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The map label for this gene is mmgC [H]

Identifier: 121609456

GI number: 121609456

Start: 2832518

End: 2833684

Strand: Direct

Name: mmgC [H]

Synonym: Veis_2500

Alternate gene names: 121609456

Gene position: 2832518-2833684 (Clockwise)

Preceding gene: 121609455

Following gene: 121609457

Centisome position: 50.88

GC content: 67.95

Gene sequence:

>1167_bases
ATGATCCGCGATCCCGAGGCCTTCGGGCATTTCATAGATCAGTTGCGCGCCTTCGTGCGCAAGGAACTGGTGCCGCACGA
AGCCGAGGTGGCGGCGCGCGACGAGGTGCCGCCCGAGATCGTGCAGCGCATGCGCGGGCAGGGCTTGTTCGGCTACTCGA
TCCCCGCCGCCTATGGCGGCGCCGGCATGACGACCGAGGAACTGATCCTGGCCGCGCTGGAGCTGTCGCAATGCGCGGTG
GCGTTTCGCGCCCGCGTCGGCACCAACACCGGGATCGGCGCGGAAGCGCTGGTGGCCGACGGCACGCCGGCGCAAAAAGA
CAAGTACCTGCCGATGCTGGCCAGCGGCGCATGGACCAGCGCCTTCGCGCTGACCGAGCCCGAGGCCGGCTCGGACGCCT
GCGCACTGCGCACGCGCGCGCTGCGCGACGCTGATCACTACCTGATCAGTGGCAGCAAATGCTTCATCACCAATGCGCCG
ATCGCGCAGCTCTTTACCGTGCTGGCGCGCACCGACCCGGCCCATCCGGGCGCGGGCGGCATCTCGGCCTTCCTGGTCGA
GCGCGACACACCGGGCCTGGTGGTCGGCAAGCCGTATCAGAAGATGGGCCAGGCCGGCTCGCCAGTGGCGCCACTGTATT
TCGACAACTGCCGCGTGCCCGCAGCGAACCTGATCGGCGGCCAGGAGGGCCGGGGCTTCAAGACCGCGATGAAGGTGCTG
AACAAGCAGCGCATTCACCTGGCGGCCCTGTGCATCGGCCCGGCCATGCGCATGTTGCAGGAGGCGGTGCAGCACACCGC
CGGGCGCCGCCAGTTCGGCCAGCCGGTGGGCAGCTTTCAGTTGGTGCAGGCCATGGTGGCCGACTGCCAGACCGAAATCC
ATGCCGCCCGCGCACTGGTGCTGGAGACAGCACGCCAGCGCGACCTGGGGCAGGACGTGGCGATGCAGGCGTCGATGTGC
AAGTACTTCGCCTCCGAAATGTGCGCCCGCGTGGCCGACCGCTGCGTGCAGATGCTCGGTGGCTACGGCTTCATTGCCGA
CAACCCGGTCGAGCGCTTTTACCGCGACGTGCGCCTGTTTCGGCTGTACGAGGGCACCAGCCAGATCCACCAATTGAACA
TTGCCCGGCGCACCTATGCGCAGGCCGGCCATGAGTTCAGGGCATGA

Upstream 100 bases:

>100_bases
ACAACGAGCAGGTGTTCGGCGCGCTCGGTCTGGGCGCTGACGAGCTCGCCTGTCTGCGCTCGGCGCAGGTGATTTGATCG
AAATCGAGGAGCCTTCCCCC

Downstream 100 bases:

>100_bases
AGTGACAGTGACGACACACCGGACCCGACGAAGATGATGAAACCCGGCACCAAAATCCTCACTGCGCTGGCGTTGGCCGC
GCTGCTGCCTGCGGCACTGG

Product: isovaleryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIRDPEAFGHFIDQLRAFVRKELVPHEAEVAARDEVPPEIVQRMRGQGLFGYSIPAAYGGAGMTTEELILAALELSQCAV
AFRARVGTNTGIGAEALVADGTPAQKDKYLPMLASGAWTSAFALTEPEAGSDACALRTRALRDADHYLISGSKCFITNAP
IAQLFTVLARTDPAHPGAGGISAFLVERDTPGLVVGKPYQKMGQAGSPVAPLYFDNCRVPAANLIGGQEGRGFKTAMKVL
NKQRIHLAALCIGPAMRMLQEAVQHTAGRRQFGQPVGSFQLVQAMVADCQTEIHAARALVLETARQRDLGQDVAMQASMC
KYFASEMCARVADRCVQMLGGYGFIADNPVERFYRDVRLFRLYEGTSQIHQLNIARRTYAQAGHEFRA

Sequences:

>Translated_388_residues
MIRDPEAFGHFIDQLRAFVRKELVPHEAEVAARDEVPPEIVQRMRGQGLFGYSIPAAYGGAGMTTEELILAALELSQCAV
AFRARVGTNTGIGAEALVADGTPAQKDKYLPMLASGAWTSAFALTEPEAGSDACALRTRALRDADHYLISGSKCFITNAP
IAQLFTVLARTDPAHPGAGGISAFLVERDTPGLVVGKPYQKMGQAGSPVAPLYFDNCRVPAANLIGGQEGRGFKTAMKVL
NKQRIHLAALCIGPAMRMLQEAVQHTAGRRQFGQPVGSFQLVQAMVADCQTEIHAARALVLETARQRDLGQDVAMQASMC
KYFASEMCARVADRCVQMLGGYGFIADNPVERFYRDVRLFRLYEGTSQIHQLNIARRTYAQAGHEFRA
>Mature_388_residues
MIRDPEAFGHFIDQLRAFVRKELVPHEAEVAARDEVPPEIVQRMRGQGLFGYSIPAAYGGAGMTTEELILAALELSQCAV
AFRARVGTNTGIGAEALVADGTPAQKDKYLPMLASGAWTSAFALTEPEAGSDACALRTRALRDADHYLISGSKCFITNAP
IAQLFTVLARTDPAHPGAGGISAFLVERDTPGLVVGKPYQKMGQAGSPVAPLYFDNCRVPAANLIGGQEGRGFKTAMKVL
NKQRIHLAALCIGPAMRMLQEAVQHTAGRRQFGQPVGSFQLVQAMVADCQTEIHAARALVLETARQRDLGQDVAMQASMC
KYFASEMCARVADRCVQMLGGYGFIADNPVERFYRDVRLFRLYEGTSQIHQLNIARRTYAQAGHEFRA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=35.6948228882834, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI226958412, Length=362, Percent_Identity=34.8066298342541, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI76496475, Length=372, Percent_Identity=35.4838709677419, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI4557235, Length=372, Percent_Identity=35.4838709677419, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI21361497, Length=362, Percent_Identity=34.5303867403315, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=35.4651162790698, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=35.6770833333333, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI4557231, Length=363, Percent_Identity=34.7107438016529, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI187960098, Length=363, Percent_Identity=34.7107438016529, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI4501857, Length=369, Percent_Identity=32.2493224932249, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI7656849, Length=360, Percent_Identity=32.7777777777778, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI48976061, Length=390, Percent_Identity=31.5384615384615, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI211971008, Length=390, Percent_Identity=31.5384615384615, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI4503943, Length=367, Percent_Identity=31.0626702997275, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=30.4225352112676, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI38505218, Length=387, Percent_Identity=29.1989664082687, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786223, Length=358, Percent_Identity=30.7262569832402, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87081958, Length=334, Percent_Identity=29.940119760479, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87081702, Length=331, Percent_Identity=25.9818731117825, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87082384, Length=300, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=37.7659574468085, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=36.8852459016393, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=34.9206349206349, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71985184, Length=368, Percent_Identity=35.3260869565217, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17569725, Length=366, Percent_Identity=35.792349726776, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17538396, Length=365, Percent_Identity=34.2465753424658, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=364, Percent_Identity=35.4395604395604, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17533517, Length=361, Percent_Identity=34.0720221606648, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=291, Percent_Identity=37.1134020618557, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71985192, Length=314, Percent_Identity=34.3949044585987, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17551932, Length=384, Percent_Identity=29.6875, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=366, Percent_Identity=30.6010928961749, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17534353, Length=363, Percent_Identity=30.0275482093664, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=36.0995850622407, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=38.7931034482759, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=32.3420074349442, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=296, Percent_Identity=30.4054054054054, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17531913, Length=175, Percent_Identity=33.1428571428571, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=282, Percent_Identity=28.7234042553192, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=282, Percent_Identity=28.7234042553192, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666513, Length=364, Percent_Identity=37.9120879120879, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI281363737, Length=349, Percent_Identity=35.8166189111748, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24660351, Length=369, Percent_Identity=36.5853658536585, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI21356377, Length=360, Percent_Identity=34.7222222222222, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI21355753, Length=363, Percent_Identity=33.0578512396694, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=34.2318059299191, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI19920834, Length=368, Percent_Identity=30.4347826086957, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24652780, Length=337, Percent_Identity=22.5519287833828, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221473076, Length=339, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550141, Length=339, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42122; Mature: 42122

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRDPEAFGHFIDQLRAFVRKELVPHEAEVAARDEVPPEIVQRMRGQGLFGYSIPAAYGG
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHCCCCCCEECCHHCCC
AGMTTEELILAALELSQCAVAFRARVGTNTGIGAEALVADGTPAQKDKYLPMLASGAWTS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHCCCCCHH
AFALTEPEAGSDACALRTRALRDADHYLISGSKCFITNAPIAQLFTVLARTDPAHPGAGG
EEEECCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCHHHHHHHHHHCCCCCCCCCC
ISAFLVERDTPGLVVGKPYQKMGQAGSPVAPLYFDNCRVPAANLIGGQEGRGFKTAMKVL
CEEEEEECCCCCEEECCCHHHHCCCCCCCCCEEECCCCCCHHHHCCCCCCCCHHHHHHHH
NKQRIHLAALCIGPAMRMLQEAVQHTAGRRQFGQPVGSFQLVQAMVADCQTEIHAARALV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LETARQRDLGQDVAMQASMCKYFASEMCARVADRCVQMLGGYGFIADNPVERFYRDVRLF
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
RLYEGTSQIHQLNIARRTYAQAGHEFRA
HHHHCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIRDPEAFGHFIDQLRAFVRKELVPHEAEVAARDEVPPEIVQRMRGQGLFGYSIPAAYGG
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHCCCCCCEECCHHCCC
AGMTTEELILAALELSQCAVAFRARVGTNTGIGAEALVADGTPAQKDKYLPMLASGAWTS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHCCCCCHH
AFALTEPEAGSDACALRTRALRDADHYLISGSKCFITNAPIAQLFTVLARTDPAHPGAGG
EEEECCCCCCCCHHHHHHHHHHCCCCEEEECCEEEEECCCHHHHHHHHHHCCCCCCCCCC
ISAFLVERDTPGLVVGKPYQKMGQAGSPVAPLYFDNCRVPAANLIGGQEGRGFKTAMKVL
CEEEEEECCCCCEEECCCHHHHCCCCCCCCCEEECCCCCCHHHHCCCCCCCCHHHHHHHH
NKQRIHLAALCIGPAMRMLQEAVQHTAGRRQFGQPVGSFQLVQAMVADCQTEIHAARALV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LETARQRDLGQDVAMQASMCKYFASEMCARVADRCVQMLGGYGFIADNPVERFYRDVRLF
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
RLYEGTSQIHQLNIARRTYAQAGHEFRA
HHHHCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]