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The map label for this gene is caiC [H]

Identifier: 121610368

GI number: 121610368

Start: 3807823

End: 3809583

Strand: Direct

Name: caiC [H]

Synonym: Veis_3436

Alternate gene names: 121610368

Gene position: 3807823-3809583 (Clockwise)

Preceding gene: 121610367

Following gene: 121610369

Centisome position: 68.4

GC content: 66.72

Gene sequence:

>1761_bases
ATGACCCCGCTGACCCCAATGACCCGGCTGACCCCGCAACAGGTTTTTGACGACATGCGCGCGCAAGGCGACATGGTGCT
CGACAAGCTCGACGAATGCGCCGCGCAGATGCCCGACAAGGTGTACCTGCACTACGGTGAAGACAACATCCGCATGCGCT
TTTCCGAGGTCAAGGCGCAAACCGACCGCATCGCTGCCGCGCTGGCGGCAATGGGCCTGCCGCCAGGCCAGCCGGTGAGC
GTGCTGACCCGCAATTCGCTCGTGGGCACGCTCGCGATGTATGCGATCTGGCGCGCCGGGGGTGTCTTCGCGCCCGTCAA
TTTCGGTTTTCGCGGCGCGCTGCTGTCCTACCAGCTCAACGACACCGCGCCGTTCGCGTTGATCACCGACAGCTCGTTTG
CAGCGGCGCTGTCGGAGATTGCCGCCGAGATCGAACTCAGGCGGCTGCTCGTGCACCGGCCGGGCGCCGGCGATCACGAC
TTCAGCGCCGGGCCGGTGCCCGATTTCGATCCACGGTTCGCGCTCAGCGACTTCGCGGCGCTGCGCGGACACAGCGGCCC
GGTGCCCCATGTGCCGCGCGGCCCCCTGGATATCGCCAACATCGTCTACACCTCGGGCACGACCGGGCCGTCCAAAGGTG
TGCTGCAGCCTTTTCGCTGGATGAACCACTACACGTACCCGCTGCGCGCAACGACCACCAGCGCCGACGTGCTCTATTGC
GACCTGCCGCTATACCATGTCGGGGGCGCCTTTGCGCTCGTCGCGCGGGCGCTGTGGCAGGGCAACACCGTCGGCCTGTG
GGACCGCTTCAGCCCGACACGGTTTTGGGAGCGCATCGAGGACTGCGGCGCGAGCAGTTGCATCTTGCTCGACGTGATGA
TCCCGTGGCTGATGAACGCCGCGCCGCGCCCCGGCGACCGCGCCAACACGCTCAACAAGGTGCACATGCAGCCGCTGCCG
GTCAACCACAACGAAGTGGCGCGCCGCTTTGGCATCGACTTCGTCAGTTGCGGCTTCGGACAAACCGAATCCGGCTCGGG
CTTCGCTTGCGTCATCGATGAACTCGGCGACCAGACGGGAACCCCGGCAGCACTGTGGAAGGGGCGCTCGAAGGCCGAGT
ACCGCGCCAGTTGCCAAGCCTCCGGGCGGCTGCTGGTCGATGGCAACCAGCCGCTGCCCAAGGGCTTCATGGGGCGCGCC
AATCCGGTGCTCGAGGTCGCGATCCTCGATGAGGACGACAACCATGTGCCGCCCGGCGCCGTCGGCCAGCTCGCCTTTCG
GCCGCGCTTTCCGGGTTTGCTGCTCCAGGAGTACCTGCGCAAGCCGCAAGTCACCGTCAAGGCGCAACGCAACTGCTGGT
TCCACACCGGCGACGCCTGCCGCCAGATCGCCGAGGCTCCCGACACCTACGCCTTCGTCGACCGCATGGGCGGCTTGTGC
CGTGTGCGCGGCGAGAACGTATCGTCCTTCGATGTCGAGGCATTGCTGGCCAGGCAGCCCGGCGTGCGCGCGGTCGCTGC
CGTGCCGATACCGGCGCAGGTGGGCGATGAAGACGAGATCGCCGTCTTCATCGAGGTGACGAGCGGCGCGACGCTCGACG
AGGCCGCAGTGCGCCGCCATGCGCAGGCGTCGATGCCAGGCTTCATGCAGCCGCGCTACATCCGCCTGGTCGATGCGCTG
CCCGTCACGGCCACCAACAAAATCGAAAAATACAAGCTCAAACAGCAACTGCTGCAAGAGTTGGGCAGCGCGGCGGCCTG
A

Upstream 100 bases:

>100_bases
ACACGCTCGGCGAGTCGCTGCGCGTGGCGCTCGACCCCACGCACCAGCGACTTTGATCCCGGCCGCAGTGCCGAACCAGT
GACCTTCCCGAAGGAACGAC

Downstream 100 bases:

>100_bases
AGGACGGCCCGGCATGAACCCACACGACGACCCTCTCGCGCAAGACCCCCTGCTGCGCGAACTCGCCGAACTGCAGCAGC
GGCACTGGCCCGCCGCCATC

Product: AMP-dependent synthetase and ligase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MTPLTPMTRLTPQQVFDDMRAQGDMVLDKLDECAAQMPDKVYLHYGEDNIRMRFSEVKAQTDRIAAALAAMGLPPGQPVS
VLTRNSLVGTLAMYAIWRAGGVFAPVNFGFRGALLSYQLNDTAPFALITDSSFAAALSEIAAEIELRRLLVHRPGAGDHD
FSAGPVPDFDPRFALSDFAALRGHSGPVPHVPRGPLDIANIVYTSGTTGPSKGVLQPFRWMNHYTYPLRATTTSADVLYC
DLPLYHVGGAFALVARALWQGNTVGLWDRFSPTRFWERIEDCGASSCILLDVMIPWLMNAAPRPGDRANTLNKVHMQPLP
VNHNEVARRFGIDFVSCGFGQTESGSGFACVIDELGDQTGTPAALWKGRSKAEYRASCQASGRLLVDGNQPLPKGFMGRA
NPVLEVAILDEDDNHVPPGAVGQLAFRPRFPGLLLQEYLRKPQVTVKAQRNCWFHTGDACRQIAEAPDTYAFVDRMGGLC
RVRGENVSSFDVEALLARQPGVRAVAAVPIPAQVGDEDEIAVFIEVTSGATLDEAAVRRHAQASMPGFMQPRYIRLVDAL
PVTATNKIEKYKLKQQLLQELGSAAA

Sequences:

>Translated_586_residues
MTPLTPMTRLTPQQVFDDMRAQGDMVLDKLDECAAQMPDKVYLHYGEDNIRMRFSEVKAQTDRIAAALAAMGLPPGQPVS
VLTRNSLVGTLAMYAIWRAGGVFAPVNFGFRGALLSYQLNDTAPFALITDSSFAAALSEIAAEIELRRLLVHRPGAGDHD
FSAGPVPDFDPRFALSDFAALRGHSGPVPHVPRGPLDIANIVYTSGTTGPSKGVLQPFRWMNHYTYPLRATTTSADVLYC
DLPLYHVGGAFALVARALWQGNTVGLWDRFSPTRFWERIEDCGASSCILLDVMIPWLMNAAPRPGDRANTLNKVHMQPLP
VNHNEVARRFGIDFVSCGFGQTESGSGFACVIDELGDQTGTPAALWKGRSKAEYRASCQASGRLLVDGNQPLPKGFMGRA
NPVLEVAILDEDDNHVPPGAVGQLAFRPRFPGLLLQEYLRKPQVTVKAQRNCWFHTGDACRQIAEAPDTYAFVDRMGGLC
RVRGENVSSFDVEALLARQPGVRAVAAVPIPAQVGDEDEIAVFIEVTSGATLDEAAVRRHAQASMPGFMQPRYIRLVDAL
PVTATNKIEKYKLKQQLLQELGSAAA
>Mature_585_residues
TPLTPMTRLTPQQVFDDMRAQGDMVLDKLDECAAQMPDKVYLHYGEDNIRMRFSEVKAQTDRIAAALAAMGLPPGQPVSV
LTRNSLVGTLAMYAIWRAGGVFAPVNFGFRGALLSYQLNDTAPFALITDSSFAAALSEIAAEIELRRLLVHRPGAGDHDF
SAGPVPDFDPRFALSDFAALRGHSGPVPHVPRGPLDIANIVYTSGTTGPSKGVLQPFRWMNHYTYPLRATTTSADVLYCD
LPLYHVGGAFALVARALWQGNTVGLWDRFSPTRFWERIEDCGASSCILLDVMIPWLMNAAPRPGDRANTLNKVHMQPLPV
NHNEVARRFGIDFVSCGFGQTESGSGFACVIDELGDQTGTPAALWKGRSKAEYRASCQASGRLLVDGNQPLPKGFMGRAN
PVLEVAILDEDDNHVPPGAVGQLAFRPRFPGLLLQEYLRKPQVTVKAQRNCWFHTGDACRQIAEAPDTYAFVDRMGGLCR
VRGENVSSFDVEALLARQPGVRAVAAVPIPAQVGDEDEIAVFIEVTSGATLDEAAVRRHAQASMPGFMQPRYIRLVDALP
VTATNKIEKYKLKQQLLQELGSAAA

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI38524616, Length=563, Percent_Identity=25.9325044404973, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI13325057, Length=584, Percent_Identity=25.6849315068493, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI40807357, Length=568, Percent_Identity=25.3521126760563, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI13236579, Length=403, Percent_Identity=24.317617866005, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI115511026, Length=554, Percent_Identity=21.841155234657, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI122937307, Length=232, Percent_Identity=27.1551724137931, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38505220, Length=220, Percent_Identity=26.3636363636364, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI58082049, Length=558, Percent_Identity=21.6845878136201, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI42544132, Length=564, Percent_Identity=20.5673758865248, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI157311624, Length=552, Percent_Identity=20.6521739130435, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI157311622, Length=552, Percent_Identity=20.6521739130435, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI221142682, Length=536, Percent_Identity=24.0671641791045, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788107, Length=182, Percent_Identity=29.6703296703297, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693145, Length=392, Percent_Identity=23.469387755102, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573631, Length=544, Percent_Identity=26.2867647058824, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI20130353, Length=544, Percent_Identity=26.2867647058824, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24583465, Length=584, Percent_Identity=22.2602739726027, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583463, Length=584, Percent_Identity=22.2602739726027, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281364798, Length=584, Percent_Identity=22.2602739726027, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 63874; Mature: 63742

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLTPMTRLTPQQVFDDMRAQGDMVLDKLDECAAQMPDKVYLHYGEDNIRMRFSEVKAQ
CCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEHHHHHHH
TDRIAAALAAMGLPPGQPVSVLTRNSLVGTLAMYAIWRAGGVFAPVNFGFRGALLSYQLN
HHHHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEC
DTAPFALITDSSFAAALSEIAAEIELRRLLVHRPGAGDHDFSAGPVPDFDPRFALSDFAA
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LRGHSGPVPHVPRGPLDIANIVYTSGTTGPSKGVLQPFRWMNHYTYPLRATTTSADVLYC
HCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEE
DLPLYHVGGAFALVARALWQGNTVGLWDRFSPTRFWERIEDCGASSCILLDVMIPWLMNA
CCCHHHHCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHCC
APRPGDRANTLNKVHMQPLPVNHNEVARRFGIDFVSCGFGQTESGSGFACVIDELGDQTG
CCCCCCCCCCCHHEECCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCEEEEEEHHCCCCC
TPAALWKGRSKAEYRASCQASGRLLVDGNQPLPKGFMGRANPVLEVAILDEDDNHVPPGA
CCHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC
VGQLAFRPRFPGLLLQEYLRKPQVTVKAQRNCWFHTGDACRQIAEAPDTYAFVDRMGGLC
CCCEEECCCCCCHHHHHHHCCCCEEEEECCCCEEECCHHHHHHHHCCCHHHHHHHCCCEE
RVRGENVSSFDVEALLARQPGVRAVAAVPIPAQVGDEDEIAVFIEVTSGATLDEAAVRRH
EECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHH
AQASMPGFMQPRYIRLVDALPVTATNKIEKYKLKQQLLQELGSAAA
HHHCCCCCCCCHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TPLTPMTRLTPQQVFDDMRAQGDMVLDKLDECAAQMPDKVYLHYGEDNIRMRFSEVKAQ
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEHHHHHHH
TDRIAAALAAMGLPPGQPVSVLTRNSLVGTLAMYAIWRAGGVFAPVNFGFRGALLSYQLN
HHHHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEC
DTAPFALITDSSFAAALSEIAAEIELRRLLVHRPGAGDHDFSAGPVPDFDPRFALSDFAA
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LRGHSGPVPHVPRGPLDIANIVYTSGTTGPSKGVLQPFRWMNHYTYPLRATTTSADVLYC
HCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEE
DLPLYHVGGAFALVARALWQGNTVGLWDRFSPTRFWERIEDCGASSCILLDVMIPWLMNA
CCCHHHHCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHCC
APRPGDRANTLNKVHMQPLPVNHNEVARRFGIDFVSCGFGQTESGSGFACVIDELGDQTG
CCCCCCCCCCCHHEECCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCEEEEEEHHCCCCC
TPAALWKGRSKAEYRASCQASGRLLVDGNQPLPKGFMGRANPVLEVAILDEDDNHVPPGA
CCHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC
VGQLAFRPRFPGLLLQEYLRKPQVTVKAQRNCWFHTGDACRQIAEAPDTYAFVDRMGGLC
CCCEEECCCCCCHHHHHHHCCCCEEEEECCCCEEECCHHHHHHHHCCCHHHHHHHCCCEE
RVRGENVSSFDVEALLARQPGVRAVAAVPIPAQVGDEDEIAVFIEVTSGATLDEAAVRRH
EECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHH
AQASMPGFMQPRYIRLVDALPVTATNKIEKYKLKQQLLQELGSAAA
HHHCCCCCCCCHHEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA