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The map label for this gene is hbd [H]

Identifier: 121611611

GI number: 121611611

Start: 5193358

End: 5194299

Strand: Direct

Name: hbd [H]

Synonym: Veis_4703

Alternate gene names: 121611611

Gene position: 5193358-5194299 (Clockwise)

Preceding gene: 121611610

Following gene: 121611612

Centisome position: 93.29

GC content: 69.11

Gene sequence:

>942_bases
ATGCAAGACCGCATTGCCATCGTCGGTGCCGGGCTCATCGGCCGCGCCTGGGCCATCGTGTTCGCGCGCGCCGGTTGCCA
GGTGCGTCTGCACGACGCCGACCCGCACGCTCTGGCCGACTGCCAGCGCCTGCTGCTGGAGAACATCGGCGACCTCGCCG
GGCATGGGTTGATCACGGAAGCCCCGGCGGCCGTGCTGGCCCGCATCAAACCGACCGCCAACCTGGCCGAGACGCTCGAA
GACGCGGCGCTGGTGCAGGAGAACGTGCGCGAGACCCTGGAAGCCAAGCGCGCCATCTTCGCCGAGATGGATGCGCTGTC
AGCACCCGATGCCATCTTGGCCAGTTCCACCTCGTGGCTCATGGCTTCGGAGTTCTCCGAAGGGCTGCCAGGGCGCCACC
GGGTCATGGTCGGACACCCCGTCAATCCGCCCTATCTGATCCCATTGGTCGAGGTCGCGCCAGCGCCGTGGACGTCCGAT
GCCGCCGTGCAGCGCGCCCACGCGCTGTACCGCCAAGCCGGGCAGTCGCCCGTGCTGCTGCGCAAGGAGATCACCGGCTT
CCTGCTGAACCGCATCCAGGGGGCGGTGCTCAACGAGGCGCTGAACCTCTACGCCGGCGGCTATGCCTCGGTGCAGGACT
TGGACAAGGTGCTCAAGGACGGCCTGGGCCTGCGCTGGTCCTTCATGGGCCCATTCGAGACCATCGACCTGAACGCACCG
GCCGGCCTGCTCGACTACGCCAGACGCTACGGCCCGACCTACCGCGACGTGGCGCGCGGCCAACAGCCCAACGACTGGGA
CGACGCGCTGGTGGCGCGCATCGATGCGGAACGCCGGGAAGCCTTGCCGGCCACCGAACTGGCCGCGCGTGCACGCTGGC
GCGACAACCGCCTCATGGCCCTGGTCGCGCATCAGCGCACCCAAGCACGCGACGCCGATTGA

Upstream 100 bases:

>100_bases
ATCGCCAACCAGATCGTTTTCATCTGCTCGCCGGCGGGCGCGACGATCAGCGGCCAAAGCCTTTCGGTGTGCGGCAACGT
CGAACATCTGGGCTGAGCCG

Downstream 100 bases:

>100_bases
CCCATCCATCCACCCCTTCCAACCGGAGCACCCCGTGCGCAAATCCAACAAAGTCATCATCACCTGTGCCGTCACCGGCG
CCATCCATACGCCGTCCATG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MQDRIAIVGAGLIGRAWAIVFARAGCQVRLHDADPHALADCQRLLLENIGDLAGHGLITEAPAAVLARIKPTANLAETLE
DAALVQENVRETLEAKRAIFAEMDALSAPDAILASSTSWLMASEFSEGLPGRHRVMVGHPVNPPYLIPLVEVAPAPWTSD
AAVQRAHALYRQAGQSPVLLRKEITGFLLNRIQGAVLNEALNLYAGGYASVQDLDKVLKDGLGLRWSFMGPFETIDLNAP
AGLLDYARRYGPTYRDVARGQQPNDWDDALVARIDAERREALPATELAARARWRDNRLMALVAHQRTQARDAD

Sequences:

>Translated_313_residues
MQDRIAIVGAGLIGRAWAIVFARAGCQVRLHDADPHALADCQRLLLENIGDLAGHGLITEAPAAVLARIKPTANLAETLE
DAALVQENVRETLEAKRAIFAEMDALSAPDAILASSTSWLMASEFSEGLPGRHRVMVGHPVNPPYLIPLVEVAPAPWTSD
AAVQRAHALYRQAGQSPVLLRKEITGFLLNRIQGAVLNEALNLYAGGYASVQDLDKVLKDGLGLRWSFMGPFETIDLNAP
AGLLDYARRYGPTYRDVARGQQPNDWDDALVARIDAERREALPATELAARARWRDNRLMALVAHQRTQARDAD
>Mature_313_residues
MQDRIAIVGAGLIGRAWAIVFARAGCQVRLHDADPHALADCQRLLLENIGDLAGHGLITEAPAAVLARIKPTANLAETLE
DAALVQENVRETLEAKRAIFAEMDALSAPDAILASSTSWLMASEFSEGLPGRHRVMVGHPVNPPYLIPLVEVAPAPWTSD
AAVQRAHALYRQAGQSPVLLRKEITGFLLNRIQGAVLNEALNLYAGGYASVQDLDKVLKDGLGLRWSFMGPFETIDLNAP
AGLLDYARRYGPTYRDVARGQQPNDWDDALVARIDAERREALPATELAARARWRDNRLMALVAHQRTQARDAD

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=306, Percent_Identity=40.5228758169935, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI296179429, Length=240, Percent_Identity=30.8333333333333, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI296179427, Length=257, Percent_Identity=28.7937743190661, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI68989263, Length=236, Percent_Identity=27.5423728813559, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI261878539, Length=236, Percent_Identity=27.5423728813559, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787661, Length=234, Percent_Identity=29.4871794871795, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790281, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788682, Length=220, Percent_Identity=26.3636363636364, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=264, Percent_Identity=35.6060606060606, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI193203623, Length=262, Percent_Identity=35.4961832061069, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17549919, Length=240, Percent_Identity=32.0833333333333, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17553560, Length=238, Percent_Identity=30.2521008403361, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71985923, Length=236, Percent_Identity=28.3898305084746, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17563036, Length=241, Percent_Identity=25.7261410788382, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45549573, Length=302, Percent_Identity=41.0596026490066, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI20129993, Length=308, Percent_Identity=42.2077922077922, Blast_Score=223, Evalue=9e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34142; Mature: 34142

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDRIAIVGAGLIGRAWAIVFARAGCQVRLHDADPHALADCQRLLLENIGDLAGHGLITE
CCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHH
APAAVLARIKPTANLAETLEDAALVQENVRETLEAKRAIFAEMDALSAPDAILASSTSWL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHH
MASEFSEGLPGRHRVMVGHPVNPPYLIPLVEVAPAPWTSDAAVQRAHALYRQAGQSPVLL
HHHHHHCCCCCCCEEEEECCCCCCEEEEEHEECCCCCCCHHHHHHHHHHHHHCCCCCCHH
RKEITGFLLNRIQGAVLNEALNLYAGGYASVQDLDKVLKDGLGLRWSFMGPFETIDLNAP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCEEEECCCC
AGLLDYARRYGPTYRDVARGQQPNDWDDALVARIDAERREALPATELAARARWRDNRLMA
CHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHCCCCEEE
LVAHQRTQARDAD
HHHHHHHHCCCCC
>Mature Secondary Structure
MQDRIAIVGAGLIGRAWAIVFARAGCQVRLHDADPHALADCQRLLLENIGDLAGHGLITE
CCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHH
APAAVLARIKPTANLAETLEDAALVQENVRETLEAKRAIFAEMDALSAPDAILASSTSWL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHH
MASEFSEGLPGRHRVMVGHPVNPPYLIPLVEVAPAPWTSDAAVQRAHALYRQAGQSPVLL
HHHHHHCCCCCCCEEEEECCCCCCEEEEEHEECCCCCCCHHHHHHHHHHHHHCCCCCCHH
RKEITGFLLNRIQGAVLNEALNLYAGGYASVQDLDKVLKDGLGLRWSFMGPFETIDLNAP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCEEEECCCC
AGLLDYARRYGPTYRDVARGQQPNDWDDALVARIDAERREALPATELAARARWRDNRLMA
CHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHCCCCEEE
LVAHQRTQARDAD
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA