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The map label for this gene is relA [H]

Identifier: 121611280

GI number: 121611280

Start: 4813401

End: 4815611

Strand: Direct

Name: relA [H]

Synonym: Veis_4366

Alternate gene names: 121611280

Gene position: 4813401-4815611 (Clockwise)

Preceding gene: 121611279

Following gene: 121611282

Centisome position: 86.47

GC content: 67.53

Gene sequence:

>2211_bases
ATGAAAATCCACCCGCCAACCCAGCCCCCAGCCCTGTCCGACGCTGCGGCGCAGCTCATCGCCGCCACCGCACCACACCC
GTTGCCCGAGCCAGCGCATGCGCTGGCGCACGCGCGCGCCTTTGCCGAGCCGCTGCTGGCCGGCGCAAGCCTGGACTCCG
GCGAGAACACCTTGGCCCACGCCGACGCCGTGGCCGCCATCCTCAAAGGCATTGGCGGCTCCGAGGCGATGCAGGCCGCC
AGCTACCTGGTGCAAGCCTGCATCCACCTGAACAAACCCGAAGAACTGATCACCAAGACCTTTGGCGCCAACTTTGCCAC
GCTGGCGCTGGAGACCACCCAACTCATGCGCGTGCAGCGGCAAGCGCGCGCGGCGCAGCCGGTCGACGACCCTGCGCTAC
AGACCGAGAACGTGCGCAAGATGCTGCTGGCCTTCTCGCGCGACCTGCGCGTGGTGCTGCTGCACCTGGCCTCGCGCTTG
CAGACGCTGCGCTTTCATGCGGCCAGCAAACGCCCCGTCTCACCCGGCCTGGTGCGCGAATCGCTGCAGGTATTTGCGCC
GCTGGCCAACCGCCTGGGCATCTGGCAGATGAAATGGGAGTTGGAAGACCTGTGCCTGCGCTTTCTCGAACCCGATGTCT
ACAAGCAGGTGGCCCGCCTGCTCGACGAAAAGCGCGGCGAACGCGAACTGTGCATAGAGCAGTTGCGCGCCCGGCTCGAA
GCCGAGTTGCGCGCGCGCAGCATCAGCGCCAGCGTGCAGGGGCGCCCCAAGCATATCTACAGCATCGTCAGAAAGATGCG
CGGCAAGGCGCTGAACTTCGACCAGGTGTTCGACATCCGCGCGCTGCGCGTGGTGGTGCCCACGGTCAAGGACTGCTACG
CCGCGCTGAGTTGGGTGCACCAGCAGTTCAAGCCCATCGAGCAAGAATTCGACGACTACATCGCCCGGCCCAAGCCCAAC
GGCTATCAGTCGCTGCACACCGTCGTGCGCGACGACAACGGCAAGCCGATCGAGATCCAGCTCCGCACCCAGGCCATGCA
CCGACATGCCGAGCATGGCATGGCCGCGCACTGGGTCTACAAGGAGGCCGGCAGCAAAGGTTACGCCGGCGTGTCTGCCA
GCAGCGCCTATGACGCCAAGATTGCCGTGCTGCGCCAACTGCTGGCCTGGGAGCGTGACCTGTCAGGCGCCCTGCCCCAG
CGGGCCCTGTTCGAAGACCGCATCTACGTGCTGACGCCCGATGCCGCCGTGGTGGAACTGCCCCAGGGCGCGACGCCGGT
CGACTTTGCCTATGCCGTGCACACCAGCGTCGGGCACCGCTGCCGGGGCGCGCGCGTGGACGGCGCCATCGTGCCGCTGA
ACACGGCGTTGCAAAACGGGCAGACGGTGGAGATCTCCACCGTCAAGGAAGGCCGCCCCTCGCGCGACTGGCTCAACGCC
GAGTTGGGCTACCTGGTCAGCTACCGCGCCAAGGCCAAGGTGCGCGCCTGGTTCAACGCCCAGGCCACGCACGAAACCAT
GGCCCGGGGCCGCGAAGCGGTAGAAAAACTGTTGCAGCGTGAGGGCAAGACCGCCCTCAAGCTCGACGACCTGGCCGCAC
AGTTGGGCTTCAAATCGGCCGACGCGCTGTTCGAGGTGGTGGGCAAGGACGAGTTCTCGCTGCGCAGCATCGAGGCCGTG
CTGCGCCCGCCCGAACCCGCCCCGCCACCGAGCACGCAGTTGCTGCACAAAAAGACGCGCAGCCACGACCCGCCGCGCAA
AGACGGCGTGCTGGTGGTGGGCATCGAATCGCTGCTGACCGAACTGGCCAAATGCTGCCGCCCCGCGCCGCCCGACGCCA
TCGTCGGCTTCGTCACACGCGGCAAGGGGGTCAGCGTGCACCGCGCCGATTGCAGCAACCTGCGCGAGATGGCCGCGCGC
AGCATCGAGCGCGTGATCGATGTCGAGTGGGGCCAGCCCCGGCCAGCCGTATCGGCCGCCGTCTACCCGGTCAACGTCGC
GGTGCAGGCCGCCGACCGCCAGGGCCTGCTGCGCGACATCTCGGAAGTCTTCGCGCGCGAAAAGACCAATGTGATCGGCG
TGCAGACCCGCTCGGTCAAAGGCACGGCATGGATGACCTTTACCGTGGAGGTCACCGACGCCATCCGCCTGAACAAGGTG
CTGGGCATCGTGGCCGACGTGCCGGGCGTGCGCTCGGCGCGCCGCCCCTGA

Upstream 100 bases:

>100_bases
GACCCCGGGCGCATGTCGTCGAGTTCGAAGGCGTGGGGCATGCCCCCATGCTGATGGCGGCCGATCAACTCGCCGCCGTC
ACGCAGTTCCTGCTGGCGCA

Downstream 100 bases:

>100_bases
GACCGCCGCAGCCGATGGGCGGCCTTGGAGAGTGGTGATCACAGCCCGATTTTGCTGGCTATAATCGCCGGCCAGACAAA
CGACAGGCGCGTAGCTCAGC

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 736; Mature: 736

Protein sequence:

>736_residues
MKIHPPTQPPALSDAAAQLIAATAPHPLPEPAHALAHARAFAEPLLAGASLDSGENTLAHADAVAAILKGIGGSEAMQAA
SYLVQACIHLNKPEELITKTFGANFATLALETTQLMRVQRQARAAQPVDDPALQTENVRKMLLAFSRDLRVVLLHLASRL
QTLRFHAASKRPVSPGLVRESLQVFAPLANRLGIWQMKWELEDLCLRFLEPDVYKQVARLLDEKRGERELCIEQLRARLE
AELRARSISASVQGRPKHIYSIVRKMRGKALNFDQVFDIRALRVVVPTVKDCYAALSWVHQQFKPIEQEFDDYIARPKPN
GYQSLHTVVRDDNGKPIEIQLRTQAMHRHAEHGMAAHWVYKEAGSKGYAGVSASSAYDAKIAVLRQLLAWERDLSGALPQ
RALFEDRIYVLTPDAAVVELPQGATPVDFAYAVHTSVGHRCRGARVDGAIVPLNTALQNGQTVEISTVKEGRPSRDWLNA
ELGYLVSYRAKAKVRAWFNAQATHETMARGREAVEKLLQREGKTALKLDDLAAQLGFKSADALFEVVGKDEFSLRSIEAV
LRPPEPAPPPSTQLLHKKTRSHDPPRKDGVLVVGIESLLTELAKCCRPAPPDAIVGFVTRGKGVSVHRADCSNLREMAAR
SIERVIDVEWGQPRPAVSAAVYPVNVAVQAADRQGLLRDISEVFAREKTNVIGVQTRSVKGTAWMTFTVEVTDAIRLNKV
LGIVADVPGVRSARRP

Sequences:

>Translated_736_residues
MKIHPPTQPPALSDAAAQLIAATAPHPLPEPAHALAHARAFAEPLLAGASLDSGENTLAHADAVAAILKGIGGSEAMQAA
SYLVQACIHLNKPEELITKTFGANFATLALETTQLMRVQRQARAAQPVDDPALQTENVRKMLLAFSRDLRVVLLHLASRL
QTLRFHAASKRPVSPGLVRESLQVFAPLANRLGIWQMKWELEDLCLRFLEPDVYKQVARLLDEKRGERELCIEQLRARLE
AELRARSISASVQGRPKHIYSIVRKMRGKALNFDQVFDIRALRVVVPTVKDCYAALSWVHQQFKPIEQEFDDYIARPKPN
GYQSLHTVVRDDNGKPIEIQLRTQAMHRHAEHGMAAHWVYKEAGSKGYAGVSASSAYDAKIAVLRQLLAWERDLSGALPQ
RALFEDRIYVLTPDAAVVELPQGATPVDFAYAVHTSVGHRCRGARVDGAIVPLNTALQNGQTVEISTVKEGRPSRDWLNA
ELGYLVSYRAKAKVRAWFNAQATHETMARGREAVEKLLQREGKTALKLDDLAAQLGFKSADALFEVVGKDEFSLRSIEAV
LRPPEPAPPPSTQLLHKKTRSHDPPRKDGVLVVGIESLLTELAKCCRPAPPDAIVGFVTRGKGVSVHRADCSNLREMAAR
SIERVIDVEWGQPRPAVSAAVYPVNVAVQAADRQGLLRDISEVFAREKTNVIGVQTRSVKGTAWMTFTVEVTDAIRLNKV
LGIVADVPGVRSARRP
>Mature_736_residues
MKIHPPTQPPALSDAAAQLIAATAPHPLPEPAHALAHARAFAEPLLAGASLDSGENTLAHADAVAAILKGIGGSEAMQAA
SYLVQACIHLNKPEELITKTFGANFATLALETTQLMRVQRQARAAQPVDDPALQTENVRKMLLAFSRDLRVVLLHLASRL
QTLRFHAASKRPVSPGLVRESLQVFAPLANRLGIWQMKWELEDLCLRFLEPDVYKQVARLLDEKRGERELCIEQLRARLE
AELRARSISASVQGRPKHIYSIVRKMRGKALNFDQVFDIRALRVVVPTVKDCYAALSWVHQQFKPIEQEFDDYIARPKPN
GYQSLHTVVRDDNGKPIEIQLRTQAMHRHAEHGMAAHWVYKEAGSKGYAGVSASSAYDAKIAVLRQLLAWERDLSGALPQ
RALFEDRIYVLTPDAAVVELPQGATPVDFAYAVHTSVGHRCRGARVDGAIVPLNTALQNGQTVEISTVKEGRPSRDWLNA
ELGYLVSYRAKAKVRAWFNAQATHETMARGREAVEKLLQREGKTALKLDDLAAQLGFKSADALFEVVGKDEFSLRSIEAV
LRPPEPAPPPSTQLLHKKTRSHDPPRKDGVLVVGIESLLTELAKCCRPAPPDAIVGFVTRGKGVSVHRADCSNLREMAAR
SIERVIDVEWGQPRPAVSAAVYPVNVAVQAADRQGLLRDISEVFAREKTNVIGVQTRSVKGTAWMTFTVEVTDAIRLNKV
LGIVADVPGVRSARRP

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=658, Percent_Identity=41.9452887537994, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1790082, Length=705, Percent_Identity=32.7659574468085, Blast_Score=352, Evalue=6e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 81037; Mature: 81037

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHPPTQPPALSDAAAQLIAATAPHPLPEPAHALAHARAFAEPLLAGASLDSGENTLAH
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
ADAVAAILKGIGGSEAMQAASYLVQACIHLNKPEELITKTFGANFATLALETTQLMRVQR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHH
QARAAQPVDDPALQTENVRKMLLAFSRDLRVVLLHLASRLQTLRFHAASKRPVSPGLVRE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
SLQVFAPLANRLGIWQMKWELEDLCLRFLEPDVYKQVARLLDEKRGERELCIEQLRARLE
HHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AELRARSISASVQGRPKHIYSIVRKMRGKALNFDQVFDIRALRVVVPTVKDCYAALSWVH
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
QQFKPIEQEFDDYIARPKPNGYQSLHTVVRDDNGKPIEIQLRTQAMHRHAEHGMAAHWVY
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHCCCHHHHHH
KEAGSKGYAGVSASSAYDAKIAVLRQLLAWERDLSGALPQRALFEDRIYVLTPDAAVVEL
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEECCCCEEEEC
PQGATPVDFAYAVHTSVGHRCRGARVDGAIVPLNTALQNGQTVEISTVKEGRPSRDWLNA
CCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECHHHHCCCCEEEEEECCCCCCCHHHHHH
ELGYLVSYRAKAKVRAWFNAQATHETMARGREAVEKLLQREGKTALKLDDLAAQLGFKSA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCHH
DALFEVVGKDEFSLRSIEAVLRPPEPAPPPSTQLLHKKTRSHDPPRKDGVLVVGIESLLT
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHH
ELAKCCRPAPPDAIVGFVTRGKGVSVHRADCSNLREMAARSIERVIDVEWGQPRPAVSAA
HHHHHCCCCCCHHHEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEE
VYPVNVAVQAADRQGLLRDISEVFAREKTNVIGVQTRSVKGTAWMTFTVEVTDAIRLNKV
EEEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEEHHHHHHHHH
LGIVADVPGVRSARRP
HHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKIHPPTQPPALSDAAAQLIAATAPHPLPEPAHALAHARAFAEPLLAGASLDSGENTLAH
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
ADAVAAILKGIGGSEAMQAASYLVQACIHLNKPEELITKTFGANFATLALETTQLMRVQR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHH
QARAAQPVDDPALQTENVRKMLLAFSRDLRVVLLHLASRLQTLRFHAASKRPVSPGLVRE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
SLQVFAPLANRLGIWQMKWELEDLCLRFLEPDVYKQVARLLDEKRGERELCIEQLRARLE
HHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AELRARSISASVQGRPKHIYSIVRKMRGKALNFDQVFDIRALRVVVPTVKDCYAALSWVH
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
QQFKPIEQEFDDYIARPKPNGYQSLHTVVRDDNGKPIEIQLRTQAMHRHAEHGMAAHWVY
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHCCCHHHHHH
KEAGSKGYAGVSASSAYDAKIAVLRQLLAWERDLSGALPQRALFEDRIYVLTPDAAVVEL
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEECCCCEEEEC
PQGATPVDFAYAVHTSVGHRCRGARVDGAIVPLNTALQNGQTVEISTVKEGRPSRDWLNA
CCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECHHHHCCCCEEEEEECCCCCCCHHHHHH
ELGYLVSYRAKAKVRAWFNAQATHETMARGREAVEKLLQREGKTALKLDDLAAQLGFKSA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCHH
DALFEVVGKDEFSLRSIEAVLRPPEPAPPPSTQLLHKKTRSHDPPRKDGVLVVGIESLLT
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHH
ELAKCCRPAPPDAIVGFVTRGKGVSVHRADCSNLREMAARSIERVIDVEWGQPRPAVSAA
HHHHHCCCCCCHHHEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEE
VYPVNVAVQAADRQGLLRDISEVFAREKTNVIGVQTRSVKGTAWMTFTVEVTDAIRLNKV
EEEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEEHHHHHHHHH
LGIVADVPGVRSARRP
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]