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The map label for this gene is purD [H]

Identifier: 121611155

GI number: 121611155

Start: 4668435

End: 4669715

Strand: Direct

Name: purD [H]

Synonym: Veis_4239

Alternate gene names: 121611155

Gene position: 4668435-4669715 (Clockwise)

Preceding gene: 121611154

Following gene: 121611156

Centisome position: 83.86

GC content: 67.6

Gene sequence:

>1281_bases
ATGAAAGTTCTCGTACTCGGCGGCGGCGGCCGTGAACACGCCATCGCCTGGAAACTGAGCCAGTCGCCCAAAGTCTCCCG
GGTGTATGTGGCGCCCGGCAATGGGGGCACGGCCCTGGGCCCGAAGCTGGAAAATGTGTCCATCCCGACTTTGCCTGAAC
TGCGCCAGTGGGCCCAGGCCGAGAAGATCGTGCTGACGGTGGTCGGCCCCGAGGCCCCTTTGGCCGCAGGCGTGGTCGAC
GAGTTCCGGGCCAACGGCCTGCGCATCTTTGGCCCCACCAAGGCCGCGGCACAGTTGGAAAGCTCCAAGGTCTTCGCCAA
AGCCTTCATGCAGCGCCACGGCATTCCCACGGCCGACTACGACAGCTTCACCGACCCGGCCGCCGCCCACGCCTTCGTCG
ACCGCCTGGGGGCGCCCTGCGTCATCAAGGCCGACGGCCTGGCCGCAGGCAAGGGCGTGGTGGTGGCGCTGACGCTGCAA
CAGGCCCATGCCGGCATCGACAGCATGCTGCTGGACAACCGCTACGGCGTGACGCACAACGCAGGCGGCGCCCGTGTGCT
GATCGAGCAGTTCCTCGAAGGCGAAGAGGCCAGCTTCATCGTGCTGTGCGATGGCAAGGACGTGCTGGCCCTGGCGACCA
GCCAGGATCACAAGCGCCTCAAGGACGGCGACGAAGGCCCCAACACCGGCGGCATGGGCGCCTATTCGCCGGCGCCGGTG
GTCACGGCCGACGTGCATGCCCGCGCCATGCGCGAGATCATCCTGCCCACCATCCGTGGCATGGAAAAAGATGGCATACC
CTACAGCGGCTTCCTGTATGCGGGCCTGATGATCGACGCCAAGGGCCACCCCAAGACGCTGGAATTCAACTGCCGCATGG
GCGACCCCGAGGCGCAACCGATCCTGATGCGGCTCAAGAGCGACCTGTTCGATCTGCTGCTCGCCGCGCTCGATGGCAAG
CTCGACCAGATGCAACTGCAATGGGACCGCCGCACCGCCTTGGGCGTGGTGATGGCGGCCCAGGGCTACCCCGACAGCCC
GCACCAGGGCGCTGCCATCACCGGCCTGCCCGCCGAGGCCGATGACGCGATGGTGTTCCATGCCGGCACGGCCTTGCAGG
ACGGCGTGCTGCGCGTCGCCGGCGGCCGCGCGCTGTGCGTGACCGCGCTGGCAGACAGCGCCCGGCAGGCGCAGCAGCGC
GCCTATGACATGGTGCGCGGCATCCATTTCGATGGAGCGCAGTACCGCCGCGACATCGGCTTTCGGGTCGTCAGAAACTG
A

Upstream 100 bases:

>100_bases
CTATGAAGACCAGTTCCCATCCCCAGTGCTCCGGTCGTCATCGATTCTTGCCCCTGCATGGAGTATCCCTGTTGCCCGGT
GCGGCATGTGGGAGCCTGGC

Downstream 100 bases:

>100_bases
TGGCAGGCGCTCCCCCGCATCCGGTGCTGCACCCGGCCGACAGCGTCGCCCGCGTGCGCGGCTACCTGCAGGGCCTGCAG
GCGCGCATCACCGATGCGCT

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKVLVLGGGGREHAIAWKLSQSPKVSRVYVAPGNGGTALGPKLENVSIPTLPELRQWAQAEKIVLTVVGPEAPLAAGVVD
EFRANGLRIFGPTKAAAQLESSKVFAKAFMQRHGIPTADYDSFTDPAAAHAFVDRLGAPCVIKADGLAAGKGVVVALTLQ
QAHAGIDSMLLDNRYGVTHNAGGARVLIEQFLEGEEASFIVLCDGKDVLALATSQDHKRLKDGDEGPNTGGMGAYSPAPV
VTADVHARAMREIILPTIRGMEKDGIPYSGFLYAGLMIDAKGHPKTLEFNCRMGDPEAQPILMRLKSDLFDLLLAALDGK
LDQMQLQWDRRTALGVVMAAQGYPDSPHQGAAITGLPAEADDAMVFHAGTALQDGVLRVAGGRALCVTALADSARQAQQR
AYDMVRGIHFDGAQYRRDIGFRVVRN

Sequences:

>Translated_426_residues
MKVLVLGGGGREHAIAWKLSQSPKVSRVYVAPGNGGTALGPKLENVSIPTLPELRQWAQAEKIVLTVVGPEAPLAAGVVD
EFRANGLRIFGPTKAAAQLESSKVFAKAFMQRHGIPTADYDSFTDPAAAHAFVDRLGAPCVIKADGLAAGKGVVVALTLQ
QAHAGIDSMLLDNRYGVTHNAGGARVLIEQFLEGEEASFIVLCDGKDVLALATSQDHKRLKDGDEGPNTGGMGAYSPAPV
VTADVHARAMREIILPTIRGMEKDGIPYSGFLYAGLMIDAKGHPKTLEFNCRMGDPEAQPILMRLKSDLFDLLLAALDGK
LDQMQLQWDRRTALGVVMAAQGYPDSPHQGAAITGLPAEADDAMVFHAGTALQDGVLRVAGGRALCVTALADSARQAQQR
AYDMVRGIHFDGAQYRRDIGFRVVRN
>Mature_426_residues
MKVLVLGGGGREHAIAWKLSQSPKVSRVYVAPGNGGTALGPKLENVSIPTLPELRQWAQAEKIVLTVVGPEAPLAAGVVD
EFRANGLRIFGPTKAAAQLESSKVFAKAFMQRHGIPTADYDSFTDPAAAHAFVDRLGAPCVIKADGLAAGKGVVVALTLQ
QAHAGIDSMLLDNRYGVTHNAGGARVLIEQFLEGEEASFIVLCDGKDVLALATSQDHKRLKDGDEGPNTGGMGAYSPAPV
VTADVHARAMREIILPTIRGMEKDGIPYSGFLYAGLMIDAKGHPKTLEFNCRMGDPEAQPILMRLKSDLFDLLLAALDGK
LDQMQLQWDRRTALGVVMAAQGYPDSPHQGAAITGLPAEADDAMVFHAGTALQDGVLRVAGGRALCVTALADSARQAQQR
AYDMVRGIHFDGAQYRRDIGFRVVRN

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=428, Percent_Identity=49.0654205607477, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI4503915, Length=428, Percent_Identity=49.0654205607477, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI209869995, Length=428, Percent_Identity=49.0654205607477, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI209869993, Length=428, Percent_Identity=49.0654205607477, Blast_Score=396, Evalue=1e-110,
Organism=Escherichia coli, GI1790438, Length=429, Percent_Identity=59.6736596736597, Blast_Score=501, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17567511, Length=428, Percent_Identity=41.588785046729, Blast_Score=303, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6321203, Length=447, Percent_Identity=41.834451901566, Blast_Score=335, Evalue=6e-93,
Organism=Drosophila melanogaster, GI62471619, Length=436, Percent_Identity=46.5596330275229, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24582400, Length=436, Percent_Identity=46.7889908256881, Blast_Score=345, Evalue=4e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 45336; Mature: 45336

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVLGGGGREHAIAWKLSQSPKVSRVYVAPGNGGTALGPKLENVSIPTLPELRQWAQA
CEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCC
EKIVLTVVGPEAPLAAGVVDEFRANGLRIFGPTKAAAQLESSKVFAKAFMQRHGIPTADY
CEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DSFTDPAAAHAFVDRLGAPCVIKADGLAAGKGVVVALTLQQAHAGIDSMLLDNRYGVTHN
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEHHHHCCHHHHHHCCCCCCEEC
AGGARVLIEQFLEGEEASFIVLCDGKDVLALATSQDHKRLKDGDEGPNTGGMGAYSPAPV
CCCHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCE
VTADVHARAMREIILPTIRGMEKDGIPYSGFLYAGLMIDAKGHPKTLEFNCRMGDPEAQP
EEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEECCCCCCCH
ILMRLKSDLFDLLLAALDGKLDQMQLQWDRRTALGVVMAAQGYPDSPHQGAAITGLPAEA
HHHHHHHHHHHHHHHHHCCCCHHEEEEHHHHHEEEEEEEECCCCCCCCCCCEEECCCCCC
DDAMVFHAGTALQDGVLRVAGGRALCVTALADSARQAQQRAYDMVRGIHFDGAQYRRDIG
CCEEEEECCCCHHCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
FRVVRN
EEEECC
>Mature Secondary Structure
MKVLVLGGGGREHAIAWKLSQSPKVSRVYVAPGNGGTALGPKLENVSIPTLPELRQWAQA
CEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCC
EKIVLTVVGPEAPLAAGVVDEFRANGLRIFGPTKAAAQLESSKVFAKAFMQRHGIPTADY
CEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DSFTDPAAAHAFVDRLGAPCVIKADGLAAGKGVVVALTLQQAHAGIDSMLLDNRYGVTHN
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEHHHHCCHHHHHHCCCCCCEEC
AGGARVLIEQFLEGEEASFIVLCDGKDVLALATSQDHKRLKDGDEGPNTGGMGAYSPAPV
CCCHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCE
VTADVHARAMREIILPTIRGMEKDGIPYSGFLYAGLMIDAKGHPKTLEFNCRMGDPEAQP
EEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEECCCCCCCH
ILMRLKSDLFDLLLAALDGKLDQMQLQWDRRTALGVVMAAQGYPDSPHQGAAITGLPAEA
HHHHHHHHHHHHHHHHHCCCCHHEEEEHHHHHEEEEEEEECCCCCCCCCCCEEECCCCCC
DDAMVFHAGTALQDGVLRVAGGRALCVTALADSARQAQQRAYDMVRGIHFDGAQYRRDIG
CCEEEEECCCCHHCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
FRVVRN
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]