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The map label for this gene is kdsB

Identifier: 121611793

GI number: 121611793

Start: 5411916

End: 5412734

Strand: Direct

Name: kdsB

Synonym: Veis_4894

Alternate gene names: 121611793

Gene position: 5411916-5412734 (Clockwise)

Preceding gene: 121611792

Following gene: 121611794

Centisome position: 97.22

GC content: 71.55

Gene sequence:

>819_bases
GTGAGCGCCGCGCCCGACGCGCAGGACTCGACAGCGAACGACCGCTTCACGGTGCTGATCCCGGCGCGCATGGCATCGAC
CCGCCTGCCGGGCAAACCCCTGGCCGACCTTGCCGGCCTGCCGATGGTGGTGCGGGTGGCCAAGCGTGCCGTGCACAGCG
CAGCCGACCGCGTGCTGGTGGCCACCGATGACGCCCGCATCCTGCAAGCCTGCGCCGCCCATGGCGTGGAGGCGATCCTG
ACCCGCGCCGACCATGCCAGCGGCAGCGACCGGCTGGCCGAGGCCTGCGCCCAGCTCGGGCTGGCGGACCAGCATATCGT
CGTCAATGTGCAGGGCGACGAACCGCTGATCGCCCCCGAACTCATCGATGCCGTGGCGGCGCTGCTGCCCGCCCGGCCCG
AAGCCGGCATGGGCACGGCCGCACATGCGATCGCAACGCTGGCCGACTACCACAACCCCCAGGTGGTCAAAGTGGTGCTC
GACGCGCGCGGCCTGGCGCAGTACTTCAGCCGCGCGCCGATTCCCTTCGCGCGCAACCCGGCAGAGCATGGCTGGTGCTC
CGCCGGCGCAGCGCCGGGCATGGGCACATTGGCCGGCCATGCCCCGCTGCGCCATATCGGCATCTACAGCTATCGCGCCG
GCTTTCTGCGGCAATTGACGCAACTCGCGCCCGCGCCGACCGAGACCATCGAGGCGCTGGAACAATTGCGGGCGCTCTGG
CATGGCCACCGCATCGCCGTGCACCTGACCGCAGCCGCCGCCGGCCCGGGCGTGGACACGCCCGAAGACCTGGAACGGGT
GCGCCGCCTTTTGCTCTGA

Upstream 100 bases:

>100_bases
TGATCTCCCGCAGCGCCAGGCTGGCCTACCCGGTGCGCGATGGCATCCCGGTGCTGCTGGAAAACGAGGCCCGCCCGCTG
ACCGACGAGGAACTGGAGCA

Downstream 100 bases:

>100_bases
GTCTGGTGTCGCGTCATCGGTCAGATGTCGCAGGCTGCGCGCAGCCATCGGAGCGCAGCGCAAAGCGCATCGCGCAGCCA
ATACCGAGCACCGAGCGTAT

Product: 3-deoxy-D-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSAAPDAQDSTANDRFTVLIPARMASTRLPGKPLADLAGLPMVVRVAKRAVHSAADRVLVATDDARILQACAAHGVEAIL
TRADHASGSDRLAEACAQLGLADQHIVVNVQGDEPLIAPELIDAVAALLPARPEAGMGTAAHAIATLADYHNPQVVKVVL
DARGLAQYFSRAPIPFARNPAEHGWCSAGAAPGMGTLAGHAPLRHIGIYSYRAGFLRQLTQLAPAPTETIEALEQLRALW
HGHRIAVHLTAAAAGPGVDTPEDLERVRRLLL

Sequences:

>Translated_272_residues
MSAAPDAQDSTANDRFTVLIPARMASTRLPGKPLADLAGLPMVVRVAKRAVHSAADRVLVATDDARILQACAAHGVEAIL
TRADHASGSDRLAEACAQLGLADQHIVVNVQGDEPLIAPELIDAVAALLPARPEAGMGTAAHAIATLADYHNPQVVKVVL
DARGLAQYFSRAPIPFARNPAEHGWCSAGAAPGMGTLAGHAPLRHIGIYSYRAGFLRQLTQLAPAPTETIEALEQLRALW
HGHRIAVHLTAAAAGPGVDTPEDLERVRRLLL
>Mature_271_residues
SAAPDAQDSTANDRFTVLIPARMASTRLPGKPLADLAGLPMVVRVAKRAVHSAADRVLVATDDARILQACAAHGVEAILT
RADHASGSDRLAEACAQLGLADQHIVVNVQGDEPLIAPELIDAVAALLPARPEAGMGTAAHAIATLADYHNPQVVKVVLD
ARGLAQYFSRAPIPFARNPAEHGWCSAGAAPGMGTLAGHAPLRHIGIYSYRAGFLRQLTQLAPAPTETIEALEQLRALWH
GHRIAVHLTAAAAGPGVDTPEDLERVRRLLL

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=253, Percent_Identity=50.9881422924901, Blast_Score=236, Evalue=9e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_VEREI (A1WSH5)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_999600.1
- ProteinModelPortal:   A1WSH5
- SMR:   A1WSH5
- STRING:   A1WSH5
- GeneID:   4691212
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4894
- NMPDR:   fig|391735.5.peg.4495
- eggNOG:   COG1212
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- PhylomeDB:   A1WSH5
- BioCyc:   VEIS391735:VEIS_4894-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 28593; Mature: 28462

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPDAQDSTANDRFTVLIPARMASTRLPGKPLADLAGLPMVVRVAKRAVHSAADRVLV
CCCCCCCCCCCCCCEEEEEEECHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCEEEE
ATDDARILQACAAHGVEAILTRADHASGSDRLAEACAQLGLADQHIVVNVQGDEPLIAPE
ECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
LIDAVAALLPARPEAGMGTAAHAIATLADYHNPQVVKVVLDARGLAQYFSRAPIPFARNP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCC
AEHGWCSAGAAPGMGTLAGHAPLRHIGIYSYRAGFLRQLTQLAPAPTETIEALEQLRALW
CCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HGHRIAVHLTAAAAGPGVDTPEDLERVRRLLL
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SAAPDAQDSTANDRFTVLIPARMASTRLPGKPLADLAGLPMVVRVAKRAVHSAADRVLV
CCCCCCCCCCCCCEEEEEEECHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCEEEE
ATDDARILQACAAHGVEAILTRADHASGSDRLAEACAQLGLADQHIVVNVQGDEPLIAPE
ECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
LIDAVAALLPARPEAGMGTAAHAIATLADYHNPQVVKVVLDARGLAQYFSRAPIPFARNP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCC
AEHGWCSAGAAPGMGTLAGHAPLRHIGIYSYRAGFLRQLTQLAPAPTETIEALEQLRALW
CCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HGHRIAVHLTAAAAGPGVDTPEDLERVRRLLL
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA