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The map label for this gene is cysS

Identifier: 121611834

GI number: 121611834

Start: 5455493

End: 5456875

Strand: Direct

Name: cysS

Synonym: Veis_4936

Alternate gene names: 121611834

Gene position: 5455493-5456875 (Clockwise)

Preceding gene: 121611832

Following gene: 121611835

Centisome position: 98.0

GC content: 65.58

Gene sequence:

>1383_bases
ATGAGTTTGCGCATCTACAACACGCTGTCGCGTGCATTGGAGGAGTTTTCCCCGCTGGAACCGGGCCATGTGCGCATGTA
TGTCTGCGGCATGACCATCTATGACCTGTGCCACATCGGCCACGCCCGCATGATGATGGCGTTCGACGTGGTGCAGCGCT
GGCTCAAGGCCCGGGGTCTGAAGGTCACCTATGTGCGCAACATCACCGATATCGACGACAAGATCATCGGGCGGGCGCTC
GAGCGCGGCATCACCATCGGCGCCCTGACCGACGAAATGATCGCCGCGATGCATGCCGACATCGGCGCCTTGGGGCTGGA
GCCACCCACGCTGGAGCCTCGCGCCACGCAGTATGTGCCCCGGATGCTGGCGCTGATCGGGCAACTTCAGGCCAAGGGCC
TGGCGTACCGCGCCAGCAATGGCGATGTGAACTATGCGGTGCGCAAGTTCCAGGGCTACGGCAAGCTCTCGGGCAAGTCG
CCGGACGAGTTGCGCGCCGGTGCGCGGGTGGCGCTGGCCGATGGCAAGACCGATCCGCTGGACTTCGTGCTGTGGAAGTC
GGCCAAGCCGCATGAGCCACCCGAGGCCCAATGGGACAGCGACTATGGGCGCGGGCGTCCCGGCTGGCATATCGAGTGCT
CGGCCATGAGTTGCGCCACCTTGGGCGAGAGCTTCGACATCCATGGCGGCGGGGCGGATCTGCAATTTCCCCACCACGAG
AACGAGATCGCCCAGAGCGAAGGGGTCACCGGCAAGCCGCTGGCACGCTTTTGGCTGCACAACGGTTTTGTACGGGTAGA
CAACGAGAAAATGAGCAAGTCGCTGGGCAACTTCTTCACCATCCGCGATGTGCTAGCGCAGTATGACGCCCAGACCGTGC
GCTTTTTCATCGTGCGCGCGCATTACCGCAGCGCGCTCAATTACAGCGACGCCCATCTCGACGATGCACGCCAGGCCCTC
AAGCGCCTGTACACCGCGCTGAGCCTGGTGCCCCCCGCGCCGGTAGCGGCCATCGACTGGACCGAGCCCCATGCCGCGCG
TTTCCAGGCGGCAATGGATGAAGACTTCGGCACGCCCGAGGCCGTGGCCGTGCTGTTCGACTTGGCCGTCGAGGTCAACA
AGAGCCACTCGCCGCAACGGGCCGGTCTGCTCAAAGCGCTCGGCGGCTGCCTGGGACTGCTGCAAGGCGACCCCCGGGCC
TTTTTGCAGGCCGGGGCGGGAACGCCCGACGAGGCCGACATCCAGGCCCGGATCGCAGCCCGCGCAGCAGCCAAGGCGCA
GCGCGACTTCGCCGAGGCCGACCGCATCCGCAATGCGCTGCTGGCCCAGGGCATCGTGCTCAAGGACGGCGCGACAGGAA
CCACATGGGAAGCCGCGCAGTGA

Upstream 100 bases:

>100_bases
GGGTACCATGGTGATACGCTGCTGCTGCCGGGTGCACCGCCTCGTCCATCCCCCTCAGATCCTTCATCGATACACCCTGA
GTCCCCGTGACTGAAATCCC

Downstream 100 bases:

>100_bases
TCTTTGCCCTGTTTGCGGCCAACGCCCCCGGGGCGAAGGGAGCGCCCGATGGCGGCTGCTAAGAAAACGACCTCTGCGGC
GGCGCAGGCCGGCACGGAGG

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSLRIYNTLSRALEEFSPLEPGHVRMYVCGMTIYDLCHIGHARMMMAFDVVQRWLKARGLKVTYVRNITDIDDKIIGRAL
ERGITIGALTDEMIAAMHADIGALGLEPPTLEPRATQYVPRMLALIGQLQAKGLAYRASNGDVNYAVRKFQGYGKLSGKS
PDELRAGARVALADGKTDPLDFVLWKSAKPHEPPEAQWDSDYGRGRPGWHIECSAMSCATLGESFDIHGGGADLQFPHHE
NEIAQSEGVTGKPLARFWLHNGFVRVDNEKMSKSLGNFFTIRDVLAQYDAQTVRFFIVRAHYRSALNYSDAHLDDARQAL
KRLYTALSLVPPAPVAAIDWTEPHAARFQAAMDEDFGTPEAVAVLFDLAVEVNKSHSPQRAGLLKALGGCLGLLQGDPRA
FLQAGAGTPDEADIQARIAARAAAKAQRDFAEADRIRNALLAQGIVLKDGATGTTWEAAQ

Sequences:

>Translated_460_residues
MSLRIYNTLSRALEEFSPLEPGHVRMYVCGMTIYDLCHIGHARMMMAFDVVQRWLKARGLKVTYVRNITDIDDKIIGRAL
ERGITIGALTDEMIAAMHADIGALGLEPPTLEPRATQYVPRMLALIGQLQAKGLAYRASNGDVNYAVRKFQGYGKLSGKS
PDELRAGARVALADGKTDPLDFVLWKSAKPHEPPEAQWDSDYGRGRPGWHIECSAMSCATLGESFDIHGGGADLQFPHHE
NEIAQSEGVTGKPLARFWLHNGFVRVDNEKMSKSLGNFFTIRDVLAQYDAQTVRFFIVRAHYRSALNYSDAHLDDARQAL
KRLYTALSLVPPAPVAAIDWTEPHAARFQAAMDEDFGTPEAVAVLFDLAVEVNKSHSPQRAGLLKALGGCLGLLQGDPRA
FLQAGAGTPDEADIQARIAARAAAKAQRDFAEADRIRNALLAQGIVLKDGATGTTWEAAQ
>Mature_459_residues
SLRIYNTLSRALEEFSPLEPGHVRMYVCGMTIYDLCHIGHARMMMAFDVVQRWLKARGLKVTYVRNITDIDDKIIGRALE
RGITIGALTDEMIAAMHADIGALGLEPPTLEPRATQYVPRMLALIGQLQAKGLAYRASNGDVNYAVRKFQGYGKLSGKSP
DELRAGARVALADGKTDPLDFVLWKSAKPHEPPEAQWDSDYGRGRPGWHIECSAMSCATLGESFDIHGGGADLQFPHHEN
EIAQSEGVTGKPLARFWLHNGFVRVDNEKMSKSLGNFFTIRDVLAQYDAQTVRFFIVRAHYRSALNYSDAHLDDARQALK
RLYTALSLVPPAPVAAIDWTEPHAARFQAAMDEDFGTPEAVAVLFDLAVEVNKSHSPQRAGLLKALGGCLGLLQGDPRAF
LQAGAGTPDEADIQARIAARAAAKAQRDFAEADRIRNALLAQGIVLKDGATGTTWEAAQ

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=392, Percent_Identity=36.734693877551, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI10835051, Length=310, Percent_Identity=36.1290322580645, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI21269877, Length=310, Percent_Identity=36.1290322580645, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI62240992, Length=339, Percent_Identity=34.2182890855457, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI303304987, Length=339, Percent_Identity=34.2182890855457, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1786737, Length=466, Percent_Identity=54.2918454935622, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17509795, Length=239, Percent_Identity=37.6569037656904, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17509797, Length=239, Percent_Identity=37.6569037656904, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324082, Length=307, Percent_Identity=29.9674267100977, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19922218, Length=509, Percent_Identity=31.041257367387, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI19922364, Length=269, Percent_Identity=36.4312267657993, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_VEREI (A1WSL6)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_999641.1
- ProteinModelPortal:   A1WSL6
- SMR:   A1WSL6
- STRING:   A1WSL6
- GeneID:   4692540
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4936
- NMPDR:   fig|391735.5.peg.4536
- eggNOG:   COG0215
- HOGENOM:   HBG327651
- OMA:   DFDALNM
- PhylomeDB:   A1WSL6
- ProtClustDB:   PRK00260
- BioCyc:   VEIS391735:VEIS_4936-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 50378; Mature: 50247

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRIYNTLSRALEEFSPLEPGHVRMYVCGMTIYDLCHIGHARMMMAFDVVQRWLKARGL
CCEEHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
KVTYVRNITDIDDKIIGRALERGITIGALTDEMIAAMHADIGALGLEPPTLEPRATQYVP
EEEEECCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RMLALIGQLQAKGLAYRASNGDVNYAVRKFQGYGKLSGKSPDELRAGARVALADGKTDPL
HHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEECCCCCCC
DFVLWKSAKPHEPPEAQWDSDYGRGRPGWHIECSAMSCATLGESFDIHGGGADLQFPHHE
EEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCCEECCCCCCCCCCCCC
NEIAQSEGVTGKPLARFWLHNGFVRVDNEKMSKSLGNFFTIRDVLAQYDAQTVRFFIVRA
CHHHHHCCCCCCHHHHHHHHCCEEEECHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHH
HYRSALNYSDAHLDDARQALKRLYTALSLVPPAPVAAIDWTEPHAARFQAAMDEDFGTPE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCCHH
AVAVLFDLAVEVNKSHSPQRAGLLKALGGCLGLLQGDPRAFLQAGAGTPDEADIQARIAA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHH
RAAAKAQRDFAEADRIRNALLAQGIVLKDGATGTTWEAAQ
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SLRIYNTLSRALEEFSPLEPGHVRMYVCGMTIYDLCHIGHARMMMAFDVVQRWLKARGL
CEEHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
KVTYVRNITDIDDKIIGRALERGITIGALTDEMIAAMHADIGALGLEPPTLEPRATQYVP
EEEEECCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RMLALIGQLQAKGLAYRASNGDVNYAVRKFQGYGKLSGKSPDELRAGARVALADGKTDPL
HHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEECCCCCCC
DFVLWKSAKPHEPPEAQWDSDYGRGRPGWHIECSAMSCATLGESFDIHGGGADLQFPHHE
EEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCCEECCCCCCCCCCCCC
NEIAQSEGVTGKPLARFWLHNGFVRVDNEKMSKSLGNFFTIRDVLAQYDAQTVRFFIVRA
CHHHHHCCCCCCHHHHHHHHCCEEEECHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHH
HYRSALNYSDAHLDDARQALKRLYTALSLVPPAPVAAIDWTEPHAARFQAAMDEDFGTPE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCCHH
AVAVLFDLAVEVNKSHSPQRAGLLKALGGCLGLLQGDPRAFLQAGAGTPDEADIQARIAA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHH
RAAAKAQRDFAEADRIRNALLAQGIVLKDGATGTTWEAAQ
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA