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The map label for this gene is zwf [H]

Identifier: 121611139

GI number: 121611139

Start: 4653142

End: 4654596

Strand: Direct

Name: zwf [H]

Synonym: Veis_4223

Alternate gene names: 121611139

Gene position: 4653142-4654596 (Clockwise)

Preceding gene: 121611136

Following gene: 121611141

Centisome position: 83.59

GC content: 66.05

Gene sequence:

>1455_bases
ATGAGTTTCGACCTCGTCCTGTTCGGCGGCACCGGCGACCTCGCCTGGCGCAAGCTCATGCCGGCATTGTTTCAGGCTTT
CCGGCATCGCACACTGCCCGAGGGCGGGCGGATCATTGCCGTGGCGCGCGACGATCTGAGCGACGAACAATACCGCAGCC
GGATAAAGTCGCGCTTCGACTGCGTGGAGTTGGCCAAGCGCCCCACGCCCGACGAGTTCGCCCGCTTTGCGGCCTTGCTG
CATTACCTGCGCATGGACCTGTCCCAAACGCAGGACTACCAGCGCCTGGCACAGACCTTGAACGCGCGCGCTGCCGATTC
GGTGGTGATGTATGTGGCCACCGCGCCCAGCCTGTTCACCAATGTGTGCGAGCAGATCGCGGCCGTCGGCCTGAACGGCC
CCGGCACCCGCGTGGTGCTGGAAAAACCCCTGGGCCACGACCTGCGCTCGAACCGGGCCATCAACGACAGCCTGCGCCGC
GTGCTGCGCGAAGAGCAGGTTTTCCGCATCGACCATTACCTGGGCAAGCCCTCGGTGCAGAACCTGTTTGCGCTGCGCTT
TGGCAATGCGCTGTTCGAGCCCCTGTGGCGGCGTGAAACCATTGCCAACATCCAGATCACCATCGCCGAAGAACTGGGCG
TGGAAACGCGCGGTGCGTTCTACGACCAGACCGGCGCGCTGCGCGACATGGTGCAAAACCATGCGCTGCAATTGCTGTGC
GCGATCGGCATGGAGCCACCGATCAACTCCGGCGCCAACGCCATCCGCGACGAGAAGCTCAAGGTGCTGCAATCGCTCAA
GCCCTGGACTGCCGACACCATCGGCCAGCATGTGATCCGCGGGCAATACGCCGCAGGCAACACGCAAGGCCAGGCCATGC
CGGGCTATTTGCAGGAAAAAGGCGTGGCGCCGGGCAGCAACACCGAGACCTTCGTCGCGCTGCGCACCGAGATCTCGAAC
TGGCGCTGGGCCGGCGTGCCGTTTTACATTCGCACCGGCAAGCGGCTGGCGGGGCGCGATGCGCATATCGTCGTCAACTT
TCACCCGGTGCCCCACCCCATCTTCAGAACCCCTGCGGGCGTGGCCAACCGGCTGGTGATCCACCTGCAGCCCAAGGACG
GGCTGGAGCTGCATCTGCTGGCCCAGGGCGCGGCGCAGCACCAGAGCGAGCCTGCGCTGTCGCAGGTGCACCTGAACCTG
GACTTCGAGCAGCGCTTTGGCACCGAGCGCGTGGGCGCCTACGAGCGCCTGCTGCTCGACGTGATTGCCGGCCGGCTGAA
CCTGTTCGTGCGCAGCGACGAGCAGCAAGAGGCCTGGCGCTGGGTGGAGCCGATACTGCAGCACTGGCAGGACGACCCGG
TCGGGCCACGACCTTATGCGGCCGGCAGTTGGGGCCCGAGCGCGGCCAGCGCGATGATCGCCCGCGACGGCTACTGCTGG
AGCGAGGAGGTCTGA

Upstream 100 bases:

>100_bases
CGCTCCGATGGCTGCGCGCAGCCTACGACATCTGATCCGTGACACGACACTAGGGCATGTAACGTGATTACAATTTCGCA
GCACTCTCGACGGAGATACC

Downstream 100 bases:

>100_bases
GCCTGGCTGCGACCGGCGCGCCAGGCACCGAAGATGGCGATCAGGCCGGGGATGAAAACGATGGCCCAGATGATCTTGTC
CAGGTTCTCCCGGACCCAGG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSFDLVLFGGTGDLAWRKLMPALFQAFRHRTLPEGGRIIAVARDDLSDEQYRSRIKSRFDCVELAKRPTPDEFARFAALL
HYLRMDLSQTQDYQRLAQTLNARAADSVVMYVATAPSLFTNVCEQIAAVGLNGPGTRVVLEKPLGHDLRSNRAINDSLRR
VLREEQVFRIDHYLGKPSVQNLFALRFGNALFEPLWRRETIANIQITIAEELGVETRGAFYDQTGALRDMVQNHALQLLC
AIGMEPPINSGANAIRDEKLKVLQSLKPWTADTIGQHVIRGQYAAGNTQGQAMPGYLQEKGVAPGSNTETFVALRTEISN
WRWAGVPFYIRTGKRLAGRDAHIVVNFHPVPHPIFRTPAGVANRLVIHLQPKDGLELHLLAQGAAQHQSEPALSQVHLNL
DFEQRFGTERVGAYERLLLDVIAGRLNLFVRSDEQQEAWRWVEPILQHWQDDPVGPRPYAAGSWGPSAASAMIARDGYCW
SEEV

Sequences:

>Translated_484_residues
MSFDLVLFGGTGDLAWRKLMPALFQAFRHRTLPEGGRIIAVARDDLSDEQYRSRIKSRFDCVELAKRPTPDEFARFAALL
HYLRMDLSQTQDYQRLAQTLNARAADSVVMYVATAPSLFTNVCEQIAAVGLNGPGTRVVLEKPLGHDLRSNRAINDSLRR
VLREEQVFRIDHYLGKPSVQNLFALRFGNALFEPLWRRETIANIQITIAEELGVETRGAFYDQTGALRDMVQNHALQLLC
AIGMEPPINSGANAIRDEKLKVLQSLKPWTADTIGQHVIRGQYAAGNTQGQAMPGYLQEKGVAPGSNTETFVALRTEISN
WRWAGVPFYIRTGKRLAGRDAHIVVNFHPVPHPIFRTPAGVANRLVIHLQPKDGLELHLLAQGAAQHQSEPALSQVHLNL
DFEQRFGTERVGAYERLLLDVIAGRLNLFVRSDEQQEAWRWVEPILQHWQDDPVGPRPYAAGSWGPSAASAMIARDGYCW
SEEV
>Mature_483_residues
SFDLVLFGGTGDLAWRKLMPALFQAFRHRTLPEGGRIIAVARDDLSDEQYRSRIKSRFDCVELAKRPTPDEFARFAALLH
YLRMDLSQTQDYQRLAQTLNARAADSVVMYVATAPSLFTNVCEQIAAVGLNGPGTRVVLEKPLGHDLRSNRAINDSLRRV
LREEQVFRIDHYLGKPSVQNLFALRFGNALFEPLWRRETIANIQITIAEELGVETRGAFYDQTGALRDMVQNHALQLLCA
IGMEPPINSGANAIRDEKLKVLQSLKPWTADTIGQHVIRGQYAAGNTQGQAMPGYLQEKGVAPGSNTETFVALRTEISNW
RWAGVPFYIRTGKRLAGRDAHIVVNFHPVPHPIFRTPAGVANRLVIHLQPKDGLELHLLAQGAAQHQSEPALSQVHLNLD
FEQRFGTERVGAYERLLLDVIAGRLNLFVRSDEQQEAWRWVEPILQHWQDDPVGPRPYAAGSWGPSAASAMIARDGYCWS
EEV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=480, Percent_Identity=36.25, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI109389365, Length=480, Percent_Identity=36.25, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI52145310, Length=495, Percent_Identity=27.0707070707071, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1788158, Length=490, Percent_Identity=43.0612244897959, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17538218, Length=490, Percent_Identity=33.469387755102, Blast_Score=284, Evalue=9e-77,
Organism=Saccharomyces cerevisiae, GI6324088, Length=497, Percent_Identity=33.8028169014084, Blast_Score=259, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24643350, Length=488, Percent_Identity=35.4508196721311, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24643352, Length=488, Percent_Identity=35.4508196721311, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI221513548, Length=492, Percent_Identity=30.4878048780488, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54282; Mature: 54151

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDLVLFGGTGDLAWRKLMPALFQAFRHRTLPEGGRIIAVARDDLSDEQYRSRIKSRFD
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
CVELAKRPTPDEFARFAALLHYLRMDLSQTQDYQRLAQTLNARAADSVVMYVATAPSLFT
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
NVCEQIAAVGLNGPGTRVVLEKPLGHDLRSNRAINDSLRRVLREEQVFRIDHYLGKPSVQ
HHHHHHHHCCCCCCCCEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
NLFALRFGNALFEPLWRRETIANIQITIAEELGVETRGAFYDQTGALRDMVQNHALQLLC
HHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AIGMEPPINSGANAIRDEKLKVLQSLKPWTADTIGQHVIRGQYAAGNTQGQAMPGYLQEK
HHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHC
GVAPGSNTETFVALRTEISNWRWAGVPFYIRTGKRLAGRDAHIVVNFHPVPHPIFRTPAG
CCCCCCCCCEEEEEEEECCCCEECCCCEEEECCCCCCCCCCEEEEEECCCCCCHHCCCCC
VANRLVIHLQPKDGLELHLLAQGAAQHQSEPALSQVHLNLDFEQRFGTERVGAYERLLLD
CCCEEEEEECCCCCCEEEEEECCHHHCCCCCCCEEEEEECCHHHHCCCHHHHHHHHHHHH
VIAGRLNLFVRSDEQQEAWRWVEPILQHWQDDPVGPRPYAAGSWGPSAASAMIARDGYCW
HHHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
SEEV
CCCC
>Mature Secondary Structure 
SFDLVLFGGTGDLAWRKLMPALFQAFRHRTLPEGGRIIAVARDDLSDEQYRSRIKSRFD
CEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
CVELAKRPTPDEFARFAALLHYLRMDLSQTQDYQRLAQTLNARAADSVVMYVATAPSLFT
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
NVCEQIAAVGLNGPGTRVVLEKPLGHDLRSNRAINDSLRRVLREEQVFRIDHYLGKPSVQ
HHHHHHHHCCCCCCCCEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
NLFALRFGNALFEPLWRRETIANIQITIAEELGVETRGAFYDQTGALRDMVQNHALQLLC
HHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AIGMEPPINSGANAIRDEKLKVLQSLKPWTADTIGQHVIRGQYAAGNTQGQAMPGYLQEK
HHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHC
GVAPGSNTETFVALRTEISNWRWAGVPFYIRTGKRLAGRDAHIVVNFHPVPHPIFRTPAG
CCCCCCCCCEEEEEEEECCCCEECCCCEEEECCCCCCCCCCEEEEEECCCCCCHHCCCCC
VANRLVIHLQPKDGLELHLLAQGAAQHQSEPALSQVHLNLDFEQRFGTERVGAYERLLLD
CCCEEEEEECCCCCCEEEEEECCHHHCCCCCCCEEEEEECCHHHHCCCHHHHHHHHHHHH
VIAGRLNLFVRSDEQQEAWRWVEPILQHWQDDPVGPRPYAAGSWGPSAASAMIARDGYCW
HHHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
SEEV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]