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The map label for this gene is folK [H]

Identifier: 121997473

GI number: 121997473

Start: 758837

End: 759379

Strand: Reverse

Name: folK [H]

Synonym: Hhal_0676

Alternate gene names: 121997473

Gene position: 759379-758837 (Counterclockwise)

Preceding gene: 121997474

Following gene: 121997472

Centisome position: 28.35

GC content: 73.66

Gene sequence:

>543_bases
ATGAGCACGGCGATCACCGCCTATGTGGGACTCGGCAGCAACCTCGATCAGCCGCGGCGGCAGATCGAGCGGGCCGTGGT
GCGCCTGGATCTGCTCCCCGGTTGCCGGGTGCGGGCCGTCTCCAGCCTCTACCGCAACCCGGCCCTGCAGGCGCCGGGCG
TGCCGCCGCAGCCGGATTTCATCAACGCGGTGGCGGCGGTGGAGACCCGGCAGGGGCCGTTGGCCCTGCTCGACGCCCTG
CTCGGCATCGAGGCCGAACACCAGCGCCGGCGCGACGGCGTGCGCTGGGGGCCGCGGACCCTGGATCTGGACCTGCTGCT
CTACGGCCAGATGCAGGTCGAGGAGCCGCGCCTGCAGGTCCCGCACCCGGAGCTGAGCCAGCGGCCGTTCGTCGTCCATC
CGCTGCTGGAGATCGCCCCGGGGGTGCGCCTGCCCGGGGCCGGGGCCCTGGCCGATGCCGCCGCGGCGGTGGCCGCTGAT
ACCCTCGAACGGATCGGGGCGGTGGCCGGTTTTGAGCACGTGTCGGTGCAGGAGCTGGCCTGA

Upstream 100 bases:

>100_bases
GTGGCGGCCGGCGCCGGCGCGGTGGTCGGGGGCGTGGCAAAGGGAGCGAAGATGGCGATCGCGCCGATACGGCGGCGTCG
AGCCCGGAGTCCTCGGCGGA

Downstream 100 bases:

>100_bases
GGACTGGACGCGGCGCGGCCATGGGTACTTCAATCGGACGCCAGTGGCGCTGTACTCTGTCCCACCTTTCTCAAGCCGAG
GTTGACCCCCATGTCGAGCG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MSTAITAYVGLGSNLDQPRRQIERAVVRLDLLPGCRVRAVSSLYRNPALQAPGVPPQPDFINAVAAVETRQGPLALLDAL
LGIEAEHQRRRDGVRWGPRTLDLDLLLYGQMQVEEPRLQVPHPELSQRPFVVHPLLEIAPGVRLPGAGALADAAAAVAAD
TLERIGAVAGFEHVSVQELA

Sequences:

>Translated_180_residues
MSTAITAYVGLGSNLDQPRRQIERAVVRLDLLPGCRVRAVSSLYRNPALQAPGVPPQPDFINAVAAVETRQGPLALLDAL
LGIEAEHQRRRDGVRWGPRTLDLDLLLYGQMQVEEPRLQVPHPELSQRPFVVHPLLEIAPGVRLPGAGALADAAAAVAAD
TLERIGAVAGFEHVSVQELA
>Mature_179_residues
STAITAYVGLGSNLDQPRRQIERAVVRLDLLPGCRVRAVSSLYRNPALQAPGVPPQPDFINAVAAVETRQGPLALLDALL
GIEAEHQRRRDGVRWGPRTLDLDLLLYGQMQVEEPRLQVPHPELSQRPFVVHPLLEIAPGVRLPGAGALADAAAAVAADT
LERIGAVAGFEHVSVQELA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=158, Percent_Identity=40.5063291139241, Blast_Score=116, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=143, Percent_Identity=31.4685314685315, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19363; Mature: 19231

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAITAYVGLGSNLDQPRRQIERAVVRLDLLPGCRVRAVSSLYRNPALQAPGVPPQPDF
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHH
INAVAAVETRQGPLALLDALLGIEAEHQRRRDGVRWGPRTLDLDLLLYGQMQVEEPRLQV
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEEEECCEEECCCCCCC
PHPELSQRPFVVHPLLEIAPGVRLPGAGALADAAAAVAADTLERIGAVAGFEHVSVQELA
CCCCCCCCCEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure 
STAITAYVGLGSNLDQPRRQIERAVVRLDLLPGCRVRAVSSLYRNPALQAPGVPPQPDF
CCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHH
INAVAAVETRQGPLALLDALLGIEAEHQRRRDGVRWGPRTLDLDLLLYGQMQVEEPRLQV
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEEEECCEEECCCCCCC
PHPELSQRPFVVHPLLEIAPGVRLPGAGALADAAAAVAADTLERIGAVAGFEHVSVQELA
CCCCCCCCCEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]