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The map label for this gene is glmS [H]

Identifier: 121609711

GI number: 121609711

Start: 3107676

End: 3109697

Strand: Direct

Name: glmS [H]

Synonym: Veis_2759

Alternate gene names: 121609711

Gene position: 3107676-3109697 (Clockwise)

Preceding gene: 121609710

Following gene: 121609713

Centisome position: 55.83

GC content: 67.41

Gene sequence:

>2022_bases
ATGTGCGGCATCGTCGGCGCGGTCTCCACGCGCAACATCGTTCCCATTCTCGTCCAGGGCCTGCAACGGCTGGAATACCG
GGGCTATGACTCCTGCGGCGTGGCCGTGCATGCCGCCAGCCGCCATGCGCCGCACCGTGGCGCGGGCCTGCAACGCGCCC
GCAGCACAGCCCGCGTGGCCGAGTTGTTGCAACAGGTGCAGGCCGAGCATATCGACGGCGCCACCGGCATTGCCCACACC
CGCTGGGCCACCCATGGTGCGCCTGCGCAGCACAACGCCCACCCCCATTTCAGCCATGGCCGGGGACATGCAGGAGCAAC
GGCAGGCAGCGCTCGAGACGCAGCGGGCCGCGCGGGAGACGCGCAGGGCAAGGCCGGAGATGCGCAGGGCAAGGCCGGAG
ACGCGCAGGGCAAGGCCGGAGACGCGGAGGGCCGCGTGGCCCTCGTGCACAACGGCATCATCGAAAACCACGAAGAACTG
AGCGCAGCCCTGCAAGCCAGCGGCTATCTGTTTACCAGCCAGACCGACACCGAGGTCATCGCGCATCTGATCGACAGCCA
CTACAGCGGCGACCTGCTGGCCGCCGTGCAGGCCAGCGTGGTGCAGTTGCATGGCGCCTACGCCATCGCCGTGATGCACA
AGGACGAACCCCACCGCGTGGTGGGCGCGTGCGCAGGCTCGCCGCTGGTCCTGGGCGTGGGCAAGAACGGCGCCGAGCAT
TTCCTGGCCAGCGACGCCATGGCCCTGGCCGGCGTGACCGACCAGATCGTCTACCTGCAAGAGGGCGATCTGGCAGACCT
GCAGCCGGGGCGCTACGCGATTGCCGGCAAGACGCAGGGTGGCGCAAGCCAACCCCTGACGCCCGCGCAACGCCCGGTGT
GCACGGTGCAGGCCCACAGCGGCGCAGTCGAACTGGGCCCGTACCGCCATTACATGCAAAAGGAAATCTTCGAGCAGCCG
CGCGTGATTGCCGACACGCTCGAAGGACTGGAAGACATCACCCCCGCACTGTTCGACGGCGCCCACCCGCATCAGGCGCG
CGCTGCGGCGCAGGTGTTCGCAGAGATCGACAGCGTGCTGATCCTGGCCTGCGGCAGCAGCTACTACAGCGGCTGCACTG
CCAAATACTGGCTCGAAGCCATCGCCGGCATCCCCACCCAGGTGGAAGTGGCCAGCGAGTACCGCTACCGCACCAGCGTG
CCCAACCCGCGCAGCCTGGTCGTCGCCATCAGCCAATCCGGCGAAACCGCCGACACCCTGGCTGCCCTGCGCCACGCGCA
GTCCCTGGACATGCAGCACCGACTGACCATCTGCAACGTGGCCACCAGCACCATGGTGCGCGAATGTCCGCTGGCCTACA
TCACCCGCGCCGGGGTCGAGATCGGCGTGGCCAGCACCAAAGCCTTCACCACGCAACTGGCGGGCCTGTTTCTGCTGACC
CTGGCCCTGGCCCGTTCCAAAGGCCGCCTGAGCCAAGAGCAGGAGGCCGCCCACCTCCAAGCCATGCGCCACCTGCCCAA
AGCCCTGCAGGCCGTGCTGGCGCTCGAACCCCAACTCATCAGTTGGGCCCAGGATTTCGCCCGCATGGAAAACGCCCTGT
TCCTGGGCCGGGGGCTGCACTACCCGATTGCATTGGAGGGGGCGCTCAAACTCAAGGAAATCAGCTACATCCACGCCGAG
GCCTACCCTGCGGGCGAACTCAAACATGGCCCGCTGGCACTGGTCACCAGCGCCATGCCCGTGGTGACGGTAGCGCCCAA
TGACGCGCTATTGGAAAAGCTCAAGAGCAACATGCAGGAGGTGCGCGCCCGCGCCGGCACGCTGTATGTGCTGGCCGATG
CCGACACCTGCATCGAAAGCAGCGCAGGTCTGCATGTGATCCGCATGCCCGGGCACGGCGGCCCGTTGAGCCCGCTGCTG
CACGTCGTGCCGCTGCAACTGCTGGCCTACCACACCGCTTGCGTGCGCGGCACGGATGTGGACAAGCCCAGGAATTTGGC
CAAGAGCGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
GGAGCGCGGGCCAGGGTGCATATGCACCCGCATCGGCGCGCAAGCCAGGCTGAGCGCCTGCGCCTTGTTACCATCGCTTT
CCACCCAAGAGGCATCCACC

Downstream 100 bases:

>100_bases
GGTCGAACCGGGCGCTCCGGGGCCAAGGCCGCTGCGGCATGCCGAGGGACATCCGGAACCCGCGCCATTTCGCAGGCATC
GTCTGCCGGGTCACTATCGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHAASRHAPHRGAGLQRARSTARVAELLQQVQAEHIDGATGIAHT
RWATHGAPAQHNAHPHFSHGRGHAGATAGSARDAAGRAGDAQGKAGDAQGKAGDAQGKAGDAEGRVALVHNGIIENHEEL
SAALQASGYLFTSQTDTEVIAHLIDSHYSGDLLAAVQASVVQLHGAYAIAVMHKDEPHRVVGACAGSPLVLGVGKNGAEH
FLASDAMALAGVTDQIVYLQEGDLADLQPGRYAIAGKTQGGASQPLTPAQRPVCTVQAHSGAVELGPYRHYMQKEIFEQP
RVIADTLEGLEDITPALFDGAHPHQARAAAQVFAEIDSVLILACGSSYYSGCTAKYWLEAIAGIPTQVEVASEYRYRTSV
PNPRSLVVAISQSGETADTLAALRHAQSLDMQHRLTICNVATSTMVRECPLAYITRAGVEIGVASTKAFTTQLAGLFLLT
LALARSKGRLSQEQEAAHLQAMRHLPKALQAVLALEPQLISWAQDFARMENALFLGRGLHYPIALEGALKLKEISYIHAE
AYPAGELKHGPLALVTSAMPVVTVAPNDALLEKLKSNMQEVRARAGTLYVLADADTCIESSAGLHVIRMPGHGGPLSPLL
HVVPLQLLAYHTACVRGTDVDKPRNLAKSVTVE

Sequences:

>Translated_673_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHAASRHAPHRGAGLQRARSTARVAELLQQVQAEHIDGATGIAHT
RWATHGAPAQHNAHPHFSHGRGHAGATAGSARDAAGRAGDAQGKAGDAQGKAGDAQGKAGDAEGRVALVHNGIIENHEEL
SAALQASGYLFTSQTDTEVIAHLIDSHYSGDLLAAVQASVVQLHGAYAIAVMHKDEPHRVVGACAGSPLVLGVGKNGAEH
FLASDAMALAGVTDQIVYLQEGDLADLQPGRYAIAGKTQGGASQPLTPAQRPVCTVQAHSGAVELGPYRHYMQKEIFEQP
RVIADTLEGLEDITPALFDGAHPHQARAAAQVFAEIDSVLILACGSSYYSGCTAKYWLEAIAGIPTQVEVASEYRYRTSV
PNPRSLVVAISQSGETADTLAALRHAQSLDMQHRLTICNVATSTMVRECPLAYITRAGVEIGVASTKAFTTQLAGLFLLT
LALARSKGRLSQEQEAAHLQAMRHLPKALQAVLALEPQLISWAQDFARMENALFLGRGLHYPIALEGALKLKEISYIHAE
AYPAGELKHGPLALVTSAMPVVTVAPNDALLEKLKSNMQEVRARAGTLYVLADADTCIESSAGLHVIRMPGHGGPLSPLL
HVVPLQLLAYHTACVRGTDVDKPRNLAKSVTVE
>Mature_673_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHAASRHAPHRGAGLQRARSTARVAELLQQVQAEHIDGATGIAHT
RWATHGAPAQHNAHPHFSHGRGHAGATAGSARDAAGRAGDAQGKAGDAQGKAGDAQGKAGDAEGRVALVHNGIIENHEEL
SAALQASGYLFTSQTDTEVIAHLIDSHYSGDLLAAVQASVVQLHGAYAIAVMHKDEPHRVVGACAGSPLVLGVGKNGAEH
FLASDAMALAGVTDQIVYLQEGDLADLQPGRYAIAGKTQGGASQPLTPAQRPVCTVQAHSGAVELGPYRHYMQKEIFEQP
RVIADTLEGLEDITPALFDGAHPHQARAAAQVFAEIDSVLILACGSSYYSGCTAKYWLEAIAGIPTQVEVASEYRYRTSV
PNPRSLVVAISQSGETADTLAALRHAQSLDMQHRLTICNVATSTMVRECPLAYITRAGVEIGVASTKAFTTQLAGLFLLT
LALARSKGRLSQEQEAAHLQAMRHLPKALQAVLALEPQLISWAQDFARMENALFLGRGLHYPIALEGALKLKEISYIHAE
AYPAGELKHGPLALVTSAMPVVTVAPNDALLEKLKSNMQEVRARAGTLYVLADADTCIESSAGLHVIRMPGHGGPLSPLL
HVVPLQLLAYHTACVRGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=738, Percent_Identity=33.0623306233062, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI205277386, Length=737, Percent_Identity=32.7001356852103, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1790167, Length=677, Percent_Identity=47.562776957164, Blast_Score=574, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17539970, Length=452, Percent_Identity=36.283185840708, Blast_Score=264, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17532899, Length=442, Percent_Identity=35.5203619909502, Blast_Score=260, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17532897, Length=442, Percent_Identity=35.5203619909502, Blast_Score=259, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322745, Length=447, Percent_Identity=35.5704697986577, Blast_Score=246, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6323731, Length=443, Percent_Identity=28.6681715575621, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21357745, Length=745, Percent_Identity=32.0805369127517, Blast_Score=347, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 71137; Mature: 71137

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHAASRHAPHRGAGLQRARSTARVA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHHHH
ELLQQVQAEHIDGATGIAHTRWATHGAPAQHNAHPHFSHGRGHAGATAGSARDAAGRAGD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AQGKAGDAQGKAGDAQGKAGDAEGRVALVHNGIIENHEELSAALQASGYLFTSQTDTEVI
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHH
AHLIDSHYSGDLLAAVQASVVQLHGAYAIAVMHKDEPHRVVGACAGSPLVLGVGKNGAEH
HHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEECCCCCEEEEECCCCHHH
FLASDAMALAGVTDQIVYLQEGDLADLQPGRYAIAGKTQGGASQPLTPAQRPVCTVQAHS
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECC
GAVELGPYRHYMQKEIFEQPRVIADTLEGLEDITPALFDGAHPHQARAAAQVFAEIDSVL
CCEECCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHEE
ILACGSSYYSGCTAKYWLEAIAGIPTQVEVASEYRYRTSVPNPRSLVVAISQSGETADTL
EEEECCHHHCCCHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCEEEEEEECCCCHHHHH
AALRHAQSLDMQHRLTICNVATSTMVRECPLAYITRAGVEIGVASTKAFTTQLAGLFLLT
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEECCCHHHHHHHHHHHHHHH
LALARSKGRLSQEQEAAHLQAMRHLPKALQAVLALEPQLISWAQDFARMENALFLGRGLH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCC
YPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSAMPVVTVAPNDALLEKLKSNMQE
CCEEECCCEEHHHHHEEEECCCCCCCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHH
VRARAGTLYVLADADTCIESSAGLHVIRMPGHGGPLSPLLHVVPLQLLAYHTACVRGTDV
HHHCCCEEEEEECCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DKPRNLAKSVTVE
CCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAVHAASRHAPHRGAGLQRARSTARVA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHHHH
ELLQQVQAEHIDGATGIAHTRWATHGAPAQHNAHPHFSHGRGHAGATAGSARDAAGRAGD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AQGKAGDAQGKAGDAQGKAGDAEGRVALVHNGIIENHEELSAALQASGYLFTSQTDTEVI
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHH
AHLIDSHYSGDLLAAVQASVVQLHGAYAIAVMHKDEPHRVVGACAGSPLVLGVGKNGAEH
HHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEECCCCCEEEEECCCCHHH
FLASDAMALAGVTDQIVYLQEGDLADLQPGRYAIAGKTQGGASQPLTPAQRPVCTVQAHS
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECC
GAVELGPYRHYMQKEIFEQPRVIADTLEGLEDITPALFDGAHPHQARAAAQVFAEIDSVL
CCEECCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHEE
ILACGSSYYSGCTAKYWLEAIAGIPTQVEVASEYRYRTSVPNPRSLVVAISQSGETADTL
EEEECCHHHCCCHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCEEEEEEECCCCHHHHH
AALRHAQSLDMQHRLTICNVATSTMVRECPLAYITRAGVEIGVASTKAFTTQLAGLFLLT
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEECCCHHHHHHHHHHHHHHH
LALARSKGRLSQEQEAAHLQAMRHLPKALQAVLALEPQLISWAQDFARMENALFLGRGLH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCC
YPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSAMPVVTVAPNDALLEKLKSNMQE
CCEEECCCEEHHHHHEEEECCCCCCCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHH
VRARAGTLYVLADADTCIESSAGLHVIRMPGHGGPLSPLLHVVPLQLLAYHTACVRGTDV
HHHCCCEEEEEECCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
DKPRNLAKSVTVE
CCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]