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The map label for this gene is nuoE

Identifier: 121639032

GI number: 121639032

Start: 3467704

End: 3468462

Strand: Direct

Name: nuoE

Synonym: BCG_3172

Alternate gene names: 121639032

Gene position: 3467704-3468462 (Clockwise)

Preceding gene: 121639031

Following gene: 121639033

Centisome position: 79.27

GC content: 67.85

Gene sequence:

>759_bases
GTGACACAGCCACCCGGTCAGCCGGTGTTCATCCGGCTCGGACCGCCACCGGACGAACCCAACCAGTTTGTCGTCGAGGG
CGCTCCGCGGTCGTATCCGCCGGACGTACTGGCGCGGCTGGAGGTCGACGCCAAGGAGATCATCGGCCGCTATCCCGACA
GGCGCTCGGCGCTGTTGCCGTTGCTGCACCTGGTGCAGGGCGAGGATTCCTACCTGACGCCGGCGGGTTTGCGGTTCTGC
GCCGATCAACTCGGGCTGACCGGGGCCGAGGTGTCGGCGGTGGCCAGCTTCTACACCATGTACCGCCGGCGCCCCACCGG
CGAGTACCTGGTGGGTGTGTGCACGAACACGCTGTGCGCCGTCATGGGTGGCGACGCCATCTTCGACCGCCTCAAAGAGC
ATCTCGGCGTCGGCCACGACGAAACCACCTCCGACGGTGTGGTCACCTTGCAACACATCGAATGCAACGCCGCCTGCGAT
TACGCACCGGTGGTGATGGTCAACTGGGAATTCTTCGACAACCAGACGCCGGAGTCCGCGCGCGAACTCGTCGACTCGCT
GCGCTCCGACACACCGAAGGCGCCCACCCGCGGCGCGCCGCTGTGCGGCTTCCGGCAAACATCGCGCATCCTGGCGGGTC
TACCCGACCAGCGTCCCGACGAAGGCCAGGGCGGTCCCGGCGCGCCCACCCTGGCCGGGCTGCAGGTGGCAAGGAAGAAC
GACATGCAGGCGCCACCAACCCCCGGAGCGGACGAATGA

Upstream 100 bases:

>100_bases
CCAACCTGCAGTCCGTCGCCGCGATGTGCGAAGGCGGGATGGTCGCCGATTTGATCGCGGCGGTCGCCAGCATTGACCCG
GTCATGGGCGGGGTGGACCG

Downstream 100 bases:

>100_bases
CCACGCAGGCCACCCCGTTGACCCCGGTGATCAGCCGCCACTGGGACGACCCGGAGTCGTGGACCCTGGCCACTTATCAA
CGCCACGATCGCTATCGGGG

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAKEIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFC
ADQLGLTGAEVSAVASFYTMYRRRPTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACD
YAPVVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEGQGGPGAPTLAGLQVARKN
DMQAPPTPGADE

Sequences:

>Translated_252_residues
MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAKEIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFC
ADQLGLTGAEVSAVASFYTMYRRRPTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACD
YAPVVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEGQGGPGAPTLAGLQVARKN
DMQAPPTPGADE
>Mature_251_residues
TQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAKEIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFCA
DQLGLTGAEVSAVASFYTMYRRRPTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACDY
APVVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEGQGGPGAPTLAGLQVARKND
MQAPPTPGADE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family

Homologues:

Organism=Homo sapiens, GI222080062, Length=191, Percent_Identity=31.413612565445, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1788621, Length=141, Percent_Identity=29.0780141843972, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561328, Length=147, Percent_Identity=35.3741496598639, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI18859877, Length=197, Percent_Identity=32.48730964467, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355353, Length=158, Percent_Identity=34.8101265822785, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOE_MYCBO (P65574)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_856818.1
- ProteinModelPortal:   P65574
- SMR:   P65574
- EnsemblBacteria:   EBMYCT00000017602
- GeneID:   1092124
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3173
- GeneTree:   EBGT00050000017073
- HOGENOM:   HBG616790
- OMA:   AACDFAP
- ProtClustDB:   PRK07539
- BioCyc:   MBOV233413:MB3173-MONOMER
- BRENDA:   1.6.99.5
- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10371
- PIRSF:   PIRSF000216
- TIGRFAMs:   TIGR01958

Pfam domain/function: PF01257 Complex1_24kDa; SSF52833 Thiordxn-like_fd

EC number: =1.6.99.5

Molecular weight: Translated: 27198; Mature: 27067

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAKEIIGRYPDRRSALLP
CCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHCCCHHHHHCCCCCHHHHHHH
LLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYRRRPTGEYLVGVCTNTLCA
HHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACDYAPVVMVNWEFFDNQTPESA
HHCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCCCHHH
RELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEGQGGPGAPTLAGLQVARKN
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHC
DMQAPPTPGADE
CCCCCCCCCCCC
>Mature Secondary Structure 
TQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAKEIIGRYPDRRSALLP
CCCCCCEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHCCCHHHHHCCCCCHHHHHHH
LLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYRRRPTGEYLVGVCTNTLCA
HHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACDYAPVVMVNWEFFDNQTPESA
HHCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCCCCCHHH
RELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEGQGGPGAPTLAGLQVARKN
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHC
DMQAPPTPGADE
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972