Click here to switch to the map view.

The map label for this gene is menB [H]

Identifier: 121611021

GI number: 121611021

Start: 4503423

End: 4504205

Strand: Direct

Name: menB [H]

Synonym: Veis_4105

Alternate gene names: 121611021

Gene position: 4503423-4504205 (Clockwise)

Preceding gene: 121611020

Following gene: 121611022

Centisome position: 80.9

GC content: 66.41

Gene sequence:

>783_bases
ATGGATTTCGAAGACATCCTGTACGCAGTGCGCAACGGCGTGGCCTGGATCACGATCAACCGGCCCGACAAGATGAATGC
CTTTCGCGGCCAGACCTGCGACGAGCTCATCGCGGCGCTGAACAAGGCCGGCTACGACCGCGAAGTGGGCGCCATCGTGC
TCGCCGGCGCCGGCGACCGGGCCTTCTGCACCGGTGGCGACCAGTCGGCCCACAGCGGCAACTACGACGGGCGCGGCACC
ATCGGTCTGCCGATGGAAGAACTGCACAGCGCCATCCGCGACGTGCCCAAGCCCGTGATCGCCCGCGTGCAGGGCTATGC
GATCGGCGGCGGCAACGTGCTGGCCACCATCTGCGACCTGACCATCTGCTCGGACAAGGCGCAGTTCGGCCAGGTGGGCC
CGAAAATGGGCTCGGTGGACCCCGGCTACGGCACCGCCTTCCTGGCCCGCGTGGTGGGCGAGAAGAAAGCCCGCGAAATC
TGGTACCTGAACCGCCGCTACGGCGGTGCCGAGGCCGTCGCCATGGGTCTGGCCAACTTCTGCTTTCCGCACGCCGAGCT
CGACGCCGAAGTGCAAAAGATCGGCGAGGAGTTGTGCGAGCGCAGCCCGACGGCGCTGGCCATCGCCAAGCGCAGTTTCA
ATGCCGACACCGCCCACCAGGCCGGCATCGCCGGCCTGGGCATGTACGCGCTCAAGCTGTACTACGACACGCAAGAATCG
CGCGAAGGCGCCAACGCGCTCAGGGAAAAGCGCAAGCCCGAATTCCGCAAGTACGCCAAGTAA

Upstream 100 bases:

>100_bases
CAGCTTCATCACGGGCCAGGTCCTCAGCGTCTCCGGCGGCCTGACCATGCACGGCTGAACCCCGCCCGCTCAAGGCAAGC
ATTCACCCCAAGGGAGCACC

Downstream 100 bases:

>100_bases
GCCGCGCAGCGACATTGGAAAAAAACGATGCCTCCGAACCCCTATGTCGACGAAGACTTGCAGGCGCTGGCCGAGCACGC
CCGGCGCTTTGCACGCGGCC

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MDFEDILYAVRNGVAWITINRPDKMNAFRGQTCDELIAALNKAGYDREVGAIVLAGAGDRAFCTGGDQSAHSGNYDGRGT
IGLPMEELHSAIRDVPKPVIARVQGYAIGGGNVLATICDLTICSDKAQFGQVGPKMGSVDPGYGTAFLARVVGEKKAREI
WYLNRRYGGAEAVAMGLANFCFPHAELDAEVQKIGEELCERSPTALAIAKRSFNADTAHQAGIAGLGMYALKLYYDTQES
REGANALREKRKPEFRKYAK

Sequences:

>Translated_260_residues
MDFEDILYAVRNGVAWITINRPDKMNAFRGQTCDELIAALNKAGYDREVGAIVLAGAGDRAFCTGGDQSAHSGNYDGRGT
IGLPMEELHSAIRDVPKPVIARVQGYAIGGGNVLATICDLTICSDKAQFGQVGPKMGSVDPGYGTAFLARVVGEKKAREI
WYLNRRYGGAEAVAMGLANFCFPHAELDAEVQKIGEELCERSPTALAIAKRSFNADTAHQAGIAGLGMYALKLYYDTQES
REGANALREKRKPEFRKYAK
>Mature_260_residues
MDFEDILYAVRNGVAWITINRPDKMNAFRGQTCDELIAALNKAGYDREVGAIVLAGAGDRAFCTGGDQSAHSGNYDGRGT
IGLPMEELHSAIRDVPKPVIARVQGYAIGGGNVLATICDLTICSDKAQFGQVGPKMGSVDPGYGTAFLARVVGEKKAREI
WYLNRRYGGAEAVAMGLANFCFPHAELDAEVQKIGEELCERSPTALAIAKRSFNADTAHQAGIAGLGMYALKLYYDTQES
REGANALREKRKPEFRKYAK

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=261, Percent_Identity=34.8659003831418, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI45643119, Length=213, Percent_Identity=27.6995305164319, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI260275230, Length=213, Percent_Identity=27.6995305164319, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI260274832, Length=213, Percent_Identity=27.6995305164319, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI31542718, Length=245, Percent_Identity=26.530612244898, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI70995211, Length=271, Percent_Identity=26.1992619926199, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4502327, Length=255, Percent_Identity=27.843137254902, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI25453481, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI51538573, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4757966, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI51538581, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788597, Length=262, Percent_Identity=48.4732824427481, Blast_Score=245, Evalue=2e-66,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=28.0155642023346, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI221142681, Length=264, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082183, Length=267, Percent_Identity=26.5917602996255, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=28.735632183908, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1788682, Length=181, Percent_Identity=25.9668508287293, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=250, Percent_Identity=34, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25145438, Length=259, Percent_Identity=32.046332046332, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17540714, Length=205, Percent_Identity=29.7560975609756, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17549921, Length=209, Percent_Identity=27.7511961722488, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=245, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=216, Percent_Identity=26.8518518518519, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=230, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=244, Percent_Identity=34.4262295081967, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653477, Length=244, Percent_Identity=34.4262295081967, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653139, Length=258, Percent_Identity=30.2325581395349, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922422, Length=252, Percent_Identity=23.4126984126984, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357171, Length=243, Percent_Identity=25.5144032921811, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19920382, Length=266, Percent_Identity=25.5639097744361, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24654903, Length=196, Percent_Identity=26.530612244898, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 28132; Mature: 28132

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEDILYAVRNGVAWITINRPDKMNAFRGQTCDELIAALNKAGYDREVGAIVLAGAGDR
CCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCC
AFCTGGDQSAHSGNYDGRGTIGLPMEELHSAIRDVPKPVIARVQGYAIGGGNVLATICDL
EEECCCCCCCCCCCCCCCCEECCCHHHHHHHHHHCCHHHHHHHCCEEECCCHHHHHHHHH
TICSDKAQFGQVGPKMGSVDPGYGTAFLARVVGEKKAREIWYLNRRYGGAEAVAMGLANF
HHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
CFPHAELDAEVQKIGEELCERSPTALAIAKRSFNADTAHQAGIAGLGMYALKLYYDTQES
HCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCHHHHHCHHHHHHHHHHHEECCHHH
REGANALREKRKPEFRKYAK
HHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MDFEDILYAVRNGVAWITINRPDKMNAFRGQTCDELIAALNKAGYDREVGAIVLAGAGDR
CCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCC
AFCTGGDQSAHSGNYDGRGTIGLPMEELHSAIRDVPKPVIARVQGYAIGGGNVLATICDL
EEECCCCCCCCCCCCCCCCEECCCHHHHHHHHHHCCHHHHHHHCCEEECCCHHHHHHHHH
TICSDKAQFGQVGPKMGSVDPGYGTAFLARVVGEKKAREIWYLNRRYGGAEAVAMGLANF
HHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
CFPHAELDAEVQKIGEELCERSPTALAIAKRSFNADTAHQAGIAGLGMYALKLYYDTQES
HCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCHHHHHCHHHHHHHHHHHEECCHHH
REGANALREKRKPEFRKYAK
HHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]