Click here to switch to the map view.

The map label for this gene is clpB [H]

Identifier: 121610528

GI number: 121610528

Start: 3976100

End: 3978703

Strand: Direct

Name: clpB [H]

Synonym: Veis_3599

Alternate gene names: 121610528

Gene position: 3976100-3978703 (Clockwise)

Preceding gene: 121610518

Following gene: 121610529

Centisome position: 71.43

GC content: 64.86

Gene sequence:

>2604_bases
ATGCGTCTCGACAAATTCACCACCAAATTCCAGGAGGCATTGAGCGATGCCCAAAGCCTGGCGCTGGGCAATGACCACGC
CTACATCGAGCCGGTGCACCTGCTCGCGGCCATGCTCAGGCAGGCCGATGGTCCCAGGGCCTTGTTGCAGCGTGCCGGCG
CCAATGTGCCTGGCCTGCTGGCAGCGGCCGAGGCGGCCGTCAAACGCCTGCCCCAGGTGCAGGGCAATGAGCAGGTGCAG
GTCGGGCCCGAACTGGGCCGTGTGCTGCAGGCCACCGAGAAAGAGGCCATCAAGCGCGGCGACCCGTTCATTGCCAGCGA
ATTGTTCCTGCTGGCCGTGATCGACAGCAAGGGCGAGGCGGCGCAACTGGCCAAAGAGCATGGCCTTGCGCGCAAGAGTC
TGGAGGCCGCGATCGAGGCCGTGCGCGGCGGCCAGAAGGTGGACAGCGCCGAGGCCGAAGGCCAGCGCGGTGCGCTCGCC
AAATACTGCCTGGACCTGACCGAGCGCGCGCGCTTGGGCAAGCTCGACCCGGTGATCGGCCGCGACGATGAAATCCGCCG
CGCGATCCAGGTGCTGCAGCGCCGCACCAAGAACAACCCGGTGCTGATCGGCGAGCCTGGCGTGGGCAAGACGGCGATCG
TCGAAGGTCTGGCCCAGCGCATCGTGGCCGGCGAGGTGCCCGAGTCGCTCAAGGGCAAGCGCGTGCTGTCGCTGGACATG
GCGGCGCTGCTGGCCGGCGCCAAGTTCCGTGGCGAATTTGAAGAGCGCCTGAAAGCCGTGCTCACCGAACTGGCCAAGGA
CCAGGGGCAGACCATCGTCTTCATCGACGAGTTGCACACCATGGTCGGCGCCGGCAAGGCCGAAGGGGCGATGGACGCGG
GCAACATGCTCAAGCCCGCGCTCGCGCGTGGCGAACTGCACTGCGTGGGCGCGACCACGCTCGACGAGTACCGCAAGTAC
ATCGAAAAAGACGCTGCGCTGGAGCGGCGTTTTCAGAAGATCCTGGTCGACGAGCCGACGGTCGAGGCGAGCATTGCCAT
CTTGCGCGGCTTGCAGGAAAAGTACGAGGTGCACCATGGCGTGGACATCACCGACCCGGCCATCGTGGCCGCCGCCGAAC
TGTCCAACCGCTACATCACCGACCGCTTTTTGCCCGACAAGGCGATCGACCTGATCGACGAGGCGGCCTCCAAGATCAAG
ATCGAGATGGATTCCAAGCCCGAGGTGATGGACAAGCTCGACCGCCGCCTGATACAGGTACAGATCGAGCGCGAGGCGGT
GCGCCGCGAAAAGGATGAAGCCTCGCAAAAGCGCCTGGCGCTGATCGAGGAGGAGATAACCCGGCTGCAAAAGGAAATCG
CCGATTACGACGAGATCTGGCAGGCGGAAAAAGCCCAGGCGCAGGGCAGCGCGCAACTGCGCGAAGCCATTGACAAGCTC
AGGTTCCAGATCGAGGAATTCACCCGCAAGGGCGACTTCAACAAGGTGGCCGAACTGCAATACGGCCAGTTGCCCGCGCT
GGAAAAGCAGCTCCGGCAAGCACAGGCCCAGGAAGCGGGCAAGGACGGCGCGCCGGCCACCCGCCGCCTGCTGCGCACGC
AGGTGGGGGCCGAGGAAATCGCCGAGGTGGTCAGCCGCGCCACCGGCATCCCGGTGGCCAAGATGATGCAAGGCGAAAAA
GACAAGCTGCTGCAGATGGAAGCCAGGCTGCACCAGCGTGTGGTGGGCCAGGACGAGGCGATCGCCGCCGTGGCCAACGC
CATCCGCCGCTCGCGCTCGGGCCTGTCGGACCCGCAGCGTCCCAGCGGCAGTTTTCTGTTCCTGGGCCCCACGGGCGTCG
GCAAAACCGAGTTGTGCAAGGCGCTGGCGGGCTTTTTGTTCGACAGCGAAGACCACATGGTGCGCATCGACATGAGCGAG
TTCATGGAAAAGCATTCCGTGGCCCGCCTGATCGGCGCACCCCCCGGTTACGTGGGCTATGAGGAGGGCGGCTATCTGAC
CGAGGCCGTGCGCCGCAAGCCCTACAGCGTGCTGCTGCTCGACGAGGTGGACAAAGCCCATCCCGACGTGTTCAACGTGC
TGCTGCAAGTGCTCGACGATGGCCGTTTGACCGACAGCCAGGGCCGCACCGTGGACTTCAAGAACACGGTGATCGTGATG
ACCAGCAACATCGGCTCGCCGCTGATCCAAGCCATGGTGGGCCAGGACCCGCAGGACATCAAGGACGCGGTGTGGGGGGA
ACTGAAGAACCATTTCCGGCCCGAATTCCTGAACCGGATCGACGAGACGGTGGTGTTCCACGCGCTCGATGCGCAGCATA
TTGCGTCGATCGCGCGGATACAGTTGCAGTCGTTGCAATCCCGGCTGGCGAAGATGGACTTGCAATTGCAGGTCTCGGAC
GCCGCTGTGGCAGAGTTGGCCAAGGTGGGGTTCGATCCGGTGTTCGGCGCGCGGCCGCTCAAGCGGGCGATACAGCAGCG
CATCGAAAACCCGCTGTCCAGGCTGCTGCTGCAAGGGCAATTCCCGCCCAAGAGCGTGATCGCGGTCAGCGTGAACCCGA
TGCTCGATCCGGGGGTGTTCCAGTTCGGCGCTGCGCCGCAGTGA

Upstream 100 bases:

>100_bases
CCATCGTCCGATGAACGCCAGTCCGCCCCGCGCCCGGGCGCGGCCCTTGAAACCAGGCTGGCCGTGCCTCATGTGCCTTG
CAATTCGGAGGATCCCCAAC

Downstream 100 bases:

>100_bases
GGCCGGGGACGGGTTCCGCGTTGTCTGAAGGAGAGGTGTCGTTTGAACCAGATCGTTACGACTTGTTTGCGCTGGCTGCT
GCGCGCGCTGCTGCTGGTCA

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 867; Mature: 867

Protein sequence:

>867_residues
MRLDKFTTKFQEALSDAQSLALGNDHAYIEPVHLLAAMLRQADGPRALLQRAGANVPGLLAAAEAAVKRLPQVQGNEQVQ
VGPELGRVLQATEKEAIKRGDPFIASELFLLAVIDSKGEAAQLAKEHGLARKSLEAAIEAVRGGQKVDSAEAEGQRGALA
KYCLDLTERARLGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
AALLAGAKFRGEFEERLKAVLTELAKDQGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCVGATTLDEYRKY
IEKDAALERRFQKILVDEPTVEASIAILRGLQEKYEVHHGVDITDPAIVAAAELSNRYITDRFLPDKAIDLIDEAASKIK
IEMDSKPEVMDKLDRRLIQVQIEREAVRREKDEASQKRLALIEEEITRLQKEIADYDEIWQAEKAQAQGSAQLREAIDKL
RFQIEEFTRKGDFNKVAELQYGQLPALEKQLRQAQAQEAGKDGAPATRRLLRTQVGAEEIAEVVSRATGIPVAKMMQGEK
DKLLQMEARLHQRVVGQDEAIAAVANAIRRSRSGLSDPQRPSGSFLFLGPTGVGKTELCKALAGFLFDSEDHMVRIDMSE
FMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVLLLDEVDKAHPDVFNVLLQVLDDGRLTDSQGRTVDFKNTVIVM
TSNIGSPLIQAMVGQDPQDIKDAVWGELKNHFRPEFLNRIDETVVFHALDAQHIASIARIQLQSLQSRLAKMDLQLQVSD
AAVAELAKVGFDPVFGARPLKRAIQQRIENPLSRLLLQGQFPPKSVIAVSVNPMLDPGVFQFGAAPQ

Sequences:

>Translated_867_residues
MRLDKFTTKFQEALSDAQSLALGNDHAYIEPVHLLAAMLRQADGPRALLQRAGANVPGLLAAAEAAVKRLPQVQGNEQVQ
VGPELGRVLQATEKEAIKRGDPFIASELFLLAVIDSKGEAAQLAKEHGLARKSLEAAIEAVRGGQKVDSAEAEGQRGALA
KYCLDLTERARLGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
AALLAGAKFRGEFEERLKAVLTELAKDQGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCVGATTLDEYRKY
IEKDAALERRFQKILVDEPTVEASIAILRGLQEKYEVHHGVDITDPAIVAAAELSNRYITDRFLPDKAIDLIDEAASKIK
IEMDSKPEVMDKLDRRLIQVQIEREAVRREKDEASQKRLALIEEEITRLQKEIADYDEIWQAEKAQAQGSAQLREAIDKL
RFQIEEFTRKGDFNKVAELQYGQLPALEKQLRQAQAQEAGKDGAPATRRLLRTQVGAEEIAEVVSRATGIPVAKMMQGEK
DKLLQMEARLHQRVVGQDEAIAAVANAIRRSRSGLSDPQRPSGSFLFLGPTGVGKTELCKALAGFLFDSEDHMVRIDMSE
FMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVLLLDEVDKAHPDVFNVLLQVLDDGRLTDSQGRTVDFKNTVIVM
TSNIGSPLIQAMVGQDPQDIKDAVWGELKNHFRPEFLNRIDETVVFHALDAQHIASIARIQLQSLQSRLAKMDLQLQVSD
AAVAELAKVGFDPVFGARPLKRAIQQRIENPLSRLLLQGQFPPKSVIAVSVNPMLDPGVFQFGAAPQ
>Mature_867_residues
MRLDKFTTKFQEALSDAQSLALGNDHAYIEPVHLLAAMLRQADGPRALLQRAGANVPGLLAAAEAAVKRLPQVQGNEQVQ
VGPELGRVLQATEKEAIKRGDPFIASELFLLAVIDSKGEAAQLAKEHGLARKSLEAAIEAVRGGQKVDSAEAEGQRGALA
KYCLDLTERARLGKLDPVIGRDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
AALLAGAKFRGEFEERLKAVLTELAKDQGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPALARGELHCVGATTLDEYRKY
IEKDAALERRFQKILVDEPTVEASIAILRGLQEKYEVHHGVDITDPAIVAAAELSNRYITDRFLPDKAIDLIDEAASKIK
IEMDSKPEVMDKLDRRLIQVQIEREAVRREKDEASQKRLALIEEEITRLQKEIADYDEIWQAEKAQAQGSAQLREAIDKL
RFQIEEFTRKGDFNKVAELQYGQLPALEKQLRQAQAQEAGKDGAPATRRLLRTQVGAEEIAEVVSRATGIPVAKMMQGEK
DKLLQMEARLHQRVVGQDEAIAAVANAIRRSRSGLSDPQRPSGSFLFLGPTGVGKTELCKALAGFLFDSEDHMVRIDMSE
FMEKHSVARLIGAPPGYVGYEEGGYLTEAVRRKPYSVLLLDEVDKAHPDVFNVLLQVLDDGRLTDSQGRTVDFKNTVIVM
TSNIGSPLIQAMVGQDPQDIKDAVWGELKNHFRPEFLNRIDETVVFHALDAQHIASIARIQLQSLQSRLAKMDLQLQVSD
AAVAELAKVGFDPVFGARPLKRAIQQRIENPLSRLLLQGQFPPKSVIAVSVNPMLDPGVFQFGAAPQ

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=316, Percent_Identity=36.3924050632911, Blast_Score=207, Evalue=3e-53,
Organism=Escherichia coli, GI1788943, Length=855, Percent_Identity=64.5614035087719, Blast_Score=1105, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=392, Percent_Identity=40.5612244897959, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6320464, Length=702, Percent_Identity=52.991452991453, Blast_Score=742, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=858, Percent_Identity=42.8904428904429, Blast_Score=679, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95359; Mature: 95359

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDKFTTKFQEALSDAQSLALGNDHAYIEPVHLLAAMLRQADGPRALLQRAGANVPGLL
CCCHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHHCCCCCCHHH
AAAEAAVKRLPQVQGNEQVQVGPELGRVLQATEKEAIKRGDPFIASELFLLAVIDSKGEA
HHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEECCCCHH
AQLAKEHGLARKSLEAAIEAVRGGQKVDSAEAEGQRGALAKYCLDLTERARLGKLDPVIG
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
RDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
CCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEHHHHH
AALLAGAKFRGEFEERLKAVLTELAKDQGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPA
HHHHHCCHHCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHHHH
LARGELHCVGATTLDEYRKYIEKDAALERRFQKILVDEPTVEASIAILRGLQEKYEVHHG
HHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
VDITDPAIVAAAELSNRYITDRFLPDKAIDLIDEAASKIKIEMDSKPEVMDKLDRRLIQV
CCCCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHH
QIEREAVRREKDEASQKRLALIEEEITRLQKEIADYDEIWQAEKAQAQGSAQLREAIDKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHH
RFQIEEFTRKGDFNKVAELQYGQLPALEKQLRQAQAQEAGKDGAPATRRLLRTQVGAEEI
HHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHH
AEVVSRATGIPVAKMMQGEKDKLLQMEARLHQRVVGQDEAIAAVANAIRRSRSGLSDPQR
HHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
PSGSFLFLGPTGVGKTELCKALAGFLFDSEDHMVRIDMSEFMEKHSVARLIGAPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
EEGGYLTEAVRRKPYSVLLLDEVDKAHPDVFNVLLQVLDDGRLTDSQGRTVDFKNTVIVM
CCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNIGSPLIQAMVGQDPQDIKDAVWGELKNHFRPEFLNRIDETVVFHALDAQHIASIARI
ECCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHH
QLQSLQSRLAKMDLQLQVSDAAVAELAKVGFDPVFGARPLKRAIQQRIENPLSRLLLQGQ
HHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
FPPKSVIAVSVNPMLDPGVFQFGAAPQ
CCCCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLDKFTTKFQEALSDAQSLALGNDHAYIEPVHLLAAMLRQADGPRALLQRAGANVPGLL
CCCHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHHCCCCCCHHH
AAAEAAVKRLPQVQGNEQVQVGPELGRVLQATEKEAIKRGDPFIASELFLLAVIDSKGEA
HHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEECCCCHH
AQLAKEHGLARKSLEAAIEAVRGGQKVDSAEAEGQRGALAKYCLDLTERARLGKLDPVIG
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
RDDEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGEVPESLKGKRVLSLDM
CCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEHHHHH
AALLAGAKFRGEFEERLKAVLTELAKDQGQTIVFIDELHTMVGAGKAEGAMDAGNMLKPA
HHHHHCCHHCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHHHH
LARGELHCVGATTLDEYRKYIEKDAALERRFQKILVDEPTVEASIAILRGLQEKYEVHHG
HHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
VDITDPAIVAAAELSNRYITDRFLPDKAIDLIDEAASKIKIEMDSKPEVMDKLDRRLIQV
CCCCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHH
QIEREAVRREKDEASQKRLALIEEEITRLQKEIADYDEIWQAEKAQAQGSAQLREAIDKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHH
RFQIEEFTRKGDFNKVAELQYGQLPALEKQLRQAQAQEAGKDGAPATRRLLRTQVGAEEI
HHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHH
AEVVSRATGIPVAKMMQGEKDKLLQMEARLHQRVVGQDEAIAAVANAIRRSRSGLSDPQR
HHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
PSGSFLFLGPTGVGKTELCKALAGFLFDSEDHMVRIDMSEFMEKHSVARLIGAPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
EEGGYLTEAVRRKPYSVLLLDEVDKAHPDVFNVLLQVLDDGRLTDSQGRTVDFKNTVIVM
CCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNIGSPLIQAMVGQDPQDIKDAVWGELKNHFRPEFLNRIDETVVFHALDAQHIASIARI
ECCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHH
QLQSLQSRLAKMDLQLQVSDAAVAELAKVGFDPVFGARPLKRAIQQRIENPLSRLLLQGQ
HHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
FPPKSVIAVSVNPMLDPGVFQFGAAPQ
CCCCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]