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The map label for this gene is mtnA

Identifier: 121997374

GI number: 121997374

Start: 650942

End: 652006

Strand: Reverse

Name: mtnA

Synonym: Hhal_0573

Alternate gene names: 121997374

Gene position: 652006-650942 (Counterclockwise)

Preceding gene: 121997382

Following gene: 121997372

Centisome position: 24.34

GC content: 72.68

Gene sequence:

>1065_bases
TTGAATACTGCCTCCCACGACACGGTTCGGGCGCTGGAGTGGCGCGACGAGGGGCTCTATCTGCTCGATCAGCGCCTGCT
CCCCGACCAGGAGCAATACCTGTGCTGCGCCGATGCCGCCAGCGTGGCCCAGGCCATCACCGACATGGTGGTCCGGGGTG
CCCCGGCCATCGGCGTGGCCGCCGGCTACGGGGCAGCGCTGGCCGGGGCGGCGGCCTGGCGGACCCATGGGTCGGGCTGG
CAGGCCGGCATGGCCGAGGACATCGACACCCTGCGCCGCTCGCGGCCCACGGCCGTCAATCTCGGCTGGGCCCTGAGGCG
TATGGAGGCCTTTGCCGCCCGGCTGCCCGAGGATCAGGACCCGGCGCCGGCCCTGCTCGCCGAGGCTCAGGCTATCCATG
AGGAGGATGTGGCGGCCAACCGGCGGATGGGACGTTCTGGCGCCGGCTTGATCCAGCCGGGCAGCGGCGTGCTGACCCAC
TGCAACACGGGCTCGCTGGCGACCGGCGGGCTGGGTACGGCGCTGGGGGTGATCCGGACCGCCTGGGCGGACGGTCGGGT
CGAGCGGGTCTTCGCCGACGAGACCCGCCCCTGGCTGCAGGGATCCCGGCTGACCGCCTGGGAGCTGGCCGCCGACGGCA
TCCCGGTGGACCTGCTGGCTGATGGCGCGGCGGCGGCCCTGATGCGCACCGGGCAGGTGCAGTGGGCCATCGTGGGCGCC
GACCGGATCGCCGCCAACGGCGACGTCGCCAACAAGATCGGTACCTATGCGGTGGCCCTGGCCGCGCGCCAGCACGGTGT
CCGCTTGATGGTGGTGGCCCCCACTTCGACCATCGATCTGGCCACCCCCGCCGGCGAGCAGATCCCTATCGAGACCCGGG
ATGCCCGGGAGGTCCTCTATGCGGGGGGGCGCCGGATCGCCCCGGAGTCCGAGGCGGTCGGCGCCTGGAACCCGGTCTTC
GATGTCACGCCGGCGGAGCTGGTGGATGTGATCGTCACCGAGCGCGGGGTGGTCCACCAGCCGGACGCCGACGGCATCGC
TCGGTTATTCGAGGGCGCTGGCTGA

Upstream 100 bases:

>100_bases
TGCCCGGTCGGCTCGACCGGGATCACCCAGCGGGCGTGGATCAGAGTGTCGACACGTTCCATAATACGCTCCGTTTTCAC
TGCAGCGAGGGTACCACGAC

Downstream 100 bases:

>100_bases
CTCCCGGAAGCGGCCCCGCACCCGCCGGGGGGTGATCGGGCGCATTCCGAACGCGCCGAGCAGCGCAGCCCAAGCAGGGG
GCCAGCGCGAACCTTTCCTG

Product: eIF-2B alpha/beta/delta-like protein

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MNTASHDTVRALEWRDEGLYLLDQRLLPDQEQYLCCADAASVAQAITDMVVRGAPAIGVAAGYGAALAGAAAWRTHGSGW
QAGMAEDIDTLRRSRPTAVNLGWALRRMEAFAARLPEDQDPAPALLAEAQAIHEEDVAANRRMGRSGAGLIQPGSGVLTH
CNTGSLATGGLGTALGVIRTAWADGRVERVFADETRPWLQGSRLTAWELAADGIPVDLLADGAAAALMRTGQVQWAIVGA
DRIAANGDVANKIGTYAVALAARQHGVRLMVVAPTSTIDLATPAGEQIPIETRDAREVLYAGGRRIAPESEAVGAWNPVF
DVTPAELVDVIVTERGVVHQPDADGIARLFEGAG

Sequences:

>Translated_354_residues
MNTASHDTVRALEWRDEGLYLLDQRLLPDQEQYLCCADAASVAQAITDMVVRGAPAIGVAAGYGAALAGAAAWRTHGSGW
QAGMAEDIDTLRRSRPTAVNLGWALRRMEAFAARLPEDQDPAPALLAEAQAIHEEDVAANRRMGRSGAGLIQPGSGVLTH
CNTGSLATGGLGTALGVIRTAWADGRVERVFADETRPWLQGSRLTAWELAADGIPVDLLADGAAAALMRTGQVQWAIVGA
DRIAANGDVANKIGTYAVALAARQHGVRLMVVAPTSTIDLATPAGEQIPIETRDAREVLYAGGRRIAPESEAVGAWNPVF
DVTPAELVDVIVTERGVVHQPDADGIARLFEGAG
>Mature_354_residues
MNTASHDTVRALEWRDEGLYLLDQRLLPDQEQYLCCADAASVAQAITDMVVRGAPAIGVAAGYGAALAGAAAWRTHGSGW
QAGMAEDIDTLRRSRPTAVNLGWALRRMEAFAARLPEDQDPAPALLAEAQAIHEEDVAANRRMGRSGAGLIQPGSGVLTH
CNTGSLATGGLGTALGVIRTAWADGRVERVFADETRPWLQGSRLTAWELAADGIPVDLLADGAAAALMRTGQVQWAIVGA
DRIAANGDVANKIGTYAVALAARQHGVRLMVVAPTSTIDLATPAGEQIPIETRDAREVLYAGGRRIAPESEAVGAWNPVF
DVTPAELVDVIVTERGVVHQPDADGIARLFEGAG

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=344, Percent_Identity=41.2790697674419, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI23943880, Length=336, Percent_Identity=35.1190476190476, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI187607323, Length=166, Percent_Identity=31.9277108433735, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI78000156, Length=166, Percent_Identity=31.9277108433735, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI78000158, Length=166, Percent_Identity=31.9277108433735, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17557462, Length=337, Percent_Identity=35.3115727002967, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325375, Length=392, Percent_Identity=34.9489795918367, Blast_Score=210, Evalue=3e-55,
Organism=Drosophila melanogaster, GI21357667, Length=364, Percent_Identity=39.010989010989, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24651647, Length=364, Percent_Identity=39.010989010989, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_HALHL (A1WUJ7)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002161.1
- ProteinModelPortal:   A1WUJ7
- SMR:   A1WUJ7
- STRING:   A1WUJ7
- GeneID:   4709641
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0573
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- PhylomeDB:   A1WUJ7
- BioCyc:   HHAL349124:HHAL_0573-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37188; Mature: 37188

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: ACT_SITE 241-241 BINDING 95-95 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTASHDTVRALEWRDEGLYLLDQRLLPDQEQYLCCADAASVAQAITDMVVRGAPAIGVA
CCCCCCCCEEEEEECCCCEEEEHHHCCCCHHHEEEHHHHHHHHHHHHHHHHCCCCCCEEC
AGYGAALAGAAAWRTHGSGWQAGMAEDIDTLRRSRPTAVNLGWALRRMEAFAARLPEDQD
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCC
PAPALLAEAQAIHEEDVAANRRMGRSGAGLIQPGSGVLTHCNTGSLATGGLGTALGVIRT
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCCCCHHHHHHHHHH
AWADGRVERVFADETRPWLQGSRLTAWELAADGIPVDLLADGAAAALMRTGQVQWAIVGA
HCCCCCEEEEECCCCCCHHCCCCCEEEEHHCCCCCHHHHCCCHHHHHHHCCCEEEEEEEC
DRIAANGDVANKIGTYAVALAARQHGVRLMVVAPTSTIDLATPAGEQIPIETRDAREVLY
CCEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCCHHHHHHH
AGGRRIAPESEAVGAWNPVFDVTPAELVDVIVTERGVVHQPDADGIARLFEGAG
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHCCCC
>Mature Secondary Structure
MNTASHDTVRALEWRDEGLYLLDQRLLPDQEQYLCCADAASVAQAITDMVVRGAPAIGVA
CCCCCCCCEEEEEECCCCEEEEHHHCCCCHHHEEEHHHHHHHHHHHHHHHHCCCCCCEEC
AGYGAALAGAAAWRTHGSGWQAGMAEDIDTLRRSRPTAVNLGWALRRMEAFAARLPEDQD
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCC
PAPALLAEAQAIHEEDVAANRRMGRSGAGLIQPGSGVLTHCNTGSLATGGLGTALGVIRT
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCCCCHHHHHHHHHH
AWADGRVERVFADETRPWLQGSRLTAWELAADGIPVDLLADGAAAALMRTGQVQWAIVGA
HCCCCCEEEEECCCCCCHHCCCCCEEEEHHCCCCCHHHHCCCHHHHHHHCCCEEEEEEEC
DRIAANGDVANKIGTYAVALAARQHGVRLMVVAPTSTIDLATPAGEQIPIETRDAREVLY
CCEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCCHHHHHHH
AGGRRIAPESEAVGAWNPVFDVTPAELVDVIVTERGVVHQPDADGIARLFEGAG
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA