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The map label for this gene is ilvD [H]

Identifier: 121611433

GI number: 121611433

Start: 5005197

End: 5006885

Strand: Direct

Name: ilvD [H]

Synonym: Veis_4523

Alternate gene names: 121611433

Gene position: 5005197-5006885 (Clockwise)

Preceding gene: 121611432

Following gene: 121611436

Centisome position: 89.91

GC content: 65.3

Gene sequence:

>1689_bases
ATGAGAAACTACCGTTCCAACTTCGAGCCAGGCACCACCCGGTGGGCCATTCGCCGTGCCCAATGGCGCGCGCTGGGCAT
CCCGGAATCCGATATGCACAAGCCAAAGATCGCCATCATCAACTCGTCCTCTGAGATGTCGATCTGTTTCAGCCATCTGG
ACGAAGTGGCCGGGATCGTCCGGCAAGCAATCCTCGACGCCGGCGGTCTGCCCTTCATCGTCAAAACGACCGCGCCAAGC
GACTTCATTACCGGCGCCGGTCGTGGTGGGCGCTACCTGATGCCAGCGCGCGACCTGCTGGTCAACGACATCGAAGTGGC
TGTCGAAGGCGCGGTGCTGGACGGCATGGTCTGCTTGAGCAGTTGCGACAAAACCGCGCCGGCGCATCTGATGGCCGCAG
CGCGGTTGAACATTCCGTCGATTCTCGTGATCGGTGGTTACCAGGGCTGTGGCCAGCGCGCGGGCCGGCCGGTCGATATC
GAAGACGTTTTCGAATCCGTCGGCGCACTGGCTGCCGGCAAGATCAGCATCCAGGACATCACCGACCTGTCCGAGGTCGC
AGTGCAAGGCCCGGGCGTGTGCGCGGGGATGGGCACGGCCAACACCATGCACATCATGGCCGAGGCATTGGGCATGGCGC
TGCCGGGTAGCGCGCCGGTGGCTGCACGCAGTGCGCGCATGAAGGAACTGGCGCGCGCTGCCGGGCGACGCATCGTAGGC
CTCGTCGATGAGGACCTCCGTCCCAAGGACATCATGACGCCTGCGGCGTTCGCCAACGCGATCCGTGTCGGCCTGGCAGT
CAGCGGCTCCATCAACCTGCTGCGCCACCTGCAAGCCATCGCCACGGAGGGCGAGATCGACGTGGACATGTTTCAACTCA
TGGATGCGCTGGGTCGCAGTGCGCAGGGCACCCGGGCCGTTCCACTGCTTTGCGCGATCAAGCCCAATGGGCCTGGCCGT
ATCGAACACCTCGAAGCGGCCGGCGGGGCCATCGCCGTGATGAAAGAACTCGAATCGCTGCTGGACGCCGAAGTTCTTAC
CGTCACCGGGCGCACGCTGCGCGAGAATCTGGCGGGCATCGAAGTGCTGGACGCACAGATCATCGGCAGCCTGACCCGCC
CCATAGGCCCTGGCCCGTCTGTGGTGATCCTCAAGGGCAGCCTGGCGCCCGATGGTGCGGTGATGAAGCTCGGGTTGGGC
GGCAAGCAGAGCGCGTTCCGGGGCGTCTGCCGCGTATTCGAAAGCCAGGAAGATGCGATGGCGGCGCTTTCCAACGGGGA
AATCACGAGCGGACAGGTGATCGTACTGCGCGGCTTGGGCGCGCGCGGAGGACCGGGCGTGGCGTCGGCCTCGTGGTTCG
TAGCGGCAGTCAATGGGGCGCATTTGGGCGACGATATCGCCGTCATCACCGACGGACAGTTCTCGGGGTTGAACCACGGC
TTCACGATTGGGCAGGTGCTGCCCGAGGCGGCGGACGGTGGCCCGATTGCGCTGGTGCGCGACGGCGACACCGTGGCCAT
CGACATCGCCGGACGCACGGTAGACCTGCTGCTCGACGCCTGCGAGTGGCAAGCCCGCCGCGCGGCGCTCGCACCGTTCG
TGCCGGGTGAAAAGAAAGGCTGGCTCAGCCTGTATCAGCACCTGGTGCAGCCGCTGTCCAAGGGCGGCACGTTGAAAGCA
AGAGGCTGA

Upstream 100 bases:

>100_bases
CATGCCGCGTGACATCGACACCGATGCGTTGCGCCGGACATTGCGCGCACAAGGCGCGATCCTGGGCGACTGAGTTCCCT
CACTTCGATACCCGAATCCG

Downstream 100 bases:

>100_bases
ACCCATGCCCTTACACACAACTTCCCCCCGCATCCTGAAGCAAGCGCATATGCTCAACACCCTGCACAAAATCCCTGACC
CGGGCAAAGCCAAGCCAGAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MRNYRSNFEPGTTRWAIRRAQWRALGIPESDMHKPKIAIINSSSEMSICFSHLDEVAGIVRQAILDAGGLPFIVKTTAPS
DFITGAGRGGRYLMPARDLLVNDIEVAVEGAVLDGMVCLSSCDKTAPAHLMAAARLNIPSILVIGGYQGCGQRAGRPVDI
EDVFESVGALAAGKISIQDITDLSEVAVQGPGVCAGMGTANTMHIMAEALGMALPGSAPVAARSARMKELARAAGRRIVG
LVDEDLRPKDIMTPAAFANAIRVGLAVSGSINLLRHLQAIATEGEIDVDMFQLMDALGRSAQGTRAVPLLCAIKPNGPGR
IEHLEAAGGAIAVMKELESLLDAEVLTVTGRTLRENLAGIEVLDAQIIGSLTRPIGPGPSVVILKGSLAPDGAVMKLGLG
GKQSAFRGVCRVFESQEDAMAALSNGEITSGQVIVLRGLGARGGPGVASASWFVAAVNGAHLGDDIAVITDGQFSGLNHG
FTIGQVLPEAADGGPIALVRDGDTVAIDIAGRTVDLLLDACEWQARRAALAPFVPGEKKGWLSLYQHLVQPLSKGGTLKA
RG

Sequences:

>Translated_562_residues
MRNYRSNFEPGTTRWAIRRAQWRALGIPESDMHKPKIAIINSSSEMSICFSHLDEVAGIVRQAILDAGGLPFIVKTTAPS
DFITGAGRGGRYLMPARDLLVNDIEVAVEGAVLDGMVCLSSCDKTAPAHLMAAARLNIPSILVIGGYQGCGQRAGRPVDI
EDVFESVGALAAGKISIQDITDLSEVAVQGPGVCAGMGTANTMHIMAEALGMALPGSAPVAARSARMKELARAAGRRIVG
LVDEDLRPKDIMTPAAFANAIRVGLAVSGSINLLRHLQAIATEGEIDVDMFQLMDALGRSAQGTRAVPLLCAIKPNGPGR
IEHLEAAGGAIAVMKELESLLDAEVLTVTGRTLRENLAGIEVLDAQIIGSLTRPIGPGPSVVILKGSLAPDGAVMKLGLG
GKQSAFRGVCRVFESQEDAMAALSNGEITSGQVIVLRGLGARGGPGVASASWFVAAVNGAHLGDDIAVITDGQFSGLNHG
FTIGQVLPEAADGGPIALVRDGDTVAIDIAGRTVDLLLDACEWQARRAALAPFVPGEKKGWLSLYQHLVQPLSKGGTLKA
RG
>Mature_562_residues
MRNYRSNFEPGTTRWAIRRAQWRALGIPESDMHKPKIAIINSSSEMSICFSHLDEVAGIVRQAILDAGGLPFIVKTTAPS
DFITGAGRGGRYLMPARDLLVNDIEVAVEGAVLDGMVCLSSCDKTAPAHLMAAARLNIPSILVIGGYQGCGQRAGRPVDI
EDVFESVGALAAGKISIQDITDLSEVAVQGPGVCAGMGTANTMHIMAEALGMALPGSAPVAARSARMKELARAAGRRIVG
LVDEDLRPKDIMTPAAFANAIRVGLAVSGSINLLRHLQAIATEGEIDVDMFQLMDALGRSAQGTRAVPLLCAIKPNGPGR
IEHLEAAGGAIAVMKELESLLDAEVLTVTGRTLRENLAGIEVLDAQIIGSLTRPIGPGPSVVILKGSLAPDGAVMKLGLG
GKQSAFRGVCRVFESQEDAMAALSNGEITSGQVIVLRGLGARGGPGVASASWFVAAVNGAHLGDDIAVITDGQFSGLNHG
FTIGQVLPEAADGGPIALVRDGDTVAIDIAGRTVDLLLDACEWQARRAALAPFVPGEKKGWLSLYQHLVQPLSKGGTLKA
RG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=578, Percent_Identity=34.4290657439446, Blast_Score=282, Evalue=5e-77,
Organism=Escherichia coli, GI2367371, Length=486, Percent_Identity=31.4814814814815, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786464, Length=492, Percent_Identity=30.4878048780488, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1788157, Length=535, Percent_Identity=29.3457943925234, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322476, Length=556, Percent_Identity=35.0719424460432, Blast_Score=285, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 58476; Mature: 58476

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNYRSNFEPGTTRWAIRRAQWRALGIPESDMHKPKIAIINSSSEMSICFSHLDEVAGIV
CCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
RQAILDAGGLPFIVKTTAPSDFITGAGRGGRYLMPARDLLVNDIEVAVEGAVLDGMVCLS
HHHHHCCCCCCEEEEECCCCHHHCCCCCCCEEECCHHHHHHHHHHHEECCHHHHHHHHHH
SCDKTAPAHLMAAARLNIPSILVIGGYQGCGQRAGRPVDIEDVFESVGALAAGKISIQDI
HCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHCCCCCCHHHHHHHHCCHHCCCEEHHHH
TDLSEVAVQGPGVCAGMGTANTMHIMAEALGMALPGSAPVAARSARMKELARAAGRRIVG
HHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
LVDEDLRPKDIMTPAAFANAIRVGLAVSGSINLLRHLQAIATEGEIDVDMFQLMDALGRS
ECCCCCCCHHCCCHHHHHHHHHEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
AQGTRAVPLLCAIKPNGPGRIEHLEAAGGAIAVMKELESLLDAEVLTVTGRTLRENLAGI
CCCCCCEEEEEEECCCCCCCEEEEHHCCCHHHHHHHHHHHHCCEEEEECCHHHHHHCCCC
EVLDAQIIGSLTRPIGPGPSVVILKGSLAPDGAVMKLGLGGKQSAFRGVCRVFESQEDAM
EEHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHH
AALSNGEITSGQVIVLRGLGARGGPGVASASWFVAAVNGAHLGDDIAVITDGQFSGLNHG
HHHCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCC
FTIGQVLPEAADGGPIALVRDGDTVAIDIAGRTVDLLLDACEWQARRAALAPFVPGEKKG
EEHHHHCCCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
WLSLYQHLVQPLSKGGTLKARG
HHHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure
MRNYRSNFEPGTTRWAIRRAQWRALGIPESDMHKPKIAIINSSSEMSICFSHLDEVAGIV
CCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
RQAILDAGGLPFIVKTTAPSDFITGAGRGGRYLMPARDLLVNDIEVAVEGAVLDGMVCLS
HHHHHCCCCCCEEEEECCCCHHHCCCCCCCEEECCHHHHHHHHHHHEECCHHHHHHHHHH
SCDKTAPAHLMAAARLNIPSILVIGGYQGCGQRAGRPVDIEDVFESVGALAAGKISIQDI
HCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHCCCCCCHHHHHHHHCCHHCCCEEHHHH
TDLSEVAVQGPGVCAGMGTANTMHIMAEALGMALPGSAPVAARSARMKELARAAGRRIVG
HHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
LVDEDLRPKDIMTPAAFANAIRVGLAVSGSINLLRHLQAIATEGEIDVDMFQLMDALGRS
ECCCCCCCHHCCCHHHHHHHHHEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
AQGTRAVPLLCAIKPNGPGRIEHLEAAGGAIAVMKELESLLDAEVLTVTGRTLRENLAGI
CCCCCCEEEEEEECCCCCCCEEEEHHCCCHHHHHHHHHHHHCCEEEEECCHHHHHHCCCC
EVLDAQIIGSLTRPIGPGPSVVILKGSLAPDGAVMKLGLGGKQSAFRGVCRVFESQEDAM
EEHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHH
AALSNGEITSGQVIVLRGLGARGGPGVASASWFVAAVNGAHLGDDIAVITDGQFSGLNHG
HHHCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCC
FTIGQVLPEAADGGPIALVRDGDTVAIDIAGRTVDLLLDACEWQARRAALAPFVPGEKKG
EEHHHHCCCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
WLSLYQHLVQPLSKGGTLKARG
HHHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA