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The map label for this gene is fabL [H]

Identifier: 121609499

GI number: 121609499

Start: 2873753

End: 2874514

Strand: Direct

Name: fabL [H]

Synonym: Veis_2543

Alternate gene names: 121609499

Gene position: 2873753-2874514 (Clockwise)

Preceding gene: 121609498

Following gene: 121609500

Centisome position: 51.62

GC content: 61.02

Gene sequence:

>762_bases
ATGGAAAGTAAGAATCAAGTTGTCTTCATCACGGGTTCGGGCCGTGGCATCGGCGAGGCCGTCGCCCGTTGGTTCATGGA
ACACGATTCGGATGTAGTCCTGAACTACCGGAAGGCCCATGGCAAGGGCGGCGCGAACATCGAACGCCTGGTGGCGTACG
CCGGCAGCCGTGGCGTGCGTGCGATCCCGGCGATCGGTGACATCTCCGAGCCCCAGGATGTGGAGAAAATGTTCCGAGCC
CTGAAGGATCAGGGCGTATCGCGCCTGGACCACTTGATTCTCAATGCGGCGGCGACGCCGTTCAAGCCATTTTCCGAGAT
GACGAGGAACGATTGGAGGCTGCTGGTGGGCACCAATCTGATCGGCAATGTCGCCTGCGTGAATCGGGCGACTGAACTCA
TGCCTCGGGGTGGCACCATCTGCGCCATTTCCAGCCTGGGCAGCCTGCGGCATCTTCCGAACTACCCGTTGGGCGTAATG
AAGGCAGCGCTGGAGCAACTCATCCGATATCTCGAGATGGAACTGTGCCCGAGAGGCATCCGATCCAACGCGGTGTGTGC
CGGCTTCGTCAACACCGACATGCTCCCAATCCTTCGGCAGAAGTGGCCTAACCTCTTTGAGCACTTGGAAAAGTCGGGCC
GCCCCTACATCATCGAACCGAACGAGGTGGCCGAGGTGGTGGGGTTCCTGACCTCCAAGGCCGCCTCCGCCGTGCGCGGC
GAAGTGCTTGTCGCGGACGCCGGCGTGTCCATTGGCATCTGA

Upstream 100 bases:

>100_bases
CGCGGCGTCGATCCTTCCCGCGCGAAGGGCCTCCAAGTTGGTGATCGCGCAAGCCTTTCGCCACAGCTAAGCGTCAAGGA
TCATTTGTTCTTTCATCACG

Downstream 100 bases:

>100_bases
TGGCCGACGACTTTTCAGGAGGAAGTATCTTGAATCACCGGTTCCTTTCGACGCTGCTCGGCCTGGCCCTGGCCGTCCCA
CTGCCTCTTGCGGCAGTGGC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MESKNQVVFITGSGRGIGEAVARWFMEHDSDVVLNYRKAHGKGGANIERLVAYAGSRGVRAIPAIGDISEPQDVEKMFRA
LKDQGVSRLDHLILNAAATPFKPFSEMTRNDWRLLVGTNLIGNVACVNRATELMPRGGTICAISSLGSLRHLPNYPLGVM
KAALEQLIRYLEMELCPRGIRSNAVCAGFVNTDMLPILRQKWPNLFEHLEKSGRPYIIEPNEVAEVVGFLTSKAASAVRG
EVLVADAGVSIGI

Sequences:

>Translated_253_residues
MESKNQVVFITGSGRGIGEAVARWFMEHDSDVVLNYRKAHGKGGANIERLVAYAGSRGVRAIPAIGDISEPQDVEKMFRA
LKDQGVSRLDHLILNAAATPFKPFSEMTRNDWRLLVGTNLIGNVACVNRATELMPRGGTICAISSLGSLRHLPNYPLGVM
KAALEQLIRYLEMELCPRGIRSNAVCAGFVNTDMLPILRQKWPNLFEHLEKSGRPYIIEPNEVAEVVGFLTSKAASAVRG
EVLVADAGVSIGI
>Mature_253_residues
MESKNQVVFITGSGRGIGEAVARWFMEHDSDVVLNYRKAHGKGGANIERLVAYAGSRGVRAIPAIGDISEPQDVEKMFRA
LKDQGVSRLDHLILNAAATPFKPFSEMTRNDWRLLVGTNLIGNVACVNRATELMPRGGTICAISSLGSLRHLPNYPLGVM
KAALEQLIRYLEMELCPRGIRSNAVCAGFVNTDMLPILRQKWPNLFEHLEKSGRPYIIEPNEVAEVVGFLTSKAASAVRG
EVLVADAGVSIGI

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=28.8537549407115, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=30.7086614173228, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=29.4354838709677, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=26.171875, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI209862901, Length=200, Percent_Identity=32, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI19923983, Length=200, Percent_Identity=32, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI40254992, Length=254, Percent_Identity=29.1338582677165, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=30.5660377358491, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786812, Length=266, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=25.390625, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=22.4899598393574, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=24.901185770751, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=28.3400809716599, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787545, Length=255, Percent_Identity=24.7058823529412, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788459, Length=256, Percent_Identity=26.953125, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=26.7716535433071, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=27.1317829457364, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=27.1375464684015, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=29.5019157088123, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=28.0898876404494, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=257, Percent_Identity=27.2373540856031, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=25.7575757575758, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=26.3779527559055, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24643142, Length=256, Percent_Identity=29.296875, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=28.4615384615385, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=27.9693486590038, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=27.5590551181102, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=261, Percent_Identity=27.2030651340996, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644337, Length=194, Percent_Identity=29.8969072164948, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 27569; Mature: 27569

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKNQVVFITGSGRGIGEAVARWFMEHDSDVVLNYRKAHGKGGANIERLVAYAGSRGVR
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHCCCCCE
AIPAIGDISEPQDVEKMFRALKDQGVSRLDHLILNAAATPFKPFSEMTRNDWRLLVGTNL
ECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCC
IGNVACVNRATELMPRGGTICAISSLGSLRHLPNYPLGVMKAALEQLIRYLEMELCPRGI
HHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
RSNAVCAGFVNTDMLPILRQKWPNLFEHLEKSGRPYIIEPNEVAEVVGFLTSKAASAVRG
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCC
EVLVADAGVSIGI
CEEEEECCCCCCC
>Mature Secondary Structure
MESKNQVVFITGSGRGIGEAVARWFMEHDSDVVLNYRKAHGKGGANIERLVAYAGSRGVR
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHCCCCCE
AIPAIGDISEPQDVEKMFRALKDQGVSRLDHLILNAAATPFKPFSEMTRNDWRLLVGTNL
ECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCC
IGNVACVNRATELMPRGGTICAISSLGSLRHLPNYPLGVMKAALEQLIRYLEMELCPRGI
HHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
RSNAVCAGFVNTDMLPILRQKWPNLFEHLEKSGRPYIIEPNEVAEVVGFLTSKAASAVRG
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCC
EVLVADAGVSIGI
CEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]