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The map label for this gene is gabT [C]

Identifier: 121997618

GI number: 121997618

Start: 908178

End: 909446

Strand: Reverse

Name: gabT [C]

Synonym: Hhal_0827

Alternate gene names: 121997618

Gene position: 909446-908178 (Counterclockwise)

Preceding gene: 121997619

Following gene: 121997617

Centisome position: 33.95

GC content: 71.55

Gene sequence:

>1269_bases
ATGAGCGACGCGCACAAGACCGGAGCCATCTCCCCCCTGCTCAAGCAGTCCAGCGACGTCGTCGCCGAACGCGGCGAAGG
CGCCTACATCATCGGCACCGACGGGCGCCGCTATCTGGACTTCACCTCGGGCATCGGCGTCACCGCCACCGGGCACTGCC
ACCCCAAGGTGGTCGAGGCCGCCCAGCGCCAGGCCGCCACCCTGGTCCACGGCCAGTACGCCATCGTTCGCCATCCGCCC
ATGCTCCGCCTCGCCGAGCGCCTCGGTGAGATCATGCCCGGAGCCATCGACCGCATCTTCTTCTCCAACGCCGGCACCGA
GGCGTGCGAGGGCGCCCTGCGCCTGGCCCGCCAGGCCACCGGCCGGCCCAACATCATCGTCTTCCAGGGGGGCTTCCATG
GCCGTACCATGGGCTCGCTGTCGATGACCTCCTCCAGCGTCGGCCTGCGCGCCGGCGTGCAGCCGATGATGGGCGGCACG
GTGTTCGCGCCGTTCCCCAATGCCCGGCGGTACGGCTGGGAGGACGAAGAGACCGCCGAGTTCTGCCTGCGCGAGCTCGA
CCACATCCTCGCCACGCAGTCGATGCCGGCCGAGTCGGCGGCGTTCTTCGTCGAGCCGATCCAGGGCGAGGCCGGCTACA
TCCCCGCCGGGCGGACCTTCATGCAGGGCCTGTGCGAGCGGGCCGACCGCCACGGCATGCTGCTCATCGCCGACGAGGTG
CAGAGCGGCTACGGGCGCAGCGGCGCCTTCTGGGCGCACAGCCACTTCGACGTGCAGCCGGACATGGTGGTCACCGCCAA
GGGGCTGGCCAGCGGCTTCCCGCTCTCGGCGGTGGCAGCGCCGCAGGCGATCATGGAGCGCGGTTGGCCCGCCTCCCAGG
GGGGCACCTACGGCGGCAACGCGGTCGCCTGTGCCGCCGCGCTGGCGTCGCTGGAGGTCATCGAAGAGGAAGGCCTGGTG
GAGAACGCCCGCGAGCAGGGCGCACACCTGCGCAGCCGGCTCGACGCCCTGTGTGCCGAGGAGCCGGCCATCGCCCACGT
CCAGGGCATGGGCCTGATGCACGGCACCGAGTTGGTGGACGAGCAGGGCCGCCCGGACGGCGATCGCGCCGCGCGGGTGC
TCAAGGCCATGGAAGAGCGCGATGTGCTGATGATTCGCTGCGGGCCGCAGGGACAGATCGTGCGCTGGCTGCCGCCGCTG
ATCATCCGCCGCGAGGAGGTCGATCGCGCGGTGGATGCCTTTGCCGAGGCGTTGCGCGCCACGGCCTGA

Upstream 100 bases:

>100_bases
AGAGCCGCCCGAAGCAAGCTAGTTTAGTCCAGAGAGGGCCGCCGCGCGGCGGCCCAGCAGTCAACGGCCAAGGCAACCGG
CCGAGCGGAGGACCTGCACC

Downstream 100 bases:

>100_bases
GCCGGCGGCCCGGCGCTACCGGAACCGATTCTTGGAGGTGAGCGGAGTCATGGATCTTTCTTCGATCCGCAACGCGTACC
GACGCTACGCGCGGTACTAC

Product: class III aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MSDAHKTGAISPLLKQSSDVVAERGEGAYIIGTDGRRYLDFTSGIGVTATGHCHPKVVEAAQRQAATLVHGQYAIVRHPP
MLRLAERLGEIMPGAIDRIFFSNAGTEACEGALRLARQATGRPNIIVFQGGFHGRTMGSLSMTSSSVGLRAGVQPMMGGT
VFAPFPNARRYGWEDEETAEFCLRELDHILATQSMPAESAAFFVEPIQGEAGYIPAGRTFMQGLCERADRHGMLLIADEV
QSGYGRSGAFWAHSHFDVQPDMVVTAKGLASGFPLSAVAAPQAIMERGWPASQGGTYGGNAVACAAALASLEVIEEEGLV
ENAREQGAHLRSRLDALCAEEPAIAHVQGMGLMHGTELVDEQGRPDGDRAARVLKAMEERDVLMIRCGPQGQIVRWLPPL
IIRREEVDRAVDAFAEALRATA

Sequences:

>Translated_422_residues
MSDAHKTGAISPLLKQSSDVVAERGEGAYIIGTDGRRYLDFTSGIGVTATGHCHPKVVEAAQRQAATLVHGQYAIVRHPP
MLRLAERLGEIMPGAIDRIFFSNAGTEACEGALRLARQATGRPNIIVFQGGFHGRTMGSLSMTSSSVGLRAGVQPMMGGT
VFAPFPNARRYGWEDEETAEFCLRELDHILATQSMPAESAAFFVEPIQGEAGYIPAGRTFMQGLCERADRHGMLLIADEV
QSGYGRSGAFWAHSHFDVQPDMVVTAKGLASGFPLSAVAAPQAIMERGWPASQGGTYGGNAVACAAALASLEVIEEEGLV
ENAREQGAHLRSRLDALCAEEPAIAHVQGMGLMHGTELVDEQGRPDGDRAARVLKAMEERDVLMIRCGPQGQIVRWLPPL
IIRREEVDRAVDAFAEALRATA
>Mature_421_residues
SDAHKTGAISPLLKQSSDVVAERGEGAYIIGTDGRRYLDFTSGIGVTATGHCHPKVVEAAQRQAATLVHGQYAIVRHPPM
LRLAERLGEIMPGAIDRIFFSNAGTEACEGALRLARQATGRPNIIVFQGGFHGRTMGSLSMTSSSVGLRAGVQPMMGGTV
FAPFPNARRYGWEDEETAEFCLRELDHILATQSMPAESAAFFVEPIQGEAGYIPAGRTFMQGLCERADRHGMLLIADEVQ
SGYGRSGAFWAHSHFDVQPDMVVTAKGLASGFPLSAVAAPQAIMERGWPASQGGTYGGNAVACAAALASLEVIEEEGLVE
NAREQGAHLRSRLDALCAEEPAIAHVQGMGLMHGTELVDEQGRPDGDRAARVLKAMEERDVLMIRCGPQGQIVRWLPPLI
IRREEVDRAVDAFAEALRATA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=424, Percent_Identity=33.9622641509434, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4557809, Length=408, Percent_Identity=31.6176470588235, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI37574042, Length=408, Percent_Identity=31.6176470588235, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI24119277, Length=402, Percent_Identity=31.3432835820896, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=32.0209973753281, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI226442705, Length=408, Percent_Identity=30.6372549019608, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=32.3076923076923, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI188536080, Length=435, Percent_Identity=26.6666666666667, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI38679950, Length=435, Percent_Identity=26.6666666666667, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI38679946, Length=435, Percent_Identity=26.6666666666667, Blast_Score=129, Evalue=7e-30,
Organism=Escherichia coli, GI1789016, Length=406, Percent_Identity=34.9753694581281, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=35.2357320099256, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1788044, Length=402, Percent_Identity=35.0746268656716, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1789759, Length=408, Percent_Identity=33.8235294117647, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI145693181, Length=404, Percent_Identity=32.4257425742574, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1786991, Length=412, Percent_Identity=29.126213592233, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786349, Length=342, Percent_Identity=31.5789473684211, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=442, Percent_Identity=33.2579185520362, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25144271, Length=408, Percent_Identity=31.6176470588235, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=29.6983758700696, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25144274, Length=401, Percent_Identity=27.930174563591, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17541228, Length=478, Percent_Identity=26.7782426778243, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71981843, Length=158, Percent_Identity=27.2151898734177, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=33.1730769230769, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=30.5825242718447, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6321456, Length=450, Percent_Identity=26, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=432, Percent_Identity=23.3796296296296, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574759, Length=435, Percent_Identity=32.4137931034483, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI161085790, Length=434, Percent_Identity=32.258064516129, Blast_Score=194, Evalue=7e-50,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=32.3255813953488, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=30.8641975308642, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI281366494, Length=439, Percent_Identity=26.4236902050114, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24667139, Length=439, Percent_Identity=26.4236902050114, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24667143, Length=439, Percent_Identity=26.4236902050114, Blast_Score=111, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 45243; Mature: 45112

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAHKTGAISPLLKQSSDVVAERGEGAYIIGTDGRRYLDFTSGIGVTATGHCHPKVVEA
CCCCCCCCCCCHHHHCCHHHHHHCCCCEEEEECCCCEEEEECCCCCEEEECCCCHHHHHH
AQRQAATLVHGQYAIVRHPPMLRLAERLGEIMPGAIDRIFFSNAGTEACEGALRLARQAT
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHC
GRPNIIVFQGGFHGRTMGSLSMTSSSVGLRAGVQPMMGGTVFAPFPNARRYGWEDEETAE
CCCCEEEEECCCCCCCCCCEEECCCCCCHHCCCCHHCCCEEEECCCCCCCCCCCCHHHHH
FCLRELDHILATQSMPAESAAFFVEPIQGEAGYIPAGRTFMQGLCERADRHGMLLIADEV
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECH
QSGYGRSGAFWAHSHFDVQPDMVVTAKGLASGFPLSAVAAPQAIMERGWPASQGGTYGGN
HCCCCCCCCEEECCCCCCCCCEEEEECHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCH
AVACAAALASLEVIEEEGLVENAREQGAHLRSRLDALCAEEPAIAHVQGMGLMHGTELVD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHH
EQGRPDGDRAARVLKAMEERDVLMIRCGPQGQIVRWLPPLIIRREEVDRAVDAFAEALRA
HCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHC
TA
CC
>Mature Secondary Structure 
SDAHKTGAISPLLKQSSDVVAERGEGAYIIGTDGRRYLDFTSGIGVTATGHCHPKVVEA
CCCCCCCCCCHHHHCCHHHHHHCCCCEEEEECCCCEEEEECCCCCEEEECCCCHHHHHH
AQRQAATLVHGQYAIVRHPPMLRLAERLGEIMPGAIDRIFFSNAGTEACEGALRLARQAT
HHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHC
GRPNIIVFQGGFHGRTMGSLSMTSSSVGLRAGVQPMMGGTVFAPFPNARRYGWEDEETAE
CCCCEEEEECCCCCCCCCCEEECCCCCCHHCCCCHHCCCEEEECCCCCCCCCCCCHHHHH
FCLRELDHILATQSMPAESAAFFVEPIQGEAGYIPAGRTFMQGLCERADRHGMLLIADEV
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECH
QSGYGRSGAFWAHSHFDVQPDMVVTAKGLASGFPLSAVAAPQAIMERGWPASQGGTYGGN
HCCCCCCCCEEECCCCCCCCCEEEEECHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCH
AVACAAALASLEVIEEEGLVENAREQGAHLRSRLDALCAEEPAIAHVQGMGLMHGTELVD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHH
EQGRPDGDRAARVLKAMEERDVLMIRCGPQGQIVRWLPPLIIRREEVDRAVDAFAEALRA
HCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHC
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA