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The map label for this gene is livH [H]

Identifier: 121611024

GI number: 121611024

Start: 4507240

End: 4508091

Strand: Direct

Name: livH [H]

Synonym: Veis_4108

Alternate gene names: 121611024

Gene position: 4507240-4508091 (Clockwise)

Preceding gene: 121611023

Following gene: 121611025

Centisome position: 80.97

GC content: 66.67

Gene sequence:

>852_bases
ATGCTGAGCATCCATCTGTTCAACGGCCTGGTGTACGGCGCGCTGCTGATCGTCATGAGTTCGGGGCTGGCGCTGATCTA
CGGCCTGCGCCGCGTGGTCAACTTTGCGCATGGTGCGCTCTACATGCTGGGCGCCTACATCGGCTACTCCGTGGCGCTGC
GCAGCAATTTCTGGCTGGCGCTGCTGGCCGCGCCGGCCGCCATGGCCGTGGTCGGCCTGCTGCTGGACCGCTATGGCTTG
CGCCTGCTGCAAGACCGCGAACCGCTGACTGTGATGCTGGTCACCTTCGGGTTGCTGCTGATTCTGGAAGACCTGGTGGC
ATTCATCTGGGGCAAGGGCAACCACTCCCTGTTCACACCGGATTTGCTCGACTTCCCGGTCCATCTTCTGGGCCACGAGG
TACCCGCCTACCGCATGGGCGTGATCGCCGTGGGGGCCCTCGTCGCCGTCGGCCTGACGCTGTGGCTGCGCCTGTCGAAG
ATCGGCCTGTATGTGCGCGCGGCGAGCACGGACCCGGTCACGAGCGCCATGCAAGGCGTCGACACCGACCTCATCAGCGC
CGTCGTCGTGGGCCTGGGCAGCGCGCTGGCGGGCCTGGCGGGTGTGGTGGCGGCACCGTTCCTGTCCCTGTCGCCGCACA
TGAGTTCGGACGTGCTGATCGACTCCTTCGTGGTGGTGGTCATTGGCGGACTGGGCTCGCTGGCCGGTGCCTTTGCCGCC
GCCCTGCTGCTGGGGATGGTGCAGGCCATCGGCGCGGTGTACATGCCCGGGGTCTCGGTGCTGCTGCCCTTCATCTTCAT
GATCGCCATCCTGATCTGCAAGCCCTCCGGGCTGGCCGGCAGCCGAACCTGA

Upstream 100 bases:

>100_bases
GGGGGACTGCTTGCCTGGGCGCGGAGATGGCCAGGAACCCCGGCAGCGGCTCCCTTCGCCGCCGTGCCGGAACGGACGGC
GGCACGCTGAAAGCCTTGCC

Downstream 100 bases:

>100_bases
GCGCAGGAGCTTCGCATGACACTTGCCCGCATCGGTGTGCTTTCGCTGCTCGCCTTGGCGCTGGGCGCCGGCATCGCCGG
ACTCGCCGGTTCCGGCAGTC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLSIHLFNGLVYGALLIVMSSGLALIYGLRRVVNFAHGALYMLGAYIGYSVALRSNFWLALLAAPAAMAVVGLLLDRYGL
RLLQDREPLTVMLVTFGLLLILEDLVAFIWGKGNHSLFTPDLLDFPVHLLGHEVPAYRMGVIAVGALVAVGLTLWLRLSK
IGLYVRAASTDPVTSAMQGVDTDLISAVVVGLGSALAGLAGVVAAPFLSLSPHMSSDVLIDSFVVVVIGGLGSLAGAFAA
ALLLGMVQAIGAVYMPGVSVLLPFIFMIAILICKPSGLAGSRT

Sequences:

>Translated_283_residues
MLSIHLFNGLVYGALLIVMSSGLALIYGLRRVVNFAHGALYMLGAYIGYSVALRSNFWLALLAAPAAMAVVGLLLDRYGL
RLLQDREPLTVMLVTFGLLLILEDLVAFIWGKGNHSLFTPDLLDFPVHLLGHEVPAYRMGVIAVGALVAVGLTLWLRLSK
IGLYVRAASTDPVTSAMQGVDTDLISAVVVGLGSALAGLAGVVAAPFLSLSPHMSSDVLIDSFVVVVIGGLGSLAGAFAA
ALLLGMVQAIGAVYMPGVSVLLPFIFMIAILICKPSGLAGSRT
>Mature_283_residues
MLSIHLFNGLVYGALLIVMSSGLALIYGLRRVVNFAHGALYMLGAYIGYSVALRSNFWLALLAAPAAMAVVGLLLDRYGL
RLLQDREPLTVMLVTFGLLLILEDLVAFIWGKGNHSLFTPDLLDFPVHLLGHEVPAYRMGVIAVGALVAVGLTLWLRLSK
IGLYVRAASTDPVTSAMQGVDTDLISAVVVGLGSALAGLAGVVAAPFLSLSPHMSSDVLIDSFVVVVIGGLGSLAGAFAA
ALLLGMVQAIGAVYMPGVSVLLPFIFMIAILICKPSGLAGSRT

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=295, Percent_Identity=26.4406779661017, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 29574; Mature: 29574

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]