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The map label for this gene is yngE [H]

Identifier: 121609370

GI number: 121609370

Start: 2726840

End: 2728453

Strand: Direct

Name: yngE [H]

Synonym: Veis_2413

Alternate gene names: 121609370

Gene position: 2726840-2728453 (Clockwise)

Preceding gene: 121609369

Following gene: 121609371

Centisome position: 48.98

GC content: 68.84

Gene sequence:

>1614_bases
ATGACACCCATCGAATCCCGAATCGACACCGCACAGGCCGCCTACGCCGAGCAGCGCCAGGGCATGCTGGCCCTGATCGA
GCGCCTGCGGCAGTTGGAGCAGCGAACCCGGGACGCCTCGGCCAAGGCCAAGGCAGCCTTCGACAAGCGCGGCGCACTGC
TGCCGAGGGAGCGCGTGGCGCGGCTGCTCGATCCTGGCGCCCCCTTCCTGGAGCTCGGCAACATGGCCGGCTACTGCGCC
GAAGGAGAAACGCCGGAGACATCGGTGCCCGGCGGTGGGCAGATCACCGGCATCGGTTTCGTGTGCGGCGTGCGCTGCAT
GGTGGCCGCCTCCGATTCGGCCATCGCTGCCGGCGCTTACGTGGACGCCGGCAGCAAGAAACTGCTGCGCGCGCAGGAGA
TCGCGCTGGAAAACCGGCTGCCCTTCATTCACCTGGTGGAGTCCGCCGGCGCCAATCTGCGCACCTACCGGGTCGAGCGC
TTCATCCGCGGCGGCGGCCTGTTCTACAACCTGGCGCGCCTGTCCGCCGCCGGCCTGCCCGTCATCACCGTCGTGCACGG
CCCATCGACCGCCGGCGGCGCCTACATGCCGGGTCTGTCGGACTATGTGGTGATGGTGCGCCGACGCGCACGCGCCTTCC
TCGCCGGCCCGCCGCTGCTCCTGGCGGCCACCGGAGAAATCGCCACCGACGAGGAACTCGGCGGTGCCGACATGCATGCC
CGGACCAGCGGCCTGGCCGAGTATGTCGGCGAGGACGACGCGCACGCGATTGCCATCGCACGCGACATCGTCGCCGCGCT
CGACTGGGCTGCTCCTGCGCCGGCACGGGCGGGCAAGCCGCCGGTGCTGGACCCGGACGAACTGGCCGGCGTGATGCCGT
TGGACGTGAAAAAGCCGGTCGACATGCAGCAGGTGATCGCCCGCATCGTCGACGAATCGGCCTGGCTCGCGTTCAAGCCC
GATTACGGCGTATCGACGCTGTGCGGGCATGCCCGCATCGAGGGGCATGGGGTCGGCCTCATCAGCAACAACGGCCCCAT
CGACCCGGCCGGTGCCACCAAGGCGGCGCAGTTCATCCAGTTGTGCAACCAGTCGGCCACGCCGATCGTCTTCATGCAGA
ACACCACCGGATTCATCGTCGGGCGCATGTCCGAGGAGGCCGGGATGATCAAGCACGGCGCCAAGATGATCCAGGCGCTG
TCCAACTCGCGCGTGCCGCATGTCACCTTGTATTGCGGCGCCTCTTTCGGTGCCGGCAACTACGGCATGTGCGGCCAGGC
GTTCCGGCCGTGCATGAGCTTTTCCTGGCCCAACGCCAAAACCGCCGTCATGGGCGGCGAGCAGGCCGCCATGACCATGG
ACATCGTGGCGCGGCAACAGGCCGGGCGCAGCGGCAAACCGGTCGACGAGGAGGCGCTGGCGCGCCAGAGGGCGCAGATC
ATCGCCAACTTCGAGCGCCAAGCCAGCGCCTTCATCACCAGCGGCCTGATGTTGGACGACGCAATCATCGACCCGCGCAG
CACCCGCGCGGTGCTCGGTTTCGTGCTGGCCATGGCGCGAGAGGCCCCATTGCGCCGGGGCCACCCCGTGCAGTTCGGCG
TGGCCCGCTTCTGA

Upstream 100 bases:

>100_bases
TCACCGGGCTGGAAATCAATCCCTTGCCGGCCAGGCCGCAGGGCCAAGGCGTGATCGCCCTGGATGCCCTGCTGCGGACC
ACGGCCGACGAGACCGCGCC

Downstream 100 bases:

>100_bases
TGCCCCCTTTTCTGGAGCACCACCATGTACACAGCAGAACACCACAGCATCATGCAAAGCATCCGCCGCTTCCTGGCCAG
CGAGGTGGACCCGTTCGTCG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTPIESRIDTAQAAYAEQRQGMLALIERLRQLEQRTRDASAKAKAAFDKRGALLPRERVARLLDPGAPFLELGNMAGYCA
EGETPETSVPGGGQITGIGFVCGVRCMVAASDSAIAAGAYVDAGSKKLLRAQEIALENRLPFIHLVESAGANLRTYRVER
FIRGGGLFYNLARLSAAGLPVITVVHGPSTAGGAYMPGLSDYVVMVRRRARAFLAGPPLLLAATGEIATDEELGGADMHA
RTSGLAEYVGEDDAHAIAIARDIVAALDWAAPAPARAGKPPVLDPDELAGVMPLDVKKPVDMQQVIARIVDESAWLAFKP
DYGVSTLCGHARIEGHGVGLISNNGPIDPAGATKAAQFIQLCNQSATPIVFMQNTTGFIVGRMSEEAGMIKHGAKMIQAL
SNSRVPHVTLYCGASFGAGNYGMCGQAFRPCMSFSWPNAKTAVMGGEQAAMTMDIVARQQAGRSGKPVDEEALARQRAQI
IANFERQASAFITSGLMLDDAIIDPRSTRAVLGFVLAMAREAPLRRGHPVQFGVARF

Sequences:

>Translated_537_residues
MTPIESRIDTAQAAYAEQRQGMLALIERLRQLEQRTRDASAKAKAAFDKRGALLPRERVARLLDPGAPFLELGNMAGYCA
EGETPETSVPGGGQITGIGFVCGVRCMVAASDSAIAAGAYVDAGSKKLLRAQEIALENRLPFIHLVESAGANLRTYRVER
FIRGGGLFYNLARLSAAGLPVITVVHGPSTAGGAYMPGLSDYVVMVRRRARAFLAGPPLLLAATGEIATDEELGGADMHA
RTSGLAEYVGEDDAHAIAIARDIVAALDWAAPAPARAGKPPVLDPDELAGVMPLDVKKPVDMQQVIARIVDESAWLAFKP
DYGVSTLCGHARIEGHGVGLISNNGPIDPAGATKAAQFIQLCNQSATPIVFMQNTTGFIVGRMSEEAGMIKHGAKMIQAL
SNSRVPHVTLYCGASFGAGNYGMCGQAFRPCMSFSWPNAKTAVMGGEQAAMTMDIVARQQAGRSGKPVDEEALARQRAQI
IANFERQASAFITSGLMLDDAIIDPRSTRAVLGFVLAMAREAPLRRGHPVQFGVARF
>Mature_536_residues
TPIESRIDTAQAAYAEQRQGMLALIERLRQLEQRTRDASAKAKAAFDKRGALLPRERVARLLDPGAPFLELGNMAGYCAE
GETPETSVPGGGQITGIGFVCGVRCMVAASDSAIAAGAYVDAGSKKLLRAQEIALENRLPFIHLVESAGANLRTYRVERF
IRGGGLFYNLARLSAAGLPVITVVHGPSTAGGAYMPGLSDYVVMVRRRARAFLAGPPLLLAATGEIATDEELGGADMHAR
TSGLAEYVGEDDAHAIAIARDIVAALDWAAPAPARAGKPPVLDPDELAGVMPLDVKKPVDMQQVIARIVDESAWLAFKPD
YGVSTLCGHARIEGHGVGLISNNGPIDPAGATKAAQFIQLCNQSATPIVFMQNTTGFIVGRMSEEAGMIKHGAKMIQALS
NSRVPHVTLYCGASFGAGNYGMCGQAFRPCMSFSWPNAKTAVMGGEQAAMTMDIVARQQAGRSGKPVDEEALARQRAQII
ANFERQASAFITSGLMLDDAIIDPRSTRAVLGFVLAMAREAPLRRGHPVQFGVARF

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=536, Percent_Identity=43.6567164179104, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI119943100, Length=475, Percent_Identity=30.7368421052632, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI295821216, Length=495, Percent_Identity=29.4949494949495, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI310133460, Length=141, Percent_Identity=48.2269503546099, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17552936, Length=543, Percent_Identity=39.4106813996317, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI25147359, Length=486, Percent_Identity=29.4238683127572, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147362, Length=486, Percent_Identity=29.4238683127572, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24586065, Length=555, Percent_Identity=42.8828828828829, Blast_Score=437, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 56955; Mature: 56824

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIESRIDTAQAAYAEQRQGMLALIERLRQLEQRTRDASAKAKAAFDKRGALLPRERVA
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHH
RLLDPGAPFLELGNMAGYCAEGETPETSVPGGGQITGIGFVCGVRCMVAASDSAIAAGAY
HHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHEEEECCCCEECCCE
VDAGSKKLLRAQEIALENRLPFIHLVESAGANLRTYRVERFIRGGGLFYNLARLSAAGLP
ECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCC
VITVVHGPSTAGGAYMPGLSDYVVMVRRRARAFLAGPPLLLAATGEIATDEELGGADMHA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHH
RTSGLAEYVGEDDAHAIAIARDIVAALDWAAPAPARAGKPPVLDPDELAGVMPLDVKKPV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCC
DMQQVIARIVDESAWLAFKPDYGVSTLCGHARIEGHGVGLISNNGPIDPAGATKAAQFIQ
CHHHHHHHHHCCCCEEEECCCCCHHHHHCCCEECCCEEEEECCCCCCCCCCHHHHHHHHH
LCNQSATPIVFMQNTTGFIVGRMSEEAGMIKHGAKMIQALSNSRVPHVTLYCGASFGAGN
HHCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
YGMCGQAFRPCMSFSWPNAKTAVMGGEQAAMTMDIVARQQAGRSGKPVDEEALARQRAQI
CCCCHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IANFERQASAFITSGLMLDDAIIDPRSTRAVLGFVLAMAREAPLRRGHPVQFGVARF
HHHHHHHHHHHHHHCCEEHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPIESRIDTAQAAYAEQRQGMLALIERLRQLEQRTRDASAKAKAAFDKRGALLPRERVA
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHH
RLLDPGAPFLELGNMAGYCAEGETPETSVPGGGQITGIGFVCGVRCMVAASDSAIAAGAY
HHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHEEEECCCCEECCCE
VDAGSKKLLRAQEIALENRLPFIHLVESAGANLRTYRVERFIRGGGLFYNLARLSAAGLP
ECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCC
VITVVHGPSTAGGAYMPGLSDYVVMVRRRARAFLAGPPLLLAATGEIATDEELGGADMHA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHH
RTSGLAEYVGEDDAHAIAIARDIVAALDWAAPAPARAGKPPVLDPDELAGVMPLDVKKPV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCC
DMQQVIARIVDESAWLAFKPDYGVSTLCGHARIEGHGVGLISNNGPIDPAGATKAAQFIQ
CHHHHHHHHHCCCCEEEECCCCCHHHHHCCCEECCCEEEEECCCCCCCCCCHHHHHHHHH
LCNQSATPIVFMQNTTGFIVGRMSEEAGMIKHGAKMIQALSNSRVPHVTLYCGASFGAGN
HHCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
YGMCGQAFRPCMSFSWPNAKTAVMGGEQAAMTMDIVARQQAGRSGKPVDEEALARQRAQI
CCCCHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IANFERQASAFITSGLMLDDAIIDPRSTRAVLGFVLAMAREAPLRRGHPVQFGVARF
HHHHHHHHHHHHHHCCEEHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]