFQAQGTPGRALVDGASELNLWGESVRVGAKVH
TVGGLSAHAGRSELIAWAEHFATAPRVALVHGEAGAMDSLAEALRGRGLEVETPEEGASIDLRQLPARSAEPPEAS

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=449, Percent_Identity=26.2806236080178, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI33300633, Length=486, Percent_Identity=25.7201646090535, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI32564696, Length=489, Percent_Identity=25.5623721881391, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32566029, Length=463, Percent_Identity=26.5658747300216, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323307, Length=464, Percent_Identity=25.6465517241379, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358523, Length=504, Percent_Identity=28.3730158730159, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24648013, Length=451, Percent_Identity=25.9423503325942, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52240; Mature: 52240

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLHFYGATRQVTGSCMLLEAGGRRVLIDCGLIQGGGKQEARNREPFPFDPTTLDAVVLT
CEEEEECCCCCCCCCEEEEECCCCEEEEEECEECCCCCCHHCCCCCCCCCCCCHHHEEEE
HAHLDHSGRLPLLVRSGYDGPIHTHTAGAALVDILLRDAAFLAERDAAIENKKRRRRHDE
HHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PVEPTYTVADAEQTIEALVGHAYDEPWQPVPGVTVRLRDAGHILGSAIVEMWIEADGERR
CCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCE
KVVFSGDLGHAGAPILRNPTEVGEADLLVMESTYGDRDHRSWEETWEELGEIIRNARASH
EEEEECCCCCCCCCCCCCCHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GNILVPAFAVGRTQELLYILARHYEAWELGDWSVFLDSPMAIEATKVYARFPELYDAETA
CCEEEEEHCCCCHHHHHHHHHHCCCCEECCCEEEEECCCCEEEHHHHHHHCCHHHCCCCE
AFYAEPDHHRFQLPNLRLTPQAEDSMAINRVQSGALIIAGSGMCNGGRIRHHFKHNLWRR
EEEECCCCCEEECCCEEECCCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHC
NCNVIMVGFQAQGTPGRALVDGASELNLWGESVRVGAKVHTVGGLSAHAGRSELIAWAEH
CCCEEEEEEECCCCCCCEEECCCHHHHHCCCCEEECEEEEEECCCCCCCCHHHHHHHHHH
FATAPRVALVHGEAGAMDSLAEALRGRGLEVETPEEGASIDLRQLPARSAEPPEAS
HCCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRLHFYGATRQVTGSCMLLEAGGRRVLIDCGLIQGGGKQEARNREPFPFDPTTLDAVVLT
CEEEEECCCCCCCCCEEEEECCCCEEEEEECEECCCCCCHHCCCCCCCCCCCCHHHEEEE
HAHLDHSGRLPLLVRSGYDGPIHTHTAGAALVDILLRDAAFLAERDAAIENKKRRRRHDE
HHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PVEPTYTVADAEQTIEALVGHAYDEPWQPVPGVTVRLRDAGHILGSAIVEMWIEADGERR
CCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCE
KVVFSGDLGHAGAPILRNPTEVGEADLLVMESTYGDRDHRSWEETWEELGEIIRNARASH
EEEEECCCCCCCCCCCCCCHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GNILVPAFAVGRTQELLYILARHYEAWELGDWSVFLDSPMAIEATKVYARFPELYDAETA
CCEEEEEHCCCCHHHHHHHHHHCCCCEECCCEEEEECCCCEEEHHHHHHHCCHHHCCCCE
AFYAEPDHHRFQLPNLRLTPQAEDSMAINRVQSGALIIAGSGMCNGGRIRHHFKHNLWRR
EEEECCCCCEEECCCEEECCCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHC
NCNVIMVGFQAQGTPGRALVDGASELNLWGESVRVGAKVHTVGGLSAHAGRSELIAWAEH
CCCEEEEEEECCCCCCCEEECCCHHHHHCCCCEEECEEEEEECCCCCCCCHHHHHHHHHH
FATAPRVALVHGEAGAMDSLAEALRGRGLEVETPEEGASIDLRQLPARSAEPPEAS
HCCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA