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The map label for this gene is ywfH [H]

Identifier: 121611030

GI number: 121611030

Start: 4513399

End: 4514178

Strand: Direct

Name: ywfH [H]

Synonym: Veis_4114

Alternate gene names: 121611030

Gene position: 4513399-4514178 (Clockwise)

Preceding gene: 121611029

Following gene: 121611031

Centisome position: 81.08

GC content: 63.85

Gene sequence:

>780_bases
ATGGATCTCGGAATCGCCGGCAAAACAGCACTGGTGTTCGGTGGCAGCAAGGGCATGGGCCGCGCCTGCGCACAGCAGCT
TGCACGCGAAGGCGTCGAGGTCTGCATCGCTGCCCGCACACAGCAGACGCTGGCGCTGGCGGCGCAGGAGATTTCCGCGC
AGACAGGCCATGCAGTGCAGTATGTCGTTGCCGACATCACGACGCCCGTCGGGCGTGATGCCGCGCTGGCGGCCTGCCCT
GCGCCGGACATTCTGGTCAACAACGCGGACGGCGCGCCGCCGGGGGATTTTCGCCAGTGGACGCCCGCCGACTGGCATGC
CGCGCTCGACTCGATGATGATAGGCCCGATAGAAATGATCCGCAGAACCGTCGATCCAATGATCGCCCGCAGGTTCGGGC
GTATCGTCAATATCGTTTCGCGCAGCGTCAAGACGCCCCAGTTCGAGTTGGGCCTGTCCAATGGCGCGCGCTCCGGGTTG
GTGGGTTTCGTTGCCGGTCTGGCGCGGCAGACGGTGCGCCACAACGTCACCATCAACAACCTTTTGCCCGGTGTATTCGC
CACCGATGCCCAGCGCCGCCACATTCAGGGCATGGTGGACAGCACAGGAAAATCGTTTGACCAGCTCTGGCAGGAACGGG
GCAGCAACAATCCCGCAGGCCGATACGGCGAGGCCGAGGAAGTGGGCGCGCTCTGTGCTTACATCTGCTCTGCCCACACG
GGATACATCACGGGCCAGAGTATTTTGATCGATGGCGGCGCGTACCCCGGAACCTACTGA

Upstream 100 bases:

>100_bases
CATCATCAAGGAATTGGGGCTGGACGAGAAGTACGGCTGGCGTTCTGCCGCACTCCAATCCTGCTGAACAGCCAATCGAC
CCGCGCCAACGCAAACCGCC

Downstream 100 bases:

>100_bases
AAAACGCCAGGCAAAAATCTTCAGCCCATTCGACCGCAGTTCATTCGGAAAGAAACATGATGCGCCTCAAGCGTCGTACA
TTCACATTCACGCAGACTGG

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MDLGIAGKTALVFGGSKGMGRACAQQLAREGVEVCIAARTQQTLALAAQEISAQTGHAVQYVVADITTPVGRDAALAACP
APDILVNNADGAPPGDFRQWTPADWHAALDSMMIGPIEMIRRTVDPMIARRFGRIVNIVSRSVKTPQFELGLSNGARSGL
VGFVAGLARQTVRHNVTINNLLPGVFATDAQRRHIQGMVDSTGKSFDQLWQERGSNNPAGRYGEAEEVGALCAYICSAHT
GYITGQSILIDGGAYPGTY

Sequences:

>Translated_259_residues
MDLGIAGKTALVFGGSKGMGRACAQQLAREGVEVCIAARTQQTLALAAQEISAQTGHAVQYVVADITTPVGRDAALAACP
APDILVNNADGAPPGDFRQWTPADWHAALDSMMIGPIEMIRRTVDPMIARRFGRIVNIVSRSVKTPQFELGLSNGARSGL
VGFVAGLARQTVRHNVTINNLLPGVFATDAQRRHIQGMVDSTGKSFDQLWQERGSNNPAGRYGEAEEVGALCAYICSAHT
GYITGQSILIDGGAYPGTY
>Mature_259_residues
MDLGIAGKTALVFGGSKGMGRACAQQLAREGVEVCIAARTQQTLALAAQEISAQTGHAVQYVVADITTPVGRDAALAACP
APDILVNNADGAPPGDFRQWTPADWHAALDSMMIGPIEMIRRTVDPMIARRFGRIVNIVSRSVKTPQFELGLSNGARSGL
VGFVAGLARQTVRHNVTINNLLPGVFATDAQRRHIQGMVDSTGKSFDQLWQERGSNNPAGRYGEAEEVGALCAYICSAHT
GYITGQSILIDGGAYPGTY

Specific function: Along with the bacABCDE operon is involved in bacilysin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=27.5193798449612, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=24.901185770751, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=27.5590551181102, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40254992, Length=255, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI66933014, Length=234, Percent_Identity=25.6410256410256, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4503301, Length=252, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI33667109, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=25.5813953488372, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=259, Percent_Identity=29.7297297297297, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=26.6409266409266, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=28.6821705426357, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=26.3779527559055, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790717, Length=262, Percent_Identity=24.0458015267176, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=24.1379310344828, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=30.3030303030303, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=257, Percent_Identity=27.6264591439689, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=30.9433962264151, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=27.906976744186, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=30.0380228136882, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=28.0898876404494, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=28.1853281853282, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=28.1368821292776, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=275, Percent_Identity=28.3636363636364, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=26.2962962962963, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=28.735632183908, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=26.8939393939394, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=264, Percent_Identity=25, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=261, Percent_Identity=26.8199233716475, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=27.3764258555133, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=259, Percent_Identity=27.4131274131274, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=27.1653543307087, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=259, Percent_Identity=27.4131274131274, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=264, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=26.4150943396226, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=27.3764258555133, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=28.8461538461538, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=27.5132275132275, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=27.5132275132275, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639444, Length=268, Percent_Identity=26.865671641791, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355319, Length=261, Percent_Identity=24.5210727969349, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=28.2352941176471, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 27395; Mature: 27395

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGIAGKTALVFGGSKGMGRACAQQLAREGVEVCIAARTQQTLALAAQEISAQTGHAVQ
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCCCCCHHH
YVVADITTPVGRDAALAACPAPDILVNNADGAPPGDFRQWTPADWHAALDSMMIGPIEMI
HHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHH
RRTVDPMIARRFGRIVNIVSRSVKTPQFELGLSNGARSGLVGFVAGLARQTVRHNVTINN
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
LLPGVFATDAQRRHIQGMVDSTGKSFDQLWQERGSNNPAGRYGEAEEVGALCAYICSAHT
HCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
GYITGQSILIDGGAYPGTY
CEEECCEEEEECCCCCCCC
>Mature Secondary Structure
MDLGIAGKTALVFGGSKGMGRACAQQLAREGVEVCIAARTQQTLALAAQEISAQTGHAVQ
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCCCCCHHH
YVVADITTPVGRDAALAACPAPDILVNNADGAPPGDFRQWTPADWHAALDSMMIGPIEMI
HHHHHHCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHH
RRTVDPMIARRFGRIVNIVSRSVKTPQFELGLSNGARSGLVGFVAGLARQTVRHNVTINN
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHH
LLPGVFATDAQRRHIQGMVDSTGKSFDQLWQERGSNNPAGRYGEAEEVGALCAYICSAHT
HCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
GYITGQSILIDGGAYPGTY
CEEECCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]