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The map label for this gene is ilvC

Identifier: 121997490

GI number: 121997490

Start: 774821

End: 775831

Strand: Reverse

Name: ilvC

Synonym: Hhal_0693

Alternate gene names: 121997490

Gene position: 775831-774821 (Counterclockwise)

Preceding gene: 121997491

Following gene: 121997489

Centisome position: 28.97

GC content: 68.55

Gene sequence:

>1011_bases
ATGAAGGTCTATTACGATCAGGACGCCGATCTTTCGCGGATCACCAGCCGTCGCGTGGCGATCATCGGCTACGGCTCCCA
GGGCCATGCGCACGCCAACAACCTCAAGGAGTCCGGCGTCAACGTGGTCGTGGGCCTGCGCCCGGGCTCGAGCTCGGCGG
CGAAGGCGCAGGAGGCCGGCCTGGAGGTCGCCTCGGTGGAGGAGGCCACCCAGGGCGCCGATGTGGTCATGATGCTCGTC
CCCGACGAGGCGGCCCCGGATATCTACAACCAGCAGGTGGCGCCGAACCTCAAGGATGGTGCGGCGATCGCCTTCGCCCA
CGGCTTCAACATTCACTACGGGCAGATCCAGCCGGCGGCCGATCACGACGTGATCATGATCGCCCCCAAGGGCCCCGGCC
ACACCGTGCGCTCGACCTACGTCGCCGGCGCCGGCGTGCCCTCGCTGATCGCCATCGAGCAGGACGCCAGCGGTCAGGCC
AAGGAGATCGCCCTGGCCTACGCCGTGGCCAACGGCGGCGGCCGCTCCGGGATCATCGAGACCTCCTTCCGCGAGGAGAC
CGAGACCGACCTCTTCGGGGAGCAGACCGTGCTCTGCGGCGGCATCGCCGCGCTCATCGAGGCCGGCTTCGAGACCCTGG
TGGAGGCCGGTTACGCCCCCGAGATGGCGTACTTCGAGTGCCTGCACGAGACCAAGCTGATCGTCGACCTGCTCTACGAG
GGCGGCCTGGCGAACATGCGCTACTCGGTCTCCAACACCGCCGAGTACGGCGACTTCACCCGCGGCCCCCGGGTCATCAA
CGAGGAGTCCCGCGAGGCGATGCGCGAGATCCTCGAGGAGATCCAGAACGGCGACTTCGCCAAGGAGTACGTGCTGGAGA
ACAAGGCCGGCGCGCCGACCCTGCACGCCCGCCGCCGTCTGGCCGCCGAGCACCCCATCGAGGAGGTGGGCGAGCGTCTG
CGCGGCATGATGCCGTGGATCGCCGCCAACAAGCTCGTCGACCGCGACTGA

Upstream 100 bases:

>100_bases
CATCAGCCGCGGCGAGCGCCATCTGCGCGTCTAGCGCCGTCCCGTCTCATCCCCGCCCGTCCGGTGGCGGGCGGACTCGC
GAATCCGTTCAGGGGGAAAC

Downstream 100 bases:

>100_bases
ACCAGCGTGCGCCGGCGGTGCGGCCCCCCGGGGTTCGCCCGCCGGCGGCGCCGGGAGCCCCATGACCGAGCTGCTGCACT
GGATCGAGGAAGACCCCGTC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKVYYDQDADLSRITSRRVAIIGYGSQGHAHANNLKESGVNVVVGLRPGSSSAAKAQEAGLEVASVEEATQGADVVMMLV
PDEAAPDIYNQQVAPNLKDGAAIAFAHGFNIHYGQIQPAADHDVIMIAPKGPGHTVRSTYVAGAGVPSLIAIEQDASGQA
KEIALAYAVANGGGRSGIIETSFREETETDLFGEQTVLCGGIAALIEAGFETLVEAGYAPEMAYFECLHETKLIVDLLYE
GGLANMRYSVSNTAEYGDFTRGPRVINEESREAMREILEEIQNGDFAKEYVLENKAGAPTLHARRRLAAEHPIEEVGERL
RGMMPWIAANKLVDRD

Sequences:

>Translated_336_residues
MKVYYDQDADLSRITSRRVAIIGYGSQGHAHANNLKESGVNVVVGLRPGSSSAAKAQEAGLEVASVEEATQGADVVMMLV
PDEAAPDIYNQQVAPNLKDGAAIAFAHGFNIHYGQIQPAADHDVIMIAPKGPGHTVRSTYVAGAGVPSLIAIEQDASGQA
KEIALAYAVANGGGRSGIIETSFREETETDLFGEQTVLCGGIAALIEAGFETLVEAGYAPEMAYFECLHETKLIVDLLYE
GGLANMRYSVSNTAEYGDFTRGPRVINEESREAMREILEEIQNGDFAKEYVLENKAGAPTLHARRRLAAEHPIEEVGERL
RGMMPWIAANKLVDRD
>Mature_336_residues
MKVYYDQDADLSRITSRRVAIIGYGSQGHAHANNLKESGVNVVVGLRPGSSSAAKAQEAGLEVASVEEATQGADVVMMLV
PDEAAPDIYNQQVAPNLKDGAAIAFAHGFNIHYGQIQPAADHDVIMIAPKGPGHTVRSTYVAGAGVPSLIAIEQDASGQA
KEIALAYAVANGGGRSGIIETSFREETETDLFGEQTVLCGGIAALIEAGFETLVEAGYAPEMAYFECLHETKLIVDLLYE
GGLANMRYSVSNTAEYGDFTRGPRVINEESREAMREILEEIQNGDFAKEYVLENKAGAPTLHARRRLAAEHPIEEVGERL
RGMMPWIAANKLVDRD

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=296, Percent_Identity=37.5, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=306, Percent_Identity=31.3725490196078, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_HALHL (A1WUW3)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002277.1
- ProteinModelPortal:   A1WUW3
- SMR:   A1WUW3
- STRING:   A1WUW3
- GeneID:   4711086
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0693
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   A1WUW3
- BioCyc:   HHAL349124:HHAL_0693-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36105; Mature: 36105

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYDQDADLSRITSRRVAIIGYGSQGHAHANNLKESGVNVVVGLRPGSSSAAKAQEAG
CEEEECCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHC
LEVASVEEATQGADVVMMLVPDEAAPDIYNQQVAPNLKDGAAIAFAHGFNIHYGQIQPAA
CCHHHHHHHCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCEEEEEECCEEEECCCCCCC
DHDVIMIAPKGPGHTVRSTYVAGAGVPSLIAIEQDASGQAKEIALAYAVANGGGRSGIIE
CCCEEEEECCCCCCCHHHEEEECCCCCEEEEEECCCCCCHHHEEEEEEEECCCCCCCEEE
TSFREETETDLFGEQTVLCGGIAALIEAGFETLVEAGYAPEMAYFECLHETKLIVDLLYE
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGLANMRYSVSNTAEYGDFTRGPRVINEESREAMREILEEIQNGDFAKEYVLENKAGAPT
CCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCH
LHARRRLAAEHPIEEVGERLRGMMPWIAANKLVDRD
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCCC
>Mature Secondary Structure
MKVYYDQDADLSRITSRRVAIIGYGSQGHAHANNLKESGVNVVVGLRPGSSSAAKAQEAG
CEEEECCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHC
LEVASVEEATQGADVVMMLVPDEAAPDIYNQQVAPNLKDGAAIAFAHGFNIHYGQIQPAA
CCHHHHHHHCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCEEEEEECCEEEECCCCCCC
DHDVIMIAPKGPGHTVRSTYVAGAGVPSLIAIEQDASGQAKEIALAYAVANGGGRSGIIE
CCCEEEEECCCCCCCHHHEEEECCCCCEEEEEECCCCCCHHHEEEEEEEECCCCCCCEEE
TSFREETETDLFGEQTVLCGGIAALIEAGFETLVEAGYAPEMAYFECLHETKLIVDLLYE
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGLANMRYSVSNTAEYGDFTRGPRVINEESREAMREILEEIQNGDFAKEYVLENKAGAPT
CCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCH
LHARRRLAAEHPIEEVGERLRGMMPWIAANKLVDRD
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA