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The map label for this gene is murC

Identifier: 121611480

GI number: 121611480

Start: 5061554

End: 5062987

Strand: Direct

Name: murC

Synonym: Veis_4571

Alternate gene names: 121611480

Gene position: 5061554-5062987 (Clockwise)

Preceding gene: 121611479

Following gene: 121611481

Centisome position: 90.92

GC content: 69.25

Gene sequence:

>1434_bases
ATGAAGCATGCCATCCGCCATATCCATTTCGTCGGCCTGGGCGGCGCCGGCATGAGCGGCATCGCCGAGGTGCTGTTCAA
CCTGGGCTACCGCATCTCGGGCTCGGACCTGGTCGACAGCGCCACGCTGCGCCGCCTGCAAGGGCTGGGCATCGGCACCT
GCCTGGGCCATGCCGGCGCGCATATCGAGGGCGCCGATGCAGTGGTCACCTCCACCGCCGTGACCGCCGACAACCCCGAG
GTGCTGGCCGCGCGCGCGAAGAAGATTCCGGTGGTGCCGCGCGCACTGATGCTGGCCGAGCTGATGCGCCTCAAGCAGGG
CATTGCGATTGCCGGCACCCATGGCAAGACCACCACCACCAGCCTGGTGACCAGCGTGCTGGCCGAGGCCGGGCTGGATC
CGACCTTCGTCATCGGCGGGCGCCTCAACAGCGTCGGCGCCCACGCCAAGCTGGGCAGCGGCGACTACATCGTGGTCGAG
GCCGACGAGTCCGACGCCTCGTTCCTGAACCTGCTGCCGGTGATGGCCGTGGTGACCAATATCGACGCCGACCATATGGA
GACTTACGGGCATGACTTCGGCCGGCTCAAGGGCGCGTTCGTCGACTTCCTGCACCGCATGCCGTTCTACGGCACGGCCA
TCTTGTGCGTCGACAGCCCGGCAGTGCGCGACATCATGCCCGGCGTGACCTGCCCGATCACCAGCTACGGCCTGTCCGAA
GACGCCCAGGTGCGGGCCGTGGACCTGCGCGCCGATGGCGCCCGGATGCACTTTACGGTGCAGCGCAGCAACGGCGTCAC
GCTGCCCGACCTGGCGGTGCAGCTCAATCTTGCGGGCGCGCACAACGTGCTCAACGCGCTGTCGGCGATTGCCGTGGCGG
TGGAATTGAACATCCCCGACGCAGCCGTGCTGCGCGCGCTGGCGGGCTTCAAGGGCGTGGGGCGGCGCTTTCAGAGCTAC
GGCCAGTTGCCGGCCAAGGACGGCGGCCAGTTCAGCGTGATCGACGACTACGGCCACCACCCGGTGGAGATGGCGGCCAC
GCTGGCGGCAGCGCGCGGCGCCTTCCCCGGGCGGCGCCTGGTGCTGGCCTTCCAGCCGCACCGCTACAGCCGCACGCGCG
ACTGCTTCGAGGACTTCGTGCGGGTCATGGGCAGCGCCGACGCGGTGCTGCTGACCGAGGTCTATGCCGCTGGCGAAGCG
CCCGTGGTGGCCGCCGACGGCCGCTCGCTGGCGCGCGCGCTGCGCGTGGCCGGCCGCGTCGAGCCGGTCTTCGTCGCCGA
CGTGGCCGATCTGCCGCAGGCCATTGCCGAGAACGCGCGCGACGGCGATCTGCTGCTGTGCATGGGCGCAGGCTCGATCG
GCGCCGTGCCTGGCAAACTACTCGAAATGCTACGAAACGATGAGCACACCGCAATGCAAAGGACTGCGCCATGA

Upstream 100 bases:

>100_bases
TGGAGCGCCCTGCGCTGCTGGACAAAGCGCTCAAAGCCCACGCGATGCAAAAGACAAGCGCCACGCAAGAGTTGGTCGGC
GCCTGCGAGGAGTTGGCCGC

Downstream 100 bases:

>100_bases
GCCTTTTTGATCCCCATCTGGACGGAGCGTCGCTGGGCAAGGTGGCGGTGCTGATGGGCGGGGTCTCGGCCGAGCGCGAG
GTTTCGCTGCTGTCCGGCGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MKHAIRHIHFVGLGGAGMSGIAEVLFNLGYRISGSDLVDSATLRRLQGLGIGTCLGHAGAHIEGADAVVTSTAVTADNPE
VLAARAKKIPVVPRALMLAELMRLKQGIAIAGTHGKTTTTSLVTSVLAEAGLDPTFVIGGRLNSVGAHAKLGSGDYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFGRLKGAFVDFLHRMPFYGTAILCVDSPAVRDIMPGVTCPITSYGLSE
DAQVRAVDLRADGARMHFTVQRSNGVTLPDLAVQLNLAGAHNVLNALSAIAVAVELNIPDAAVLRALAGFKGVGRRFQSY
GQLPAKDGGQFSVIDDYGHHPVEMAATLAAARGAFPGRRLVLAFQPHRYSRTRDCFEDFVRVMGSADAVLLTEVYAAGEA
PVVAADGRSLARALRVAGRVEPVFVADVADLPQAIAENARDGDLLLCMGAGSIGAVPGKLLEMLRNDEHTAMQRTAP

Sequences:

>Translated_477_residues
MKHAIRHIHFVGLGGAGMSGIAEVLFNLGYRISGSDLVDSATLRRLQGLGIGTCLGHAGAHIEGADAVVTSTAVTADNPE
VLAARAKKIPVVPRALMLAELMRLKQGIAIAGTHGKTTTTSLVTSVLAEAGLDPTFVIGGRLNSVGAHAKLGSGDYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFGRLKGAFVDFLHRMPFYGTAILCVDSPAVRDIMPGVTCPITSYGLSE
DAQVRAVDLRADGARMHFTVQRSNGVTLPDLAVQLNLAGAHNVLNALSAIAVAVELNIPDAAVLRALAGFKGVGRRFQSY
GQLPAKDGGQFSVIDDYGHHPVEMAATLAAARGAFPGRRLVLAFQPHRYSRTRDCFEDFVRVMGSADAVLLTEVYAAGEA
PVVAADGRSLARALRVAGRVEPVFVADVADLPQAIAENARDGDLLLCMGAGSIGAVPGKLLEMLRNDEHTAMQRTAP
>Mature_477_residues
MKHAIRHIHFVGLGGAGMSGIAEVLFNLGYRISGSDLVDSATLRRLQGLGIGTCLGHAGAHIEGADAVVTSTAVTADNPE
VLAARAKKIPVVPRALMLAELMRLKQGIAIAGTHGKTTTTSLVTSVLAEAGLDPTFVIGGRLNSVGAHAKLGSGDYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFGRLKGAFVDFLHRMPFYGTAILCVDSPAVRDIMPGVTCPITSYGLSE
DAQVRAVDLRADGARMHFTVQRSNGVTLPDLAVQLNLAGAHNVLNALSAIAVAVELNIPDAAVLRALAGFKGVGRRFQSY
GQLPAKDGGQFSVIDDYGHHPVEMAATLAAARGAFPGRRLVLAFQPHRYSRTRDCFEDFVRVMGSADAVLLTEVYAAGEA
PVVAADGRSLARALRVAGRVEPVFVADVADLPQAIAENARDGDLLLCMGAGSIGAVPGKLLEMLRNDEHTAMQRTAP

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=463, Percent_Identity=51.6198704103672, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1790680, Length=470, Percent_Identity=29.3617021276596, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_VEREI (A1WRL2)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_999287.1
- ProteinModelPortal:   A1WRL2
- SMR:   A1WRL2
- STRING:   A1WRL2
- GeneID:   4694111
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4571
- NMPDR:   fig|391735.5.peg.4191
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A1WRL2
- ProtClustDB:   PRK00421
- BioCyc:   VEIS391735:VEIS_4571-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50122; Mature: 50122

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHAIRHIHFVGLGGAGMSGIAEVLFNLGYRISGSDLVDSATLRRLQGLGIGTCLGHAGA
CCCCCEEEEEEEECCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHCCCHHHHHCCCCC
HIEGADAVVTSTAVTADNPEVLAARAKKIPVVPRALMLAELMRLKQGIAIAGTHGKTTTT
CCCCCCEEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVTSVLAEAGLDPTFVIGGRLNSVGAHAKLGSGDYIVVEADESDASFLNLLPVMAVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHC
IDADHMETYGHDFGRLKGAFVDFLHRMPFYGTAILCVDSPAVRDIMPGVTCPITSYGLSE
CCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCC
DAQVRAVDLRADGARMHFTVQRSNGVTLPDLAVQLNLAGAHNVLNALSAIAVAVELNIPD
CCEEEEEEEECCCCEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHEEEEEECCCH
AAVLRALAGFKGVGRRFQSYGQLPAKDGGQFSVIDDYGHHPVEMAATLAAARGAFPGRRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
VLAFQPHRYSRTRDCFEDFVRVMGSADAVLLTEVYAAGEAPVVAADGRSLARALRVAGRV
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EPVFVADVADLPQAIAENARDGDLLLCMGAGSIGAVPGKLLEMLRNDEHTAMQRTAP
CCEEEECHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure
MKHAIRHIHFVGLGGAGMSGIAEVLFNLGYRISGSDLVDSATLRRLQGLGIGTCLGHAGA
CCCCCEEEEEEEECCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHCCCHHHHHCCCCC
HIEGADAVVTSTAVTADNPEVLAARAKKIPVVPRALMLAELMRLKQGIAIAGTHGKTTTT
CCCCCCEEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVTSVLAEAGLDPTFVIGGRLNSVGAHAKLGSGDYIVVEADESDASFLNLLPVMAVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHC
IDADHMETYGHDFGRLKGAFVDFLHRMPFYGTAILCVDSPAVRDIMPGVTCPITSYGLSE
CCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCC
DAQVRAVDLRADGARMHFTVQRSNGVTLPDLAVQLNLAGAHNVLNALSAIAVAVELNIPD
CCEEEEEEEECCCCEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHEEEEEECCCH
AAVLRALAGFKGVGRRFQSYGQLPAKDGGQFSVIDDYGHHPVEMAATLAAARGAFPGRRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
VLAFQPHRYSRTRDCFEDFVRVMGSADAVLLTEVYAAGEAPVVAADGRSLARALRVAGRV
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EPVFVADVADLPQAIAENARDGDLLLCMGAGSIGAVPGKLLEMLRNDEHTAMQRTAP
CCEEEECHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA