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The map label for this gene is thrC [H]

Identifier: 121609618

GI number: 121609618

Start: 3006941

End: 3008491

Strand: Direct

Name: thrC [H]

Synonym: Veis_2664

Alternate gene names: 121609618

Gene position: 3006941-3008491 (Clockwise)

Preceding gene: 121609617

Following gene: 121609619

Centisome position: 54.02

GC content: 67.7

Gene sequence:

>1551_bases
ATGAAATACATCAGCACCCGTGGCCAGGCAGGGCGCAGACCGTTTTGCGACATCCTGCTCGAGGGCCTGGCCCCCGACGG
CGGCCTGTACCTGCCCGAGCATTACCCGCAGATCGATGACGCAGCCCTGACGCGCTTGCGCCAGGTCTGGCACGAGCAGG
GCTACGCCGAACTGGCATACCAGTTGCTGTCGCTGTACATCGACGACATTCCCGCCGCCGACCTGCGGGCGCTGTGCGCC
AAGACCTACATCGCCGAAGTCTTCGGCAGCCGCTCCATCGTGCCGCTGCGCCCGCTCGAAGCCGGCCTGTGGCTGCAAGC
ACTGTCCAACGGCCCGACGCTGGCCTTCAAGGACCTGGCCATGCAGTTGCTGGGCCATTTGTTCGAGTACGAACTGGCGC
GCCGTGGCGAGCAACTGAACATCCTGGGCGCCACCAGCGGCGACACCGGCAGTGCGGCCGAATACGCGCTGCGCGGCAAG
ACCGGCGTGCGCGTATTCATGACCAGCCCGGATGGCCGCATGAGCGCCTTCCAGCAGGCGCAGATGTTCAGCCTGCAAGA
CGCCAACATCCACAACCTGGCCATCGACGGCGTGTTCGACGACTGCCAGGACATCGTCAAGGCCGTCAGCCGCGACCAGA
CCTTCAAGCGCAGGCACCGGATCGGCACCATCAACTCCATCAACTGGGCGCGCCTGCTGGCGCAGGTGGTGTACTACTTT
GCCGGCTACCTGCAAGCCAGCGCAAGCAACGCGCAGCAGGTCAGCTTCACGGTGCCCAGCGGCAACTTCGGCAATGTCTG
CGCCGGCCATGTGGCGCGCATGATGGGCCTGCCCATCGACCGGCTGGTGGTGGCCACCAACGAGAACGATGTGCTCGACG
AATTCTTTCGCACCGGCGTCTACCGCGTGCGCAGCAGCGCCGATACGCGCGCCACCTCCAGCCCCTCGATGGACATCAGC
AAAGCCAGCAACTTCGAGCGCTTCGTGTTCGACCTGCTCGGCCGCGACGGCGCGCGCGTCGAGACGCTGTTCGGCCAGAC
CCTGGCCACCCGGGGCCGGATCGACCTGAGCGGCGACCCGCGCTTTGCCGAAGCCGCAACGCGCTACGGTTTTGCCAGCG
GCAAGAGCACCCATGCCGACCGGCTGGCGACCATCCGCGACAACCACCAGCGCCATCGCGTCACGCTGGACCCCCACACC
GCCGACGGGGTGAAGGTGGCGCGCGAGCACTTGGCGCAGAGGGCGCGCGAGCGCCCGGCGCAAGACCCGCCCGCAGCGCC
GATGATCGTGCTGGAGACGGCGCTGCCGATCAAGTTCGCCGCGACCATCATCGAAGCCCTGGGCCAGGCGCCCGAGAGAC
CCGCGCAGTTCGCCGGCATCGAAAACCTGCCCCGGCGCGTGCAGCGGCTGCCTGCCGATGCGCAACAGGTCAAAGCCTAT
ATCGAGCGCCACTGCACGGCGGATGCGGATGCGGGCGCCAAACCGCAGGCGCCGGGCGCCAGCAGCGCCGGGCGCGATGA
CTGCCATGCCCCCATGGGGAGCGATGGATGA

Upstream 100 bases:

>100_bases
GTCATGGCCCGGATGCAGGCCCTGACGACAGTGCTGGCGCCGATCACACGCCTGCGCAAGGAAGCACTGAACTGAATGCG
AATACCGACCGGCTTGCACC

Downstream 100 bases:

>100_bases
AAGTCGCAGGTTTTGCCGGCTTTTCCGGCAGTGGCAAAACCACGCTGATCGAGCAACTGATCCCGGCGCTGCGGCGGCAG
GGACTGCGCGTGTCGGTGGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MKYISTRGQAGRRPFCDILLEGLAPDGGLYLPEHYPQIDDAALTRLRQVWHEQGYAELAYQLLSLYIDDIPAADLRALCA
KTYIAEVFGSRSIVPLRPLEAGLWLQALSNGPTLAFKDLAMQLLGHLFEYELARRGEQLNILGATSGDTGSAAEYALRGK
TGVRVFMTSPDGRMSAFQQAQMFSLQDANIHNLAIDGVFDDCQDIVKAVSRDQTFKRRHRIGTINSINWARLLAQVVYYF
AGYLQASASNAQQVSFTVPSGNFGNVCAGHVARMMGLPIDRLVVATNENDVLDEFFRTGVYRVRSSADTRATSSPSMDIS
KASNFERFVFDLLGRDGARVETLFGQTLATRGRIDLSGDPRFAEAATRYGFASGKSTHADRLATIRDNHQRHRVTLDPHT
ADGVKVAREHLAQRARERPAQDPPAAPMIVLETALPIKFAATIIEALGQAPERPAQFAGIENLPRRVQRLPADAQQVKAY
IERHCTADADAGAKPQAPGASSAGRDDCHAPMGSDG

Sequences:

>Translated_516_residues
MKYISTRGQAGRRPFCDILLEGLAPDGGLYLPEHYPQIDDAALTRLRQVWHEQGYAELAYQLLSLYIDDIPAADLRALCA
KTYIAEVFGSRSIVPLRPLEAGLWLQALSNGPTLAFKDLAMQLLGHLFEYELARRGEQLNILGATSGDTGSAAEYALRGK
TGVRVFMTSPDGRMSAFQQAQMFSLQDANIHNLAIDGVFDDCQDIVKAVSRDQTFKRRHRIGTINSINWARLLAQVVYYF
AGYLQASASNAQQVSFTVPSGNFGNVCAGHVARMMGLPIDRLVVATNENDVLDEFFRTGVYRVRSSADTRATSSPSMDIS
KASNFERFVFDLLGRDGARVETLFGQTLATRGRIDLSGDPRFAEAATRYGFASGKSTHADRLATIRDNHQRHRVTLDPHT
ADGVKVAREHLAQRARERPAQDPPAAPMIVLETALPIKFAATIIEALGQAPERPAQFAGIENLPRRVQRLPADAQQVKAY
IERHCTADADAGAKPQAPGASSAGRDDCHAPMGSDG
>Mature_516_residues
MKYISTRGQAGRRPFCDILLEGLAPDGGLYLPEHYPQIDDAALTRLRQVWHEQGYAELAYQLLSLYIDDIPAADLRALCA
KTYIAEVFGSRSIVPLRPLEAGLWLQALSNGPTLAFKDLAMQLLGHLFEYELARRGEQLNILGATSGDTGSAAEYALRGK
TGVRVFMTSPDGRMSAFQQAQMFSLQDANIHNLAIDGVFDDCQDIVKAVSRDQTFKRRHRIGTINSINWARLLAQVVYYF
AGYLQASASNAQQVSFTVPSGNFGNVCAGHVARMMGLPIDRLVVATNENDVLDEFFRTGVYRVRSSADTRATSSPSMDIS
KASNFERFVFDLLGRDGARVETLFGQTLATRGRIDLSGDPRFAEAATRYGFASGKSTHADRLATIRDNHQRHRVTLDPHT
ADGVKVAREHLAQRARERPAQDPPAAPMIVLETALPIKFAATIIEALGQAPERPAQFAGIENLPRRVQRLPADAQQVKAY
IERHCTADADAGAKPQAPGASSAGRDDCHAPMGSDG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=474, Percent_Identity=31.8565400843882, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI153792148, Length=471, Percent_Identity=33.7579617834395, Blast_Score=207, Evalue=3e-53,
Organism=Escherichia coli, GI1786185, Length=485, Percent_Identity=28.2474226804124, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319901, Length=476, Percent_Identity=41.3865546218487, Blast_Score=328, Evalue=1e-90,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 56472; Mature: 56472

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYISTRGQAGRRPFCDILLEGLAPDGGLYLPEHYPQIDDAALTRLRQVWHEQGYAELAY
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
QLLSLYIDDIPAADLRALCAKTYIAEVFGSRSIVPLRPLEAGLWLQALSNGPTLAFKDLA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHH
MQLLGHLFEYELARRGEQLNILGATSGDTGSAAEYALRGKTGVRVFMTSPDGRMSAFQQA
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHH
QMFSLQDANIHNLAIDGVFDDCQDIVKAVSRDQTFKRRHRIGTINSINWARLLAQVVYYF
HHHHCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AGYLQASASNAQQVSFTVPSGNFGNVCAGHVARMMGLPIDRLVVATNENDVLDEFFRTGV
HHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHHH
YRVRSSADTRATSSPSMDISKASNFERFVFDLLGRDGARVETLFGQTLATRGRIDLSGDP
HHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEECCCCC
RFAEAATRYGFASGKSTHADRLATIRDNHQRHRVTLDPHTADGVKVAREHLAQRARERPA
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCC
QDPPAAPMIVLETALPIKFAATIIEALGQAPERPAQFAGIENLPRRVQRLPADAQQVKAY
CCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCHHHHHHH
IERHCTADADAGAKPQAPGASSAGRDDCHAPMGSDG
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKYISTRGQAGRRPFCDILLEGLAPDGGLYLPEHYPQIDDAALTRLRQVWHEQGYAELAY
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
QLLSLYIDDIPAADLRALCAKTYIAEVFGSRSIVPLRPLEAGLWLQALSNGPTLAFKDLA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHH
MQLLGHLFEYELARRGEQLNILGATSGDTGSAAEYALRGKTGVRVFMTSPDGRMSAFQQA
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHH
QMFSLQDANIHNLAIDGVFDDCQDIVKAVSRDQTFKRRHRIGTINSINWARLLAQVVYYF
HHHHCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AGYLQASASNAQQVSFTVPSGNFGNVCAGHVARMMGLPIDRLVVATNENDVLDEFFRTGV
HHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHHH
YRVRSSADTRATSSPSMDISKASNFERFVFDLLGRDGARVETLFGQTLATRGRIDLSGDP
HHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEECCCCC
RFAEAATRYGFASGKSTHADRLATIRDNHQRHRVTLDPHTADGVKVAREHLAQRARERPA
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCC
QDPPAAPMIVLETALPIKFAATIIEALGQAPERPAQFAGIENLPRRVQRLPADAQQVKAY
CCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCHHHHHHH
IERHCTADADAGAKPQAPGASSAGRDDCHAPMGSDG
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2127631; 12948626 [H]