Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 121611141

GI number: 121611141

Start: 4655354

End: 4657417

Strand: Direct

Name: mutL [H]

Synonym: Veis_4225

Alternate gene names: 121611141

Gene position: 4655354-4657417 (Clockwise)

Preceding gene: 121611139

Following gene: 121611142

Centisome position: 83.63

GC content: 69.86

Gene sequence:

>2064_bases
ATGCCCGACATGCAGCACAGCACCCCTGCCGCACCGCCCGCCCACCGCCCCATCCGCGACCTGCCCGAGGAACTCATCAG
CCAGATCGCGGCCGGCGAGGTGGTCGAGCGCCCGGCCTCGGTGGTGCGCGAACTGCTGGACAACGCCCTCGACGCAGGGG
CCACGCAGGTCACCGTGCGGCTATCGGCCGGCGGGGTGCGGCTGATCGCCGTGGAAGACGATGGCAGCGGCATTGCCCAA
GACGAGCTAGCGGTGGCGCTGCGCCGCCATGCGACCAGCAAAATCAGCAGCCTGAGCGACCTGGAGACCGTTGCCACGAT
GGGCTTCAGGGGCGAGGCCCTGGCCGCCATTGCCTCGGTGTCGGAACTGTCGCTGCTCTCGCGCCCGGCCGCCCAGGCCA
GCGCCTTCGTGCTCGACGCGCGCAGCGGCGAGCTGCGCCCTGCGGCCCGCAGCACGGGCACCACGGTGGAGGTCAAAGAG
CTGTTCTTCTCCACCCCCGCGCGCCGCAAATTCCTCAAAGCCGATGCCACCGAACTGGCGCATTGCCTCGAATCGGTGCG
CCGCCATGCGCTGGCGCGGCCCGATGTGGGCTTTGCCGTCTGGCACGACGGCAAACTGGTCGAGCAATGGCGCGCCAGCT
TCGTGCCCGGACAGGGCGATGCCCGGGATGCGCTGGCACGCCGCCTGTCGGACGTGCTCGGCGCCGACTTCGTCGCGCAG
TCGGTGGCACTACAGCACCGTGGAGGCTCGGTCACCGTGACCGGCCACGCCGGCCTGCCCGACGCGGCGCGCGCGCGCGC
CGACCACCAGTATTGCTACGTGAACGGCCGCTTCGTGCGCGACAAGGTGATAAGCCATGCGGCGCGCAGCGCATACGAGG
ATGTGCTGCACGGCCACAAGCAGCCGGTATATGTGCTGTACCTGGAGATCGACCCGGCCCGCGTCGACGTGAACGTGCAC
CCGACCAAGATCGAACTGCGCTTTCGCGACAGCCGCGAAGTGCACCAGGCCGTGCGCCACGCCGTGGAAAACGCGCTGGC
CACACCCCGTGCGGCAGCGCTGGCAGCCGCAGAAGCAGGCGCCGCCGTCACGGCAGCCAAACAGCCGCAGGCGCATGCCT
GGCGTGCGCAGTCTGCCCTCCGATTAGAGGAGCGCGGCCACCATGTGGCGGATCTGCAAGCGCTGTGGGGGCCGAAAAAA
GACCCTCCACCCGACAGCGGGCAGGCCCACGGACAGAGCAGCGAACCGTGGGCCGGACCACGCCTGGCGCAGCGCGCACC
CGCGCCGCCGCTCAGCCCGGCGGGCACAGCCGCCCGGGACATCGGCACAGAGGCCCAGCGCCCGACCCTGCCCCCCGGCA
GCCAGGAGCAGGGCCATGCCTTGCCTTCAGGCCGTGAAGGTCAGGAGGTTGCCCGGTCTTTGGACCAGGAAGGCCGGGAG
GCCGCTTGGCCACTGGGCCAGGAAGGTCAGGAAGTCGCTTGGCCATTGGGCCGAGCGGTGGCCCAGATCCATGGCGTCTA
TATCCTGGCCGAGAACGCCCAGGGCATGGTGATCGTGGACATGCATGCCGCGCACGAGCGCATCGTCTACGAGCGCCTGA
AGGCCCAGTTGGACAGCGGTGCGCGCATGGCCAGCCAACCCCTGCTGATCCCCGGCACTTTCGCCGCCACCGCCGAGGAA
GTGGCCACCGCCGAAGAATCGGCCGAGGTGCTGGCCACACTGGGACTGGAAGTGATTCCGTTCTCGCCCAAAACCCTGGC
CGTGCGCGCCGTGCCCGCCGTGCTGGCGCAGGGCGATGCGGTGGAACTGGCCCGCAGCGTGCTGGCCGAACTGGCCGCGC
ACGACACCAGCACCGTGGTGCAGCGCGCCCGCAACGAACTGCTGGGCACCATGGCCTGCCACGGCGCAGTGCGCGCCAAC
CGGCACCTGACCATCGACGAGATGAACGCCCTGCTGCGCCAGATGGAGGCCACCGAGCGCTCAGACCAATGCAACCATGG
CCGCCCGACATGGCGGCAGCTATCGATGAAAGAGTTGGACGCGCTGTTCCTGCGCGGACGCTGA

Upstream 100 bases:

>100_bases
AAGCGGCACATTATCCTCGTCGCCCGCCATCGTCCCGCCATCCCCCGCTGCGGCGCCAGCACAGCGCAGCCCCGGCCCTA
AAATCGACCAGTCCAACGAC

Downstream 100 bases:

>100_bases
CCGATCAGATGTCGTAGGCTGCGCGCAGCCATCGGAGCGCAGCGCAAGGCGCAGCGCGCAGCCCATACCGGGCTGTATTG
GCAAGCGATGCAACGCCGCG

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MPDMQHSTPAAPPAHRPIRDLPEELISQIAAGEVVERPASVVRELLDNALDAGATQVTVRLSAGGVRLIAVEDDGSGIAQ
DELAVALRRHATSKISSLSDLETVATMGFRGEALAAIASVSELSLLSRPAAQASAFVLDARSGELRPAARSTGTTVEVKE
LFFSTPARRKFLKADATELAHCLESVRRHALARPDVGFAVWHDGKLVEQWRASFVPGQGDARDALARRLSDVLGADFVAQ
SVALQHRGGSVTVTGHAGLPDAARARADHQYCYVNGRFVRDKVISHAARSAYEDVLHGHKQPVYVLYLEIDPARVDVNVH
PTKIELRFRDSREVHQAVRHAVENALATPRAAALAAAEAGAAVTAAKQPQAHAWRAQSALRLEERGHHVADLQALWGPKK
DPPPDSGQAHGQSSEPWAGPRLAQRAPAPPLSPAGTAARDIGTEAQRPTLPPGSQEQGHALPSGREGQEVARSLDQEGRE
AAWPLGQEGQEVAWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIVYERLKAQLDSGARMASQPLLIPGTFAATAEE
VATAEESAEVLATLGLEVIPFSPKTLAVRAVPAVLAQGDAVELARSVLAELAAHDTSTVVQRARNELLGTMACHGAVRAN
RHLTIDEMNALLRQMEATERSDQCNHGRPTWRQLSMKELDALFLRGR

Sequences:

>Translated_687_residues
MPDMQHSTPAAPPAHRPIRDLPEELISQIAAGEVVERPASVVRELLDNALDAGATQVTVRLSAGGVRLIAVEDDGSGIAQ
DELAVALRRHATSKISSLSDLETVATMGFRGEALAAIASVSELSLLSRPAAQASAFVLDARSGELRPAARSTGTTVEVKE
LFFSTPARRKFLKADATELAHCLESVRRHALARPDVGFAVWHDGKLVEQWRASFVPGQGDARDALARRLSDVLGADFVAQ
SVALQHRGGSVTVTGHAGLPDAARARADHQYCYVNGRFVRDKVISHAARSAYEDVLHGHKQPVYVLYLEIDPARVDVNVH
PTKIELRFRDSREVHQAVRHAVENALATPRAAALAAAEAGAAVTAAKQPQAHAWRAQSALRLEERGHHVADLQALWGPKK
DPPPDSGQAHGQSSEPWAGPRLAQRAPAPPLSPAGTAARDIGTEAQRPTLPPGSQEQGHALPSGREGQEVARSLDQEGRE
AAWPLGQEGQEVAWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIVYERLKAQLDSGARMASQPLLIPGTFAATAEE
VATAEESAEVLATLGLEVIPFSPKTLAVRAVPAVLAQGDAVELARSVLAELAAHDTSTVVQRARNELLGTMACHGAVRAN
RHLTIDEMNALLRQMEATERSDQCNHGRPTWRQLSMKELDALFLRGR
>Mature_686_residues
PDMQHSTPAAPPAHRPIRDLPEELISQIAAGEVVERPASVVRELLDNALDAGATQVTVRLSAGGVRLIAVEDDGSGIAQD
ELAVALRRHATSKISSLSDLETVATMGFRGEALAAIASVSELSLLSRPAAQASAFVLDARSGELRPAARSTGTTVEVKEL
FFSTPARRKFLKADATELAHCLESVRRHALARPDVGFAVWHDGKLVEQWRASFVPGQGDARDALARRLSDVLGADFVAQS
VALQHRGGSVTVTGHAGLPDAARARADHQYCYVNGRFVRDKVISHAARSAYEDVLHGHKQPVYVLYLEIDPARVDVNVHP
TKIELRFRDSREVHQAVRHAVENALATPRAAALAAAEAGAAVTAAKQPQAHAWRAQSALRLEERGHHVADLQALWGPKKD
PPPDSGQAHGQSSEPWAGPRLAQRAPAPPLSPAGTAARDIGTEAQRPTLPPGSQEQGHALPSGREGQEVARSLDQEGREA
AWPLGQEGQEVAWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIVYERLKAQLDSGARMASQPLLIPGTFAATAEEV
ATAEESAEVLATLGLEVIPFSPKTLAVRAVPAVLAQGDAVELARSVLAELAAHDTSTVVQRARNELLGTMACHGAVRANR
HLTIDEMNALLRQMEATERSDQCNHGRPTWRQLSMKELDALFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=333, Percent_Identity=30.6306306306306, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI4505911, Length=354, Percent_Identity=29.6610169491525, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI189458898, Length=354, Percent_Identity=29.6610169491525, Blast_Score=136, Evalue=8e-32,
Organism=Homo sapiens, GI4505913, Length=346, Percent_Identity=26.3005780346821, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI310128478, Length=346, Percent_Identity=26.3005780346821, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI189458896, Length=344, Percent_Identity=27.906976744186, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI310128480, Length=301, Percent_Identity=24.9169435215947, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI91992160, Length=345, Percent_Identity=24.9275362318841, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI91992162, Length=345, Percent_Identity=24.9275362318841, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1790612, Length=613, Percent_Identity=39.3148450244698, Blast_Score=336, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI71991825, Length=330, Percent_Identity=33.9393939393939, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=358, Percent_Identity=26.2569832402235, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=341, Percent_Identity=28.7390029325513, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324247, Length=333, Percent_Identity=26.4264264264264, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6325093, Length=290, Percent_Identity=25.5172413793103, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=355, Percent_Identity=23.6619718309859, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17136968, Length=342, Percent_Identity=31.2865497076023, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17136970, Length=362, Percent_Identity=27.0718232044199, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 73679; Mature: 73548

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDMQHSTPAAPPAHRPIRDLPEELISQIAAGEVVERPASVVRELLDNALDAGATQVTVR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
LSAGGVRLIAVEDDGSGIAQDELAVALRRHATSKISSLSDLETVATMGFRGEALAAIASV
EECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SELSLLSRPAAQASAFVLDARSGELRPAARSTGTTVEVKELFFSTPARRKFLKADATELA
HHHHHHHCCHHHHCEEEEECCCCCCCCCCCCCCCEEEHHHHHHCCHHHHHHHHCCHHHHH
HCLESVRRHALARPDVGFAVWHDGKLVEQWRASFVPGQGDARDALARRLSDVLGADFVAQ
HHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
SVALQHRGGSVTVTGHAGLPDAARARADHQYCYVNGRFVRDKVISHAARSAYEDVLHGHK
HHHHHCCCCEEEEEECCCCCHHHHHCCCCCEEEECCEEHHHHHHHHHHHHHHHHHHCCCC
QPVYVLYLEIDPARVDVNVHPTKIELRFRDSREVHQAVRHAVENALATPRAAALAAAEAG
CCEEEEEEEECCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
AAVTAAKQPQAHAWRAQSALRLEERGHHVADLQALWGPKKDPPPDSGQAHGQSSEPWAGP
CCEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
RLAQRAPAPPLSPAGTAARDIGTEAQRPTLPPGSQEQGHALPSGREGQEVARSLDQEGRE
HHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCH
AAWPLGQEGQEVAWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIVYERLKAQLDSG
HCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCC
ARMASQPLLIPGTFAATAEEVATAEESAEVLATLGLEVIPFSPKTLAVRAVPAVLAQGDA
CHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEHHHHHHHHHCCCH
VELARSVLAELAAHDTSTVVQRARNELLGTMACHGAVRANRHLTIDEMNALLRQMEATER
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SDQCNHGRPTWRQLSMKELDALFLRGR
CCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDMQHSTPAAPPAHRPIRDLPEELISQIAAGEVVERPASVVRELLDNALDAGATQVTVR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
LSAGGVRLIAVEDDGSGIAQDELAVALRRHATSKISSLSDLETVATMGFRGEALAAIASV
EECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SELSLLSRPAAQASAFVLDARSGELRPAARSTGTTVEVKELFFSTPARRKFLKADATELA
HHHHHHHCCHHHHCEEEEECCCCCCCCCCCCCCCEEEHHHHHHCCHHHHHHHHCCHHHHH
HCLESVRRHALARPDVGFAVWHDGKLVEQWRASFVPGQGDARDALARRLSDVLGADFVAQ
HHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
SVALQHRGGSVTVTGHAGLPDAARARADHQYCYVNGRFVRDKVISHAARSAYEDVLHGHK
HHHHHCCCCEEEEEECCCCCHHHHHCCCCCEEEECCEEHHHHHHHHHHHHHHHHHHCCCC
QPVYVLYLEIDPARVDVNVHPTKIELRFRDSREVHQAVRHAVENALATPRAAALAAAEAG
CCEEEEEEEECCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
AAVTAAKQPQAHAWRAQSALRLEERGHHVADLQALWGPKKDPPPDSGQAHGQSSEPWAGP
CCEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
RLAQRAPAPPLSPAGTAARDIGTEAQRPTLPPGSQEQGHALPSGREGQEVARSLDQEGRE
HHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCH
AAWPLGQEGQEVAWPLGRAVAQIHGVYILAENAQGMVIVDMHAAHERIVYERLKAQLDSG
HCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCC
ARMASQPLLIPGTFAATAEEVATAEESAEVLATLGLEVIPFSPKTLAVRAVPAVLAQGDA
CHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEHHHHHHHHHCCCH
VELARSVLAELAAHDTSTVVQRARNELLGTMACHGAVRANRHLTIDEMNALLRQMEATER
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SDQCNHGRPTWRQLSMKELDALFLRGR
CCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]