Click here to switch to the map view.

The map label for this gene is nuoD [H]

Identifier: 121639031

GI number: 121639031

Start: 3466385

End: 3467707

Strand: Direct

Name: nuoD [H]

Synonym: BCG_3171

Alternate gene names: 121639031

Gene position: 3466385-3467707 (Clockwise)

Preceding gene: 121639030

Following gene: 121639032

Centisome position: 79.24

GC content: 63.27

Gene sequence:

>1323_bases
ATGACGGCAATCGCCGACTCGGCTGGCGGCGCCGGCGAGACCGTCCTGGTCGCTGGCGGGCAGGACTGGCAGCAGGTCGT
GGACGCCGCGCGCAGCGCGGATCCCGGTGAACGCATCGTCGTCAACATGGGGCCCCAGCACCCGTCTACCCACGGGGTGT
TGCGGTTAATCCTGGAGATCGAGGGCGAAACAGTCGTCGAAGCCCGGTGCGGAATCGGCTACCTGCACACCGGAATCGAG
AAGAACCTCGAATACCGGTACTGGACCCAGGGCGTCACCTTCGTGACCCGAATGGATTACCTGTCACCGTTTTTCAACGA
AACCGCCTACTGCCTCGGCGTGGAGAAGCTGCTCGGCATCACCGATGAGATACCCGAGCGGGTCAATGTCATCCGCGTGC
TGATGATGGAGCTCAACCGGATCTCGTCGCATTTGGTCGCATTGGCGACCGGGGGCATGGAATTGGGCGCCATGACTCCG
ATGTTCGTCGGCTTCCGGGCACGCGAGATCGTGCTCACGCTGTTCGAAAAGATCACCGGTTTGCGGATGAACAGCGCCTA
CATCCGACCCGGCGGCGTGGCGCAGGACTTACCGCCCAACGCGGCCACCGAAATCGCGGAAGCACTCAAGCAGTTGCGCC
AACCACTGCGCGAAATGGGCGAGCTGCTCAACGAAAACGCCATCTGGAAGGCCCGCACCCAGGGCGTCGGATACCTGGAT
CTGACCGGATGCATGGCACTGGGCATCACCGGCCCGATACTGCGTTCCACTGGGTTGCCCCACGACCTGCGGAAAAGCGA
GCCCTACTGCGGATACCAGCACTATGAATTCGATGTGATCACCGACGACAGCTGTGATGCCTACGGGCGCTACATGATTC
GCGTCAAAGAGATGTGGGAGTCGATGAAGATCGTGGAGCAGTGTCTGGACAAGTTACGACCCGGCCCGACCATGATCTCC
GATCGCAAGCTCGCCTGGCCGGCCGACCTGCAGGTGGGGCCCGACGGCCTGGGCAACTCACCCAAGCACATCGCCAAAAT
CATGGGCTCCTCGATGGAAGCGCTGATCCACCACTTCAAACTGGTCACCGAGGGCATCCGGGTGCCGGCGGGCCAGGTCT
ACGTCGCGGTGGAGTCCCCCCGTGGTGAGCTCGGCGTACACATGGTCAGCGACGGTGGCACCCGCCCCTACCGGGTGCAC
TACCGGGATCCCTCCTTCACCAACCTGCAGTCCGTCGCCGCGATGTGCGAAGGCGGGATGGTCGCCGATTTGATCGCGGC
GGTCGCCAGCATTGACCCGGTCATGGGCGGGGTGGACCGGTGA

Upstream 100 bases:

>100_bases
AGGGGCATCCGCAACGCAAGGACTACCCTCTCGGCGGCATCCCGGTCGAATACAAGGGCGCGCAGATACCCCCGCCCGAC
GAGCGGAGGGGCTACAACTG

Downstream 100 bases:

>100_bases
CACAGCCACCCGGTCAGCCGGTGTTCATCCGGCTCGGACCGCCACCGGACGAACCCAACCAGTTTGTCGTCGAGGGCGCT
CCGCGGTCGTATCCGCCGGA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGPQHPSTHGVLRLILEIEGETVVEARCGIGYLHTGIE
KNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTP
MFVGFRAREIVLTLFEKITGLRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGELLNENAIWKARTQGVGYLD
LTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVITDDSCDAYGRYMIRVKEMWESMKIVEQCLDKLRPGPTMIS
DRKLAWPADLQVGPDGLGNSPKHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVH
YRDPSFTNLQSVAAMCEGGMVADLIAAVASIDPVMGGVDR

Sequences:

>Translated_440_residues
MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGPQHPSTHGVLRLILEIEGETVVEARCGIGYLHTGIE
KNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTP
MFVGFRAREIVLTLFEKITGLRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGELLNENAIWKARTQGVGYLD
LTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVITDDSCDAYGRYMIRVKEMWESMKIVEQCLDKLRPGPTMIS
DRKLAWPADLQVGPDGLGNSPKHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVH
YRDPSFTNLQSVAAMCEGGMVADLIAAVASIDPVMGGVDR
>Mature_439_residues
TAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGPQHPSTHGVLRLILEIEGETVVEARCGIGYLHTGIEK
NLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTPM
FVGFRAREIVLTLFEKITGLRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGELLNENAIWKARTQGVGYLDL
TGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVITDDSCDAYGRYMIRVKEMWESMKIVEQCLDKLRPGPTMISD
RKLAWPADLQVGPDGLGNSPKHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVHY
RDPSFTNLQSVAAMCEGGMVADLIAAVASIDPVMGGVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=404, Percent_Identity=43.3168316831683, Blast_Score=334, Evalue=9e-92,
Organism=Homo sapiens, GI260898743, Length=394, Percent_Identity=42.8934010152284, Blast_Score=325, Evalue=5e-89,
Organism=Escherichia coli, GI145693162, Length=411, Percent_Identity=38.4428223844282, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1789076, Length=403, Percent_Identity=26.7990074441687, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788832, Length=404, Percent_Identity=27.4752475247525, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17568379, Length=404, Percent_Identity=41.0891089108911, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17555284, Length=404, Percent_Identity=40.5940594059406, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI221459469, Length=431, Percent_Identity=39.2111368909513, Blast_Score=344, Evalue=7e-95,
Organism=Drosophila melanogaster, GI24638644, Length=402, Percent_Identity=41.044776119403, Blast_Score=338, Evalue=5e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48165; Mature: 48034

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGPQHPSTHGVLRLILEI
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEEE
EGETVVEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGI
CCCEEEEHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHEEHHHHHCC
TDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTPMFVGFRAREIVLTLFEKITG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHC
LRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGELLNENAIWKARTQGVGYLD
CCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
LTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVITDDSCDAYGRYMIRVKEMWE
HHHHHHHCCCCHHHHCCCCCCHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHH
SMKIVEQCLDKLRPGPTMISDRKLAWPADLQVGPDGLGNSPKHIAKIMGSSMEALIHHFK
HHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQSVAAMCEGGM
HHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCCH
VADLIAAVASIDPVMGGVDR
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGPQHPSTHGVLRLILEI
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEEE
EGETVVEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGI
CCCEEEEHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHEEHHHHHCC
TDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTPMFVGFRAREIVLTLFEKITG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHC
LRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGELLNENAIWKARTQGVGYLD
CCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
LTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVITDDSCDAYGRYMIRVKEMWE
HHHHHHHCCCCHHHHCCCCCCHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHH
SMKIVEQCLDKLRPGPTMISDRKLAWPADLQVGPDGLGNSPKHIAKIMGSSMEALIHHFK
HHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQSVAAMCEGGM
HHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHCCCH
VADLIAAVASIDPVMGGVDR
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA