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The map label for this gene is penA [H]

Identifier: 121611473

GI number: 121611473

Start: 5051415

End: 5053157

Strand: Direct

Name: penA [H]

Synonym: Veis_4564

Alternate gene names: 121611473

Gene position: 5051415-5053157 (Clockwise)

Preceding gene: 121611472

Following gene: 121611474

Centisome position: 90.74

GC content: 66.95

Gene sequence:

>1743_bases
ATGAGCCGCAGCGTGCTCTACACCTTGAGCCCGTTGCTGGCCAGCAAGACGCCGGTATGGCGCAGCAAGCTCATCGTGGC
GCTGATTGCGCTGGGCTTTGTCGGGCTGGGCGCGCGCGCGGCCCATGTGCAGGTGTTCGACAATGCCTTCTTCCAGCGCC
AGGGCGAGGTGCGCTTTGCCCGCACACTGGCGTTGCCCGCCAACCGCGGCCGAATTTTGGATCGCAACGGCCTGCTCCTG
GCTTCCAGCGTTCCTGCGGCCAGCATCTGGGCCATCCCCGAAGACGTGCTCCAGGACAGCCCCGCAGACCGCGCCAAGCT
CGGGCAGTTGGCCGGGTTGCTGGACATGCCGCAGGCCGAATTGCAGAAAAAGCTGGCCGATGAGGACAAGAGCTTTGTCT
GGATCAAGCGCCAACTCGACTGGGAGCAGGGCCAGCGCATTGCCGCGCTCGACATCAAGGGCATCTACCAGCGCAAGGAA
TACAAGCGCCAATACCCCGAGGGCGAGGCCGCCGCCCATGTGGTCGGCTTTACCAATGTGGAGGACCAGGGCCAGGAAGG
GGTGGAACTGGCCTTCGACGCGCTGCTGGCCGGCAAGGCCGGCTCGCGCCGCGTGATCAAGGACCGGTTCGGCCGCGTGG
TCGAAGGCGTGGGCGAAACCATGCCCCCGGTCGATGGCCGCGACATGCAGTTGTCGATCGACAGCAAGGTGCAGTTTTTT
GCCTACCAGAAACTGCGCGATCAGGTCATGGCCCACAAGGCCAAGGCCGGCAGCGTGGTGGTGCTCGACGCCCATACCGG
CGAGGTGCTGGCACTGGCCAATTACCCGAGCTACCTGCCCGAGCAGCGCCAGGGCCTGAGCGGCGAGCAACTGCGCAACC
GCGCGCTGACCGACGTGTTCGAGCCCGGCTCGACGATCAAGCCGTTCACCGTCGGCCTGGCGCTGGACAGCGGCCGCGTG
CGCCCCGAGACCATCGTCGACACCAGCCCGGGGCGCACCACGGTCACCGGCTTGACCATCTCCGACACGCACAACTACGG
CCTGCTCACGGTCGAGGGGGTGATACAGAAGTCGAGCAACGTCGGCGTGACCAAGATCGCAATGCAGATGCCGGCGCGCG
AGATGTGGGAGACCTTCTCGGCCGCCGGCTTCGGGCAAAAGCCGCAACTGCGCTTTCCCGGCGTGGTGACCGGGCGGCTG
CGCCCGTACAAAAGCTGGCGCCCGATCGAGCAGGCCACCATGGCCTATGGCTACGGCCTGTCGGCCAGCCTGTTCCAGAT
GGCGCGCTCGTACACCGTGTTTGCCAACGCAGGCCGGGTGATTCCGGCCACGATACTCAAGAGCGACGCAGCCGCCGTGG
GCGTGCCGGTGTTCTCCGAACGCACGGCGACCCAAGTGCGCAAGATGCTGCAAATGGCCGCAGGCCCGGGCGGCACCGGC
CAGAAGGCGCAGACCGTGGGCTACTCGGTCGGCGGCAAGTCGGGCACCGCGCGCAAGCAGGTGGGCAAGAACTACGCCTC
GGGCAAATACCGCGCCTGGTTCACCGGCATGGCCCCGATAGACCAGCCGCGCATCATCGTCGCGGTGATGATCGACGAGC
CCGGCAACGGCCAGTTCTACGGCGGCGCGGTGGCCGCGCCGGTGTTCAGCAGCGTCGTGCAGCAAACGCTGCGCATGTTG
GGCGTGCCGCCCGATCAGGCCGTCAAGCCGCAGATCGTGGCCCACGTGCAGGAGCCGCTGTGA

Upstream 100 bases:

>100_bases
ACATGCGGCTGGTCACGCCCGCGATCACCCGCTATGTGTCCGACCCGCAAGGGATGGCGCCGGGCGCCGGCTCCACCTTT
GCGTCCGAAGGTGCGCAGCC

Downstream 100 bases:

>100_bases
TGTCTGCGCCGCTGCCTGCCCCACTGCATGTGCTGCATACGCCGCATGCGCTGCAATGCGCCGGCGCGGCCTTGCCATGG
CTGCGCGCGCGCGTGAGCGG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSRSVLYTLSPLLASKTPVWRSKLIVALIALGFVGLGARAAHVQVFDNAFFQRQGEVRFARTLALPANRGRILDRNGLLL
ASSVPAASIWAIPEDVLQDSPADRAKLGQLAGLLDMPQAELQKKLADEDKSFVWIKRQLDWEQGQRIAALDIKGIYQRKE
YKRQYPEGEAAAHVVGFTNVEDQGQEGVELAFDALLAGKAGSRRVIKDRFGRVVEGVGETMPPVDGRDMQLSIDSKVQFF
AYQKLRDQVMAHKAKAGSVVVLDAHTGEVLALANYPSYLPEQRQGLSGEQLRNRALTDVFEPGSTIKPFTVGLALDSGRV
RPETIVDTSPGRTTVTGLTISDTHNYGLLTVEGVIQKSSNVGVTKIAMQMPAREMWETFSAAGFGQKPQLRFPGVVTGRL
RPYKSWRPIEQATMAYGYGLSASLFQMARSYTVFANAGRVIPATILKSDAAAVGVPVFSERTATQVRKMLQMAAGPGGTG
QKAQTVGYSVGGKSGTARKQVGKNYASGKYRAWFTGMAPIDQPRIIVAVMIDEPGNGQFYGGAVAAPVFSSVVQQTLRML
GVPPDQAVKPQIVAHVQEPL

Sequences:

>Translated_580_residues
MSRSVLYTLSPLLASKTPVWRSKLIVALIALGFVGLGARAAHVQVFDNAFFQRQGEVRFARTLALPANRGRILDRNGLLL
ASSVPAASIWAIPEDVLQDSPADRAKLGQLAGLLDMPQAELQKKLADEDKSFVWIKRQLDWEQGQRIAALDIKGIYQRKE
YKRQYPEGEAAAHVVGFTNVEDQGQEGVELAFDALLAGKAGSRRVIKDRFGRVVEGVGETMPPVDGRDMQLSIDSKVQFF
AYQKLRDQVMAHKAKAGSVVVLDAHTGEVLALANYPSYLPEQRQGLSGEQLRNRALTDVFEPGSTIKPFTVGLALDSGRV
RPETIVDTSPGRTTVTGLTISDTHNYGLLTVEGVIQKSSNVGVTKIAMQMPAREMWETFSAAGFGQKPQLRFPGVVTGRL
RPYKSWRPIEQATMAYGYGLSASLFQMARSYTVFANAGRVIPATILKSDAAAVGVPVFSERTATQVRKMLQMAAGPGGTG
QKAQTVGYSVGGKSGTARKQVGKNYASGKYRAWFTGMAPIDQPRIIVAVMIDEPGNGQFYGGAVAAPVFSSVVQQTLRML
GVPPDQAVKPQIVAHVQEPL
>Mature_579_residues
SRSVLYTLSPLLASKTPVWRSKLIVALIALGFVGLGARAAHVQVFDNAFFQRQGEVRFARTLALPANRGRILDRNGLLLA
SSVPAASIWAIPEDVLQDSPADRAKLGQLAGLLDMPQAELQKKLADEDKSFVWIKRQLDWEQGQRIAALDIKGIYQRKEY
KRQYPEGEAAAHVVGFTNVEDQGQEGVELAFDALLAGKAGSRRVIKDRFGRVVEGVGETMPPVDGRDMQLSIDSKVQFFA
YQKLRDQVMAHKAKAGSVVVLDAHTGEVLALANYPSYLPEQRQGLSGEQLRNRALTDVFEPGSTIKPFTVGLALDSGRVR
PETIVDTSPGRTTVTGLTISDTHNYGLLTVEGVIQKSSNVGVTKIAMQMPAREMWETFSAAGFGQKPQLRFPGVVTGRLR
PYKSWRPIEQATMAYGYGLSASLFQMARSYTVFANAGRVIPATILKSDAAAVGVPVFSERTATQVRKMLQMAAGPGGTGQ
KAQTVGYSVGGKSGTARKQVGKNYASGKYRAWFTGMAPIDQPRIIVAVMIDEPGNGQFYGGAVAAPVFSSVVQQTLRMLG
VPPDQAVKPQIVAHVQEPL

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=550, Percent_Identity=40.5454545454545, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1786854, Length=617, Percent_Identity=24.9594813614263, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62872; Mature: 62741

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSVLYTLSPLLASKTPVWRSKLIVALIALGFVGLGARAAHVQVFDNAFFQRQGEVRFA
CCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCCEEEE
RTLALPANRGRILDRNGLLLASSVPAASIWAIPEDVLQDSPADRAKLGQLAGLLDMPQAE
EEEECCCCCCEEEECCCEEEECCCCCCEEECCCHHHHCCCCCCHHHHHHHHHHHCCCHHH
LQKKLADEDKSFVWIKRQLDWEQGQRIAALDIKGIYQRKEYKRQYPEGEAAAHVVGFTNV
HHHHHHCCCCCEEEEEEECCHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCC
EDQGQEGVELAFDALLAGKAGSRRVIKDRFGRVVEGVGETMPPVDGRDMQLSIDSKVQFF
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHH
AYQKLRDQVMAHKAKAGSVVVLDAHTGEVLALANYPSYLPEQRQGLSGEQLRNRALTDVF
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHH
EPGSTIKPFTVGLALDSGRVRPETIVDTSPGRTTVTGLTISDTHNYGLLTVEGVIQKSSN
CCCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEEEEECCCCCCEEEEEEHHHCCCC
VGVTKIAMQMPAREMWETFSAAGFGQKPQLRFPGVVTGRLRPYKSWRPIEQATMAYGYGL
CCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCCCC
SASLFQMARSYTVFANAGRVIPATILKSDAAAVGVPVFSERTATQVRKMLQMAAGPGGTG
CHHHHHHHHCEEEEECCCCEEEHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCC
QKAQTVGYSVGGKSGTARKQVGKNYASGKYRAWFTGMAPIDQPRIIVAVMIDEPGNGQFY
CCCCEEEEECCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEE
GGAVAAPVFSSVVQQTLRMLGVPPDQAVKPQIVAHVQEPL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
SRSVLYTLSPLLASKTPVWRSKLIVALIALGFVGLGARAAHVQVFDNAFFQRQGEVRFA
CCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCCEEEE
RTLALPANRGRILDRNGLLLASSVPAASIWAIPEDVLQDSPADRAKLGQLAGLLDMPQAE
EEEECCCCCCEEEECCCEEEECCCCCCEEECCCHHHHCCCCCCHHHHHHHHHHHCCCHHH
LQKKLADEDKSFVWIKRQLDWEQGQRIAALDIKGIYQRKEYKRQYPEGEAAAHVVGFTNV
HHHHHHCCCCCEEEEEEECCHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCC
EDQGQEGVELAFDALLAGKAGSRRVIKDRFGRVVEGVGETMPPVDGRDMQLSIDSKVQFF
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHH
AYQKLRDQVMAHKAKAGSVVVLDAHTGEVLALANYPSYLPEQRQGLSGEQLRNRALTDVF
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHH
EPGSTIKPFTVGLALDSGRVRPETIVDTSPGRTTVTGLTISDTHNYGLLTVEGVIQKSSN
CCCCCCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEEEEECCCCCCEEEEEEHHHCCCC
VGVTKIAMQMPAREMWETFSAAGFGQKPQLRFPGVVTGRLRPYKSWRPIEQATMAYGYGL
CCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCCCC
SASLFQMARSYTVFANAGRVIPATILKSDAAAVGVPVFSERTATQVRKMLQMAAGPGGTG
CHHHHHHHHCEEEEECCCCEEEHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCC
QKAQTVGYSVGGKSGTARKQVGKNYASGKYRAWFTGMAPIDQPRIIVAVMIDEPGNGQFY
CCCCEEEEECCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEE
GGAVAAPVFSSVVQQTLRMLGVPPDQAVKPQIVAHVQEPL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]