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The map label for this gene is cobW [H]

Identifier: 121611211

GI number: 121611211

Start: 4740067

End: 4741167

Strand: Direct

Name: cobW [H]

Synonym: Veis_4296

Alternate gene names: 121611211

Gene position: 4740067-4741167 (Clockwise)

Preceding gene: 121611210

Following gene: 121611213

Centisome position: 85.15

GC content: 73.02

Gene sequence:

>1101_bases
ATGCACGGGCCTCGGCAGCGCCTGCCGCTGACCGTGGTCGGCGGCTTCCTGGGCGCCGGCAAGACCACGCTGCTCAACCA
CTGGCTGCGCCATGCCGGGGGGCTGCGCATTGCGGTGCTGGTCAACGACTTCGGCGCGCTCAACATCGACGCCGGGCTGA
TGGCCGCCGCTCGGGACGACACGCCGGCGCCGGCGGCGCTGATGGAACTGATGGAACTGACCAACGGCTGCGCGTGCTGC
CAGATCGGCGACGACCTGGGGCGCGCGCTGGTGCAGGTGATTGAGGCGGCCCGGCCCTTCGACGCGGTGCTGATCGAGGC
CAGCGGCGTCTCCGACCCGTGGCGCATCGCGCAGATCGGCATGGCAGAGCCGCAACTGAGCCTGGAGGGCGTGATCGTGC
TGGTCGATGCCAGCAGCGCGGCGCAGCAGGCGCGCGACCCGCTGCTGGCAGACACGCTGGCGCGGCAACTGCGATCGGCC
GACCTGGTGCTGCTCAACAAGACAGACCTGGCCAGCGCTGCGGCGCTGGCCGGTGCCCGGGCCTGGATCGAGGCCAGCGC
CCCGGGAACGCCGTGCCTCGAAACGACACGAGGGGCGCTACCGCTGGCGCTGCTGTCCGGCCTGGCGCCGACCATGGGTG
CCGCCCGGCCGCCCGAAGGCGCTCATACCGCAGCCGAAGGCGAAGGTATCCCAGTGCGCGCTGCACGGCCGCCCGAAGGC
GCTCATACCGTAGCCGAAGGCGAAGGTATTCCAGCGAGCGCGCAGGCCGACGCGGCCTGCCACCATGACGCGCAGCCGCA
CGCGCCGGCGCATGGCGCGCTGTTTCAGACCTGGAGCGCCCGGCCGCAGGCGGTGATTCCCGTCGCCACCCTGCGCGCCT
GGCTGCGCGACATGCCGCCGGGCGTGCTGCGGCTCAAGGGCCTGCTGCGCACCGGCGGCGCAGCGCCCGACGAGCAATGG
ACCGAGGTCCAGTACGCCGGCCGCCACGGCTGGCTGCGCAAGGCCAGCGCAGCGCCCGGCCCTGCAGGCGCCGGCGTGGT
CGCCATCGGCCTGCGCGGGCAATTGCCTGAAGACGCGCTGACAAGGTTCTTCGCGGGCTGA

Upstream 100 bases:

>100_bases
GCGTGCTGCACGACGACCCGCTGGAGAGCGCGCCGATGGCGCTCAAGGATCTGCGCATATGGGGCACGGTGCTGTCGGGC
CGGGTGTTCGAGGCGCAGTG

Downstream 100 bases:

>100_bases
CCCCGCGCCACCGGGTGCGCGCCAGCGCTGCTGCGGCCCTGGAATCTGCTGCCAGCATGGGCGCCCCATGCCGTTTTTCA
GCGGCGCCGGCGCCGGATCT

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MHGPRQRLPLTVVGGFLGAGKTTLLNHWLRHAGGLRIAVLVNDFGALNIDAGLMAAARDDTPAPAALMELMELTNGCACC
QIGDDLGRALVQVIEAARPFDAVLIEASGVSDPWRIAQIGMAEPQLSLEGVIVLVDASSAAQQARDPLLADTLARQLRSA
DLVLLNKTDLASAAALAGARAWIEASAPGTPCLETTRGALPLALLSGLAPTMGAARPPEGAHTAAEGEGIPVRAARPPEG
AHTVAEGEGIPASAQADAACHHDAQPHAPAHGALFQTWSARPQAVIPVATLRAWLRDMPPGVLRLKGLLRTGGAAPDEQW
TEVQYAGRHGWLRKASAAPGPAGAGVVAIGLRGQLPEDALTRFFAG

Sequences:

>Translated_366_residues
MHGPRQRLPLTVVGGFLGAGKTTLLNHWLRHAGGLRIAVLVNDFGALNIDAGLMAAARDDTPAPAALMELMELTNGCACC
QIGDDLGRALVQVIEAARPFDAVLIEASGVSDPWRIAQIGMAEPQLSLEGVIVLVDASSAAQQARDPLLADTLARQLRSA
DLVLLNKTDLASAAALAGARAWIEASAPGTPCLETTRGALPLALLSGLAPTMGAARPPEGAHTAAEGEGIPVRAARPPEG
AHTVAEGEGIPASAQADAACHHDAQPHAPAHGALFQTWSARPQAVIPVATLRAWLRDMPPGVLRLKGLLRTGGAAPDEQW
TEVQYAGRHGWLRKASAAPGPAGAGVVAIGLRGQLPEDALTRFFAG
>Mature_366_residues
MHGPRQRLPLTVVGGFLGAGKTTLLNHWLRHAGGLRIAVLVNDFGALNIDAGLMAAARDDTPAPAALMELMELTNGCACC
QIGDDLGRALVQVIEAARPFDAVLIEASGVSDPWRIAQIGMAEPQLSLEGVIVLVDASSAAQQARDPLLADTLARQLRSA
DLVLLNKTDLASAAALAGARAWIEASAPGTPCLETTRGALPLALLSGLAPTMGAARPPEGAHTAAEGEGIPVRAARPPEG
AHTVAEGEGIPASAQADAACHHDAQPHAPAHGALFQTWSARPQAVIPVATLRAWLRDMPPGVLRLKGLLRTGGAAPDEQW
TEVQYAGRHGWLRKASAAPGPAGAGVVAIGLRGQLPEDALTRFFAG

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=205, Percent_Identity=32.1951219512195, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI223941779, Length=205, Percent_Identity=31.219512195122, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI126722884, Length=204, Percent_Identity=30.8823529411765, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI148727351, Length=204, Percent_Identity=30.3921568627451, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI146231952, Length=204, Percent_Identity=29.9019607843137, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI223941776, Length=193, Percent_Identity=30.5699481865285, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI119120938, Length=139, Percent_Identity=32.3741007194245, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI87082430, Length=207, Percent_Identity=36.231884057971, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788499, Length=207, Percent_Identity=28.0193236714976, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324356, Length=185, Percent_Identity=27.5675675675676, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 37752; Mature: 37752

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGPRQRLPLTVVGGFLGAGKTTLLNHWLRHAGGLRIAVLVNDFGALNIDAGLMAAARDD
CCCCCCCCCEEEECHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCEEECCCC
TPAPAALMELMELTNGCACCQIGDDLGRALVQVIEAARPFDAVLIEASGVSDPWRIAQIG
CCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHCCC
MAEPQLSLEGVIVLVDASSAAQQARDPLLADTLARQLRSADLVLLNKTDLASAAALAGAR
CCCCCCCCCEEEEEEECCHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
AWIEASAPGTPCLETTRGALPLALLSGLAPTMGAARPPEGAHTAAEGEGIPVRAARPPEG
HEEECCCCCCCCHHHHCCCHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCCCC
AHTVAEGEGIPASAQADAACHHDAQPHAPAHGALFQTWSARPQAVIPVATLRAWLRDMPP
CCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHCCCCCCEECHHHHHHHHHHHCCC
GVLRLKGLLRTGGAAPDEQWTEVQYAGRHGWLRKASAAPGPAGAGVVAIGLRGQLPEDAL
HHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHH
TRFFAG
HHHHCC
>Mature Secondary Structure
MHGPRQRLPLTVVGGFLGAGKTTLLNHWLRHAGGLRIAVLVNDFGALNIDAGLMAAARDD
CCCCCCCCCEEEECHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCEEECCCC
TPAPAALMELMELTNGCACCQIGDDLGRALVQVIEAARPFDAVLIEASGVSDPWRIAQIG
CCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHCCC
MAEPQLSLEGVIVLVDASSAAQQARDPLLADTLARQLRSADLVLLNKTDLASAAALAGAR
CCCCCCCCCEEEEEEECCHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
AWIEASAPGTPCLETTRGALPLALLSGLAPTMGAARPPEGAHTAAEGEGIPVRAARPPEG
HEEECCCCCCCCHHHHCCCHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCCCC
AHTVAEGEGIPASAQADAACHHDAQPHAPAHGALFQTWSARPQAVIPVATLRAWLRDMPP
CCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHCCCCCCEECHHHHHHHHHHHCCC
GVLRLKGLLRTGGAAPDEQWTEVQYAGRHGWLRKASAAPGPAGAGVVAIGLRGQLPEDAL
HHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHH
TRFFAG
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]