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The map label for this gene is gyrA [H]

Identifier: 121997372

GI number: 121997372

Start: 646287

End: 648857

Strand: Reverse

Name: gyrA [H]

Synonym: Hhal_0571

Alternate gene names: 121997372

Gene position: 648857-646287 (Counterclockwise)

Preceding gene: 121997374

Following gene: 121997371

Centisome position: 24.23

GC content: 68.18

Gene sequence:

>2571_bases
ATGACCGGCGTTGCCCGCGAGATCCTCCCTGTAAACCTCGAAGACGAGATGCGGCAGTCGTACCTCGATTACGCCATGAG
CGTAATCGTCGGGCGTGCCCTTCCCGATGTCCGCGACGGCCTCAAGCCCGTGCACCGGCGTGTTCTCTACGCCATGCGCG
AGCTGGGCAACGACTACAATAAGCCGTACAAGAAGTCGGCGCGTGTGGTCGGTGACGTCATCGGTAAGTACCACCCCCAC
GGCGACGCCGCGGTCTACGACACCATTGTGCGCCTGGCCCAGAGCTTTAGCATGCGCTACCGGCTGGTGGACGGCCAGGG
CAACTTCGGCTCCATCGATGGCGACTCGCCGGCGGCCATGCGGTACACCGAGGTGCGCATGGCGCGCCTGGCGCACGAGC
TGCTGGCCGATATCGACAAGGAGACGGTGGACTTCGTCGACAACTACGACGGCTCCGAGCAGGAGCCGCACGTGTTGCCG
ACCCGGCTGCCCAACCTGTTGGTCAACGGCGGCTCCGGCATCGCCGTGGGCATGGCCACCAACATCCCGCCGCACAACCT
GCGCGAGGTGATCGACGCCTGCGTGGCCCTGGTCGACGACCCGGAACTGCCCGTCGAGTCGCTGATCGAGTATGTGCCGG
CGCCGGATCTGCCCACCGGCGGCATCATCTTCGGTACCGCGGGCATCCATCAGGCCTTCCGCACTGGCCGCGGGCGCATG
GTCCTGCGCGCCCGCGCGGAGGTCGAGGAGATGACCGCCGACCGCGAGCGCATCGTGGTCACCGAGCTCCCCTACCAGGT
CAACAAGGCGCGGCTGGTCGAGAAGATCGCCGAGCTGGTCAAGGAGCGCCGCCTGGAGGGCATCTCCGAGCTGCGTGACG
AATCCGACAAGGAAGGCATCCGCATCGTCCTTGAGCTCAAGCGCGGCGAGGCCGGCGAGATCGTCCTCAACAACCTCTAC
CGCCACACCCAGATGCAGACCGTCTTCGGCATCAACGTGGTGGCACTGCACGAAGGCCAGCCGCGCACGCTCAACCTCAG
GCAGGTGCTCGAGGCCTTCATCCGCCACCGCCGCGAGGTGGTCACCCGGCGGACCATCTACGAGCTGCGCAAGGCCCGCG
AGCGGGCCCACGTGCTCGAGGGGCTGGCGGTCGCCCTGGCCAACATCGACGAGGTCATCGCCCTGATCAAGGGGTCCTCG
GGGCCGGCCGAGGCGAAGGCCGAGCTGGTCGCGCGTGAGTGGCGCCCGGGGGTGGTCACCGAGATGCTCGAGCGCGCCGG
TGCCGCCGCCACCCGCCCGGAGGATCTGGCCGATCACTTCGGCCTCGATGCCGACTCCGGCATCTACCGCCTCTCCGAGG
CCCAGGCCCAGGCGATCCTCGATCTGCGCCTGCACCGCTTGACGGCCATGGAGCAGGACAAGATCGTCGAGGAGTACAGC
AACCTCCTCGAGCGCATCGCCGAACTGATTCACATCCTCGACAGCGGCGAGCGGCTGATGGAGGTGATCCGCGAGGAGCT
GGTGGCCATCCGCGATCAGTACGGCGACGAGCGCAAGACCGAGATCCGCGAGGACACCGCCGAGCTCTCGCTGGAGGACC
TGATCAGCGAGGAGGACATGGTGGTCACGCTCTCCCACCACGGCTATGTCAAGGCGCAGCCGCTCGACGGCTACCGCGCG
CAGCGCCGTGGCGGGCGGGGCAAGAGCGCCACCGCGATGAAGGACGAGGACTTCATCGACAAGCTGTTCATCGCCAACAC
CCACGATACGCTGCTGTGCTTCTCGAGCACCGGCAAGTGCTACTGGCGCAAGGTCTACGAGCTCCCGCAGGGCAGCCGCA
CCTCCCGTGGGCGGCCGATGGTCAACCTGCTGCCGCTCGAAGAGGACGAGCGCATCAACGCCGTGGTCCCCGTTCGCGAG
TTCGACGAGGACCACTTCGTGTTTATGGCCACGCGCAACGGGACGGTCAAGAAGACGCCCCTGTCGCACTTCTCGCGGCC
GCGTTCGAGCGGGATCATCGCCGTGGAGCTGCGCGGCGACGACACCCTGGTGGATGCCGAGATCACCAATGGGGATCGCG
AGGTGATGCTGCTCTCCGACGCCGGCAAGGCGCTGCGCTTCCACGAGTCGGACGTGCGGGCCATGGGCCGCACGGCCGGC
GGCGTGCGGGGCATCCGCCTGGAGTCCGGGCAGCGGGTGATCGCGCTGCTGATCCTTGGCGAGGGCGATATCCTCACCGC
CACCGAGCACGGCTACGGCAAGCGCACCCCGGTGGAGGACTACCCGCGGCGGGGCCGTGGCGGCATGGGTGTGATCTGCA
TCCGGACCACCGAGCGCAACGGCCGGGTGGTCGGCGCGGTGCAGGCCGCCGAGGACGACGAGATCATGCTGGTCAGCCGC
AGTGGCACGCTGGTCCGCACGCCGGTGGCCGATGTCTCGCGGGTCGGGCGCAACACCCAGGGGGTCAAGCTCATCAGCCT
CGACGAGGCCGAGCAGTTGGTCGGCCTCGAGCGGGTCGAAGGGCTCGCCGAGGGGGAGGCACCGGAGGCGCCGGATGCGC
CCGAGATGTAG

Upstream 100 bases:

>100_bases
GTTGGTTGGTCAAGTCCAAGCGGACGGCTCCCTGCGCTCCCGGTCGGGCGGCGGTATGATACCATCGGCCTTTTCCCCAG
GAGAGTCTTGAGAAGAGCGC

Downstream 100 bases:

>100_bases
GCAGTCAGGGGTCGACGGCCGGCGGTGTCGCTGCCGGGGCCCGGGTATTCGTGTTTCGCAACCGAGGATCACCGCATGAG
TAGAGTCTTCAACTTCAGTG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 856; Mature: 855

Protein sequence:

>856_residues
MTGVAREILPVNLEDEMRQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMRELGNDYNKPYKKSARVVGDVIGKYHPH
GDAAVYDTIVRLAQSFSMRYRLVDGQGNFGSIDGDSPAAMRYTEVRMARLAHELLADIDKETVDFVDNYDGSEQEPHVLP
TRLPNLLVNGGSGIAVGMATNIPPHNLREVIDACVALVDDPELPVESLIEYVPAPDLPTGGIIFGTAGIHQAFRTGRGRM
VLRARAEVEEMTADRERIVVTELPYQVNKARLVEKIAELVKERRLEGISELRDESDKEGIRIVLELKRGEAGEIVLNNLY
RHTQMQTVFGINVVALHEGQPRTLNLRQVLEAFIRHRREVVTRRTIYELRKARERAHVLEGLAVALANIDEVIALIKGSS
GPAEAKAELVAREWRPGVVTEMLERAGAAATRPEDLADHFGLDADSGIYRLSEAQAQAILDLRLHRLTAMEQDKIVEEYS
NLLERIAELIHILDSGERLMEVIREELVAIRDQYGDERKTEIREDTAELSLEDLISEEDMVVTLSHHGYVKAQPLDGYRA
QRRGGRGKSATAMKDEDFIDKLFIANTHDTLLCFSSTGKCYWRKVYELPQGSRTSRGRPMVNLLPLEEDERINAVVPVRE
FDEDHFVFMATRNGTVKKTPLSHFSRPRSSGIIAVELRGDDTLVDAEITNGDREVMLLSDAGKALRFHESDVRAMGRTAG
GVRGIRLESGQRVIALLILGEGDILTATEHGYGKRTPVEDYPRRGRGGMGVICIRTTERNGRVVGAVQAAEDDEIMLVSR
SGTLVRTPVADVSRVGRNTQGVKLISLDEAEQLVGLERVEGLAEGEAPEAPDAPEM

Sequences:

