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The map label for this gene is cbl [H]

Identifier: 121611825

GI number: 121611825

Start: 5446117

End: 5447058

Strand: Direct

Name: cbl [H]

Synonym: Veis_4926

Alternate gene names: 121611825

Gene position: 5446117-5447058 (Clockwise)

Preceding gene: 121611824

Following gene: 121611826

Centisome position: 97.83

GC content: 63.27

Gene sequence:

>942_bases
ATGAACCTGCACCAATTTCGCTTCGTCCAAGAGGCTGCGCGCCGCAACCTGAACCTGACCGAGGCCGCCAAGGCCCTGCA
CACATCGCAGCCGGGCGTCTCCAAAGCCATCCTGGATCTGGAAGAAGAACTGGGCGTGGACATCTTTGCGCGCCATGGCA
AACGCCTCAAGCGCATCACCGAGCCCGGCCAGCATGTTCTCAAGAGCATAGAAGTCATCATGCGCGAGTTGGGCAACCTC
AAACGCATTGGCGAGCAGTTCAGCGCGCAAGACAGCGGCACCCTGAGCATCGCCACCACCCACACCCAGGCCCGCTACGT
GCTGCCCATCCCCGTGGCCCGTTTGCGTGACGCCTACCCCAAGGTCAACATCAGCCTGCACCAGGCCACGCCGCAGGAAG
TGGCGCGCATGGTCATCGACGAAGTGGCAGACATCGGCATGGCCACCGAGTCGCTGGCCGATTACCCCGAACTGGTCACG
CTGCCCTGCTACGAATGGCAGCATGTGTTGGTGCTCCCTGGCGATCACCCGCTGGCCCACAAGGAGCGCATTGGCCTGGA
CGACCTGGCCCACGAAGCGCTGATCACCTACCACCCGTCGTTCACCGGTCGCGGCAAGATCGACCACAGCTTCGGCGCCC
GCAAGCTGCAACCGCGCATCGTGCTCGAAGCCATAGACTCCGACGTGATCAAGACCTATGTGCGCCTGGGCCTGGGCATC
GGCATCGTGGCCGAAATGGCCATGCGCGAAGACCCGGTGGGGGATCTGGCGGTGCGACCCGTGGGGCACCTGTTCGGCCA
GAACGTCACGCGCGTGGCCTTCAAGCGCGGGGCCTATCTGCGCAACTTCGTCTATAAATTCGCCGAACTGATCAGTGAGC
GCCTGAGCCGCGAACTCATCGCCCAGGCGATGAGCGGGCAGGCCAATGACTACGAACTCTGA

Upstream 100 bases:

>100_bases
TGACGTGCAGGCGGCCATTGGCGCAGACCCGCGCGTCACCGCATTGATGGCGGACATCGCGTGCGAGGCCCCGCCGGAGT
CGAAACCTTTCTGAACTGCC

Downstream 100 bases:

>100_bases
CTTCCACGCCGCCACGCCCCATGACTGAAGCCACCCAAGCCAGCCCGACCGCCCGCACACCGGCCTTGCCGAACAAGCTG
CCGCAGGTGGGCACCACCAT

Product: transcriptional regulator CysB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAILDLEEELGVDIFARHGKRLKRITEPGQHVLKSIEVIMRELGNL
KRIGEQFSAQDSGTLSIATTHTQARYVLPIPVARLRDAYPKVNISLHQATPQEVARMVIDEVADIGMATESLADYPELVT
LPCYEWQHVLVLPGDHPLAHKERIGLDDLAHEALITYHPSFTGRGKIDHSFGARKLQPRIVLEAIDSDVIKTYVRLGLGI
GIVAEMAMREDPVGDLAVRPVGHLFGQNVTRVAFKRGAYLRNFVYKFAELISERLSRELIAQAMSGQANDYEL

Sequences:

>Translated_313_residues
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAILDLEEELGVDIFARHGKRLKRITEPGQHVLKSIEVIMRELGNL
KRIGEQFSAQDSGTLSIATTHTQARYVLPIPVARLRDAYPKVNISLHQATPQEVARMVIDEVADIGMATESLADYPELVT
LPCYEWQHVLVLPGDHPLAHKERIGLDDLAHEALITYHPSFTGRGKIDHSFGARKLQPRIVLEAIDSDVIKTYVRLGLGI
GIVAEMAMREDPVGDLAVRPVGHLFGQNVTRVAFKRGAYLRNFVYKFAELISERLSRELIAQAMSGQANDYEL
>Mature_313_residues
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAILDLEEELGVDIFARHGKRLKRITEPGQHVLKSIEVIMRELGNL
KRIGEQFSAQDSGTLSIATTHTQARYVLPIPVARLRDAYPKVNISLHQATPQEVARMVIDEVADIGMATESLADYPELVT
LPCYEWQHVLVLPGDHPLAHKERIGLDDLAHEALITYHPSFTGRGKIDHSFGARKLQPRIVLEAIDSDVIKTYVRLGLGI
GIVAEMAMREDPVGDLAVRPVGHLFGQNVTRVAFKRGAYLRNFVYKFAELISERLSRELIAQAMSGQANDYEL

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=316, Percent_Identity=45.5696202531646, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1787530, Length=312, Percent_Identity=41.6666666666667, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI157672245, Length=244, Percent_Identity=31.1475409836066, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788887, Length=301, Percent_Identity=28.9036544850498, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788481, Length=225, Percent_Identity=30.6666666666667, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1789204, Length=253, Percent_Identity=29.6442687747036, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790399, Length=298, Percent_Identity=24.8322147651007, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693105, Length=252, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=242, Percent_Identity=26.0330578512397, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34994; Mature: 34994

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAILDLEEELGVDIFARHGKRLKRIT
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHCCHHHHHHC
EPGQHVLKSIEVIMRELGNLKRIGEQFSAQDSGTLSIATTHTQARYVLPIPVARLRDAYP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCCHHHHHHCCC
KVNISLHQATPQEVARMVIDEVADIGMATESLADYPELVTLPCYEWQHVLVLPGDHPLAH
CCEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCH
KERIGLDDLAHEALITYHPSFTGRGKIDHSFGARKLQPRIVLEAIDSDVIKTYVRLGLGI
HHHCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
GIVAEMAMREDPVGDLAVRPVGHLFGQNVTRVAFKRGAYLRNFVYKFAELISERLSRELI
HHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQAMSGQANDYEL
HHHHCCCCCCCCC
>Mature Secondary Structure
MNLHQFRFVQEAARRNLNLTEAAKALHTSQPGVSKAILDLEEELGVDIFARHGKRLKRIT
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHCCHHHHHHC
EPGQHVLKSIEVIMRELGNLKRIGEQFSAQDSGTLSIATTHTQARYVLPIPVARLRDAYP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCCHHHHHHCCC
KVNISLHQATPQEVARMVIDEVADIGMATESLADYPELVTLPCYEWQHVLVLPGDHPLAH
CCEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCH
KERIGLDDLAHEALITYHPSFTGRGKIDHSFGARKLQPRIVLEAIDSDVIKTYVRLGLGI
HHHCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
GIVAEMAMREDPVGDLAVRPVGHLFGQNVTRVAFKRGAYLRNFVYKFAELISERLSRELI
HHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQAMSGQANDYEL
HHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]