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The map label for this gene is adk

Identifier: 121611794

GI number: 121611794

Start: 5413032

End: 5413688

Strand: Direct

Name: adk

Synonym: Veis_4895

Alternate gene names: 121611794

Gene position: 5413032-5413688 (Clockwise)

Preceding gene: 121611793

Following gene: 121611799

Centisome position: 97.24

GC content: 66.06

Gene sequence:

>657_bases
ATGAGACTGATTCTGTTGGGCGCCCCCGGCGCCGGAAAGGGCACGCAAGCGGGCTTCATCTGCCAACGATACGGCATCCC
GCAAATCTCCACCGGCGACATGCTGCGCGCCGCCGTCAAGGCCGGCACGCCACTGGGCCTGCAGGCCAAGGCAGTGATGG
ACTCGGGGTCCTTGGTCAGTGACGACATCATCATCCATCTGGTCAAAGAGCGCATCGCGCAGCCGGACTGCGCCCAAGGC
TTTTTGTTCGACGGTTTTCCCCGCACCATTGCGCAGGCCGATGCGCTGAAGGCCGCAGGCGTCAGGCTCGATTACGTGCT
CGAAATCGACGTGCCCTTCGAGGCCATCATCGAGCGCATGAGCGGCCGCCGCTCGCACCCGGCCAGCGGTCGCACCTACC
ATGTCCGGTTCAACCCGCCCAAGATCGACGGCAAGGACGACCTGACCGGCGAAGCACTGCTACAGCGCGAAGACGACAAG
GAAGAAACCGTCAGAAAGCGCCTGCAGGTCTACAGCGCGCAGACCCGCCCCCTGGTGGACTACTACAGCCACTGGGCCCG
GGTCGAACCCGCCGCCGCCCCCCGGTACCGCTGCATCAGCGGCACAGGCCGCGTCGATGAGATCACCGCGCGCGCGCTGC
AGGCGCTGGCCTGCTGA

Upstream 100 bases:

>100_bases
GATCCCAGCGCAGCCCACATGCTATCCTCGACCGCAGCACCGCATCCCGGGCGCAGGGCGCATCCAGCGGCTTGGTACGC
CACAACCTTTGAGGATTTCC

Downstream 100 bases:

>100_bases
TTCCATTGCCAAATCGTTCGCGAAGGCGAAGCGCAGACAGTACAGATGACAGATGCGCGGCAAGCGACGCCGGCAAAGTG
CGCGGACGATTCAGGAATGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRLILLGAPGAGKGTQAGFICQRYGIPQISTGDMLRAAVKAGTPLGLQAKAVMDSGSLVSDDIIIHLVKERIAQPDCAQG
FLFDGFPRTIAQADALKAAGVRLDYVLEIDVPFEAIIERMSGRRSHPASGRTYHVRFNPPKIDGKDDLTGEALLQREDDK
EETVRKRLQVYSAQTRPLVDYYSHWARVEPAAAPRYRCISGTGRVDEITARALQALAC

Sequences:

>Translated_218_residues
MRLILLGAPGAGKGTQAGFICQRYGIPQISTGDMLRAAVKAGTPLGLQAKAVMDSGSLVSDDIIIHLVKERIAQPDCAQG
FLFDGFPRTIAQADALKAAGVRLDYVLEIDVPFEAIIERMSGRRSHPASGRTYHVRFNPPKIDGKDDLTGEALLQREDDK
EETVRKRLQVYSAQTRPLVDYYSHWARVEPAAAPRYRCISGTGRVDEITARALQALAC
>Mature_218_residues
MRLILLGAPGAGKGTQAGFICQRYGIPQISTGDMLRAAVKAGTPLGLQAKAVMDSGSLVSDDIIIHLVKERIAQPDCAQG
FLFDGFPRTIAQADALKAAGVRLDYVLEIDVPFEAIIERMSGRRSHPASGRTYHVRFNPPKIDGKDDLTGEALLQREDDK
EETVRKRLQVYSAQTRPLVDYYSHWARVEPAAAPRYRCISGTGRVDEITARALQALAC

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=48.3870967741936, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=48.3870967741936, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=47.2527472527472, Blast_Score=179, Evalue=1e-45,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=41.7582417582418, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=41.7582417582418, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=41.7582417582418, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=41.7582417582418, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=30.8108108108108, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=27.906976744186, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=29.1479820627803, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI28144897, Length=202, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI28144899, Length=202, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=25.8992805755396, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786680, Length=210, Percent_Identity=64.2857142857143, Blast_Score=277, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17552384, Length=219, Percent_Identity=44.2922374429224, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=205, Percent_Identity=32.6829268292683, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=216, Percent_Identity=32.8703703703704, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17533833, Length=200, Percent_Identity=28, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=197, Percent_Identity=26.9035532994924, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=49.5049504950495, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=43.6170212765958, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322828, Length=199, Percent_Identity=28.643216080402, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=47.5409836065574, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17737899, Length=183, Percent_Identity=44.8087431693989, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24645822, Length=183, Percent_Identity=44.8087431693989, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17647141, Length=215, Percent_Identity=29.7674418604651, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24663208, Length=215, Percent_Identity=29.7674418604651, Blast_Score=103, Evalue=6e-23,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_VEREI (A1WSH6)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_999601.1
- ProteinModelPortal:   A1WSH6
- SMR:   A1WSH6
- STRING:   A1WSH6
- GeneID:   4693825
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4895
- NMPDR:   fig|391735.5.peg.4496
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   A1WSH6
- ProtClustDB:   PRK00279
- BioCyc:   VEIS391735:VEIS_4895-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23836; Mature: 23836

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQAGFICQRYGIPQISTGDMLRAAVKAGTPLGLQAKAVMDSGSLVS
CEEEEEECCCCCCCCCCCEEHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCH
DDIIIHLVKERIAQPDCAQGFLFDGFPRTIAQADALKAAGVRLDYVLEIDVPFEAIIERM
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRSHPASGRTYHVRFNPPKIDGKDDLTGEALLQREDDKEETVRKRLQVYSAQTRPLVD
CCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH
YYSHWARVEPAAAPRYRCISGTGRVDEITARALQALAC
HHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQAGFICQRYGIPQISTGDMLRAAVKAGTPLGLQAKAVMDSGSLVS
CEEEEEECCCCCCCCCCCEEHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCH
DDIIIHLVKERIAQPDCAQGFLFDGFPRTIAQADALKAAGVRLDYVLEIDVPFEAIIERM
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRSHPASGRTYHVRFNPPKIDGKDDLTGEALLQREDDKEETVRKRLQVYSAQTRPLVD
CCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH
YYSHWARVEPAAAPRYRCISGTGRVDEITARALQALAC
HHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA