Click here to switch to the map view.

The map label for this gene is nrdZ [H]

Identifier: 121611904

GI number: 121611904

Start: 5557038

End: 5559479

Strand: Direct

Name: nrdZ [H]

Synonym: Veis_5007

Alternate gene names: 121611904

Gene position: 5557038-5559479 (Clockwise)

Preceding gene: 121611903

Following gene: 121611907

Centisome position: 99.83

GC content: 68.35

Gene sequence:

>2442_bases
ATGCAACGCGAACCCCAACCCTGTCCCGACCTCGGCTTGCAGCCCATCAGCCAGGATGTGCTGTGCGAGAAATACCTCAA
GCCCGGTGAAACCACGGCGCAAATGCTCTACCAGCGCGTGGCGCGGGCCTTGGCGTCGGTGGAAGCCCCGGAACTGCGCA
GCCGATACGAGGCCCTGTTCCTGGCCAACCTGCAAGCCGGAGCGATTGGCGCGGGCCGCATCATGAGCGCCGCCGGCACC
GACATCCAGGCCACGTTGATCAACTGCTTCGTGCAGCCGGTGGGCGACTGCATACAGGGCCAGGACGAGGACGGCTTTCC
CGGCATCTACGAGGCGCTGCGCGAGGCGGCCGAGACCATGCGGCGCGGCGGCGGCGTGGGCTACGACTTCTCGCGCATCC
GGCCCAAGGGCGCGCGGGTCATGGCCACGGCGTCGATGGCCTCGGGGCCTTGCAGCTACATGAACGTGTTCGACCAGTCC
TGCGCCACCGTGGAGAGCGCCGGCGCGCGCCGGGGCGCGCAAATGGGCGTGCTGCGCATAGACCACCCCGATGTGCACGA
ATTCATCAGCGCCAAGCGCCAGCCGGGCCGGTGGAACAACTTCAATGTGTCGGTGAGCGTGCCCGATGCGTTCATTCAGG
CGCTGCAAGACGACGCTGCCTGGGATCTGGTGCACAAGGCCCGCCCCGGCGCCGCCTTGCTGGCCCAGGGCGCGCACCAG
CGCGCCGACGGCCAGTGGGTCTATGCCAGCGTGCCGGCGCGCGCGCTGTGGGAGCGCATCATGCGTTCGGCCTACGACTA
TGCCGAGCCGGGCATCCTGTTCCTGGGCCGCATCAACGAGGACAACAACCTACATTACTGCGAGACCATCACGGCCACCA
ACCCCTGCGGCGAGCAGCCCCTGCCCGCCTATGGCTGCTGCGACCTGGGCCCCGTCATCCTGCCCCGCTTCGTGCGCCAC
CCTTTTGGCTTTGGCGGTGCCGCGGCTTTCGACTTCGAGGCTTTCGCGCAGGCCGTGGCGTTGCAGGTGCGGGCGCTGGA
CAATGTGCTCGACCTGACCTATTGGCCGCTGCCGCAGCAGCGCGAGGAGGCCATGGCCAAGCGCCGCATCGGGGTGGGCT
TTACCGGCCTGGGCAACACGCTGGCCATGCTGTGCCTGCGCTACGACCGGCCCGAGGGCCGCGCCATGGCGGTGCGCATT
GCCCGGTGCATGCGCGATGCCGCTTATCGCGCGTCGGTCGACCTGGCACGCGAGAAAGGGGCCTTCCCCCACTTTTCTGC
CGGGCCGTACCTGGCCGAGGGCCGTTTTGCCAGCCGCCTGCCCGAGGCGCTCAAGGCCGCGATCCGCCAGCATGGCATCC
GCAACAGCCATCTGCTGTCGATCGCCCCCACCGGCACCGTCAGCCTGGCTTTTGCCGACAACGCCTCCAACGGCATCGAG
CCTTCGTTCGCGTGGACCTACAAGCGCAAAAAACGCGCGGCCGACGGCGGCAGCACCGAGTACGCGGTGCAAGACCATGC
CTGGCGCCTGTACCGCGAACTCGGCGGCGATGCGCAGGCCCTGCCGGACTATTTCGTCTCGGCCCTGGACATGCCCGTCC
AGGCGCATATTGCGATGATGGAGGCGGTGCAGCCCTGGGTCGATACGGCCATCTCCAAGACGGTCAACATTCCTGTCGAC
TACCCCTACGAAGACTTCAAAGACCTGTACCTGCAAGCCTGGCGCGCGCGGCTCAAGGGCCTGGCGACCTACCGGCCCAA
TGCCATCCTGGGCGCGGTGCTGGAGACCGATGCGGCCCCGGCTACGGTCCCGGCTGCGTCACCTGCTGCACCAGCGGCAG
CGCCTGCGGTGCCCCCGGTCGATCCGATGCGCGCCGTGATCGAAAGCCGGCCGCAGGGCGGTCTGCCGGCAGTGGCCGAG
AAACTGGAGTATTGGACGCAGGAAGGCCACAAGACGCTGTACCTGATCGTCTCGTTCCTGCCCGTTGCCACGGGCCAGGG
CAGCGTCGACCGGGCCATCGAGTTTTTCATGCCGGTGGGCCAAAGCGGCGAATCCCAGCAGTGGATCACGTCGAGCATGC
GCATGCTGTCGCTGGCAGCGCGCGGCGGCTTTCTGGAGCGCGCGCTCGGCGACATGCGCAAGGTGGCCTGGGACCGGGGC
CCGGTGCGCCTGGGCAGCCACCGCAAGGACGACGGCACGCTGGTGCCGATGTGGCACGACTCCGAAGTGGCGGCCATGGC
CTATGCGATCCAGAACATCCTGGCGCGCCGCGTGCGCGACCCGGTGCAGCAACGGCTGCCGCTGGACGAACCGGCGCCCC
CCCTGCCCGTGCCGCAGGCCATGATCGGCAAGAAATGCAACGAATGCGGCGCCCATGCCGTGATCCGCAAGGACGGCTGC
GACTACTGCACCCAATGCGGCCAACTCGGCGCCTGCGGGTGA

Upstream 100 bases:

>100_bases
TGTGTCGGCGTCGCTTGCCGTACATCTGTACTGTCTGCGCTGCGCCTTCGCGTTCACGAACGATTCAGGAATGGAATGAA
CCCCGAACCATCTGCCCCCC

Downstream 100 bases:

>100_bases
GCGCGGGCCGCGCGCGGCCTCACAGCGGATGCTCGGTGTAGAACTTGCCCCCGTGGTACAGCAGCGGCGGTACGCCTTGG
CGGTGCGCGCAGCGCTCGAC

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MQREPQPCPDLGLQPISQDVLCEKYLKPGETTAQMLYQRVARALASVEAPELRSRYEALFLANLQAGAIGAGRIMSAAGT
DIQATLINCFVQPVGDCIQGQDEDGFPGIYEALREAAETMRRGGGVGYDFSRIRPKGARVMATASMASGPCSYMNVFDQS
CATVESAGARRGAQMGVLRIDHPDVHEFISAKRQPGRWNNFNVSVSVPDAFIQALQDDAAWDLVHKARPGAALLAQGAHQ
RADGQWVYASVPARALWERIMRSAYDYAEPGILFLGRINEDNNLHYCETITATNPCGEQPLPAYGCCDLGPVILPRFVRH
PFGFGGAAAFDFEAFAQAVALQVRALDNVLDLTYWPLPQQREEAMAKRRIGVGFTGLGNTLAMLCLRYDRPEGRAMAVRI
ARCMRDAAYRASVDLAREKGAFPHFSAGPYLAEGRFASRLPEALKAAIRQHGIRNSHLLSIAPTGTVSLAFADNASNGIE
PSFAWTYKRKKRAADGGSTEYAVQDHAWRLYRELGGDAQALPDYFVSALDMPVQAHIAMMEAVQPWVDTAISKTVNIPVD
YPYEDFKDLYLQAWRARLKGLATYRPNAILGAVLETDAAPATVPAASPAAPAAAPAVPPVDPMRAVIESRPQGGLPAVAE
KLEYWTQEGHKTLYLIVSFLPVATGQGSVDRAIEFFMPVGQSGESQQWITSSMRMLSLAARGGFLERALGDMRKVAWDRG
PVRLGSHRKDDGTLVPMWHDSEVAAMAYAIQNILARRVRDPVQQRLPLDEPAPPLPVPQAMIGKKCNECGAHAVIRKDGC
DYCTQCGQLGACG

Sequences:

>Translated_813_residues
MQREPQPCPDLGLQPISQDVLCEKYLKPGETTAQMLYQRVARALASVEAPELRSRYEALFLANLQAGAIGAGRIMSAAGT
DIQATLINCFVQPVGDCIQGQDEDGFPGIYEALREAAETMRRGGGVGYDFSRIRPKGARVMATASMASGPCSYMNVFDQS
CATVESAGARRGAQMGVLRIDHPDVHEFISAKRQPGRWNNFNVSVSVPDAFIQALQDDAAWDLVHKARPGAALLAQGAHQ
RADGQWVYASVPARALWERIMRSAYDYAEPGILFLGRINEDNNLHYCETITATNPCGEQPLPAYGCCDLGPVILPRFVRH
PFGFGGAAAFDFEAFAQAVALQVRALDNVLDLTYWPLPQQREEAMAKRRIGVGFTGLGNTLAMLCLRYDRPEGRAMAVRI
ARCMRDAAYRASVDLAREKGAFPHFSAGPYLAEGRFASRLPEALKAAIRQHGIRNSHLLSIAPTGTVSLAFADNASNGIE
PSFAWTYKRKKRAADGGSTEYAVQDHAWRLYRELGGDAQALPDYFVSALDMPVQAHIAMMEAVQPWVDTAISKTVNIPVD
YPYEDFKDLYLQAWRARLKGLATYRPNAILGAVLETDAAPATVPAASPAAPAAAPAVPPVDPMRAVIESRPQGGLPAVAE
KLEYWTQEGHKTLYLIVSFLPVATGQGSVDRAIEFFMPVGQSGESQQWITSSMRMLSLAARGGFLERALGDMRKVAWDRG
PVRLGSHRKDDGTLVPMWHDSEVAAMAYAIQNILARRVRDPVQQRLPLDEPAPPLPVPQAMIGKKCNECGAHAVIRKDGC
DYCTQCGQLGACG
>Mature_813_residues
MQREPQPCPDLGLQPISQDVLCEKYLKPGETTAQMLYQRVARALASVEAPELRSRYEALFLANLQAGAIGAGRIMSAAGT
DIQATLINCFVQPVGDCIQGQDEDGFPGIYEALREAAETMRRGGGVGYDFSRIRPKGARVMATASMASGPCSYMNVFDQS
CATVESAGARRGAQMGVLRIDHPDVHEFISAKRQPGRWNNFNVSVSVPDAFIQALQDDAAWDLVHKARPGAALLAQGAHQ
RADGQWVYASVPARALWERIMRSAYDYAEPGILFLGRINEDNNLHYCETITATNPCGEQPLPAYGCCDLGPVILPRFVRH
PFGFGGAAAFDFEAFAQAVALQVRALDNVLDLTYWPLPQQREEAMAKRRIGVGFTGLGNTLAMLCLRYDRPEGRAMAVRI
ARCMRDAAYRASVDLAREKGAFPHFSAGPYLAEGRFASRLPEALKAAIRQHGIRNSHLLSIAPTGTVSLAFADNASNGIE
PSFAWTYKRKKRAADGGSTEYAVQDHAWRLYRELGGDAQALPDYFVSALDMPVQAHIAMMEAVQPWVDTAISKTVNIPVD
YPYEDFKDLYLQAWRARLKGLATYRPNAILGAVLETDAAPATVPAASPAAPAAAPAVPPVDPMRAVIESRPQGGLPAVAE
KLEYWTQEGHKTLYLIVSFLPVATGQGSVDRAIEFFMPVGQSGESQQWITSSMRMLSLAARGGFLERALGDMRKVAWDRG
PVRLGSHRKDDGTLVPMWHDSEVAAMAYAIQNILARRVRDPVQQRLPLDEPAPPLPVPQAMIGKKCNECGAHAVIRKDGC
DYCTQCGQLGACG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=438, Percent_Identity=24.8858447488584, Blast_Score=140, Evalue=4e-33,
Organism=Escherichia coli, GI1789030, Length=566, Percent_Identity=23.4982332155477, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI2367133, Length=626, Percent_Identity=23.961661341853, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17555242, Length=421, Percent_Identity=26.8408551068884, Blast_Score=155, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6322123, Length=428, Percent_Identity=25.9345794392523, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320914, Length=508, Percent_Identity=23.6220472440945, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI17352481, Length=528, Percent_Identity=23.8636363636364, Blast_Score=151, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 88591; Mature: 88591

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREPQPCPDLGLQPISQDVLCEKYLKPGETTAQMLYQRVARALASVEAPELRSRYEALF
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LANLQAGAIGAGRIMSAAGTDIQATLINCFVQPVGDCIQGQDEDGFPGIYEALREAAETM
HCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RRGGGVGYDFSRIRPKGARVMATASMASGPCSYMNVFDQSCATVESAGARRGAQMGVLRI
HHCCCCCCCHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
DHPDVHEFISAKRQPGRWNNFNVSVSVPDAFIQALQDDAAWDLVHKARPGAALLAQGAHQ
CCCCHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCC
RADGQWVYASVPARALWERIMRSAYDYAEPGILFLGRINEDNNLHYCETITATNPCGEQP
CCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCC
LPAYGCCDLGPVILPRFVRHPFGFGGAAAFDFEAFAQAVALQVRALDNVLDLTYWPLPQQ
CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
REEAMAKRRIGVGFTGLGNTLAMLCLRYDRPEGRAMAVRIARCMRDAAYRASVDLAREKG
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
AFPHFSAGPYLAEGRFASRLPEALKAAIRQHGIRNSHLLSIAPTGTVSLAFADNASNGIE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCCCC
PSFAWTYKRKKRAADGGSTEYAVQDHAWRLYRELGGDAQALPDYFVSALDMPVQAHIAMM
CCCEEHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHH
EAVQPWVDTAISKTVNIPVDYPYEDFKDLYLQAWRARLKGLATYRPNAILGAVLETDAAP
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
ATVPAASPAAPAAAPAVPPVDPMRAVIESRPQGGLPAVAEKLEYWTQEGHKTLYLIVSFL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHH
PVATGQGSVDRAIEFFMPVGQSGESQQWITSSMRMLSLAARGGFLERALGDMRKVAWDRG
HHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
PVRLGSHRKDDGTLVPMWHDSEVAAMAYAIQNILARRVRDPVQQRLPLDEPAPPLPVPQA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
MIGKKCNECGAHAVIRKDGCDYCTQCGQLGACG
HHHHHHHHHCCCEEEECCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MQREPQPCPDLGLQPISQDVLCEKYLKPGETTAQMLYQRVARALASVEAPELRSRYEALF
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LANLQAGAIGAGRIMSAAGTDIQATLINCFVQPVGDCIQGQDEDGFPGIYEALREAAETM
HCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RRGGGVGYDFSRIRPKGARVMATASMASGPCSYMNVFDQSCATVESAGARRGAQMGVLRI
HHCCCCCCCHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
DHPDVHEFISAKRQPGRWNNFNVSVSVPDAFIQALQDDAAWDLVHKARPGAALLAQGAHQ
CCCCHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCC
RADGQWVYASVPARALWERIMRSAYDYAEPGILFLGRINEDNNLHYCETITATNPCGEQP
CCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCCC
LPAYGCCDLGPVILPRFVRHPFGFGGAAAFDFEAFAQAVALQVRALDNVLDLTYWPLPQQ
CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
REEAMAKRRIGVGFTGLGNTLAMLCLRYDRPEGRAMAVRIARCMRDAAYRASVDLAREKG
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
AFPHFSAGPYLAEGRFASRLPEALKAAIRQHGIRNSHLLSIAPTGTVSLAFADNASNGIE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCCCC
PSFAWTYKRKKRAADGGSTEYAVQDHAWRLYRELGGDAQALPDYFVSALDMPVQAHIAMM
CCCEEHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHH
EAVQPWVDTAISKTVNIPVDYPYEDFKDLYLQAWRARLKGLATYRPNAILGAVLETDAAP
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
ATVPAASPAAPAAAPAVPPVDPMRAVIESRPQGGLPAVAEKLEYWTQEGHKTLYLIVSFL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHH
PVATGQGSVDRAIEFFMPVGQSGESQQWITSSMRMLSLAARGGFLERALGDMRKVAWDRG
HHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
PVRLGSHRKDDGTLVPMWHDSEVAAMAYAIQNILARRVRDPVQQRLPLDEPAPPLPVPQA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
MIGKKCNECGAHAVIRKDGCDYCTQCGQLGACG
HHHHHHHHHCCCEEEECCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]