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The map label for this gene is ldcA [H]

Identifier: 121611218

GI number: 121611218

Start: 4745550

End: 4746530

Strand: Direct

Name: ldcA [H]

Synonym: Veis_4303

Alternate gene names: 121611218

Gene position: 4745550-4746530 (Clockwise)

Preceding gene: 121611217

Following gene: 121611219

Centisome position: 85.25

GC content: 68.09

Gene sequence:

>981_bases
TTGCACCACGACCACGACCCCTTGCCCGGCAACCACGACCATGGCGCCAAGCATCTGTACATCTATTCCCCCTCCAGCGC
GGTGCGTGACAAGGCCGCTTTCAGGCGCGGCATCGCGCGCTTGCAGGCCCAGGGCCATCAGGTGGAGGTCGATGTGTCTG
CGCTGGCCACGCACACCCGTTTTGCCGGCGACGACGCCACGCGCCTGGCCGCCATCCACCGCGCCGCAGCCAGTGGCGCC
GATGTGGCGCTGATCTCACGCGGTGGCTATGGCCTGACGCGCATCCTGCCGGGGATACGCTACAAGGCGGTGGCCAAGGC
CATTGCCAAGGGCACGCATTTCGTCGGGCTGAGCGACTTCACCGCGTTCCAACTGGCCGTGCTGGCCCGCACCGGTGCCA
GCACCTGGGCCGGGCCGGCGCTGAGCGCAGATTTTGGTGTCGCCGGCGCGCCTGACGAGATCATGCAAGCCTGCTTCGAC
GACCTGCTGGCCGGCCACGGCGAGGGCACCGGCTGGCGCCTGCCGCGCCCCCGACCCGATGCCGCCGCCGACCGGCCTGT
GCAGCCCGCGATGCACCTCAAGCGCGCCACGCTGTGGGGCGGCAATCTGTCCATGCTCACCTCCTTGCTGGGCACGCCGT
ACTTTCCGGACATCGCCGGCGGCGTGCTGTTTCTGGAGGATGTGCATGAGCATCCCTACCGCATCGAACGCCTGCTCACC
CAGTTGCTGCACGCCGGGGTGCTGGCCAGGCAAAAGGCGGTGCTGCTCGGGCAGTTCACCGATTTCAAGCTGACGCCCCA
TGACAAGGGCTACCGGCTGCAGTCCGTGGTCGACTGGCTGCGCACGCAGATCAAGGCCCCTGTGCTGACCCATCTGCCGT
TCGGCCATGTCGCGACCAAGGTGCTTTTGCCCGTGGGCGCCACGGTGTCGCTGTCGGTGCAAGAGCGCGATGCGCTGATC
TACTGGGGCCCCCGGCACTAA

Upstream 100 bases:

>100_bases
GCAGCGCAGCGATTCCATTTCGTGCAGCTATTTGCGGGACGGTACACTGGCCGGGTCTACCCTTGTTGACGGAGCTGGCC
TGCCAAGGGCCGGAGCGCTT

Downstream 100 bases:

>100_bases
AGCCATGCCGTTGCCAAAATACGGGAGACCAACGCCATGACTTGGAGCATGACTCGGGCCACGACCTGGGTCCGCTGGGC
AGCCATCACTCTGGTGGCGG

Product: muramoyltetrapeptide carboxypeptidase

Products: NA

Alternate protein names: LD-carboxypeptidase A; Muramoyltetrapeptide carboxypeptidase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MHHDHDPLPGNHDHGAKHLYIYSPSSAVRDKAAFRRGIARLQAQGHQVEVDVSALATHTRFAGDDATRLAAIHRAAASGA
DVALISRGGYGLTRILPGIRYKAVAKAIAKGTHFVGLSDFTAFQLAVLARTGASTWAGPALSADFGVAGAPDEIMQACFD
DLLAGHGEGTGWRLPRPRPDAAADRPVQPAMHLKRATLWGGNLSMLTSLLGTPYFPDIAGGVLFLEDVHEHPYRIERLLT
QLLHAGVLARQKAVLLGQFTDFKLTPHDKGYRLQSVVDWLRTQIKAPVLTHLPFGHVATKVLLPVGATVSLSVQERDALI
YWGPRH

Sequences:

>Translated_326_residues
MHHDHDPLPGNHDHGAKHLYIYSPSSAVRDKAAFRRGIARLQAQGHQVEVDVSALATHTRFAGDDATRLAAIHRAAASGA
DVALISRGGYGLTRILPGIRYKAVAKAIAKGTHFVGLSDFTAFQLAVLARTGASTWAGPALSADFGVAGAPDEIMQACFD
DLLAGHGEGTGWRLPRPRPDAAADRPVQPAMHLKRATLWGGNLSMLTSLLGTPYFPDIAGGVLFLEDVHEHPYRIERLLT
QLLHAGVLARQKAVLLGQFTDFKLTPHDKGYRLQSVVDWLRTQIKAPVLTHLPFGHVATKVLLPVGATVSLSVQERDALI
YWGPRH
>Mature_326_residues
MHHDHDPLPGNHDHGAKHLYIYSPSSAVRDKAAFRRGIARLQAQGHQVEVDVSALATHTRFAGDDATRLAAIHRAAASGA
DVALISRGGYGLTRILPGIRYKAVAKAIAKGTHFVGLSDFTAFQLAVLARTGASTWAGPALSADFGVAGAPDEIMQACFD
DLLAGHGEGTGWRLPRPRPDAAADRPVQPAMHLKRATLWGGNLSMLTSLLGTPYFPDIAGGVLFLEDVHEHPYRIERLLT
QLLHAGVLARQKAVLLGQFTDFKLTPHDKGYRLQSVVDWLRTQIKAPVLTHLPFGHVATKVLLPVGATVSLSVQERDALI
YWGPRH

Specific function: Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. Can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc- tetrapeptide, G

COG id: COG1619

COG function: function code V; Uncharacterized proteins, homologs of microcin C7 resistance protein MccF

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S66 family [H]

Homologues:

Organism=Escherichia coli, GI1787441, Length=296, Percent_Identity=38.8513513513513, Blast_Score=184, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003507 [H]

Pfam domain/function: PF02016 Peptidase_S66 [H]

EC number: NA

Molecular weight: Translated: 35248; Mature: 35248

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHDHDPLPGNHDHGAKHLYIYSPSSAVRDKAAFRRGIARLQAQGHQVEVDVSALATHTR
CCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHH
FAGDDATRLAAIHRAAASGADVALISRGGYGLTRILPGIRYKAVAKAIAKGTHFVGLSDF
CCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCEEEECCHH
TAFQLAVLARTGASTWAGPALSADFGVAGAPDEIMQACFDDLLAGHGEGTGWRLPRPRPD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AAADRPVQPAMHLKRATLWGGNLSMLTSLLGTPYFPDIAGGVLFLEDVHEHPYRIERLLT
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHCCEEEEHHHHCCHHHHHHHHH
QLLHAGVLARQKAVLLGQFTDFKLTPHDKGYRLQSVVDWLRTQIKAPVLTHLPFGHVATK
HHHHHHHHHHHHHHEEECCCCCEECCCCCCCCHHHHHHHHHHHHCCCHHHCCCCHHHHHH
VLLPVGATVSLSVQERDALIYWGPRH
HHHHCCCEEEEEEECCCEEEEECCCC
>Mature Secondary Structure
MHHDHDPLPGNHDHGAKHLYIYSPSSAVRDKAAFRRGIARLQAQGHQVEVDVSALATHTR
CCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHH
FAGDDATRLAAIHRAAASGADVALISRGGYGLTRILPGIRYKAVAKAIAKGTHFVGLSDF
CCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCEEEECCHH
TAFQLAVLARTGASTWAGPALSADFGVAGAPDEIMQACFDDLLAGHGEGTGWRLPRPRPD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AAADRPVQPAMHLKRATLWGGNLSMLTSLLGTPYFPDIAGGVLFLEDVHEHPYRIERLLT
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHCCEEEEHHHHCCHHHHHHHHH
QLLHAGVLARQKAVLLGQFTDFKLTPHDKGYRLQSVVDWLRTQIKAPVLTHLPFGHVATK
HHHHHHHHHHHHHHEEECCCCCEECCCCCCCCHHHHHHHHHHHHCCCHHHCCCCHHHHHH
VLLPVGATVSLSVQERDALIYWGPRH
HHHHCCCEEEEEEECCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]