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The map label for this gene is hom [H]

Identifier: 121609617

GI number: 121609617

Start: 3005581

End: 3006915

Strand: Direct

Name: hom [H]

Synonym: Veis_2663

Alternate gene names: 121609617

Gene position: 3005581-3006915 (Clockwise)

Preceding gene: 121609616

Following gene: 121609618

Centisome position: 53.99

GC content: 68.16

Gene sequence:

>1335_bases
ATGAAACCCATTCAAGCAGGTCTGCTCGGCCTGGGCACCGTCGGTGGCGGTGTGTTCGACGTGCTGCGGCGCAACCAGGA
CGAAATCAGCCGCCGCGCCGGCCGGGGCATTCAGATCACCATGGTCGCGGCCCGGGATGTGGCGCGCGCGCAAAGCCTGG
TCGGCCCCGATGTGCAGGTGCTCGGCGATGCCAGCGCGATCATCGCCAACCCGGACATCGCCATCGTCATCGAACTGATC
GGCGGCTGCGGCATTGCCAAGACGCTGGTGCTTGAGGCCATTGCGGCCGGCAAGCATGTGGTCACGGCGAACAAGGCGCT
GCTGGCCGTGCATGGCAGCGAGATCTTCGCGGCCGCATCGGCCCGGGGCGTGATGGTGGCTTTCGAGGCCGCCGTGGCCG
GGGGCATCCCCATCATCAAGGCGTTGCGCGAGGGGCTGACCGCCAACCGCATACAGTGGCTCGCCGGCATCATCAATGGC
ACGACCAACTTCATCCTGTCCGAGATGCGCAGCCAGGGCCGCGATTTCGATGTGGTGCTCGAGGAGGCGCAGCGCCTGGG
CTACGCCGAGGCCGACCCCGGCTTCGACATCCAGGGCGTGGATGCGGCCCACAAGCTCACGCTGATGAGCGCGATCGCGT
TCGGCATTCCGGTGCAGTTCGACAAGGCCCATGTGGAAGGCATCACGGCGCTGGCGACGGCCGACATCCGCTACGCCGAG
CAACTGGGCTACCGCATCAAGCTGCTGGGCATCACCAAGCGCGTCGACAAGGGGGTGGAACTGCGCGTGCACCCCTGCCT
GGTGCCGGCCAAGCGCCTGATCGCGAATGTCGAAGGCGCGATGAACGCCGTGGTGGTGCAAGGCGACGCCGTCGGCACCA
CGCTGTACTACGGCAAAGGCGCGGGCGCCGAGCCGACCGCCAGCGCCGTGATTGCCGACCTGGTGGACATCGCCCGCCTG
CACACCGCCGACCCCGAGCACCGCGTGCCGCACCTGGCCTTCCAGCCCCATACCCTGGCCGACGCGATGGACGCGCTGCC
GGTGCTGCCGATGAGCGAAGTGGTCACCAGCTACTACCTGCGCTTGCGCGTGGCCGACCAGGCCGGCGTGCTGGCCCAGG
TCACCGGCCTGCTGGCCGAGGCCGGGGTGAGCATCGATGCCGTGCTGCAGCGCGAAGCCGACGAGGTAGGCGGCGCAGGC
TCGGCCCAGACCGATCTGATCATCCTCACGCACGACACGCGCGAAGGTACGATGGACGCCGTCATGGCCCGGATGCAGGC
CCTGACGACAGTGCTGGCGCCGATCACACGCCTGCGCAAGGAAGCACTGAACTGA

Upstream 100 bases:

>100_bases
GCGCTCGAGGATGCGGCGCGCATCTCCCGGCGCAGGCTCCGGCGGCCGGCCCGCGAGGGGCCAGGCCCCCTTTTTCAAAA
ACCGATAAGTCAGTCAACGC

Downstream 100 bases:

>100_bases
ATGCGAATACCGACCGGCTTGCACCATGAAATACATCAGCACCCGTGGCCAGGCAGGGCGCAGACCGTTTTGCGACATCC
TGCTCGAGGGCCTGGCCCCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKPIQAGLLGLGTVGGGVFDVLRRNQDEISRRAGRGIQITMVAARDVARAQSLVGPDVQVLGDASAIIANPDIAIVIELI
GGCGIAKTLVLEAIAAGKHVVTANKALLAVHGSEIFAAASARGVMVAFEAAVAGGIPIIKALREGLTANRIQWLAGIING
TTNFILSEMRSQGRDFDVVLEEAQRLGYAEADPGFDIQGVDAAHKLTLMSAIAFGIPVQFDKAHVEGITALATADIRYAE
QLGYRIKLLGITKRVDKGVELRVHPCLVPAKRLIANVEGAMNAVVVQGDAVGTTLYYGKGAGAEPTASAVIADLVDIARL
HTADPEHRVPHLAFQPHTLADAMDALPVLPMSEVVTSYYLRLRVADQAGVLAQVTGLLAEAGVSIDAVLQREADEVGGAG
SAQTDLIILTHDTREGTMDAVMARMQALTTVLAPITRLRKEALN

Sequences:

>Translated_444_residues
MKPIQAGLLGLGTVGGGVFDVLRRNQDEISRRAGRGIQITMVAARDVARAQSLVGPDVQVLGDASAIIANPDIAIVIELI
GGCGIAKTLVLEAIAAGKHVVTANKALLAVHGSEIFAAASARGVMVAFEAAVAGGIPIIKALREGLTANRIQWLAGIING
TTNFILSEMRSQGRDFDVVLEEAQRLGYAEADPGFDIQGVDAAHKLTLMSAIAFGIPVQFDKAHVEGITALATADIRYAE
QLGYRIKLLGITKRVDKGVELRVHPCLVPAKRLIANVEGAMNAVVVQGDAVGTTLYYGKGAGAEPTASAVIADLVDIARL
HTADPEHRVPHLAFQPHTLADAMDALPVLPMSEVVTSYYLRLRVADQAGVLAQVTGLLAEAGVSIDAVLQREADEVGGAG
SAQTDLIILTHDTREGTMDAVMARMQALTTVLAPITRLRKEALN
>Mature_444_residues
MKPIQAGLLGLGTVGGGVFDVLRRNQDEISRRAGRGIQITMVAARDVARAQSLVGPDVQVLGDASAIIANPDIAIVIELI
GGCGIAKTLVLEAIAAGKHVVTANKALLAVHGSEIFAAASARGVMVAFEAAVAGGIPIIKALREGLTANRIQWLAGIING
TTNFILSEMRSQGRDFDVVLEEAQRLGYAEADPGFDIQGVDAAHKLTLMSAIAFGIPVQFDKAHVEGITALATADIRYAE
QLGYRIKLLGITKRVDKGVELRVHPCLVPAKRLIANVEGAMNAVVVQGDAVGTTLYYGKGAGAEPTASAVIADLVDIARL
HTADPEHRVPHLAFQPHTLADAMDALPVLPMSEVVTSYYLRLRVADQAGVLAQVTGLLAEAGVSIDAVLQREADEVGGAG
SAQTDLIILTHDTREGTMDAVMARMQALTTVLAPITRLRKEALN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322599, Length=133, Percent_Identity=33.8345864661654, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46589; Mature: 46589

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIQAGLLGLGTVGGGVFDVLRRNQDEISRRAGRGIQITMVAARDVARAQSLVGPDVQV
CCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCCCEE
LGDASAIIANPDIAIVIELIGGCGIAKTLVLEAIAAGKHVVTANKALLAVHGSEIFAAAS
ECCCEEEEECCCCEEEEEHHCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCHHEEHHC
ARGVMVAFEAAVAGGIPIIKALREGLTANRIQWLAGIINGTTNFILSEMRSQGRDFDVVL
CCCEEEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
EEAQRLGYAEADPGFDIQGVDAAHKLTLMSAIAFGIPVQFDKAHVEGITALATADIRYAE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECHHHHCCHHHHHHHHHHHHH
QLGYRIKLLGITKRVDKGVELRVHPCLVPAKRLIANVEGAMNAVVVQGDAVGTTLYYGKG
HCCCEEEEEEEHHHHCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCC
AGAEPTASAVIADLVDIARLHTADPEHRVPHLAFQPHTLADAMDALPVLPMSEVVTSYYL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHH
RLRVADQAGVLAQVTGLLAEAGVSIDAVLQREADEVGGAGSAQTDLIILTHDTREGTMDA
EEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHH
VMARMQALTTVLAPITRLRKEALN
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPIQAGLLGLGTVGGGVFDVLRRNQDEISRRAGRGIQITMVAARDVARAQSLVGPDVQV
CCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCCCEE
LGDASAIIANPDIAIVIELIGGCGIAKTLVLEAIAAGKHVVTANKALLAVHGSEIFAAAS
ECCCEEEEECCCCEEEEEHHCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCHHEEHHC
ARGVMVAFEAAVAGGIPIIKALREGLTANRIQWLAGIINGTTNFILSEMRSQGRDFDVVL
CCCEEEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
EEAQRLGYAEADPGFDIQGVDAAHKLTLMSAIAFGIPVQFDKAHVEGITALATADIRYAE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECHHHHCCHHHHHHHHHHHHH
QLGYRIKLLGITKRVDKGVELRVHPCLVPAKRLIANVEGAMNAVVVQGDAVGTTLYYGKG
HCCCEEEEEEEHHHHCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCC
AGAEPTASAVIADLVDIARLHTADPEHRVPHLAFQPHTLADAMDALPVLPMSEVVTSYYL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHH
RLRVADQAGVLAQVTGLLAEAGVSIDAVLQREADEVGGAGSAQTDLIILTHDTREGTMDA
EEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHH
VMARMQALTTVLAPITRLRKEALN
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]