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The map label for this gene is lpxK

Identifier: 121611792

GI number: 121611792

Start: 5410627

End: 5411919

Strand: Direct

Name: lpxK

Synonym: Veis_4893

Alternate gene names: 121611792

Gene position: 5410627-5411919 (Clockwise)

Preceding gene: 121611791

Following gene: 121611793

Centisome position: 97.2

GC content: 71.77

Gene sequence:

>1293_bases
ATGGGCGCCTTGCGGCCGCAGCCGCCCCGCATGCCGGCAGGGCATGTTGCGCCAGCGTACTGGCAAAAACGCGGCCTGGC
CGCCTGGGCGCTGTGGCCGCTGGCACAGTTGTATCGCGCCCTGGTGGCAGCGCGGCGCGGGCTGTACCGGGCCGGATGGC
TCAAGGCGCAGCACCCGGGCCGCCCCGTCATCGTCGTCGGCAATGTGATTGCCGGCGGAGCGGGCAAGACCCCCGTGGTC
ATCGCCCTGGCGCGCCACCTGCAGGCGCGCGGCCTGCGCGTTGGCGTGATTGCACGCGGCCATGGCCGCAGCCGCCGCGA
CTGCCGCGCGGTGCTGCCCGACAGCCCGGCCAGCGCCGTGGGCGATGAGCCCGCGCTGATCGCGCGCCATTTCGCCAACG
GGCCTGCCGTCCCCGTCTTTGTCGCCCGGCGCCGCATCAGCGCCGCCCGCGCCCTGCTGGCCGCCCACCCCGATACCGAC
GTGCTCCTGTGCGACGACGGCCTGCAGCACCTGGCCCTGCGCCGGGATCTGGAAATTTGCGTGTTCAACGACCAGGGCCT
TGGCAACGGCTTTTTGCAGCCCGCCGGCCCGCTGCGCGAACCCTGGCCACGCAGCGTGGACTTCGTGCTGCATGCCGGCG
CCGCCCCCGGCGGATCGCCGGCCCCGGCCTTTGGCGTGCAGCGCAGCCTGGCCCCCTGCGCATTGCGCTCGGACGGAGCC
GCAGTGCCGCTGGCCCGGCTGCAAGGCCAGCCCCTGCATGCGCTGGCGGCCGTGGCCCGGCCGGGCGAATTCTTTGCCAT
GCTGCAAGCCCGGGGACTGACGCTGGCGCATACCGAGGCCCTGCCGGACCACTATGACTTGCAGCGCTGGGAACGCATGA
CGGACCCGCGCCTGACGCTGATCTGCACCGAAAAAGATGCGGTCAAACTGTGGCCCTTGCACCCGGACGCGCTGGCCGTG
CCGCTGGTGCTGCACATCGACCCCGGCTTTTTTGCCGCCCTCGATGCCTGGCTGCCGGCCCGGCGCGCCATGCCGGAAAT
CGCGCCGGGGAGCGACGCCGCCGCTATCATCGCCGGGACTGAACCCACCCTCCCGGAGAACCACCGCCCCATGGACCCCA
AACTGCTGCAATTGCTGGTCTGCCCTGTCACCAAAGGCCCGCTGCGCTATGACCGTGCAGCGCAGGAACTGATCTCCCGC
AGCGCCAGGCTGGCCTACCCGGTGCGCGATGGCATCCCGGTGCTGCTGGAAAACGAGGCCCGCCCGCTGACCGACGAGGA
ACTGGAGCAGTGA

Upstream 100 bases:

>100_bases
TGGTCACGGTGATGGAGGCCGCGCGCCGCTTGGGCCTGGCCCAGATCACGTTTGCCACGCAGTCCTCGGCCTCGGCACGG
GCCAGCGGTCGCTGACCGGC

Downstream 100 bases:

>100_bases
GCGCCGCGCCCGACGCGCAGGACTCGACAGCGAACGACCGCTTCACGGTGCTGATCCCGGCGCGCATGGCATCGACCCGC
CTGCCGGGCAAACCCCTGGC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MGALRPQPPRMPAGHVAPAYWQKRGLAAWALWPLAQLYRALVAARRGLYRAGWLKAQHPGRPVIVVGNVIAGGAGKTPVV
IALARHLQARGLRVGVIARGHGRSRRDCRAVLPDSPASAVGDEPALIARHFANGPAVPVFVARRRISAARALLAAHPDTD
VLLCDDGLQHLALRRDLEICVFNDQGLGNGFLQPAGPLREPWPRSVDFVLHAGAAPGGSPAPAFGVQRSLAPCALRSDGA
AVPLARLQGQPLHALAAVARPGEFFAMLQARGLTLAHTEALPDHYDLQRWERMTDPRLTLICTEKDAVKLWPLHPDALAV
PLVLHIDPGFFAALDAWLPARRAMPEIAPGSDAAAIIAGTEPTLPENHRPMDPKLLQLLVCPVTKGPLRYDRAAQELISR
SARLAYPVRDGIPVLLENEARPLTDEELEQ

Sequences:

>Translated_430_residues
MGALRPQPPRMPAGHVAPAYWQKRGLAAWALWPLAQLYRALVAARRGLYRAGWLKAQHPGRPVIVVGNVIAGGAGKTPVV
IALARHLQARGLRVGVIARGHGRSRRDCRAVLPDSPASAVGDEPALIARHFANGPAVPVFVARRRISAARALLAAHPDTD
VLLCDDGLQHLALRRDLEICVFNDQGLGNGFLQPAGPLREPWPRSVDFVLHAGAAPGGSPAPAFGVQRSLAPCALRSDGA
AVPLARLQGQPLHALAAVARPGEFFAMLQARGLTLAHTEALPDHYDLQRWERMTDPRLTLICTEKDAVKLWPLHPDALAV
PLVLHIDPGFFAALDAWLPARRAMPEIAPGSDAAAIIAGTEPTLPENHRPMDPKLLQLLVCPVTKGPLRYDRAAQELISR
SARLAYPVRDGIPVLLENEARPLTDEELEQ
>Mature_429_residues
GALRPQPPRMPAGHVAPAYWQKRGLAAWALWPLAQLYRALVAARRGLYRAGWLKAQHPGRPVIVVGNVIAGGAGKTPVVI
ALARHLQARGLRVGVIARGHGRSRRDCRAVLPDSPASAVGDEPALIARHFANGPAVPVFVARRRISAARALLAAHPDTDV
LLCDDGLQHLALRRDLEICVFNDQGLGNGFLQPAGPLREPWPRSVDFVLHAGAAPGGSPAPAFGVQRSLAPCALRSDGAA
VPLARLQGQPLHALAAVARPGEFFAMLQARGLTLAHTEALPDHYDLQRWERMTDPRLTLICTEKDAVKLWPLHPDALAVP
LVLHIDPGFFAALDAWLPARRAMPEIAPGSDAAAIIAGTEPTLPENHRPMDPKLLQLLVCPVTKGPLRYDRAAQELISRS
ARLAYPVRDGIPVLLENEARPLTDEELEQ

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the UPF0434 family

Homologues:

Organism=Escherichia coli, GI1787144, Length=288, Percent_Identity=38.8888888888889, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787146, Length=57, Percent_Identity=56.140350877193, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_VEREI (A1WSH4)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_999599.1
- ProteinModelPortal:   A1WSH4
- SMR:   A1WSH4
- STRING:   A1WSH4
- GeneID:   4694796
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4893
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   RLELICK
- PhylomeDB:   A1WSH4
- ProtClustDB:   PRK00652
- BioCyc:   VEIS391735:VEIS_4893-MONOMER
- HAMAP:   MF_00409
- HAMAP:   MF_01187
- InterPro:   IPR003758
- InterPro:   IPR005651
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK; PF03966 Trm112p

EC number: =2.7.1.130

Molecular weight: Translated: 46357; Mature: 46226

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGALRPQPPRMPAGHVAPAYWQKRGLAAWALWPLAQLYRALVAARRGLYRAGWLKAQHPG
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCEECCCCC
RPVIVVGNVIAGGAGKTPVVIALARHLQARGLRVGVIARGHGRSRRDCRAVLPDSPASAV
CCEEEECCEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHEECCCCCHHHC
GDEPALIARHFANGPAVPVFVARRRISAARALLAAHPDTDVLLCDDGLQHLALRRDLEIC
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCEEE
VFNDQGLGNGFLQPAGPLREPWPRSVDFVLHAGAAPGGSPAPAFGVQRSLAPCALRSDGA
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCEECCCCC
AVPLARLQGQPLHALAAVARPGEFFAMLQARGLTLAHTEALPDHYDLQRWERMTDPRLTL
CCCHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCEEEEHHCCCCHHHHHHHHHCCCCCEEE
ICTEKDAVKLWPLHPDALAVPLVLHIDPGFFAALDAWLPARRAMPEIAPGSDAAAIIAGT
EEECCCCEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
EPTLPENHRPMDPKLLQLLVCPVTKGPLRYDRAAQELISRSARLAYPVRDGIPVLLENEA
CCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCEEECCCC
RPLTDEELEQ
CCCCHHHHCC
>Mature Secondary Structure 
GALRPQPPRMPAGHVAPAYWQKRGLAAWALWPLAQLYRALVAARRGLYRAGWLKAQHPG
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCEECCCCC
RPVIVVGNVIAGGAGKTPVVIALARHLQARGLRVGVIARGHGRSRRDCRAVLPDSPASAV
CCEEEECCEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHEECCCCCHHHC
GDEPALIARHFANGPAVPVFVARRRISAARALLAAHPDTDVLLCDDGLQHLALRRDLEIC
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCEEE
VFNDQGLGNGFLQPAGPLREPWPRSVDFVLHAGAAPGGSPAPAFGVQRSLAPCALRSDGA
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCEECCCCC
AVPLARLQGQPLHALAAVARPGEFFAMLQARGLTLAHTEALPDHYDLQRWERMTDPRLTL
CCCHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCEEEEHHCCCCHHHHHHHHHCCCCCEEE
ICTEKDAVKLWPLHPDALAVPLVLHIDPGFFAALDAWLPARRAMPEIAPGSDAAAIIAGT
EEECCCCEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
EPTLPENHRPMDPKLLQLLVCPVTKGPLRYDRAAQELISRSARLAYPVRDGIPVLLENEA
CCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCEEECCCC
RPLTDEELEQ
CCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA