Click here to switch to the map view.

The map label for this gene is fabG2 [H]

Identifier: 121611421

GI number: 121611421

Start: 4991109

End: 4991828

Strand: Direct

Name: fabG2 [H]

Synonym: Veis_4510

Alternate gene names: 121611421

Gene position: 4991109-4991828 (Clockwise)

Preceding gene: 121611420

Following gene: 121611422

Centisome position: 89.66

GC content: 67.64

Gene sequence:

>720_bases
ATGAAGCCCGTCGCCATCGTCACCGGTGGGTCCAGCAACATCGGCTGGGCCTGCGTGCAACGCTTCTGCGCCGACCACCG
GGTGCTGATCGCCGATCTGCAGCCGCCACAGGCGCCACTGCCCGAAGGCGTGTCCTTCATCCAGACCGATGTCACCAGCC
AGGCGCAGTGCGCCGCGCTCATACAACGAGCGGCGACGCAGGGCGCGCTTGCGGCCTTGGTGCATTCGGCAGCGATCACC
GCAGAGGCCAAGCCCTTCGATCAGATCGATGCAGCCGAATGGCACCGGCTACTGGAGGTCAACCTCACGGGCAGTTTCCT
GGTCGCGCAGTCGGCCATTGCGCTGCTTCGCCGCAGCCGTGGGGCGATGGTGTTGGTCTCGTCGCGCGCCGCGCGCACCG
GCTACGCCGCGCTCACCGCATCGGGCAGCGGGACCAAGCCGCACTACTGCGCATCGAAAGCCGGGGTGTTGTCGCTGGTG
AAGTCATTGGCCGTTGAACTGGCCGGTGACGGCGTGCGCGTCAACGCTGTGGTGCCGGGCGCGATCGAGGGCGCCATGAT
CCCGCAACAGCGCTGGGCCGAACTCTCGGCCCGCATCCCGCTGGGCCGCCTCGGGCTTGCGGCCGAGGTGGCAGATGCAG
CCCATTACCTGTGTTCCAGCGGCGCCCGGTACGTGACAGGCCATGCGCTCGACATCAACGGTGGCACATGGATGAACTGA

Upstream 100 bases:

>100_bases
CCATCGCAGCCGCCCGCAGCGCCGATCTGCCGACGGTCATCGACCTGGCCATCGACCCTGCGGCCAGCCACATCGCGGCC
TCGGACTACTGAGCGTGGCC

Downstream 100 bases:

>100_bases
AGCCACGCAAGAAGGAGACTCCATGATGAACATGCCCAGCCAGACATCGCGCCGCAGCGCGCTGAAGGCCCTGGCCCTCG
CGGCCGGCACCCAGGCGGCG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKPVAIVTGGSSNIGWACVQRFCADHRVLIADLQPPQAPLPEGVSFIQTDVTSQAQCAALIQRAATQGALAALVHSAAIT
AEAKPFDQIDAAEWHRLLEVNLTGSFLVAQSAIALLRRSRGAMVLVSSRAARTGYAALTASGSGTKPHYCASKAGVLSLV
KSLAVELAGDGVRVNAVVPGAIEGAMIPQQRWAELSARIPLGRLGLAAEVADAAHYLCSSGARYVTGHALDINGGTWMN

Sequences:

>Translated_239_residues
MKPVAIVTGGSSNIGWACVQRFCADHRVLIADLQPPQAPLPEGVSFIQTDVTSQAQCAALIQRAATQGALAALVHSAAIT
AEAKPFDQIDAAEWHRLLEVNLTGSFLVAQSAIALLRRSRGAMVLVSSRAARTGYAALTASGSGTKPHYCASKAGVLSLV
KSLAVELAGDGVRVNAVVPGAIEGAMIPQQRWAELSARIPLGRLGLAAEVADAAHYLCSSGARYVTGHALDINGGTWMN
>Mature_239_residues
MKPVAIVTGGSSNIGWACVQRFCADHRVLIADLQPPQAPLPEGVSFIQTDVTSQAQCAALIQRAATQGALAALVHSAAIT
AEAKPFDQIDAAEWHRLLEVNLTGSFLVAQSAIALLRRSRGAMVLVSSRAARTGYAALTASGSGTKPHYCASKAGVLSLV
KSLAVELAGDGVRVNAVVPGAIEGAMIPQQRWAELSARIPLGRLGLAAEVADAAHYLCSSGARYVTGHALDINGGTWMN

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=151, Percent_Identity=35.7615894039735, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=29.9212598425197, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI59889578, Length=208, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=30.0813008130081, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=25.6, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI40254992, Length=142, Percent_Identity=33.8028169014084, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4503301, Length=159, Percent_Identity=31.4465408805031, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=30.241935483871, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI66933014, Length=225, Percent_Identity=24.4444444444444, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=32.2709163346614, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1786812, Length=246, Percent_Identity=32.520325203252, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=28.0155642023346, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=27.0161290322581, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788459, Length=264, Percent_Identity=28.4090909090909, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1789208, Length=190, Percent_Identity=29.4736842105263, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=29.1497975708502, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789057, Length=268, Percent_Identity=26.4925373134328, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082160, Length=246, Percent_Identity=26.4227642276423, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=34.4, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=34.2629482071713, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17560676, Length=175, Percent_Identity=31.4285714285714, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=29.296875, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=258, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=28.2352941176471, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=26.3779527559055, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=253, Percent_Identity=28.4584980237154, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=195, Percent_Identity=29.2307692307692, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=29.0322580645161, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=31.3253012048193, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=31.6, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=31.8367346938775, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644337, Length=191, Percent_Identity=30.8900523560209, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571526, Length=204, Percent_Identity=30.8823529411765, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737361, Length=258, Percent_Identity=26.7441860465116, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24790; Mature: 24790

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVAIVTGGSSNIGWACVQRFCADHRVLIADLQPPQAPLPEGVSFIQTDVTSQAQCAAL
CCCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHH
IQRAATQGALAALVHSAAITAEAKPFDQIDAAEWHRLLEVNLTGSFLVAQSAIALLRRSR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEECCCHHHHHHHHHHHHHHCC
GAMVLVSSRAARTGYAALTASGSGTKPHYCASKAGVLSLVKSLAVELAGDGVRVNAVVPG
CCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
AIEGAMIPQQRWAELSARIPLGRLGLAAEVADAAHYLCSSGARYVTGHALDINGGTWMN
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCC
>Mature Secondary Structure
MKPVAIVTGGSSNIGWACVQRFCADHRVLIADLQPPQAPLPEGVSFIQTDVTSQAQCAAL
CCCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHH
IQRAATQGALAALVHSAAITAEAKPFDQIDAAEWHRLLEVNLTGSFLVAQSAIALLRRSR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEECCCHHHHHHHHHHHHHHCC
GAMVLVSSRAARTGYAALTASGSGTKPHYCASKAGVLSLVKSLAVELAGDGVRVNAVVPG
CCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
AIEGAMIPQQRWAELSARIPLGRLGLAAEVADAAHYLCSSGARYVTGHALDINGGTWMN
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]