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The map label for this gene is hemF [H]

Identifier: 121611156

GI number: 121611156

Start: 4669715

End: 4670686

Strand: Direct

Name: hemF [H]

Synonym: Veis_4240

Alternate gene names: 121611156

Gene position: 4669715-4670686 (Clockwise)

Preceding gene: 121611155

Following gene: 121611158

Centisome position: 83.89

GC content: 68.21

Gene sequence:

>972_bases
ATGGCAGGCGCTCCCCCGCATCCGGTGCTGCACCCGGCCGACAGCGTCGCCCGCGTGCGCGGCTACCTGCAGGGCCTGCA
GGCGCGCATCACCGATGCGCTGCAAGCGCTGGAAACCGAGGGCGGCGCGCGCTTTCGGGCCGATGCCTGGAGCAAACCGC
CCGGCGCGTCATTGTCAGGCGACGGCAACACCCTGATTTTGGAGGGCGGCCGCGTGTTCGAGCGCGCAGGCTGCGGCCTG
AGCCATGTGCGCGGGCCGCATCTGCCGCCCTCGGCCAGCGCGCACCGGAGCGCGCTGGCGGGCGCACCGTTCGAGGCCAT
GGGCCTGTCGCTGGTGCTACACCCGCGCAACCCCTATGTGCCGACGGTGCACATGAATGTGCGCATGATCGCCGCCGCGC
ATCCGGGCCAGGCGCCGAGTTGCTGGTTTGGCGGCGGCATGGACCTGACGCCCTGCTACGGCTTCGAGGAAGACGTGGTG
CACTTTCACCGCCATTGCCGTGCTGCGCTGGCACCGTTTGGCGCGGACAAATACCCGCGCTTCAAGCAGTGGTGCGATGA
GTACTTCTACCTCAAGCACCGCAACGAGCAACGCGGCGCAGGCGGCGTGTTCTACGATGACCTGGCAGAACCGGACTTTG
AGCAAAGCCTGGCGCTGACGCAATCGGTGGGCGAAGCCTTCGTGCCGGCCTACCTGCCCATCGTGCAAAAGCGCCAGGCC
ACGCCCTATGGCGAGCGCGAGCGCGACTTCCAGTCGTATCGCCGTGGCCGCTATGTCGAGTTCAACCTGGTGTGGGACCG
GGGCACGCATTTCGGGCTGCAATCGGGCGGGCGCACCGAATCCATCCTGCTATCGATGCCGCCGCTGGCAGCGTGGTCGT
ACCAGCGCCGGGACGCCACCGGCTCGGCCGAAGCGGCGCTCACGCAACGATTTCTGGTGCGCCGGGACTGGCTCGCAGAC
ATCCCTGAATGA

Upstream 100 bases:

>100_bases
CCCGGCAGGCGCAGCAGCGCGCCTATGACATGGTGCGCGGCATCCATTTCGATGGAGCGCAGTACCGCCGCGACATCGGC
TTTCGGGTCGTCAGAAACTG

Downstream 100 bases:

>100_bases
CGGCCTTATGCCATTTTCAAATCGTTCGTGAACGCGAAGCCGACAAAGTGCACGGATGATTTAGGAATGGACTGAAACAG
CGCAGTTTCAGCAACCGTTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MAGAPPHPVLHPADSVARVRGYLQGLQARITDALQALETEGGARFRADAWSKPPGASLSGDGNTLILEGGRVFERAGCGL
SHVRGPHLPPSASAHRSALAGAPFEAMGLSLVLHPRNPYVPTVHMNVRMIAAAHPGQAPSCWFGGGMDLTPCYGFEEDVV
HFHRHCRAALAPFGADKYPRFKQWCDEYFYLKHRNEQRGAGGVFYDDLAEPDFEQSLALTQSVGEAFVPAYLPIVQKRQA
TPYGERERDFQSYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAAWSYQRRDATGSAEAALTQRFLVRRDWLAD
IPE

Sequences:

>Translated_323_residues
MAGAPPHPVLHPADSVARVRGYLQGLQARITDALQALETEGGARFRADAWSKPPGASLSGDGNTLILEGGRVFERAGCGL
SHVRGPHLPPSASAHRSALAGAPFEAMGLSLVLHPRNPYVPTVHMNVRMIAAAHPGQAPSCWFGGGMDLTPCYGFEEDVV
HFHRHCRAALAPFGADKYPRFKQWCDEYFYLKHRNEQRGAGGVFYDDLAEPDFEQSLALTQSVGEAFVPAYLPIVQKRQA
TPYGERERDFQSYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAAWSYQRRDATGSAEAALTQRFLVRRDWLAD
IPE
>Mature_322_residues
AGAPPHPVLHPADSVARVRGYLQGLQARITDALQALETEGGARFRADAWSKPPGASLSGDGNTLILEGGRVFERAGCGLS
HVRGPHLPPSASAHRSALAGAPFEAMGLSLVLHPRNPYVPTVHMNVRMIAAAHPGQAPSCWFGGGMDLTPCYGFEEDVVH
FHRHCRAALAPFGADKYPRFKQWCDEYFYLKHRNEQRGAGGVFYDDLAEPDFEQSLALTQSVGEAFVPAYLPIVQKRQAT
PYGERERDFQSYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAAWSYQRRDATGSAEAALTQRFLVRRDWLADI
PE

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=315, Percent_Identity=41.5873015873016, Blast_Score=248, Evalue=5e-66,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=58.8039867109634, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320249, Length=310, Percent_Identity=41.6129032258065, Blast_Score=248, Evalue=9e-67,
Organism=Drosophila melanogaster, GI17864388, Length=309, Percent_Identity=43.3656957928803, Blast_Score=256, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35685; Mature: 35553

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGAPPHPVLHPADSVARVRGYLQGLQARITDALQALETEGGARFRADAWSKPPGASLSG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCC
DGNTLILEGGRVFERAGCGLSHVRGPHLPPSASAHRSALAGAPFEAMGLSLVLHPRNPYV
CCCEEEEECCCCHHHHCCCHHHCCCCCCCCCCCHHHHHHCCCCHHHCCEEEEEECCCCCC
PTVHMNVRMIAAAHPGQAPSCWFGGGMDLTPCYGFEEDVVHFHRHCRAALAPFGADKYPR
CEEEEEEEEEEECCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHH
FKQWCDEYFYLKHRNEQRGAGGVFYDDLAEPDFEQSLALTQSVGEAFVPAYLPIVQKRQA
HHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPYGERERDFQSYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAAWSYQRRDAT
CCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHCCHHCCCC
GSAEAALTQRFLVRRDWLADIPE
CCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AGAPPHPVLHPADSVARVRGYLQGLQARITDALQALETEGGARFRADAWSKPPGASLSG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCC
DGNTLILEGGRVFERAGCGLSHVRGPHLPPSASAHRSALAGAPFEAMGLSLVLHPRNPYV
CCCEEEEECCCCHHHHCCCHHHCCCCCCCCCCCHHHHHHCCCCHHHCCEEEEEECCCCCC
PTVHMNVRMIAAAHPGQAPSCWFGGGMDLTPCYGFEEDVVHFHRHCRAALAPFGADKYPR
CEEEEEEEEEEECCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHH
FKQWCDEYFYLKHRNEQRGAGGVFYDDLAEPDFEQSLALTQSVGEAFVPAYLPIVQKRQA
HHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPYGERERDFQSYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAAWSYQRRDAT
CCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHCCHHCCCC
GSAEAALTQRFLVRRDWLADIPE
CCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA