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The map label for this gene is bioA [C]

Identifier: 121611351

GI number: 121611351

Start: 4900352

End: 4901713

Strand: Direct

Name: bioA [C]

Synonym: Veis_4437

Alternate gene names: 121611351

Gene position: 4900352-4901713 (Clockwise)

Preceding gene: 121611344

Following gene: 121611352

Centisome position: 88.03

GC content: 66.59

Gene sequence:

>1362_bases
ATGAGCTTCGTGAATCTCGAAAAACCCGCCGCCGGCGCCGAAGGCCCGCGCATGGACGCCCAGTGGCTCGATGCGCACTG
GATGCCCTACACGGCCAACCGCCAGTTCAAGGCCCAGCCGCGCATGATCGTTGCCGGCAGCGGCGCCTACTACACCGACG
CCGAAGGGCGCAAGATTTTCGACGGCCTGTCGGGCCTGTGGTGCGCGGGCCTGGGCCATGGCCGCCGCGAGATCGCCGAT
GCGATAGGCAAACAGGCGCTCCGGCTCGACTACGCGCCGGCATTCCAGTTCGGCCACCCGCTGTCGTTCGAGCTGGCCAA
CCGCATCAAGGCGCTGACGCCGGCAGGGCTGGACTATGTGTTCTTCACCAGTTCAGGCTCGGAAGCGGCCGACACCTCGC
TGAAAATGGCCCGCGCCTACTGGCGCGCCAAGGGCCAGGGCCACAAGACGCGCCTGATCGGCCGCGAAAAGGGCTACCAC
GGCGTGAACTTCGGCGGCATCTCGGTCGGCGGCATAGGGGCCAACCGCAAGCTGTTCGGCCAGACCATCGAGGCCGACCA
CCTGCCCCATACCCAGCCGCCCGCAGGCTCCTTCCACAAGGGCCAGCCGCCCACGGGCAAGGAACTGGCCGACCGCCTGC
TCGACATGATTGCGCTGCACGATGCATCGAACATTGCCGCCGTGATCGTCGAGCCATTTGCCGGCTCCGCCGGGGTGCTG
GTCCCGCCCGTGGGCTACCTGCAGCGGCTGCGCGATATCTGCACGCAAAACGGCATCCTGCTGATTTTTGACGAAGTGAT
CAGCGGCTTTGGCCGCTCCGGCGCCTGGACCGGCGCCGAGGCTTTCGGCGTGACGCCCGACCTGCTGAACTTCGCCAAGC
AGATCACCAACGGCGTGCAGCCGCTGGGCGGCGTGGTGGCGAGCAAGGAGATCTACGACAGCTTCATGGCCGCAGGCGGC
CCCGACTACATGCTGGAGTTTCCGCATGGCTACACCTACTCGGCCCACCCCGTGTCCTGCGCCGCCGGCATTGCGGCGCT
CGACCTGCTGCAAAAGGAAGACATGATCGGCCGCGTGCAGGCGCTGGCCCCGCACTTCGAGCAAGCCGTGCACAGCCTCA
AGGGCGCCAAACATGTGCTGGACATCCGCAACTTCAGCCTGGCAGCGGGTCTGACGATCGCGCCGGCGCCGGGCGAGCCG
GCCAGGCGGCCCTACGAGATTGCGATGAACTGCTGGAGAAAGGGCTTTTATGTGCGCTACGGCGCCGACACCATCCAACT
GGCGCCACCGTTCATCAGCGAAAAGGCCGAGATCGACCGCCTGGTCAACGCCCTCGGCGATGCGCTGACCGAAACGGCAT
GA

Upstream 100 bases:

>100_bases
GATGATCGGTGACGCGACACCAGGCCCCATCCCGCCGTGGACAGCGATGACCGGGACGGCCCTGCTTTCCATCCCGTTTG
GCTTGTACAGGAGATATTCC

Downstream 100 bases:

>100_bases
GCGCCGCCCGGCCGCCCGAAGGCGCTCATACCGTAGCCGAAGGCGAAGGTATCCCAGTGCGCGTCGCCCGGCCGCCCGAA
GGCGCTCATTCCGCAGCCGA

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSFVNLEKPAAGAEGPRMDAQWLDAHWMPYTANRQFKAQPRMIVAGSGAYYTDAEGRKIFDGLSGLWCAGLGHGRREIAD
AIGKQALRLDYAPAFQFGHPLSFELANRIKALTPAGLDYVFFTSSGSEAADTSLKMARAYWRAKGQGHKTRLIGREKGYH
GVNFGGISVGGIGANRKLFGQTIEADHLPHTQPPAGSFHKGQPPTGKELADRLLDMIALHDASNIAAVIVEPFAGSAGVL
VPPVGYLQRLRDICTQNGILLIFDEVISGFGRSGAWTGAEAFGVTPDLLNFAKQITNGVQPLGGVVASKEIYDSFMAAGG
PDYMLEFPHGYTYSAHPVSCAAGIAALDLLQKEDMIGRVQALAPHFEQAVHSLKGAKHVLDIRNFSLAAGLTIAPAPGEP
ARRPYEIAMNCWRKGFYVRYGADTIQLAPPFISEKAEIDRLVNALGDALTETA

Sequences:

>Translated_453_residues
MSFVNLEKPAAGAEGPRMDAQWLDAHWMPYTANRQFKAQPRMIVAGSGAYYTDAEGRKIFDGLSGLWCAGLGHGRREIAD
AIGKQALRLDYAPAFQFGHPLSFELANRIKALTPAGLDYVFFTSSGSEAADTSLKMARAYWRAKGQGHKTRLIGREKGYH
GVNFGGISVGGIGANRKLFGQTIEADHLPHTQPPAGSFHKGQPPTGKELADRLLDMIALHDASNIAAVIVEPFAGSAGVL
VPPVGYLQRLRDICTQNGILLIFDEVISGFGRSGAWTGAEAFGVTPDLLNFAKQITNGVQPLGGVVASKEIYDSFMAAGG
PDYMLEFPHGYTYSAHPVSCAAGIAALDLLQKEDMIGRVQALAPHFEQAVHSLKGAKHVLDIRNFSLAAGLTIAPAPGEP
ARRPYEIAMNCWRKGFYVRYGADTIQLAPPFISEKAEIDRLVNALGDALTETA
>Mature_452_residues
SFVNLEKPAAGAEGPRMDAQWLDAHWMPYTANRQFKAQPRMIVAGSGAYYTDAEGRKIFDGLSGLWCAGLGHGRREIADA
IGKQALRLDYAPAFQFGHPLSFELANRIKALTPAGLDYVFFTSSGSEAADTSLKMARAYWRAKGQGHKTRLIGREKGYHG
VNFGGISVGGIGANRKLFGQTIEADHLPHTQPPAGSFHKGQPPTGKELADRLLDMIALHDASNIAAVIVEPFAGSAGVLV
PPVGYLQRLRDICTQNGILLIFDEVISGFGRSGAWTGAEAFGVTPDLLNFAKQITNGVQPLGGVVASKEIYDSFMAAGGP
DYMLEFPHGYTYSAHPVSCAAGIAALDLLQKEDMIGRVQALAPHFEQAVHSLKGAKHVLDIRNFSLAAGLTIAPAPGEPA
RRPYEIAMNCWRKGFYVRYGADTIQLAPPFISEKAEIDRLVNALGDALTETA

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=447, Percent_Identity=28.8590604026846, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI226442705, Length=447, Percent_Identity=28.6353467561521, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=26.1851015801354, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=26.6826923076923, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442709, Length=412, Percent_Identity=29.126213592233, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=25.4545454545455, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI24119277, Length=392, Percent_Identity=26.7857142857143, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786991, Length=432, Percent_Identity=28.0092592592593, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI145693181, Length=419, Percent_Identity=28.4009546539379, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789759, Length=399, Percent_Identity=28.3208020050125, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=27.431421446384, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789016, Length=340, Percent_Identity=27.9411764705882, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787560, Length=438, Percent_Identity=26.9406392694064, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786349, Length=327, Percent_Identity=28.7461773700306, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=439, Percent_Identity=27.1070615034169, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=421, Percent_Identity=25.1781472684086, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=441, Percent_Identity=26.7573696145125, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=243, Percent_Identity=27.5720164609054, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323470, Length=431, Percent_Identity=24.3619489559165, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=413, Percent_Identity=24.2130750605327, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324386, Length=427, Percent_Identity=24.1217798594848, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321456, Length=281, Percent_Identity=22.4199288256228, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574759, Length=448, Percent_Identity=26.7857142857143, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357415, Length=409, Percent_Identity=24.6943765281174, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI21356575, Length=440, Percent_Identity=25.9090909090909, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161085790, Length=445, Percent_Identity=25.8426966292135, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48693; Mature: 48562

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVNLEKPAAGAEGPRMDAQWLDAHWMPYTANRQFKAQPRMIVAGSGAYYTDAEGRKIF
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCHHH
DGLSGLWCAGLGHGRREIADAIGKQALRLDYAPAFQFGHPLSFELANRIKALTPAGLDYV
HCCCHHHHHCCCCCHHHHHHHHHHHHEEECCCCHHHCCCCCCHHHHHHHHHCCCCCCEEE
FFTSSGSEAADTSLKMARAYWRAKGQGHKTRLIGREKGYHGVNFGGISVGGIGANRKLFG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHC
QTIEADHLPHTQPPAGSFHKGQPPTGKELADRLLDMIALHDASNIAAVIVEPFAGSAGVL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
VPPVGYLQRLRDICTQNGILLIFDEVISGFGRSGAWTGAEAFGVTPDLLNFAKQITNGVQ
CCCHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCC
PLGGVVASKEIYDSFMAAGGPDYMLEFPHGYTYSAHPVSCAAGIAALDLLQKEDMIGRVQ
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAPHFEQAVHSLKGAKHVLDIRNFSLAAGLTIAPAPGEPARRPYEIAMNCWRKGFYVRY
HHHHHHHHHHHHHHCHHHHHHHCCCEEECCCEEECCCCCCCCCHHHHHHHHHHCCCEEEE
GADTIQLAPPFISEKAEIDRLVNALGDALTETA
CCCEEEECCCHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFVNLEKPAAGAEGPRMDAQWLDAHWMPYTANRQFKAQPRMIVAGSGAYYTDAEGRKIF
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCHHH
DGLSGLWCAGLGHGRREIADAIGKQALRLDYAPAFQFGHPLSFELANRIKALTPAGLDYV
HCCCHHHHHCCCCCHHHHHHHHHHHHEEECCCCHHHCCCCCCHHHHHHHHHCCCCCCEEE
FFTSSGSEAADTSLKMARAYWRAKGQGHKTRLIGREKGYHGVNFGGISVGGIGANRKLFG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHC
QTIEADHLPHTQPPAGSFHKGQPPTGKELADRLLDMIALHDASNIAAVIVEPFAGSAGVL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
VPPVGYLQRLRDICTQNGILLIFDEVISGFGRSGAWTGAEAFGVTPDLLNFAKQITNGVQ
CCCHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCC
PLGGVVASKEIYDSFMAAGGPDYMLEFPHGYTYSAHPVSCAAGIAALDLLQKEDMIGRVQ
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAPHFEQAVHSLKGAKHVLDIRNFSLAAGLTIAPAPGEPARRPYEIAMNCWRKGFYVRY
HHHHHHHHHHHHHHCHHHHHHHCCCEEECCCEEECCCCCCCCCHHHHHHHHHHCCCEEEE
GADTIQLAPPFISEKAEIDRLVNALGDALTETA
CCCEEEECCCHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]