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The map label for this gene is ruvA

Identifier: 121610984

GI number: 121610984

Start: 4461174

End: 4461749

Strand: Direct

Name: ruvA

Synonym: Veis_4068

Alternate gene names: 121610984

Gene position: 4461174-4461749 (Clockwise)

Preceding gene: 121610981

Following gene: 121610985

Centisome position: 80.14

GC content: 63.89

Gene sequence:

>576_bases
ATGATAGGCAAATTGACCGGCACTCTGCTGGAGAAAAATCCCCCCGAGGTGCTGCTCGACTGCCACGGCGTGGGCTACGA
GGTGAATGTGCCGATGAGCAGCTTTTATAATCTGCCCGCCGTGGGCGAGCGTATCAGCCTGCTCACGCAGTTCATCGTGC
GCGAGGACGCCCAACTGCTGTATGGCTTTGCCACTGCGCCTGAGCGCCAGGCGTTTCGCGCGCTGATCAAGATAACGGGG
GTGGGGCCGCGCATGGCGCTGTCGATACTTTCCGGCATGAGCGTGGCGGATCTGGCCCAGGCGATTGCACGGCAGGAGGC
GGCCCGCCTGGTCAAGGTGCCGGGCGTTGGCAAAAGAACTGCCGAGCGATTGCTGCTGGAACTCAAGGGAAAGCTGGGCG
CGGACTTGGGCGCCAGCCATGGCCCCGCAGTCAGCGGCGCGCAGGCGGATATCCTGCAGGCCCTGTTGGCTTTGGGCTAC
AACGACAAGGAGGCCGCAGCAGCGCTCAAGGCGCTGCCGGCGCAGGTAGAGGTCAGCGACGGCATCAAGTGGGCGCTCAA
GGCCTTGACGAAGTAG

Upstream 100 bases:

>100_bases
TGAAGGTGTGGCGCAGGATCACGCTGATAATTCCAGTCAGGCAACGGACATGGCAAGATGGCGCTGTAGCAGTTTGCGCG
GGCGCCGACAAAGGACAGCA

Downstream 100 bases:

>100_bases
CATCCGGACGCTTGCGTGCCGTCTTGTCACATGCTTGGCACACTGCGAACATCCAACCACCTTACTGAGTGAGGACGAGA
AATGAAAAATCCCGGGTTTG

Product: Holliday junction DNA helicase RuvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MIGKLTGTLLEKNPPEVLLDCHGVGYEVNVPMSSFYNLPAVGERISLLTQFIVREDAQLLYGFATAPERQAFRALIKITG
VGPRMALSILSGMSVADLAQAIARQEAARLVKVPGVGKRTAERLLLELKGKLGADLGASHGPAVSGAQADILQALLALGY
NDKEAAAALKALPAQVEVSDGIKWALKALTK

Sequences:

>Translated_191_residues
MIGKLTGTLLEKNPPEVLLDCHGVGYEVNVPMSSFYNLPAVGERISLLTQFIVREDAQLLYGFATAPERQAFRALIKITG
VGPRMALSILSGMSVADLAQAIARQEAARLVKVPGVGKRTAERLLLELKGKLGADLGASHGPAVSGAQADILQALLALGY
NDKEAAAALKALPAQVEVSDGIKWALKALTK
>Mature_191_residues
MIGKLTGTLLEKNPPEVLLDCHGVGYEVNVPMSSFYNLPAVGERISLLTQFIVREDAQLLYGFATAPERQAFRALIKITG
VGPRMALSILSGMSVADLAQAIARQEAARLVKVPGVGKRTAERLLLELKGKLGADLGASHGPAVSGAQADILQALLALGY
NDKEAAAALKALPAQVEVSDGIKWALKALTK

Specific function: The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday

COG id: COG0632

COG function: function code L; Holliday junction resolvasome, DNA-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvA family

Homologues:

Organism=Escherichia coli, GI1788168, Length=178, Percent_Identity=48.314606741573, Blast_Score=171, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVA_VEREI (A1WQ66)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_998791.1
- ProteinModelPortal:   A1WQ66
- SMR:   A1WQ66
- STRING:   A1WQ66
- GeneID:   4695263
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4068
- eggNOG:   COG0632
- HOGENOM:   HBG635309
- OMA:   LSIETYV
- PhylomeDB:   A1WQ66
- BioCyc:   VEIS391735:VEIS_4068-MONOMER
- HAMAP:   MF_00031
- InterPro:   IPR011114
- InterPro:   IPR013849
- InterPro:   IPR003583
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR000085
- InterPro:   IPR010994
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00278
- TIGRFAMs:   TIGR00084

Pfam domain/function: PF07499 RuvA_C; PF01330 RuvA_N; SSF50249 Nucleic_acid_OB; SSF47781 RuvA_2_like; SSF46929 RuvA_C-like

EC number: =3.6.4.12

Molecular weight: Translated: 20141; Mature: 20141

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGKLTGTLLEKNPPEVLLDCHGVGYEVNVPMSSFYNLPAVGERISLLTQFIVREDAQLL
CCCCHHHHHHCCCCCCEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
YGFATAPERQAFRALIKITGVGPRMALSILSGMSVADLAQAIARQEAARLVKVPGVGKRT
HHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCHHH
AERLLLELKGKLGADLGASHGPAVSGAQADILQALLALGYNDKEAAAALKALPAQVEVSD
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCC
GIKWALKALTK
CHHHHHHHHCC
>Mature Secondary Structure
MIGKLTGTLLEKNPPEVLLDCHGVGYEVNVPMSSFYNLPAVGERISLLTQFIVREDAQLL
CCCCHHHHHHCCCCCCEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
YGFATAPERQAFRALIKITGVGPRMALSILSGMSVADLAQAIARQEAARLVKVPGVGKRT
HHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCHHH
AERLLLELKGKLGADLGASHGPAVSGAQADILQALLALGYNDKEAAAALKALPAQVEVSD
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCC
GIKWALKALTK
CHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA