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The map label for this gene is dapA [H]

Identifier: 121611029

GI number: 121611029

Start: 4512430

End: 4513365

Strand: Direct

Name: dapA [H]

Synonym: Veis_4113

Alternate gene names: 121611029

Gene position: 4512430-4513365 (Clockwise)

Preceding gene: 121611028

Following gene: 121611030

Centisome position: 81.06

GC content: 57.91

Gene sequence:

>936_bases
ATGTCGAAGATGAAGGTCGAGGGCTCTTTCGTAGCCCTCATCACGCCATTCAACCAGGATGGAACCACCGACTTTGGCGC
GTTCCGGACGCTGCTGAAATTCCAGGAAAACCATGGCACCGGCGCCGTGCTCATCATGGGTTCCACCGGCGAGGTTTCCA
TGCTTTCGCAGCAGGAACGCCAGGCCATCATCGTGGAAACTGCGAAGATGAAAACCGGCAGGATGAAATTCTTCTACGGT
TGCACCGGCAACAATACCGAAACCACCAAAGACTATCTGCGTTTCGCCAAGGCCAATGGTGCTGACGGTGCGATTTTGGC
CGCGCCCTCTTACATCTGCGGCCTGGAATCCGATATCGAAGACTACTTTCTCGAAGTTGCCGATGCCACGGACCTGCCGC
TCGGGCTCTACAACAACCCGCCGCGCGTCAAGACCGACCTGCATTGGGATAACCTGATCCGGATTTTCAAGCATCCCAAC
TATGTGGTGCATAAAGAATCGACCACGCGCGTTGGCCAGGTGGCCCAGGTATTGCGCGCAAACACGGACGTGGCCGTGAT
GTGCTGCGATTCGCCGAACCTCGGATTGCTCGTCCCGACCATGAGTCTTGGCGGCCACGGCACGGCCAACATGACCGGCA
ATATCGCCCCGTCCGAGATGGCCGCGCTGTCGACACCGTGGACGACGCCGGATATATCCGTCAGTTTCCGCGCCACCTAT
CTGCATATTCTTTCCCTGCTGCACTTTTCCTATTCCGCCATCAACCCCGTCGCCATCAAATCGCTGATGAAAGCCGTGGG
CCTGCCCGCCGGTGAACTGCGCAAACCCCTCAAAGGACTGGAAGGCGAGGCCCTGCTCAAAGGCTTGCGCATCATCAAGG
AATTGGGGCTGGACGAGAAGTACGGCTGGCGTTCTGCCGCACTCCAATCCTGCTGA

Upstream 100 bases:

>100_bases
GCGCCGCATCGTCGAGCAACTGCCGGCGCTCCCGATCCCGGGCATCCTTGGCCTCGGGGGCGGGATCACTGAAGAAAACA
GATTTGAAAAAGGGTTTGTC

Downstream 100 bases:

>100_bases
ACAGCCAATCGACCCGCGCCAACGCAAACCGCCATGGATCTCGGAATCGCCGGCAAAACAGCACTGGTGTTCGGTGGCAG
CAAGGGCATGGGCCGCGCCT

Product: dihydrodipicolinate synthetase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSKMKVEGSFVALITPFNQDGTTDFGAFRTLLKFQENHGTGAVLIMGSTGEVSMLSQQERQAIIVETAKMKTGRMKFFYG
CTGNNTETTKDYLRFAKANGADGAILAAPSYICGLESDIEDYFLEVADATDLPLGLYNNPPRVKTDLHWDNLIRIFKHPN
YVVHKESTTRVGQVAQVLRANTDVAVMCCDSPNLGLLVPTMSLGGHGTANMTGNIAPSEMAALSTPWTTPDISVSFRATY
LHILSLLHFSYSAINPVAIKSLMKAVGLPAGELRKPLKGLEGEALLKGLRIIKELGLDEKYGWRSAALQSC

Sequences:

>Translated_311_residues
MSKMKVEGSFVALITPFNQDGTTDFGAFRTLLKFQENHGTGAVLIMGSTGEVSMLSQQERQAIIVETAKMKTGRMKFFYG
CTGNNTETTKDYLRFAKANGADGAILAAPSYICGLESDIEDYFLEVADATDLPLGLYNNPPRVKTDLHWDNLIRIFKHPN
YVVHKESTTRVGQVAQVLRANTDVAVMCCDSPNLGLLVPTMSLGGHGTANMTGNIAPSEMAALSTPWTTPDISVSFRATY
LHILSLLHFSYSAINPVAIKSLMKAVGLPAGELRKPLKGLEGEALLKGLRIIKELGLDEKYGWRSAALQSC
>Mature_310_residues
SKMKVEGSFVALITPFNQDGTTDFGAFRTLLKFQENHGTGAVLIMGSTGEVSMLSQQERQAIIVETAKMKTGRMKFFYGC
TGNNTETTKDYLRFAKANGADGAILAAPSYICGLESDIEDYFLEVADATDLPLGLYNNPPRVKTDLHWDNLIRIFKHPNY
VVHKESTTRVGQVAQVLRANTDVAVMCCDSPNLGLLVPTMSLGGHGTANMTGNIAPSEMAALSTPWTTPDISVSFRATYL
HILSLLHFSYSAINPVAIKSLMKAVGLPAGELRKPLKGLEGEALLKGLRIIKELGLDEKYGWRSAALQSC

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=232, Percent_Identity=25.4310344827586, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788823, Length=274, Percent_Identity=27.3722627737226, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082415, Length=271, Percent_Identity=28.4132841328413, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786463, Length=276, Percent_Identity=27.536231884058, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789620, Length=184, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33825; Mature: 33694

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKMKVEGSFVALITPFNQDGTTDFGAFRTLLKFQENHGTGAVLIMGSTGEVSMLSQQER
CCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCC
QAIIVETAKMKTGRMKFFYGCTGNNTETTKDYLRFAKANGADGAILAAPSYICGLESDIE
CEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCHHCCCCCCCHH
DYFLEVADATDLPLGLYNNPPRVKTDLHWDNLIRIFKHPNYVVHKESTTRVGQVAQVLRA
HHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHC
NTDVAVMCCDSPNLGLLVPTMSLGGHGTANMTGNIAPSEMAALSTPWTTPDISVSFRATY
CCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEHHHHH
LHILSLLHFSYSAINPVAIKSLMKAVGLPAGELRKPLKGLEGEALLKGLRIIKELGLDEK
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
YGWRSAALQSC
CCCHHHHHCCC
>Mature Secondary Structure 
SKMKVEGSFVALITPFNQDGTTDFGAFRTLLKFQENHGTGAVLIMGSTGEVSMLSQQER
CCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHCC
QAIIVETAKMKTGRMKFFYGCTGNNTETTKDYLRFAKANGADGAILAAPSYICGLESDIE
CEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCHHCCCCCCCHH
DYFLEVADATDLPLGLYNNPPRVKTDLHWDNLIRIFKHPNYVVHKESTTRVGQVAQVLRA
HHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHC
NTDVAVMCCDSPNLGLLVPTMSLGGHGTANMTGNIAPSEMAALSTPWTTPDISVSFRATY
CCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEHHHHH
LHILSLLHFSYSAINPVAIKSLMKAVGLPAGELRKPLKGLEGEALLKGLRIIKELGLDEK
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
YGWRSAALQSC
CCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]