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The map label for this gene is moeA [H]

Identifier: 121609619

GI number: 121609619

Start: 3009072

End: 3010358

Strand: Direct

Name: moeA [H]

Synonym: Veis_2666

Alternate gene names: 121609619

Gene position: 3009072-3010358 (Clockwise)

Preceding gene: 121609618

Following gene: 121609620

Centisome position: 54.05

GC content: 69.93

Gene sequence:

>1287_bases
ATGAAACCCCTGAAACCCCTGGACGAAGCACTGGCCGAGCTACTGGCCCAGGCCCGGCCCCTGCCGGCCACCGACCAGGT
GAGCACGCTCGACGCCGATGGCCGCGTGCTGGCGCAAGACTGCATCTCGGCGCTGCAAGTGCCGGCGCAGGACAATAGCG
CGATGGACGGCTACGCCGTGCGCTGCGCCGATGTAACGGCACCGGGCAGCGTCTTGCCGGTAGCGCAGCGCATCACCGCA
GGCAGCGCCTGCGCAGCGCTGCCACCAGGCAGCGCCGCGCGCATCTTCACCGGCGCCCCGATGCCTGCGGGAGCCGACGC
CATCGTGTTGCAGGAAGACTGTCAGGCCCTGGCCGTCGAGCGCCAGACGCCATCCGGCAGCGCTCAGATGCCCTCCGGCA
GCGGCCAGACATCGCCCGATCACGGCCTGGGCCAGGTGCAGATCAACGCCCGGCCCCAGCCCGGCCAATGGCTGCGCCAT
GCGGGCGAAGACATTCGCCGTGGCGCCGTGGTGCTGACGGCCGGCACGCGCCTGACGCCGGCTACGCTGGGCCTGGCCGC
CAGCATCGGCCTGGACCGGCTGCAAGTGGCGCGCCGCCCACGGGTGGCGCTGTTTTCCACCGGCGACGAACTGGTCATGC
CCGGCACCGTGCCGCCCGGGCAGATGCGCCCCGGCGCCATCTACAACAGCAACCGATTCTTCCTGCGCGCGATGCTGCTG
CGCCTGGCATGCGAGGTGAGCGACCTGGGCATCGTCCCCGACCAGCGCGAGGCCACCGAACAAGCCCTGCAGGCCGCCAG
CGCTGCGCATGACCTGATCCTGACCAGTGGCGGCGTCTCGGTGGGCGAAGAAGACCATGTCAAACCCGCCGTTCAGGCGC
TGGGGCGGCTGGACCTGTGGCAGATCGCGATCAAGCCCGGCAAACCCTTCGCCTACGGCCGGGTCGGGCCGGCGCACTTC
ATCGGGCTGCCCGGCAACCCGGTGTCGAGCTTTCTGACCTTTGCGTTGCTGGTGCGGCCCTTTGTGCTGCGCTTGCAGGG
CATGACCGACGTGGCCCCGAAACCCATCGCCGCCAGCGCCCGTTTCGCCTGGCCCAAGGCCGATCAGCGCCGCGAATTCC
TGCGCGTGCGCCAGCACCCGATGGGCGGGTTGGAACTGTTTGGCAACCAAAGCTCCGGCGTGCTCAGTTCCGCCGCCTGG
GGCGACGGCGTGGTCGACAACCCGGCCGGCCAGACCATTGCACCGGGCGACAGCGTGCAGTTCATTGCGTTTTCGCAACT
GCTGTGA

Upstream 100 bases:

>100_bases
TCGACGCCCCGGACCAGGTCGCCGGCTGGCTGATCCGGCAAGGACAGCGCTTCGGGTACGAGCGGCCACTGCATGGAGGA
AGGCTGCGATGCGCCCCGCA

Downstream 100 bases:

>100_bases
TGAAGGTCACGCTGCGTTACTTCGCCGCCATCCGCGAGGCCATGGGCCAGGGCAGCGAGTCCGTAGAGACGACGGCGGCC
ACGCTGGGCGCGCTGCGCGA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKPLKPLDEALAELLAQARPLPATDQVSTLDADGRVLAQDCISALQVPAQDNSAMDGYAVRCADVTAPGSVLPVAQRITA
GSACAALPPGSAARIFTGAPMPAGADAIVLQEDCQALAVERQTPSGSAQMPSGSGQTSPDHGLGQVQINARPQPGQWLRH
AGEDIRRGAVVLTAGTRLTPATLGLAASIGLDRLQVARRPRVALFSTGDELVMPGTVPPGQMRPGAIYNSNRFFLRAMLL
RLACEVSDLGIVPDQREATEQALQAASAAHDLILTSGGVSVGEEDHVKPAVQALGRLDLWQIAIKPGKPFAYGRVGPAHF
IGLPGNPVSSFLTFALLVRPFVLRLQGMTDVAPKPIAASARFAWPKADQRREFLRVRQHPMGGLELFGNQSSGVLSSAAW
GDGVVDNPAGQTIAPGDSVQFIAFSQLL

Sequences:

>Translated_428_residues
MKPLKPLDEALAELLAQARPLPATDQVSTLDADGRVLAQDCISALQVPAQDNSAMDGYAVRCADVTAPGSVLPVAQRITA
GSACAALPPGSAARIFTGAPMPAGADAIVLQEDCQALAVERQTPSGSAQMPSGSGQTSPDHGLGQVQINARPQPGQWLRH
AGEDIRRGAVVLTAGTRLTPATLGLAASIGLDRLQVARRPRVALFSTGDELVMPGTVPPGQMRPGAIYNSNRFFLRAMLL
RLACEVSDLGIVPDQREATEQALQAASAAHDLILTSGGVSVGEEDHVKPAVQALGRLDLWQIAIKPGKPFAYGRVGPAHF
IGLPGNPVSSFLTFALLVRPFVLRLQGMTDVAPKPIAASARFAWPKADQRREFLRVRQHPMGGLELFGNQSSGVLSSAAW
GDGVVDNPAGQTIAPGDSVQFIAFSQLL
>Mature_428_residues
MKPLKPLDEALAELLAQARPLPATDQVSTLDADGRVLAQDCISALQVPAQDNSAMDGYAVRCADVTAPGSVLPVAQRITA
GSACAALPPGSAARIFTGAPMPAGADAIVLQEDCQALAVERQTPSGSAQMPSGSGQTSPDHGLGQVQINARPQPGQWLRH
AGEDIRRGAVVLTAGTRLTPATLGLAASIGLDRLQVARRPRVALFSTGDELVMPGTVPPGQMRPGAIYNSNRFFLRAMLL
RLACEVSDLGIVPDQREATEQALQAASAAHDLILTSGGVSVGEEDHVKPAVQALGRLDLWQIAIKPGKPFAYGRVGPAHF
IGLPGNPVSSFLTFALLVRPFVLRLQGMTDVAPKPIAASARFAWPKADQRREFLRVRQHPMGGLELFGNQSSGVLSSAAW
GDGVVDNPAGQTIAPGDSVQFIAFSQLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=415, Percent_Identity=33.4939759036145, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI66932975, Length=415, Percent_Identity=33.4939759036145, Blast_Score=195, Evalue=8e-50,
Organism=Escherichia coli, GI1787049, Length=410, Percent_Identity=42.1951219512195, Blast_Score=270, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI25147659, Length=386, Percent_Identity=27.979274611399, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562606, Length=430, Percent_Identity=23.2558139534884, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=380, Percent_Identity=30.5263157894737, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24638841, Length=380, Percent_Identity=30.5263157894737, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44816; Mature: 44816

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLKPLDEALAELLAQARPLPATDQVSTLDADGRVLAQDCISALQVPAQDNSAMDGYAV
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCEEE
RCADVTAPGSVLPVAQRITAGSACAALPPGSAARIFTGAPMPAGADAIVLQEDCQALAVE
EEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHC
RQTPSGSAQMPSGSGQTSPDHGLGQVQINARPQPGQWLRHAGEDIRRGAVVLTAGTRLTP
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCHHHHCCEEEEEECCCCCH
ATLGLAASIGLDRLQVARRPRVALFSTGDELVMPGTVPPGQMRPGAIYNSNRFFLRAMLL
HHHHHHHHCCHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCEEECCCHHHHHHHHH
RLACEVSDLGIVPDQREATEQALQAASAAHDLILTSGGVSVGEEDHVKPAVQALGRLDLW
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHCCCCEE
QIAIKPGKPFAYGRVGPAHFIGLPGNPVSSFLTFALLVRPFVLRLQGMTDVAPKPIAASA
EEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
RFAWPKADQRREFLRVRQHPMGGLELFGNQSSGVLSSAAWGDGVVDNPAGQTIAPGDSVQ
EECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCCCCCCCCCCCCCEECCCCCEE
FIAFSQLL
EEEHHHCC
>Mature Secondary Structure
MKPLKPLDEALAELLAQARPLPATDQVSTLDADGRVLAQDCISALQVPAQDNSAMDGYAV
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCEEE
RCADVTAPGSVLPVAQRITAGSACAALPPGSAARIFTGAPMPAGADAIVLQEDCQALAVE
EEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHC
RQTPSGSAQMPSGSGQTSPDHGLGQVQINARPQPGQWLRHAGEDIRRGAVVLTAGTRLTP
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCHHHHCCEEEEEECCCCCH
ATLGLAASIGLDRLQVARRPRVALFSTGDELVMPGTVPPGQMRPGAIYNSNRFFLRAMLL
HHHHHHHHCCHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCEEECCCHHHHHHHHH
RLACEVSDLGIVPDQREATEQALQAASAAHDLILTSGGVSVGEEDHVKPAVQALGRLDLW
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHCCCCEE
QIAIKPGKPFAYGRVGPAHFIGLPGNPVSSFLTFALLVRPFVLRLQGMTDVAPKPIAASA
EEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
RFAWPKADQRREFLRVRQHPMGGLELFGNQSSGVLSSAAWGDGVVDNPAGQTIAPGDSVQ
EECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCCCCCCCCCCCCCEECCCCCEE
FIAFSQLL
EEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]