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The map label for this gene is hflC [H]

Identifier: 121997460

GI number: 121997460

Start: 745393

End: 746301

Strand: Reverse

Name: hflC [H]

Synonym: Hhal_0663

Alternate gene names: 121997460

Gene position: 746301-745393 (Counterclockwise)

Preceding gene: 121997461

Following gene: 121997459

Centisome position: 27.86

GC content: 64.8

Gene sequence:

>909_bases
ATGCGAATCCTGAAGAACGTCGTGTTGCCCCTGCTGGTGGTGGCCGCGATTCTCGGCTACTTCTCGGTGTTCACCGTCTC
CGAAAAGGAGGTGGCACTGAAGTTCCGGCTCGGTGAGATCATTAAGGCGGATTTCGATCCGGGGCTGCACTTCAAGACGC
CGTTCGTCAACAACGTCCGCAAGTTCGACGCTCGGGTGCAGAACCTGGACGAGGAGCCGGAGCGTTTCCTGACGGTCGAG
CAGAAGAACCTCATCGTCGACTCCTTCGTAAAGTGGCGGGTGGACGACGCCGAGCGTTACTACACCACGGTCCGCGGTGA
GCCGGAGCGGGCTAACCAGCGTCTGCGCGAGATCATCCGCGACGCCCTGCGCGCCGAGTTCGGTAAGCGTACGGTGCAGG
ACATCATCTCCGGTGAGCGCGTGCAGATCATGGACATCCTGCGGGTGACCACCGCCGAGGCGGCGCAGAGCCTGGGCCTG
GAGGTGCTCGATGTGCGCCTCAAGCGCATCGATCTGCCCGAAGACGTCACCGACTCCATCTTCGATCGCATGGTGGCGGA
TCGTGAGCGGGTCGCCCGCGAGATCCGTGCCCGCGGTGAGGAGGCCGGTGAGCGCATCCGCGCCGATGCCGACCGTCAGC
GCACGGTCCTCCTCGCCGAGGCGTACCGGGACGGTGAGTCCCTGCGTGGTGAGGGTGATGCCACGGCGGCGGAGATCTAC
GCCAGCGCCTACGGGCAGGAGTCGGACTTCTTCGCCTTCCAGCGCAGCCTGAGGGCCTACCGCGAGTCCTTCCAGGGTGA
CGACGACCTGTTCGTCCTGTCGCCGGATTCGCAGTTCTTCCGCTTCTTCGACGGCGGTGAGCAGCTGCCGGGGCTCAACG
GCGAGGTCGGTTCCCCCGATCAGGACTAA

Upstream 100 bases:

>100_bases
CGCTCTCTGGCGAGACCAATATCGATGTACCGCAGGAACGGGACGCCATCTCGCCGACCCAGCGAGCACGAGAGGCGCTC
CGTGATAGGGGGACGCGCTG

Downstream 100 bases:

>100_bases
CCGACAGAGGGGGGGGGGATCCTCGTGGAGATGGGTGACCTGCTCACCGCGATCGCCCTCCTGCTGGTGATCGAGGGTGT
ACTACCTGCAGCGAACCCCG

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MRILKNVVLPLLVVAAILGYFSVFTVSEKEVALKFRLGEIIKADFDPGLHFKTPFVNNVRKFDARVQNLDEEPERFLTVE
QKNLIVDSFVKWRVDDAERYYTTVRGEPERANQRLREIIRDALRAEFGKRTVQDIISGERVQIMDILRVTTAEAAQSLGL
EVLDVRLKRIDLPEDVTDSIFDRMVADRERVAREIRARGEEAGERIRADADRQRTVLLAEAYRDGESLRGEGDATAAEIY
ASAYGQESDFFAFQRSLRAYRESFQGDDDLFVLSPDSQFFRFFDGGEQLPGLNGEVGSPDQD

Sequences:

>Translated_302_residues
MRILKNVVLPLLVVAAILGYFSVFTVSEKEVALKFRLGEIIKADFDPGLHFKTPFVNNVRKFDARVQNLDEEPERFLTVE
QKNLIVDSFVKWRVDDAERYYTTVRGEPERANQRLREIIRDALRAEFGKRTVQDIISGERVQIMDILRVTTAEAAQSLGL
EVLDVRLKRIDLPEDVTDSIFDRMVADRERVAREIRARGEEAGERIRADADRQRTVLLAEAYRDGESLRGEGDATAAEIY
ASAYGQESDFFAFQRSLRAYRESFQGDDDLFVLSPDSQFFRFFDGGEQLPGLNGEVGSPDQD
>Mature_302_residues
MRILKNVVLPLLVVAAILGYFSVFTVSEKEVALKFRLGEIIKADFDPGLHFKTPFVNNVRKFDARVQNLDEEPERFLTVE
QKNLIVDSFVKWRVDDAERYYTTVRGEPERANQRLREIIRDALRAEFGKRTVQDIISGERVQIMDILRVTTAEAAQSLGL
EVLDVRLKRIDLPEDVTDSIFDRMVADRERVAREIRARGEEAGERIRADADRQRTVLLAEAYRDGESLRGEGDATAAEIY
ASAYGQESDFFAFQRSLRAYRESFQGDDDLFVLSPDSQFFRFFDGGEQLPGLNGEVGSPDQD

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=310, Percent_Identity=40.9677419354839, Blast_Score=231, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI32566490, Length=192, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281365664, Length=206, Percent_Identity=28.6407766990291, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI62484448, Length=206, Percent_Identity=28.6407766990291, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24657857, Length=197, Percent_Identity=29.4416243654822, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62484274, Length=206, Percent_Identity=28.6407766990291, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 34496; Mature: 34496

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILKNVVLPLLVVAAILGYFSVFTVSEKEVALKFRLGEIIKADFDPGLHFKTPFVNNVR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
KFDARVQNLDEEPERFLTVEQKNLIVDSFVKWRVDDAERYYTTVRGEPERANQRLREIIR
HHHHHHHCCCCCHHHHEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
DALRAEFGKRTVQDIISGERVQIMDILRVTTAEAAQSLGLEVLDVRLKRIDLPEDVTDSI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHH
FDRMVADRERVAREIRARGEEAGERIRADADRQRTVLLAEAYRDGESLRGEGDATAAEIY
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHCCCCCCHHHHHHH
ASAYGQESDFFAFQRSLRAYRESFQGDDDLFVLSPDSQFFRFFDGGEQLPGLNGEVGSPD
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCC
QD
CC
>Mature Secondary Structure
MRILKNVVLPLLVVAAILGYFSVFTVSEKEVALKFRLGEIIKADFDPGLHFKTPFVNNVR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
KFDARVQNLDEEPERFLTVEQKNLIVDSFVKWRVDDAERYYTTVRGEPERANQRLREIIR
HHHHHHHCCCCCHHHHEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
DALRAEFGKRTVQDIISGERVQIMDILRVTTAEAAQSLGLEVLDVRLKRIDLPEDVTDSI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHH
FDRMVADRERVAREIRARGEEAGERIRADADRQRTVLLAEAYRDGESLRGEGDATAAEIY
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHCCCCCCHHHHHHH
ASAYGQESDFFAFQRSLRAYRESFQGDDDLFVLSPDSQFFRFFDGGEQLPGLNGEVGSPD
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCC
QD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]