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The map label for this gene is nuoA

Identifier: 121639028

GI number: 121639028

Start: 3464729

End: 3465115

Strand: Direct

Name: nuoA

Synonym: BCG_3168

Alternate gene names: 121639028

Gene position: 3464729-3465115 (Clockwise)

Preceding gene: 121639026

Following gene: 121639029

Centisome position: 79.2

GC content: 63.57

Gene sequence:

>387_bases
TTGAACGTCTACATACCCATCCTGGTACTGGCGGCGCTGGCCGCCGCCTTCGCCGTGGTGTCGGTGGTGATCGCGAGCCT
GGTCGGCCCGTCGCGGTTCAACCGGTCAAAGCAGGCCGCCTACGAATGCGGGATCGAGCCCGCTAGCACTGGAGCCAGAA
CCTCCATTGGCCCCGGCGCGGCGAGCGGGCAGCGGTTCCCCATCAAGTACTACCTGACCGCGATGTTGTTCATCGTCTTC
GACATCGAAATTGTGTTCCTCTACCCGTGGGCGGTCAGCTACGACTCGCTGGGCACGTTCGCGCTGGTCGAGATGGCGAT
ATTCATGCTCACGGTGTTCGTGGCCTACGCGTATGTGTGGCGCCGCGGGGGCCTGACGTGGGATTGA

Upstream 100 bases:

>100_bases
GAAGGGCACTGTGACGGCCCGAAGCCCCGGTTCGTCACGGCAGCCCGGTCACCGCCCGGCCGCCGCGCTGGCGGCCCCGT
ACGACGGATCATGGAGCGAG

Downstream 100 bases:

>100_bases
GGTAGGGCGTGGGACTGGAAGAACAGCTGCCCGGCGGGATCCTGCTGTCGACCGTCGAGAAGGTGGCGGGCTATGTCCGC
AAAAACTCCCTGTGGCCGGC

Product: NADH dehydrogenase subunit A

Products: NA

Alternate protein names: NADH dehydrogenase I subunit A; NDH-1 subunit A; NUO1

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGIEPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVF
DIEIVFLYPWAVSYDSLGTFALVEMAIFMLTVFVAYAYVWRRGGLTWD

Sequences:

>Translated_128_residues
MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGIEPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVF
DIEIVFLYPWAVSYDSLGTFALVEMAIFMLTVFVAYAYVWRRGGLTWD
>Mature_128_residues
MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGIEPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVF
DIEIVFLYPWAVSYDSLGTFALVEMAIFMLTVFVAYAYVWRRGGLTWD

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0838

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 3 (chain A)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 3 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOA_MYCBO (P65564)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_856814.1
- EnsemblBacteria:   EBMYCT00000015951
- GeneID:   1092963
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3169
- GeneTree:   EBGT00050000016339
- HOGENOM:   HBG605540
- OMA:   IGFAYEW
- ProtClustDB:   PRK07928
- BioCyc:   MBOV233413:MB3169-MONOMER
- BRENDA:   1.6.99.5
- GO:   GO:0006810
- HAMAP:   MF_01394
- InterPro:   IPR023043
- InterPro:   IPR000440
- PANTHER:   PTHR11058

Pfam domain/function: PF00507 Oxidored_q4

EC number: =1.6.99.5

Molecular weight: Translated: 13976; Mature: 13976

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1880b054)-; HASH(0x18583818)-; HASH(0x189f9eb4)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGIEPASTGARTSIGPGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCC
ASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFALVEMAIFMLTVFVAYAYVW
CCCCCCHHHHHHHHHHHHHHHHHHHEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RRGGLTWD
HCCCCCCH
>Mature Secondary Structure
MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGIEPASTGARTSIGPGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCC
ASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFALVEMAIFMLTVFVAYAYVW
CCCCCCHHHHHHHHHHHHHHHHHHHEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RRGGLTWD
HCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972