>Translated_856_residues
MTGVAREILPVNLEDEMRQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMRELGNDYNKPYKKSARVVGDVIGKYHPH
GDAAVYDTIVRLAQSFSMRYRLVDGQGNFGSIDGDSPAAMRYTEVRMARLAHELLADIDKETVDFVDNYDGSEQEPHVLP
TRLPNLLVNGGSGIAVGMATNIPPHNLREVIDACVALVDDPELPVESLIEYVPAPDLPTGGIIFGTAGIHQAFRTGRGRM
VLRARAEVEEMTADRERIVVTELPYQVNKARLVEKIAELVKERRLEGISELRDESDKEGIRIVLELKRGEAGEIVLNNLY
RHTQMQTVFGINVVALHEGQPRTLNLRQVLEAFIRHRREVVTRRTIYELRKARERAHVLEGLAVALANIDEVIALIKGSS
GPAEAKAELVAREWRPGVVTEMLERAGAAATRPEDLADHFGLDADSGIYRLSEAQAQAILDLRLHRLTAMEQDKIVEEYS
NLLERIAELIHILDSGERLMEVIREELVAIRDQYGDERKTEIREDTAELSLEDLISEEDMVVTLSHHGYVKAQPLDGYRA
QRRGGRGKSATAMKDEDFIDKLFIANTHDTLLCFSSTGKCYWRKVYELPQGSRTSRGRPMVNLLPLEEDERINAVVPVRE
FDEDHFVFMATRNGTVKKTPLSHFSRPRSSGIIAVELRGDDTLVDAEITNGDREVMLLSDAGKALRFHESDVRAMGRTAG
GVRGIRLESGQRVIALLILGEGDILTATEHGYGKRTPVEDYPRRGRGGMGVICIRTTERNGRVVGAVQAAEDDEIMLVSR
SGTLVRTPVADVSRVGRNTQGVKLISLDEAEQLVGLERVEGLAEGEAPEAPDAPEM
>Mature_855_residues
TGVAREILPVNLEDEMRQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMRELGNDYNKPYKKSARVVGDVIGKYHPHG
DAAVYDTIVRLAQSFSMRYRLVDGQGNFGSIDGDSPAAMRYTEVRMARLAHELLADIDKETVDFVDNYDGSEQEPHVLPT
RLPNLLVNGGSGIAVGMATNIPPHNLREVIDACVALVDDPELPVESLIEYVPAPDLPTGGIIFGTAGIHQAFRTGRGRMV
LRARAEVEEMTADRERIVVTELPYQVNKARLVEKIAELVKERRLEGISELRDESDKEGIRIVLELKRGEAGEIVLNNLYR
HTQMQTVFGINVVALHEGQPRTLNLRQVLEAFIRHRREVVTRRTIYELRKARERAHVLEGLAVALANIDEVIALIKGSSG
PAEAKAELVAREWRPGVVTEMLERAGAAATRPEDLADHFGLDADSGIYRLSEAQAQAILDLRLHRLTAMEQDKIVEEYSN
LLERIAELIHILDSGERLMEVIREELVAIRDQYGDERKTEIREDTAELSLEDLISEEDMVVTLSHHGYVKAQPLDGYRAQ
RRGGRGKSATAMKDEDFIDKLFIANTHDTLLCFSSTGKCYWRKVYELPQGSRTSRGRPMVNLLPLEEDERINAVVPVREF
DEDHFVFMATRNGTVKKTPLSHFSRPRSSGIIAVELRGDDTLVDAEITNGDREVMLLSDAGKALRFHESDVRAMGRTAGG
VRGIRLESGQRVIALLILGEGDILTATEHGYGKRTPVEDYPRRGRGGMGVICIRTTERNGRVVGAVQAAEDDEIMLVSRS
GTLVRTPVADVSRVGRNTQGVKLISLDEAEQLVGLERVEGLAEGEAPEAPDAPEM

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=321, Percent_Identity=26.1682242990654, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913406, Length=317, Percent_Identity=25.8675078864353, Blast_Score=85, Evalue=3e-16,
Organism=Escherichia coli, GI1788562, Length=841, Percent_Identity=65.0416171224733, Blast_Score=1123, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=717, Percent_Identity=35.1464435146443, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=503, Percent_Identity=24.4532803180915, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=390, Percent_Identity=26.4102564102564, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=346, Percent_Identity=24.2774566473988, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=176, Percent_Identity=32.3863636363636, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136538, Length=415, Percent_Identity=25.7831325301205, Blast_Score=85, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 95271; Mature: 95140

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGVAREILPVNLEDEMRQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMRELGNDYN
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDAAVYDTIVRLAQSFSMRYRLVDGQGNFGSIDGDSPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCHH
RYTEVRMARLAHELLADIDKETVDFVDNYDGSEQEPHVLPTRLPNLLVNGGSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHCCCHHEEECCCCEEEEEEC
NIPPHNLREVIDACVALVDDPELPVESLIEYVPAPDLPTGGIIFGTAGIHQAFRTGRGRM
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECHHHHHHHHCCCCCE
VLRARAEVEEMTADRERIVVTELPYQVNKARLVEKIAELVKERRLEGISELRDESDKEGI
EEEEHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
RIVLELKRGEAGEIVLNNLYRHTQMQTVFGINVVALHEGQPRTLNLRQVLEAFIRHRREV
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEECHHHHHHHHHHHHHHH
VTRRTIYELRKARERAHVLEGLAVALANIDEVIALIKGSSGPAEAKAELVAREWRPGVVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
EMLERAGAAATRPEDLADHFGLDADSGIYRLSEAQAQAILDLRLHRLTAMEQDKIVEEYS
HHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLERIAELIHILDSGERLMEVIREELVAIRDQYGDERKTEIREDTAELSLEDLISEEDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCE
VVTLSHHGYVKAQPLDGYRAQRRGGRGKSATAMKDEDFIDKLFIANTHDTLLCFSSTGKC
EEEEECCCEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHEECCCCEEEEEECCCCH
YWRKVYELPQGSRTSRGRPMVNLLPLEEDERINAVVPVREFDEDHFVFMATRNGTVKKTP
HHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEECHHHCCCCCEEEEEECCCCEEECC
LSHFSRPRSSGIIAVELRGDDTLVDAEITNGDREVMLLSDAGKALRFHESDVRAMGRTAG
HHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEEECHHHHHHHHHCCC
GVRGIRLESGQRVIALLILGEGDILTATEHGYGKRTPVEDYPRRGRGGMGVICIRTTERN
CEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCCHHCCCCCCCCEEEEEEEEECCC
GRVVGAVQAAEDDEIMLVSRSGTLVRTPVADVSRVGRNTQGVKLISLDEAEQLVGLERVE
CEEEEEEEECCCCCEEEEECCCCEEECCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHH
GLAEGEAPEAPDAPEM
HHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TGVAREILPVNLEDEMRQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMRELGNDYN
CCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDAAVYDTIVRLAQSFSMRYRLVDGQGNFGSIDGDSPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCHH
RYTEVRMARLAHELLADIDKETVDFVDNYDGSEQEPHVLPTRLPNLLVNGGSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHCCCHHEEECCCCEEEEEEC
NIPPHNLREVIDACVALVDDPELPVESLIEYVPAPDLPTGGIIFGTAGIHQAFRTGRGRM
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECHHHHHHHHCCCCCE
VLRARAEVEEMTADRERIVVTELPYQVNKARLVEKIAELVKERRLEGISELRDESDKEGI
EEEEHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
RIVLELKRGEAGEIVLNNLYRHTQMQTVFGINVVALHEGQPRTLNLRQVLEAFIRHRREV
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEECHHHHHHHHHHHHHHH
VTRRTIYELRKARERAHVLEGLAVALANIDEVIALIKGSSGPAEAKAELVAREWRPGVVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
EMLERAGAAATRPEDLADHFGLDADSGIYRLSEAQAQAILDLRLHRLTAMEQDKIVEEYS
HHHHHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLERIAELIHILDSGERLMEVIREELVAIRDQYGDERKTEIREDTAELSLEDLISEEDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCE
VVTLSHHGYVKAQPLDGYRAQRRGGRGKSATAMKDEDFIDKLFIANTHDTLLCFSSTGKC
EEEEECCCEEEECCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHEECCCCEEEEEECCCCH
YWRKVYELPQGSRTSRGRPMVNLLPLEEDERINAVVPVREFDEDHFVFMATRNGTVKKTP
HHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEECHHHCCCCCEEEEEECCCCEEECC
LSHFSRPRSSGIIAVELRGDDTLVDAEITNGDREVMLLSDAGKALRFHESDVRAMGRTAG
HHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEEECHHHHHHHHHCCC
GVRGIRLESGQRVIALLILGEGDILTATEHGYGKRTPVEDYPRRGRGGMGVICIRTTERN
CEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCCHHCCCCCCCCEEEEEEEEECCC
GRVVGAVQAAEDDEIMLVSRSGTLVRTPVADVSRVGRNTQGVKLISLDEAEQLVGLERVE
CEEEEEEEECCCCCEEEEECCCCEEECCHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHH
GLAEGEAPEAPDAPEM
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]