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The map label for this gene is livM [H]

Identifier: 121611025

GI number: 121611025

Start: 4508107

End: 4509084

Strand: Direct

Name: livM [H]

Synonym: Veis_4109

Alternate gene names: 121611025

Gene position: 4508107-4509084 (Clockwise)

Preceding gene: 121611024

Following gene: 121611026

Centisome position: 80.98

GC content: 66.46

Gene sequence:

>978_bases
ATGACACTTGCCCGCATCGGTGTGCTTTCGCTGCTCGCCTTGGCGCTGGGCGCCGGCATCGCCGGACTCGCCGGTTCCGG
CAGTCTGCTGGGAGTGCTGACGCAGGCCGTCATCTACGCCATCTTTGCCCTGGGCGTTGGCGTGCTGCTGCGGCAAAGCG
GCCTGGTGAGCTTCGGCCATGCCCTGTTCTTCGGCGCGGCCGGCTACGGCATGGGCGTCGTGCTGGCGCTCGATTGGATG
CCGGCGGAGGCGGCCATTCCCGTGGTTCTGTTGGCCATCGGCGTGCTGGCCTTCCTGATCGGGCTGGTCATCGTCCGCGT
GCCCGGCATTGCCTTTGGCATGTTGACACTGGCCATCGGGCAAATGGCCTATCTGCTGGCCTTTCGCGCCCGCGGCCTGA
CCGGCGGCGCGGACGGCATGGGCATCCACTGGCCGGCAACCCTGTTCGGGTATTCACAGTCCGCGCTGCTCAAGCCCGCC
ACGGTGTTCCTGATCGCGTGGGTATCGATGGTGCTGACGACGGTGCTGCTGCTGTTCATCCTGAGAACGCGCTTTGGCGC
CATTACCGAGGCGATCCGCGACAACGAGGAGCGCGCCCGCTTCATCGGCATCGGCACCACGGCACCCCGTGCGGCGGTCT
ATGCGCTGTCGGCCGTGGTCGCCGGCATTGCCGGCATTCTGTCCTCGCTCAATACCGGGTTTGTCTCGCCGGAGAACCTG
CACTGGAGCGTCTCGGCCATCACGCTGCTGATGGTGATCGTCGGCGGCTTCGAGAAGCTCGCCGGCCCCATCATCGGCGC
CATTGTCTACGTCATGTTCAAGGACCTGCTGGGCGGCTACGCCACCCACTCGATGGCCCTCTTTGGCGCCGCGCTGATTG
CCGTCATCGTGTTCTCGCCGCACGGCATCGCCGGCGCGCTGGAGCGTCTGTACATTCGCTTGCGCCATGGCCCCGGCGTC
CGCAGGGAATCGGTATGA

Upstream 100 bases:

>100_bases
CGGGGTCTCGGTGCTGCTGCCCTTCATCTTCATGATCGCCATCCTGATCTGCAAGCCCTCCGGGCTGGCCGGCAGCCGAA
CCTGAGCGCAGGAGCTTCGC

Downstream 100 bases:

>100_bases
CGCCCTATGTGTTGCAAGCCGAGGATGTGGCCATCCATTACGGCGGCACCAAGGCCCTCGACGGTGTTGCGCTGACCTTG
GAGAAAGCCCAGATTCGCGG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTLARIGVLSLLALALGAGIAGLAGSGSLLGVLTQAVIYAIFALGVGVLLRQSGLVSFGHALFFGAAGYGMGVVLALDWM
PAEAAIPVVLLAIGVLAFLIGLVIVRVPGIAFGMLTLAIGQMAYLLAFRARGLTGGADGMGIHWPATLFGYSQSALLKPA
TVFLIAWVSMVLTTVLLLFILRTRFGAITEAIRDNEERARFIGIGTTAPRAAVYALSAVVAGIAGILSSLNTGFVSPENL
HWSVSAITLLMVIVGGFEKLAGPIIGAIVYVMFKDLLGGYATHSMALFGAALIAVIVFSPHGIAGALERLYIRLRHGPGV
RRESV

Sequences:

>Translated_325_residues
MTLARIGVLSLLALALGAGIAGLAGSGSLLGVLTQAVIYAIFALGVGVLLRQSGLVSFGHALFFGAAGYGMGVVLALDWM
PAEAAIPVVLLAIGVLAFLIGLVIVRVPGIAFGMLTLAIGQMAYLLAFRARGLTGGADGMGIHWPATLFGYSQSALLKPA
TVFLIAWVSMVLTTVLLLFILRTRFGAITEAIRDNEERARFIGIGTTAPRAAVYALSAVVAGIAGILSSLNTGFVSPENL
HWSVSAITLLMVIVGGFEKLAGPIIGAIVYVMFKDLLGGYATHSMALFGAALIAVIVFSPHGIAGALERLYIRLRHGPGV
RRESV
>Mature_324_residues
TLARIGVLSLLALALGAGIAGLAGSGSLLGVLTQAVIYAIFALGVGVLLRQSGLVSFGHALFFGAAGYGMGVVLALDWMP
AEAAIPVVLLAIGVLAFLIGLVIVRVPGIAFGMLTLAIGQMAYLLAFRARGLTGGADGMGIHWPATLFGYSQSALLKPAT
VFLIAWVSMVLTTVLLLFILRTRFGAITEAIRDNEERARFIGIGTTAPRAAVYALSAVVAGIAGILSSLNTGFVSPENLH
WSVSAITLLMVIVGGFEKLAGPIIGAIVYVMFKDLLGGYATHSMALFGAALIAVIVFSPHGIAGALERLYIRLRHGPGVR
RESV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=304, Percent_Identity=26.6447368421053, Blast_Score=92, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 33670; Mature: 33539

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLARIGVLSLLALALGAGIAGLAGSGSLLGVLTQAVIYAIFALGVGVLLRQSGLVSFGH
CCHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALFFGAAGYGMGVVLALDWMPAEAAIPVVLLAIGVLAFLIGLVIVRVPGIAFGMLTLAIG
HHHHHHCCCCCEEHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
QMAYLLAFRARGLTGGADGMGIHWPATLFGYSQSALLKPATVFLIAWVSMVLTTVLLLFI
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTRFGAITEAIRDNEERARFIGIGTTAPRAAVYALSAVVAGIAGILSSLNTGFVSPENL
HHHHHHHHHHHHHCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HWSVSAITLLMVIVGGFEKLAGPIIGAIVYVMFKDLLGGYATHSMALFGAALIAVIVFSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HGIAGALERLYIRLRHGPGVRRESV
CCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TLARIGVLSLLALALGAGIAGLAGSGSLLGVLTQAVIYAIFALGVGVLLRQSGLVSFGH
CHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALFFGAAGYGMGVVLALDWMPAEAAIPVVLLAIGVLAFLIGLVIVRVPGIAFGMLTLAIG
HHHHHHCCCCCEEHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
QMAYLLAFRARGLTGGADGMGIHWPATLFGYSQSALLKPATVFLIAWVSMVLTTVLLLFI
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTRFGAITEAIRDNEERARFIGIGTTAPRAAVYALSAVVAGIAGILSSLNTGFVSPENL
HHHHHHHHHHHHHCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HWSVSAITLLMVIVGGFEKLAGPIIGAIVYVMFKDLLGGYATHSMALFGAALIAVIVFSP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HGIAGALERLYIRLRHGPGVRRESV
CCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]