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The map label for this gene is dut [H]

Identifier: 121609609

GI number: 121609609

Start: 2998966

End: 2999412

Strand: Direct

Name: dut [H]

Synonym: Veis_2655

Alternate gene names: 121609609

Gene position: 2998966-2999412 (Clockwise)

Preceding gene: 121609608

Following gene: 121609610

Centisome position: 53.87

GC content: 65.77

Gene sequence:

>447_bases
GTGAAGATCGACATCAAGATTCTGGACCCGCGCATCGCGGATCGATTGCCCGGCTACGCCACCCCCGGCAGCGCGGGCCT
GGACCTGCGCGCCTGCCTGGATGCGCCTTTGACATTGCAGCCCGATGCCTGGCAACTGGTGGCGACCGGCATCTCGGTGT
TCATCAAAGACCCGGGCTACGCCGCGTTGATCCTGCCGCGCTCGGGCCTGGGCCACAAGCATGGCATCGTGCTGGGCAAC
CTGGTGGGGTTGATCGACAGCGACTACCAGGGGCCGCTGATGGTCAGCGCCTGGAACCGCAGCCAGCAGGCGTATACGCT
CTTGCCGATGGAGCGGCTGGCACAACTGGTCATCGTGCCTGTGGTTCAGGCGCAGTTCAATGTGGTCACCGAGTTTGCTG
CGACCGGGCGCGGGGCGGGCGGTTATGGGTCTACCGGCACGGCCTGA

Upstream 100 bases:

>100_bases
AGCGCGCTTGCCGCCGCTGCCGTCCTGATGGCCGTCGCACAGCGGCTGCGGCAGACGGCCCGATGGCGCCCGGGCCGGCA
ACACAAGGAAACGAGCCAAC

Downstream 100 bases:

>100_bases
GCGGCGGTGCCGGACGGCGCCGGCCTTGCGCGGCGGTGGTGGTCGACGCACGGCGGGCCGGCTCCCGTCGGGCCGGATTT
TCAGGAGGTCGACATGCAGT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKIDIKILDPRIADRLPGYATPGSAGLDLRACLDAPLTLQPDAWQLVATGISVFIKDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGPLMVSAWNRSQQAYTLLPMERLAQLVIVPVVQAQFNVVTEFAATGRGAGGYGSTGTA

Sequences:

>Translated_148_residues
MKIDIKILDPRIADRLPGYATPGSAGLDLRACLDAPLTLQPDAWQLVATGISVFIKDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGPLMVSAWNRSQQAYTLLPMERLAQLVIVPVVQAQFNVVTEFAATGRGAGGYGSTGTA
>Mature_148_residues
MKIDIKILDPRIADRLPGYATPGSAGLDLRACLDAPLTLQPDAWQLVATGISVFIKDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGPLMVSAWNRSQQAYTLLPMERLAQLVIVPVVQAQFNVVTEFAATGRGAGGYGSTGTA

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI4503423, Length=130, Percent_Identity=33.0769230769231, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI70906444, Length=130, Percent_Identity=33.0769230769231, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI70906441, Length=123, Percent_Identity=34.1463414634146, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1790071, Length=147, Percent_Identity=63.9455782312925, Blast_Score=196, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71988561, Length=130, Percent_Identity=36.9230769230769, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319729, Length=133, Percent_Identity=37.593984962406, Blast_Score=74, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583610, Length=151, Percent_Identity=32.4503311258278, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19921126, Length=151, Percent_Identity=32.4503311258278, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15626; Mature: 15626

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDIKILDPRIADRLPGYATPGSAGLDLRACLDAPLTLQPDAWQLVATGISVFIKDPGY
CEEEEEEECCHHHHHCCCCCCCCCCCCEEHHHCCCCCEECCCCCEEEECCEEEEEECCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSAWNRSQQAYTLLPMERLAQLVIVP
EEEEEECCCCCCCCCEEEHHHHHHCCCCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHH
VVQAQFNVVTEFAATGRGAGGYGSTGTA
HHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIDIKILDPRIADRLPGYATPGSAGLDLRACLDAPLTLQPDAWQLVATGISVFIKDPGY
CEEEEEEECCHHHHHCCCCCCCCCCCCEEHHHCCCCCEECCCCCEEEECCEEEEEECCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSAWNRSQQAYTLLPMERLAQLVIVP
EEEEEECCCCCCCCCEEEHHHHHHCCCCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHH
VVQAQFNVVTEFAATGRGAGGYGSTGTA
HHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA