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The map label for this gene is hflK [H]

Identifier: 121997461

GI number: 121997461

Start: 746301

End: 747488

Strand: Reverse

Name: hflK [H]

Synonym: Hhal_0664

Alternate gene names: 121997461

Gene position: 747488-746301 (Counterclockwise)

Preceding gene: 121997462

Following gene: 121997460

Centisome position: 27.91

GC content: 68.18

Gene sequence:

>1188_bases
ATGGCGTGGAATGAGCCCGGCGGCGGCAGCCGCGACCCCTGGGGCGGTGGCCCCAAAGGAGGCGGCAGTGGGGGGCCGCC
CGATCTGGATGAGGTCTTCCGTAAGCTGCGTGCGCAGGTGCAGGGCCTGTTCGGTGGGCGCATGCCCAGTGGGCCCTCCC
GCGGCCCCGGGGCGACCGGCATCAGCCTCTTGGCCCTGGGTGCCTTCGTGGTCTGGATGCTCTCCGGGATCTACATCGTC
GACCAGGGCTGGCGCGGGGTGGAGCTGACCTTCGGTCGCCACTCGGATACCACGGAGCCCGGGCCGCACTGGCACTGGCC
GCGGCCCATCGGCCAGGTCGAGCGGGTCAACGTCGAGCAGCGGCGCATCGCCGAGGTCGGCTACGAGTCGATGCAGAATC
GTGCCCGGCCGGTTTCTGCCGAGGCGTTGATGATTACCCGCGACGAGAACATCGTCGATGTGCGGATCGCGGCGCAGTAC
GAGGTCAGCGATCCGTTCCTCTACCTGTTCAACTTCCGCATGCCGGAGCAGACCCTCAAGCAGGTCACCGAGAGCGCGGT
GCGCGAGATCATCGGCAAGCGCGAGCTTCAGTACGTGCTGACCGAGGGGCGGACCGAGGTGGCCCAGGAAACCGGACGGC
TGCTCCAGGAAGTGATGGATGACTACCGCACGGGTCTGTCGGTGGTGCAGGTGGCGGTCCAGGATATCCAGCCCCCGGAG
CCGGTACAGCCGGCCTTCGAGGATGCCATCCGCGCCCGCGAGGACGAGCAGCGCACCATCAACCGGGCCCAGGCCTACGC
CAACGAGTTGATCCCGCGGGCCCAGGGCCAGGCGGCGCGCATTCTCGAGGAAGCAGACGGTTACCGCGAGCAGGTCATCG
CCCAGGCCGAGGGTGACGCCGCCCGCTTCGAGGCGCTGGTGCCGCAGTACCGGGCCGACCCGCAGCTGATGCGTCAGCGC
ATCTACCTGGAGACTATGGAGGAGATCCTGGGCCGGGTGCCCAAGGTGATGCTCGACTCGGAGTCCAGCCAGTCGCTGAT
GTACCTGCCGCTCGACAAGCTCATGGATCGTCGGGGGAGCACCACGGCGCTCTCTGGCGAGACCAATATCGATGTACCGC
AGGAACGGGACGCCATCTCGCCGACCCAGCGAGCACGAGAGGCGCTCCGTGATAGGGGGACGCGCTGA

Upstream 100 bases:

>100_bases
GTTGTCCCGGCCTGACTTCGGTTGCGGTTGGCGGGGCAGCTCCCTAGAATCGGACCGTTCGATCGACGGCAGATCGTCTT
AGTCACATACGGAGTCCTGA

Downstream 100 bases:

>100_bases
TGCGAATCCTGAAGAACGTCGTGTTGCCCCTGCTGGTGGTGGCCGCGATTCTCGGCTACTTCTCGGTGTTCACCGTCTCC
GAAAAGGAGGTGGCACTGAA

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAWNEPGGGSRDPWGGGPKGGGSGGPPDLDEVFRKLRAQVQGLFGGRMPSGPSRGPGATGISLLALGAFVVWMLSGIYIV
DQGWRGVELTFGRHSDTTEPGPHWHWPRPIGQVERVNVEQRRIAEVGYESMQNRARPVSAEALMITRDENIVDVRIAAQY
EVSDPFLYLFNFRMPEQTLKQVTESAVREIIGKRELQYVLTEGRTEVAQETGRLLQEVMDDYRTGLSVVQVAVQDIQPPE
PVQPAFEDAIRAREDEQRTINRAQAYANELIPRAQGQAARILEEADGYREQVIAQAEGDAARFEALVPQYRADPQLMRQR
IYLETMEEILGRVPKVMLDSESSQSLMYLPLDKLMDRRGSTTALSGETNIDVPQERDAISPTQRAREALRDRGTR

Sequences:

>Translated_395_residues
MAWNEPGGGSRDPWGGGPKGGGSGGPPDLDEVFRKLRAQVQGLFGGRMPSGPSRGPGATGISLLALGAFVVWMLSGIYIV
DQGWRGVELTFGRHSDTTEPGPHWHWPRPIGQVERVNVEQRRIAEVGYESMQNRARPVSAEALMITRDENIVDVRIAAQY
EVSDPFLYLFNFRMPEQTLKQVTESAVREIIGKRELQYVLTEGRTEVAQETGRLLQEVMDDYRTGLSVVQVAVQDIQPPE
PVQPAFEDAIRAREDEQRTINRAQAYANELIPRAQGQAARILEEADGYREQVIAQAEGDAARFEALVPQYRADPQLMRQR
IYLETMEEILGRVPKVMLDSESSQSLMYLPLDKLMDRRGSTTALSGETNIDVPQERDAISPTQRAREALRDRGTR
>Mature_394_residues
AWNEPGGGSRDPWGGGPKGGGSGGPPDLDEVFRKLRAQVQGLFGGRMPSGPSRGPGATGISLLALGAFVVWMLSGIYIVD
QGWRGVELTFGRHSDTTEPGPHWHWPRPIGQVERVNVEQRRIAEVGYESMQNRARPVSAEALMITRDENIVDVRIAAQYE
VSDPFLYLFNFRMPEQTLKQVTESAVREIIGKRELQYVLTEGRTEVAQETGRLLQEVMDDYRTGLSVVQVAVQDIQPPEP
VQPAFEDAIRAREDEQRTINRAQAYANELIPRAQGQAARILEEADGYREQVIAQAEGDAARFEALVPQYRADPQLMRQRI
YLETMEEILGRVPKVMLDSESSQSLMYLPLDKLMDRRGSTTALSGETNIDVPQERDAISPTQRAREALRDRGTR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=375, Percent_Identity=41.6, Blast_Score=258, Evalue=7e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 44154; Mature: 44023

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNEPGGGSRDPWGGGPKGGGSGGPPDLDEVFRKLRAQVQGLFGGRMPSGPSRGPGATG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
ISLLALGAFVVWMLSGIYIVDQGWRGVELTFGRHSDTTEPGPHWHWPRPIGQVERVNVEQ
HHHHHHHHHHHHHHCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCHHH
RRIAEVGYESMQNRARPVSAEALMITRDENIVDVRIAAQYEVSDPFLYLFNFRMPEQTLK
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEEEEECCCCEEEEEECCCCHHHHH
QVTESAVREIIGKRELQYVLTEGRTEVAQETGRLLQEVMDDYRTGLSVVQVAVQDIQPPE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVQPAFEDAIRAREDEQRTINRAQAYANELIPRAQGQAARILEEADGYREQVIAQAEGDA
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCCCCH
ARFEALVPQYRADPQLMRQRIYLETMEEILGRVPKVMLDSESSQSLMYLPLDKLMDRRGS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEECHHHHHCCCCC
TTALSGETNIDVPQERDAISPTQRAREALRDRGTR
CEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AWNEPGGGSRDPWGGGPKGGGSGGPPDLDEVFRKLRAQVQGLFGGRMPSGPSRGPGATG
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
ISLLALGAFVVWMLSGIYIVDQGWRGVELTFGRHSDTTEPGPHWHWPRPIGQVERVNVEQ
HHHHHHHHHHHHHHCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCHHH
RRIAEVGYESMQNRARPVSAEALMITRDENIVDVRIAAQYEVSDPFLYLFNFRMPEQTLK
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEEEEECCCCEEEEEECCCCHHHHH
QVTESAVREIIGKRELQYVLTEGRTEVAQETGRLLQEVMDDYRTGLSVVQVAVQDIQPPE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVQPAFEDAIRAREDEQRTINRAQAYANELIPRAQGQAARILEEADGYREQVIAQAEGDA
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCCCCH
ARFEALVPQYRADPQLMRQRIYLETMEEILGRVPKVMLDSESSQSLMYLPLDKLMDRRGS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEECHHHHHCCCCC
TTALSGETNIDVPQERDAISPTQRAREALRDRGTR
CEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]